Salvage Endoscopic Full-Thickness Resection of Colorectal Carcinoma after Radiotherapy in a Patient Not Eligible for Surgery

For early, superficial colorectal carcinoma, endoscopic resection is an accepted curative treatment with an excellent long-term prognosis. Our report is the first report describing endoscopic full-thickness resection (eFTR) of residual recto-sigmoid carcinoma after radiotherapy. Our patient with cT2N0M0 recto-sigmoid carcinoma had been treated with radiotherapy because severe comorbidity precluded surgical resection. When the residual tumor was observed endoscopically, complete remission was achieved by endoscopic full thickness resection. There were no endoscopic or radiological signs of recurrent malignancy after the two-years follow-up period. In selected cases, eFTR after radiotherapy could be a curative treatment option.

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Salvage endoscopic resection in patients with esophageal adenocarcinoma after chemoradiotherapy

Endoscopy International Open ◽

10.1055/a-0599-6008 ◽

2018 ◽

Vol 06 (09) ◽

pp. E1126-E1129 ◽

Cited By ~ 1

Author(s):

Irma C. Noordzij ◽

Wouter L. Curvers ◽

Clément J. Huysentruyt ◽

Grard A.P. Nieuwenhuijzen ◽

Geert-Jan Creemers ◽

...

Keyword(s):

Esophageal Adenocarcinoma ◽

Endoscopic Resection ◽

Argon Plasma Coagulation ◽

Case Series ◽

Argon Plasma ◽

Residual Tumor ◽

Esophageal Resection ◽

Sustained Remission ◽

Long Term Prognosis

Abstract Background and study aims For early esophageal adenocarcinoma, endoscopic resection is an accepted curative treatment with an excellent long-term prognosis. Case series from Japan have reported endoscopic resection of residual esophageal squamous cell carcinoma after chemoradiotherapy. This is the first report describing endoscopic resection of residual esophageal adenocarcinoma after chemoradiotherapy. Two patients with advanced esophageal adenocarcinoma had been treated with chemoradiotherapy because comorbidity precluded esophageal resection. When residual tumor was observed endoscopically, complete remission was achieved by salvage endoscopic therapy alone or in combination with argon plasma coagulation (APC). Both patients achieved long-term sustained remission and died of non-tumor-related causes.

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Comparative Study of Endoscopic Full Thickness Resection and Defect Closure of the Gastric Wall Using New Devices and Routine Laparoscopic Resection in a Prospective Long Term Survival Animal Study

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2009.03.663 ◽

2009 ◽

Vol 69 (5) ◽

pp. AB257

Author(s):

Annette Fritscher-Ravens ◽

Olufemi A. Olagbaiye ◽

Christopher Holland ◽

Amir Ghanbari ◽

Klaus-Gerd Hadeler ◽

...

Keyword(s):

Comparative Study ◽

Animal Study ◽

Laparoscopic Resection ◽

Gastric Wall ◽

Defect Closure ◽

Full Thickness ◽

Term Survival ◽

Long Term Survival ◽

Endoscopic Full Thickness Resection

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Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms

Clinical and Developmental Immunology ◽

10.1155/2011/174149 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 10

Author(s):

Luis de la Cruz-Merino ◽

Fernando Henao Carrasco ◽

David Vicente Baz ◽

Esteban Nogales Fernández ◽

Juan José Reina Zoilo ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Colorectal Carcinoma ◽

Tumor Cells ◽

Immune Reaction ◽

Current Knowledge ◽

Immune Microenvironment ◽

Long Term Prognosis ◽

Infiltrating Lymphocytes

Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.

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Endoscopic full-thickness resection in the colorectum: a single-center case series evaluating indication, efficacy and safety

Endoscopy International Open ◽

10.1055/a-0672-1138 ◽

2018 ◽

Vol 06 (10) ◽

pp. E1227-E1234 ◽

Cited By ~ 5

Author(s):

Krijn Haasnoot ◽

Bas van der Spek ◽

Christof Meischl ◽

Dimitri Heine

Keyword(s):

Colorectal Carcinoma ◽

Adverse Events ◽

R0 Resection ◽

Radical Excision ◽

Full Thickness ◽

Efficacy And Safety ◽

Technical Success ◽

Endoscopic Techniques ◽

T1 Colorectal Carcinoma ◽

Endoscopic Full Thickness Resection

Abstract Background and study aims Endoscopic full-thickness resection (eFTR) allows en-bloc and transmural resection of colorectal lesions for which other advanced endoscopic techniques are unsuitable. We present our experience with a novel “clip first, cut later” eFTR-device and evaluate its indications, efficacy and safety. Patients and methods From July 2015 through October 2017, 51 eFTR-procedures were performed in 48 patients. Technical success and R0-resection rates were prospectively recorded and retrospectively analyzed. Results Indications for eFTR were non-lifting adenoma (n = 19), primary resection of malignant lesion (n = 2), resection of scar tissue after incomplete endoscopic resection of low-risk T1 colorectal carcinoma (n = 26), adenoma involving a diverticulum (n = 2) and neuroendocrine tumor (n = 2). Two lesions were treated by combining endoscopic mucosal resection and eFTR. Technical success was achieved in 45 of 51 procedures (88 %). Histopathology confirmed full-thickness resection in 43 of 50 specimens (86 %) and radical resection (R0) in 40 procedures (80 %). eFTR-specimens, obtained for indeterminate previous T1 colorectal carcinoma resection, were free of residual carcinoma in 25 of 26 cases (96 %). In six patients (13 %) a total of eight adverse events occurred within 30 days after eFTR. One perforation occurred, which was corrected endoscopically. No emergency surgery was necessary. Conclusion In this study eFTR appears to be safe and effective for the resection of colorectal lesions. Technical success, R0-resection and major adverse events rate were reasonable and comparable with eFTR data reported elsewhere. Mean specimen diameter (23 mm) limits its use to relatively small lesions. A clinical algorithm for eFTR case selection is proposed. eFTR ensured local radical excision where other endoscopic techniques did not suffice and reduced the need for surgery in selected cases.

