scholarly journals Verneuil’s Disease or Hidradenitis Suppurativa Complicated by Verrucous Carcinoma: Description of a Case with Extremely Extended Pathology in Pregnancy

2020 ◽  
pp. 1-4
Author(s):  
Domenico Parmeggiani ◽  
Domenico Parmeggiani ◽  
Roberto Ruggiero ◽  
Giuseppe Chiacchio ◽  
Franco Faccenda ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Verrucous Carcinoma ◽  
Maximum Diameter ◽  
Excision Biopsy ◽  
Milk Analysis ◽  
Hormonal Activity ◽  
Sinus Pilonidalis ◽  
Apocrine Glands ◽  
Verneuil’S Disease ◽  
In Pregnancy

Background: Verneuil’s disease is a rare suppurative pathology of apocrine glands and pilosebaceous system of the inguinal-pelvis and perianal region with a multifactorial aetiology. The disease produces skin fistulas, draining a serum-purulent material on the skin, and finally with spontaneous healing. Verneuil’s disease can be complicated by recurrence, and unfortunately, by squamous carcinoma. We have found in literature, just 2 cases of Hidradenitis Suppurativa, complicated by Verrucous Carcinoma. Main Observation: we describe a patient F, 34-year-old, comes to our observation at 4th gestational month, with suppurative sinus pilonidalis diagnosis and with the absolute indication of the gynaecologist to the abortion. We decided to continue the pregnancy. The patient gives birth with C. to 9 months; the new-born baby was perfectly healthy and after the maternal milk analysis, the baby also nursed for about 2 months. Finally, we decided to perform a wide excision biopsy and after a controversial histology (first Warty Carcinoma, then after a “second view” Suppurative Hidradenitis), we started a series of medical treatments, including biological therapy with Infliximab, but unfortunately with fleeting results. The patient did not answer substantially. Therefore, the last chance appears a combined demolitive and plastic surgical treatment. The histology described a Verrucous squamous cell carcinoma maximum diameter of 38 x 26 cm, with lateral deep margins free of neoplastic involvement. Conclusion: This very advanced clinical behaviour of the Hidradenitis Suppurativa can present in pregnancy, therefore, motivating the interruption of the same one. Our experience contributes to underlining the possibility to bring to term the pregnancy. This case report shows how the hormonal activity can anyway influence the development of the hidradenitis and an interesting hypothesis could consider the hormonal activity of the pregnancy and the HPV promoting gene regulation (RB) from inflammatory pathology to neoplastic pathology in VC like a model to study.

Surgical treatment of extensive perianal hidradenitis

2020 ◽  
Vol 99 (9) ◽  
Keyword(s):  
Surgical Treatment ◽  
Hidradenitis Suppurativa ◽  
Soft Tissues ◽  
Case Reports ◽  
Radical Excision ◽  
Skin Flaps ◽  
Perianal Area ◽  
Apocrine Glands ◽  
Patient Preparation ◽  
Two Stages

Introduction: Perianal hidradenitis suppurativa is a chronic recurrent inflammatory, suppurative, and fistulising disease of apocrine glands, adjacent anal canal and soft tissues. Perianal area is the second most common affected area after axilla. There are three grades of the disease. Hidradenitis suppurativa represents a chronic, recurrent, deep-seated folliculitis resulting in abscesses, followed by the formation of sinus tracts and subsequent scarring. Perianal hidradenitis suppurativa is the last and the most serious grade of the disease and a specific access is needed for patient preparation and surgical treatment alone. The currently preferred method of treatment for patients with extensive perianal hidradentitis is excision and closure with combination of skin flaps, primary suture and skin graft in one or two stages. Case reports: There are three case reports of perianal hidradenitis suppurativa in this article. The local and overall initial treatment of patients followed by a radical excision and closure with a rotation skin flaps and skin grafts is described. The final results were satisfactory, with no recurrence or serious complication.

Certolizumab pegol and its role in pregnancy‐age hidradenitis suppurativa

2021 ◽  
Author(s):  
Federica Repetto ◽  
Lorenza Burzi ◽  
Alice Ramondetta ◽  
Giulia Rozzo ◽  
Matteo Licciardello ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Certolizumab Pegol ◽  
In Pregnancy

Squamous-cell cancer in Verneuil's disease (hidradenitis suppurativa)

The Lancet ◽  
1996 ◽  
Vol 348 (9039) ◽  
pp. 1449 ◽  
Author(s):  
Mariano Malaguarnera ◽  
Tindaro Pontillo ◽  
Giovanni Pistone ◽  
Lino Succi
Keyword(s):  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Verneuil’S Disease

Verrucous carcinoma arising in hidradenitis suppurativa

2000 ◽  
Vol 15 (5-6) ◽  
pp. 342-346 ◽  
Author(s):  
Bard C. Cosman ◽  
Terence C. O'Grady ◽  
Susan Pekarske
Keyword(s):  
Hidradenitis Suppurativa ◽  
Verrucous Carcinoma

P15: RELAPSING EROSIVE POLYARTHRITIS ASSOCIATED WITH HIDRADENITIS SUPPURATIVA

2016 ◽  
Vol 64 (3) ◽  
pp. 823.1-823
Author(s):  
AG Adiga ◽  
JS Pixley
Keyword(s):  
Hidradenitis Suppurativa ◽  
Skin Lesions ◽  
Laboratory Evaluation ◽  
Inflammatory Back Pain ◽  
Apocrine Glands ◽  
Chronic Disorder ◽  
Multicenter Analysis ◽  
Distal Interphalangeal ◽  
Polymerase Chain ◽  
Joint Examination

Purpose of StudyHidradenitis Suppurativa (HS) is a chronic disorder involving apocrine glands characterized by comedo like follicular occlusion and a chronic relapsing inflammation; sinus tracts and scarring. We observed a case of HS in a young African American (AA) male with relapsing polyarthritis.Methods UsedThe patient first developed HS as a teenager and then arthritis 10 years later. On this presentation he had multiple nodular skin lesions, predominately in intertriginous areas in the axilla and inguinal area; few of them presenting as draining pustules which had increased in size and number as well as generalized arthritis. This occurs 1–2 times yearly subsiding in association with antibiotic treatment. Physical examination was notable for generalized suppurate nodules chronic scars and sinuses. Joint examination revealed generalized polyarthritis with effusions in ankles, knees and elbows. Laboratory evaluation revealed marked inflammation. Autoantibody studies were negative. Radiographs revealed demineralization, erosions including the distal interphalangeal joints with suggestion of pencil/cup deformity in an asymmetric manner. All cultures were negative. Urine Chlamydia and Neisseria polymerase chain reaction testing was also negative.Summary of ResultsMusculoskeletal association with HS has been reported. Most note an association of skin flares and that it tends to occur years after the onset of skin disease. Most reports are anecdotal. We identified one multicenter analysis. The pattern of disease described resembles the spondyloarthropathy manifestations including sacroiliitis, dactylitis, inflammatory back pain and entesthitis. Our patient's findings were consistent with the limited literature available.ConclusionsIn conclusion, we propose that inflammatory spondyloarthropathy may be a complication of HS.

scholarly journals GIANT OVARIAN CYST IN PREGNANCY

2016 ◽  
Vol 3 (1) ◽  
pp. 23-28
Author(s):  
G. Radu ◽  
Nicoleta Prună ◽  
S. Prună ◽  
Mirela Moarcăș ◽  
Adriana Andrei ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Acute Abdominal Pain ◽  
Correct Diagnosis ◽  
First Trimester ◽  
Maximum Diameter ◽  
Abdominal Mri ◽  
Giant Tumor ◽  
Adnexal Tumors ◽  
Abdominal Cyst ◽  
In Pregnancy

Before the use of ultrasound, many ovarian tumors remained undiagnosed until cesarean section oruntil they became symptomatic. Now, many symptomatic or non-symptomatic adnexal tumors arediagnosed by ultrasound during pregnancy follow-up.In most cases, the adnexal tumors discoveredduring pregnancy are benign with a maximum diameter of 5 cm. Approximately 70% of the cysticadnexal tumors identified in the first trimester resorb spontaneously until the beginning of thesecond trimester (usually those are functional cysts). Persistent adnexal tumors larger than 5 cmare generally mature teratomas (dermoid).In this case, at the emergency room a 34 year-old-women came with almost 20 weeks pregnancy, accusing acute abdominal pain, nausea andvomiting. One week before, the patient went for a routine ultrasound for pregnancy and the doctordiscovered a giant tumor larger than 15 cm (due to the size it could not be measured) with fluidcontent. Two days before the symptoms, the patient went for an abdominal MRI where a voluminouspelvic-abdominal cyst with almost 30 cm in diameter was discovered. Differential diagnosis:ovarian torsion or ruptured cyst complicating pregnancy. What is the correct diagnosis and what isto be done since there is a 20 weeks pregnancy?

scholarly journals Surgical treatment of chronic hidradenitis suppurativa in the gluteal and perianal regions

2012 ◽  
Vol 59 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Sokol Bilali ◽  
Vangjel Todi ◽  
Ali Lila ◽  
Valbona Bilali ◽  
Julian Habibaj
Keyword(s):  
Wound Healing ◽  
Successful Treatment ◽  
Hidradenitis Suppurativa ◽  
Surgical Excision ◽  
Healing Time ◽  
Complete Healing ◽  
Sweat Glands ◽  
Apocrine Glands ◽  
Treatment Methods ◽  
Complete Wound Healing

Introduction: Verneuil disease, or perianal hidradenitis suppurativa (HS), is a chronic suppurative disease with a tendency to develop sinus formation, fibrosis, and sclerosis, having a great impact on quality of life. HS affect the apocrine sweat glands or sebaceous glands and may arise in each of the regions where the apocrine glands are prominent: the axilla, breast aureole, umbilicus, perineum, groin, and buttocks. We present here moderate and extensive HS cases, with their respective treatment methods and outcomes. Methods: A retrospective re-view of 6 patients? medical records from January 2001 to December 2010. Results: The 6 patients underwent treatment for HS in the gluteal and perianal regions with surgical excision. Five of the patients were male (83%). The median age was 42.5 years. We performed a total of 8 operations on these patients. In 3 patients, the wound was left open for secondary healing, and the mean time for complete wound healing was 11.3 weeks (range: 9.5-19 weeks). Delayed skin grafting was used for 2 patients in whom the wounds had been left open after the first operation. In this group, complete wound healing took 2 months in total. One patient underwent primary wound closure using rotation flaps, with a complete healing time of 2 weeks. Successful treatment without recurrence was accomplished in 5 (83.3%) of the patients. Conclusion: The conservative treatment methods had little effect, particularly on gluteal and perianal/perineal HS. The only successful treatment was wide surgical excision. Management of the wound after wide excision should be tailored to the individual patient.

scholarly journals Demographic and Clinical Features of Hidradenitis Suppurativa in Turkey

2019 ◽  
Vol 24 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Mavişe Yüksel ◽  
Pelin Basım
Keyword(s):  
Odds Ratio ◽  
Hidradenitis Suppurativa ◽  
Severe Disease ◽  
High Body Mass Index ◽  
Education Level ◽  
Disease Stage ◽  
Apocrine Glands ◽  
Male Predominance ◽  
Low Education ◽  
Disease Stages

Background The literature contains conflicting reports on the epidemiology and frequency of hidradenitis suppurativa (HS), a chronic, recurrent inflammatory disease of the apocrine glands. Objective To evaluate the clinical and demographic characteristics of HS cases in Turkey and investigate the similarities with world epidemiology. Method The records of 208 patients that presented to our polyclinics and were diagnosed with HS between June 2012 and July 2017 were retrospectively evaluated. Results Of the cases, 68.3% were male and 31.7% were female. Of the patients, 75.5% had no family history of HS, 60.6% were smokers, 39.4% were aged 20-29 years, and 36.1% were aged 30-39 years. The most commonly involved regions were the axilla (62%), groin (50.5%), and gluteus (15.9%). According to univariate analyses, male patients had higher disease stages than females (odds ratio=1.67). The patients with groin involvement, high body mass index (BMI), and low education level (0-8 years) had higher risk of severe disease stage (odds ratio=1.63, 8.91, and 1.51, respectively). The most commonly used treatment was oral antibiotics in Hurley stages I and II, and surgical intervention in Hurley III. In all 3 Hurley stages, clavulanic acid–amoxicillin combination was the mostly used systemic antibiotic (41.8%, 43.2%, and 47.8%, respectively). Conclusions This is the first epidemiological study on HS in the Turkish population, where HS shows male predominance. Male gender, low education level, absence of acne, high BMI, and groin involvement were associated with severe disease stages. Determining associated comorbidities and possible risk factors is important in progression and prevention of the disease.

Reconstructive options in severe cases of Hidradenitis suppurativa

Open Medicine ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. 674-678 ◽  
Author(s):  
Birol Civelek ◽  
Kadir Aksoy ◽  
Esra Bilgen ◽  
Ibrahim İnal ◽  
Unal. Sahin ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Skin Grafting ◽  
Surgical Removal ◽  
Apocrine Glands ◽  
Reconstruction Methods ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Topical Antibacterial ◽  
Systemic Antibiotics

AbstractHidradenitis suppurativa is a chronic, debilitating inflammatory disease of apocrine glands characterized with abscesses and nodular lesions. The treatment of Hidradenitis suppurativa consists of topical antibacterial or antiseptic solutions, systemic antibiotics, steroids, hormonal therapy, anti-tumor necrosis factor, and various surgical procedures. In this report, we present a series of 14 cases with severe Hidradenitis suppurativa. Surgical options are reviewed to show the best outcomes in the long term. A total of 14 patients (9 female, 5 male) were treated for advanced cases of Hidradenitis suppurativa. They underwent excision of the affected regions followed by reconstruction. The reconstruction methods consisted of split-thickness skin grafting and various cutaneous and myocutaneous flaps. There was no flap necrosis or dehiscence. One patient developed contracture in the axilla, for which he underwent release surgery. There were recurrences in 4 cases. There was no limitation of the arm movements in cases with flap reconstruction. In the long-term, they were satisfied with the results. In conclusion, incision and drainage should be avoided because it is of limited value. Surgical removal of the involved tissue should be the first treatment of choice. Depending on the defect following excision, local flaps should be preferred over the grafts for recurrence prevention.

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