scholarly journals Multiple Paraneoplastic Neurological and Rheumatological Syndromes Revealing an Ovarian Cancer

2021 ◽  
pp. 1-3
Author(s):  
Ioana Maria Ion ◽  
Anca Badoiu ◽  
Eric Thouvenot ◽  
Morgane Petot ◽  
Vincent Boudousq ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Detection ◽  
Early Detection Of Cancer ◽  
Multiple Organ ◽  
Paraneoplastic Syndromes ◽  
Cerebellar Syndrome ◽  
Onconeural Antibodies ◽  
Organ Systems ◽  
Sensory Motor ◽  
Palmar Fasciitis

Multiple paraneoplastic syndromes are a rare clinical manifestation. We describe the case of an 82-year-old woman who presented with neurological (rapidly progressive cerebellar syndrome and combined sensory-motor neuronopathy) and rheumatological (palmar fasciitis and polyarthritis syndrome) paraneoplastic syndromes associated with two onconeural antibodies (anti-Yo and Zic4), that revealed an ovarian cancer. The involvement of multiple organ systems should be a clue to take into consideration a paraneoplastic etiology that could permit early detection of cancer. However, despite the existence of treatments, the prognosis of these conditions remains poor.

scholarly journals Ovarian Cancer Revealed by Paraneoplastic Cerebellar Degeneration Anti-Yo Positive: A Case Report

2020 ◽  
Vol 5 (12) ◽  
pp. 635-637
Author(s):  
Hayat Erraichi ◽  
Niaina Ezra Randriamanovontsoa ◽  
Valère Litique ◽  
Jean-Marc Limacher ◽  
S. Berrad ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ovarian Cancer ◽  
Gynecological Cancer ◽  
Cerebellar Degeneration ◽  
Small Cell ◽  
Paraneoplastic Syndromes ◽  
Tumor Treatment ◽  
Small Cell Lung ◽  
Cerebellar Syndrome ◽  
Onconeural Antibodies

Neurological paraneoplastic syndromes are rare, often associated with gynecological cancer or small cell lung cancer. This article reports a case of ovarian cancer to discuss the difficulties in the management of neurological paraneoplastic syndromes. This is a case of paraneoplastic cerebellar syndrome with anti-Yo antibodies. Neurological syndromes, testing for onconeural antibodies and testing for underlying cancer provide a basis for the diagnosis. The anti-tumor treatment constitutes the mainstay of the care.

scholarly journals Clinical Utility of Preoperative Assessment in Ovarian Cancer Cytoreduction

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 568
Author(s):  
Pratistha Koirala ◽  
Ashley S Moon ◽  
Linus Chuang
Keyword(s):  
Ovarian Cancer ◽  
Clinical Utility ◽  
Gynecologic Cancer ◽  
Preoperative Assessment ◽  
Late Presentation ◽  
Multiple Organ ◽  
Optimal Management ◽  
Novel Therapies ◽  
Organ Systems ◽  
Disseminated Disease

Ovarian cancer is the deadliest gynecologic cancer, in part due to late presentation. Many women have vague early symptoms and present with disseminated disease. Cytoreductive surgery can be extensive, involving multiple organ systems. Novel therapies and recent clinical trials have provided evidence that, compared to primary cytoreduction, neoadjuvant chemotherapy has equivalent survival outcomes with less morbidity. There is increasing need for validated tools and mechanisms for clinicians to determine the optimal management of ovarian cancer patients.

Microprobe analysis of inclusion bodies related to two benzofuran derivatives

1987 ◽  
Vol 45 ◽  
pp. 672-673
Author(s):  
T. L. Benning ◽  
P. Ingram ◽  
J. D. Shelburne
Keyword(s):  
Inclusion Bodies ◽  
Uranyl Acetate ◽  
Multiple Organ ◽  
High Dose ◽  
En Bloc ◽  
Tissue Samples ◽  
Transmission Electron ◽  
Organ Systems ◽  
Dense Inclusion ◽  
Melanin Complex

Two benzofuran derivatives, chlorpromazine and amiodarone, are known to produce inclusion bodies in human tissues. Prolonged high dose chlorpromazine therapy causes hyperpigmentation of the skin with electron-dense inclusion bodies present in dermal histiocytes and endothelial cells ultrastructurally. The nature of the deposits is not known although a drug-melanin complex has been hypothesized. Amiodarone may also cause cutaneous hyperpigmentation and lamellar lysosomal inclusion bodies have been demonstrated within the cells of multiple organ systems. These lamellar bodies are believed to be the product of an amiodarone-induced phospholipid storage disorder. We performed transmission electron microscopy (TEM) and energy dispersive x-ray microanalysis (EDXA) on tissue samples from patients treated with these drugs, attempting to detect the sulfur atom of chlorpromazine and the iodine atom of amiodarone within their respective inclusion bodies.A skin biopsy from a patient with hyperpigmentation due to prolonged chlorpromazine therapy was fixed in 4% glutaraldehyde and processed without osmium tetroxide or en bloc uranyl acetate for Epon embedding.

Impairment Rating and Spinal Cord Injuries: Revisiting the Guides

2010 ◽  
Vol 15 (3) ◽  
pp. 1-7
Author(s):  
Richard T. Katz
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injuries ◽  
Functional Independence ◽  
Outcome Data ◽  
Multiple Organ ◽  
Loss Of Function ◽  
Sixth Edition ◽  
Organ Systems ◽  
Cord Injury ◽  
Impairment Ratings

Abstract This article addresses some criticisms of the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) by comparing previously published outcome data from a group of complete spinal cord injury (SCI) persons with impairment ratings for a corresponding level of injury calculated using the AMA Guides, Sixth Edition. Results of the comparison show that impairment ratings using the sixth edition scale poorly with the level of impairments of activities of daily living (ADL) in SCI patients as assessed by the Functional Independence Measure (FIM) motor scale and the extended FIM motor scale. Because of the combinations of multiple impairments, the AMA Guides potentially overrates the impairment of paraplegics compared with that of quadriplegics. The use and applicability of the Combined Values formula should be further investigated, and complete loss of function of two upper extremities seems consistent with levels of quadriplegia using the SCI model. Some aspects of the AMA Guides contain inconsistencies. The concept of diminishing impairment values is not easily translated between specific losses of function per organ system and “overall” loss of ADLs involving multiple organ systems, and the notion of “catastrophic thresholds” involving multiple organ systems may support the understanding that variations in rating may exist in higher rating cases such as those that involve an SCI.

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