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Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-199702000-00014 ◽

1997 ◽

Vol 9 (2) ◽

pp. 183-186 ◽

Cited By ~ 13

Author(s):

Teresa Starzynska ◽

Mike Bromley ◽

Krzysztof Marlicz ◽

Stephen A. Roberts ◽

Michal Ucinski ◽

...

Keyword(s):

Colorectal Carcinoma ◽

Long Term Prognosis

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Predictive importance of comorbidity in patients with myocardial infarction and different strategy of treatment

Medical alphabet ◽

10.33667/2078-5631-2019-2-30(405)-33-36 ◽

2019 ◽

Vol 2 (30) ◽

pp. 33-36 ◽

Cited By ~ 1

Author(s):

M. V. Zykov ◽

V. V. Kashtalap ◽

V. A. Poltaranina ◽

N. V. Dyachenko ◽

I. V. Lukyanchenko ◽

...

Keyword(s):

Myocardial Infarction ◽

Conservative Treatment ◽

Coronary Intervention ◽

Number Needed To Treat ◽

City Hospital ◽

Percutaneous Coronary ◽

Severe Comorbidity ◽

Comorbidity Index ◽

Long Term Prognosis

The aim of the study was to compare the 1-year results of conservative and invasive tactics of treating myocardial infarction (MI) in patients with different severity of comorbid background.Material and methods. The presented results are based on registry in City Hospital No. 4 of Sochi. The present analysis included patients with a diagnosis of myocardial infarction (n = 1 176). Upon discharge from the hospital, all patients underwent analysis of the severity of comorbidity using the Charlson Comorbidity Index (CCI). A year later, 791 patients managed to find out the prognosis after discharge from the hospital. 1-year mortality was 12.6 % (n = 100).Results. The frequency of coronary angiography (CA) and percutaneous coronary intervention (PCI) in patients with CCI = 0 (no or minimal comorbidity, n = 408) was 84.3 % and 63.5 %, with a CCI of 1–2 (moderate comorbidity), n = 438) was 68.0 % and 44.8 %, with CCI ≥ 3 (expressed comorbidity, n = 330) was 50.3 % and 25.8 %, respectively. At the same time, conducting PCI at the hospital observation stage was associated with a decrease mortality during the year after discharge from the hospital from 18.5 % to 5.8 %, p < 0.0001. The greatest positive effect of PCI for optimizing the long-term prognosis of (1 year) was achieved in the group of patients with severe comorbidity (CCI ≥ 3), where the NNT (number needed to treat) was 7. The relative risk of 1-year mortality in patients with severe comorbidity compared to the minimum in the PCI group was 6.75, in the conservative treatment group was 4.63.Conclusion. The results of this study showed that PCI in MI is more often performed by younger, less comorbid patients with a lower risk on the GRACE scale. At the same time, the 1-year survival of patients with MI was significantly higher after PCI compared to the primary conservative treatment strategy, regardless of the severity of comorbidity, and the greatest improvement in the long-term prognosis of PCI was observed in patients with severe comorbidity, as determined by the CCI ≥ 3.

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The influence of postoperative complications on long-term prognosis in patients with colorectal carcinoma

International Journal of Colorectal Disease ◽

10.1007/s00384-020-03557-3 ◽

2020 ◽

Vol 35 (6) ◽

pp. 1055-1066 ◽

Cited By ~ 2

Author(s):

Clemens Beck ◽

Klaus Weber ◽

Maximilian Brunner ◽

Abbas Agaimy ◽

Sabine Semrau ◽

...

Keyword(s):

Postoperative Complications ◽

Colorectal Carcinoma ◽

Long Term Prognosis

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Editorial. Prevention of Hepatocellular Carcinoma

Infection International ◽

10.1515/ii-2017-0002 ◽

2012 ◽

Vol 1 (1) ◽

pp. 7-13

Author(s):

Ryota Masuzaki ◽

Masao Omata

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Development ◽

Tumor Stage ◽

Curative Treatment ◽

Percutaneous Ablation ◽

Hepatitis Viruses ◽

Liver Disease Progression ◽

Long Term Prognosis ◽

Related Mortality

Abstract Hepatocellular carcinoma (HCC) is the fifth common cancer in the world, showing the third highest cancer related mortality. The prognosis of HCC patients depends not only on tumor stage but also on the background liver function reservoir. Effective treatments for HCC include percutaneous ablation, surgical resection and liver transplantation. Although short-term prognosis of HCC patients has been much improved recently due to advances in early diagnosis and treatment, long-term prognosis is as yet far from satisfactory as indicated by the overall survival at 10 years after apparently curative treatment of only 22%-35%. Primary prevention aims to evade the tumor development with health measures that prevent people from exposure to known risk factors like hepatitis viruses or alcohol, or attenuating liver disease progression to HCC. While secondary prevention aims to diagnose HCC at an early, potentially curable stage, tertiary prevention aims to reduce the risk of HCC recurrence after curative treatment. In this article we focus on prevention of HCC and the new advance in this field.

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