Medium-Term Supplementation With Herbal Extract for Exercise Performance and Antioxidant Status

The main aim of this study was to examine the effects of medium-term supplementation with an eight-herbs extract on running performance, biomarkers of antioxidant status and telomere length, and self-reported outcome measures of safety events in healthy men. Ten healthy young men (age 23.1±3.2 years, weight 73.7±9.9kg, and height 179.4±8.0cm) volunteered to participate in this randomized controlled trial. The participants were allocated in a double-blind cross-over design to receive either an eight-herbs extract or placebo during a 6-week intervention period. Two-way mixed analysis of variance (treatment vs. time interaction) revealed no significant differences for exercise performance outcomes and telomere length between groups (P>0.05). Compared with placebo, P-DNA provoked a significant rise in serum total antioxidant capacity (316.0±183.4µmol/mL at baseline; 792.7±68.1µmol/mL at follow-up in the eight-herbs extract group vs. 298.1±90.7µmol/mL at follow-up in the placebo group; P<0.001), and less reduction in serum superoxide dismutase levels at follow-up (150.4±5.1IU/mL at baseline; 145.5±3.0IU/mL at follow-up in the eight-herbs extract group vs. 139.3±3.3IU/mL at follow-up in the placebo group; P=0.01). No participant reported any side effects of either intervention. The eight-herbs extract can thus be recommended as a well tolerated dietary supplement that can enhance antioxidant capacity in healthy men. This trial was registered at ClinicalTrials.gov (NCT04263246).

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The role of poly-herbal extract in sodium chloride-induced oxidative stress and hyperlipidemia in male Wistar rats

10.21203/rs.3.rs-420441/v1 ◽

2021 ◽

Author(s):

Olumide Fadahunsi ◽

Peter Adegbola ◽

Olayemi Adebola Akintola ◽

Bamidele Stephen Ajilore ◽

olubukola sinbad Olorunnisola

Keyword(s):

Nitric Oxide ◽

Serum Lipid ◽

Antioxidant Status ◽

Wistar Rats ◽

Density Lipoprotein ◽

High Salt ◽

Herbal Extract ◽

High Salt Diet ◽

Salt Diet ◽

Male Wistar Rats

Abstract Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Thirty-five male Wistar rats were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat and 16 % high salt diet only respectively. Animals in groups 3, 4, and 5 were fed 16% high salt diet with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE) respectively once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. PHE (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentration and increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.

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Impact of Oral Glycine Propionyl-L-Carnitine on Oxidative Stress, Antioxidant Status, and Exercise Performance

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000273582.65612.70 ◽

2007 ◽

Vol 39 (Supplement) ◽

pp. S159

Author(s):

Richard J. Bloomer ◽

Webb A. Smith ◽

Andrew C. Fry ◽

Lesley C. Tschume ◽

Andrea K. Creasy

Keyword(s):

Oxidative Stress ◽

Exercise Performance ◽

Antioxidant Status

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The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats

Medicines ◽

10.3390/medicines8060025 ◽

2021 ◽

Vol 8 (6) ◽

pp. 25

Author(s):

Olubukola Sinbad Olorunnisola ◽

Peter Ifeoluwa Adegbola ◽

Bamidele Stephen Ajilore ◽

Olayemi Adebola Akintola ◽

Olumide Samuel Fadahunsi

Keyword(s):

Nitric Oxide ◽

Serum Lipid ◽

Antioxidant Status ◽

Wistar Rats ◽

Density Lipoprotein ◽

High Salt ◽

Herbal Extract ◽

High Salt Diet ◽

Salt Diet ◽

Male Wistar Rats

Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals, which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Out of the total fifty male Wistar rats obtained, fifteen were used for acute toxicity study, while the remaining thirty-five were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat chow (NRC) and 16% high salt diet (HSD) only, respectively. Animals in groups 3, 4 and 5 were fed 16% HSD with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE), respectively, once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. Poly-herbal extract (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentrations and also increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high-salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.

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Protective Effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis Extract on Liver Injury in Rats

The American Journal of Chinese Medicine ◽

10.1142/s0192415x07005466 ◽

2007 ◽

Vol 35 (06) ◽

pp. 995-1009 ◽

Cited By ~ 25

Author(s):

Hsin-Fang Chang ◽

Yun-Ho Lin ◽

Chia-Chou Chu ◽

Shu-Ju Wu ◽

Ya-Hui Tsai ◽

...

Keyword(s):

Liver Fibrosis ◽

Liver Injury ◽

Panax Ginseng ◽

Ginkgo Biloba ◽

Antioxidant Status ◽

Low Dose ◽

Herbal Extract ◽

High Dose ◽

Schizandra Chinensis ◽

Tgf Β1

This study investigated the effects of the combined extracts of Ginkgo biloba, Panax ginseng, and Schizandra chinensis at different doses on hepatic antioxidant status and fibrosis in rats with carbon tetrachloride ( CCl 4)-induced liver injury. Male Sprague-Dawley rats ( n = 8–12 per group) were divided into the control, CCl 4, CCl 4 + silymarin (0.35%), CCl 4 + low-dose herbal extract (0.24% of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract at 1:1:1; LE), and CCl 4 + high-dose herbal extract (1.20% of the same herbal extract; HE) groups. Silymarin or herbal extract was orally given to rats a week before chronic intraperitoneal injection with CCl 4 for 6 weeks. The pathological results showed that herbal extract suppressed hepatic bile duct proliferation, and low-dose herbal extract inhibited liver fibrosis. Hepatic superoxide dismutase (SOD) activity was lower in the CCl 4 group, but there was no difference in the silymarin or herbal extract treated groups compared to the control group. Hepatic catalase activity and the ratio of reduced to oxidized glutathione were significantly higher ( p < 0.05) in the HE group than those in the CCl 4 group. Silymarin and herbal extract reversed the impaired hepatic total antioxidant status ( p < 0.05). Herbal extract partially reduced the elevated hepatic lipid peroxides. Hepatic transforming growth factor-β1 (TGF-β1) level decreased significantly ( p < 0.05) in the LE group. Therefore, high-dose herbal extract improved hepatic antioxidant capacity through enhancing catalase activity and glutathione redox status, whereas low-dose herbal extract inhibited liver fibrosis through decreasing hepatic TGF-β1 level in rats with CCl 4-induced liver injury.

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