Combined Toxicity of Copper, Cadmium and Lead Toward Daphnia magna: Recommendation for Bioassay-Based Whole Effluent Toxicity (WET) Testing in China

Metals cause popular attention worldwide due to their non-degradability and universal distribution in the aquatic ecosystem. In this study, the single, binary, and ternary combined toxicity of copper, cadmium, and lead toward survival rate of Daphnia magna were investigated based on different level fixed equivalenteffect concentration ratios. Furthermore, the combined toxicity was predicted by concentration addition and independent action models based on an established concentration-response relationship of a single toxicant and compared with the experimental data. The results indicated both binary and ternary mixture of the three metals had a strongly synergistic effect (EC50mix<1 TU) on the survival of Daphnia magna in all designed mixture ratios, which is meaning that there may be potential risks even when the single toxicant meets the discharged standards just based on chemical analysis. So, it is suggested that biological testing of whole effluents toxicity based on aquatic organisms should be applied in environment and risk management in China.

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Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

10.21203/rs.3.rs-608054/v2 ◽

2021 ◽

Author(s):

Yunfeng Ma ◽

Dong Xu ◽

Chenyang Li ◽

Shu Wei ◽

Ruixin Guo ◽

...

Keyword(s):

Feeding Behavior ◽

Daphnia Magna ◽

Ingestion Rate ◽

Recovery Period ◽

Aquatic Organisms ◽

Exposure Period ◽

Psychoactive Drugs ◽

Inhibitory Effects ◽

Combined Toxicity ◽

Active Substances

Abstract Citalopram (CTP) and mirtazapine (MTP) are two typical psychoactive drugs used for the depression treatment. As emerging pollutants, CTP and MTP has been given widely concern because they are active substances for organisms. Therefore, the ecotoxicological risks of aquatic organisms should be paid more attention to. In this study, the effects of CTP and MTP on the feeding behavior, heartbeat, nutritional enzymes and related gene transcriptions of Daphnia magna were investigated under single and mixed environmental stress. Meanwhile, the recovery of exposed D. magna was studied to analyze the toxic persistence of those pollutants. After 24-hexposure, the ingestion rate decreased by 34.2% and 21.5%, in the group of C-H and Mix-H respectively. After 24-h recovery, the feeding behavior of D. magna was stimulated by compensatory stimulation. In exposure period, the heartbeat rate of D. magna increased by 132.3%, 69%, 111.9%, 139.4%, and 92.4%, in the group of C-L, C-H, M-L, M-H and Mix-L respectively, and was recovered during the recovery period. The activity of α-amylase (AMS) and trypsin were significantly changed in most of the exposed daphnia, both in the exposure period and recovery period. CTP/MTP exposure stimulated transcription of the α-amylase gene. M-H and Mix-H exposure inhibited transcription of the trypsin gene and other stimulated transcriptions. After 24-h recovery, the stimulative or inhibitory effects were alleviated. There were different responses between gene transcription and enzyme activity. In conclusion, our results highlighted the toxic effects of single and mixed pollution of CTP and MTP on feeding, heartbeat, enzymes and genes of D. magna.

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Interactive toxic effects of agrochemicals on aquatic organisms

Water Science & Technology ◽

10.2166/wst.1999.0067 ◽

1999 ◽

Vol 40 (1) ◽

pp. 357-364 ◽

Cited By ~ 8

Author(s):

A. Kungolos ◽

P. Samaras ◽

A. M. Kipopoulou ◽

A. Zoumboulis ◽

G. P. Sakellaropoulos

Keyword(s):

Daphnia Magna ◽

Marine Bacterium ◽

Methyl Parathion ◽

Vibrio Fischeri ◽

Interactive Effect ◽

Algal Growth ◽

Aquatic Organisms ◽

Interactive Effects ◽

Selenastrum Capricornutum ◽

Toxic Compound

The effects of three common agrochemicals, lindane, methyl parathion and atrazine, on crustacean Daphnia magna, alga Selenastrum capricornutum and marine bacterium Vibrio fischeri were investigated in this study. Methyl parathion was the most toxic compound towards all three organisms, while lindane was more toxic to Daphnia magna and Vibrio fischeri than atrazine, and atrazine was more toxic to Selenastrum capricornutum than lindane. Among the three aquatic organisms, Selenastrum capricornutum was most sensitive in detecting lindane and atrazine toxicity, while Daphnia magna was most sensitive in detecting methyl parathion toxicity. The interactive effects of the pesticides were also investigated. The interactive effect between lindane and methyl parathion on survival of Daphnia magna was synergistic, while the ones between lindane and atrazine and between methyl parathion and atrazine were generally additive. The interactive effect of the three pesticides applied together on Daphnia magna was synergistic. The interactive effect of the three pesticides on the growth of Selenastrum capricornutum was antagonistic with few cases of addition, while the effect of all the three pairs of pesticides on algal growth was also antagonistic. The interactive effect of lindane and methyl parathion on Vibrio fischeri was additive.

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Toxicity investigation of CeO2 nanoparticles coated with glucose and exopolysaccharides levan and pullulan on the bacterium Vibrio fischeri and aquatic organisms Daphnia magna and Danio rerio

Aquatic Toxicology ◽

10.1016/j.aquatox.2021.105867 ◽

2021 ◽

pp. 105867

Author(s):

Ivana Milenković ◽

Ksenija Radotić ◽

Jovana Despotović ◽

Branka Lončarević ◽

Marija Lješević ◽

...

Keyword(s):

Daphnia Magna ◽

Danio Rerio ◽

Vibrio Fischeri ◽

Aquatic Organisms ◽

Ceo2 Nanoparticles

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Analysis of the palladium response relationship of a receiving water body under multiple scenario changes in rainfall-runoff pollution

Environmental Science and Pollution Research ◽

10.1007/s11356-021-12597-3 ◽

2021 ◽

Author(s):

Fangfang Ding ◽

Yuyan Liu ◽

Lin Wang ◽

Haofeng Liu ◽

Caiye Ji ◽

...

Keyword(s):

Water Body ◽

Response Relationship ◽

Rainfall Runoff ◽

Relationship Of ◽

Receiving Water ◽

Runoff Pollution

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Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.ijom.2006.09.006 ◽

2007 ◽

Vol 36 (1) ◽

pp. 26-31 ◽

Cited By ~ 24

Author(s):

A.M. Calvo ◽

V.T. Sakai ◽

F.P.M. Giglio ◽

K.C.S. Modena ◽

B.L. Colombini ◽

...

Keyword(s):

Crossover Study ◽

Dose Response ◽

Third Molar ◽

Response Relationship ◽

Dose Response Relationship ◽

Double Blind ◽

Anti Inflammatory ◽

Relationship Of ◽

Randomized Crossover Study

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Underestimation of Dose - Response Relationship with Particular Reference to the Relationship between the Dietary Intake of Mercury and its Concentration in Blood

Human Toxicology ◽

10.1177/096032718800700204 ◽

1988 ◽

Vol 7 (2) ◽

pp. 129-132 ◽

Cited By ~ 16

Author(s):

J.C. Sherlock ◽

M.J. Quinn

Keyword(s):

Linear Regression ◽

Dietary Intake ◽

Dose Response ◽

Mercury Concentration ◽

Response Relationship ◽

Dose Response Relationship ◽

Blood Mercury ◽

Relationship Of ◽

The Relationship ◽

Blood Mercury Concentration

Wide discrepancies have been observed between controlled and uncontrolled intake studies of the relationship of blood mercury concentration to intake of mercury. The probable reason for the apparent discrepancies is that the within-subject variation of mercury intake in the uncontrolled studies was almost certainly considerably larger than the within-subject variation in blood mercury concentration; in these circumstances, the apparent slope obtained from a linear regression of blood mercury on intake will invariably be much smaller than the true slope. Studies of the exposure or intake of any substance should therefore include a consideration of the likely within-subject variation in the exposure or intake relative to that in the effect.

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