Chronic kidney disease (CKD) affects ~10% of Qatar’s population. Recently, dysbiosis in the gut microbiome has been associated with CKD. It is not understood whether CKD affects the gut microbiome or the dysbiotic gut microbiome leads to CKD. Gum Arabic (GA) is a fiber-rich dietary substance that has a potential to enhance the gut microbiome, therefore it could treat CKD. The aim of this study is to quantify the gut microbiome in CKD rats and to evaluate the GA as a potential treatment for CKD.
Abstract
Alport syndrome is a rare genetic disease that results in disordered basement membrane type IV collagen resulting in occular and auditory defects as well of progressive kidney disease. Although no ‘cure’ currently exists, therapeutic blockade of the renin–angiotensin–aldosterone system can slow the progression to end-stage kidney disease (ESKD). Clinical trials for treatments in preventing chronic kidney disease have largely been negative over the last two decades until recent trials have shown positive cardiovascular and renal outcomes of sodium–glucose co-transporter-2 (SGLT2) inhibitors in patients with diabetes mellitus. Although marketed as medications for Type 2 diabetes, SGLT2 inhibitors have been found to have additional properties that are nephroprotective which makes them a potential candidate for treatment for those with other forms of progressive kidney disease. This review discusses the evidence for the use of SGLT2 inhibitors as a potential treatment in Alport syndrome that may slow the progression of chronic kidney disease and prevent patients reaching ESKD.
Finerenone: A Potential Treatment for Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus
