scholarly journals High Complexity Fertilization in Cuba: Egg Donation

2021 ◽  
Vol 5 (3) ◽  
pp. 01-02
Author(s):  
Georgina Álvarez Medina
Keyword(s):  
In Vitro Fertilization ◽  
Preterm Births ◽  
High Rate ◽  
Human Reproduction ◽  
Egg Donation ◽  
Infertile Couple ◽  
High Complexity ◽  
Vitro Fertilization ◽  
Number Of Patients

The decades of the 70s and 80s of the last century in our country, allowed us to glimpse that the possibilities of treatment for the infertile couple were considerably expanded. Until that moment, infertile couples had very limited options such as adoption, insemination using a donor or conforming to not having children. In Cuba, since 1979, the first steps were taken in the field of assisted reproduction in animals. Human reproduction studies have been carried out at the National Institute of Endocrinology and the Ramón González Coro Gyneco-obstetric Hospital, the first birth having occurred in 1986. Since 2006 and with the aim of guaranteeing perinatological care specialized in pregnant patients as a result of in vitro fertilization, it was decided to create a consultation at the Ramón González Coro Hospital given the high rate of twin and triple pregnancies, preterm births and complications. The number of patients treated had to proceed with high complexity in vitro fertilization and sometimes ICSI and it was not until 2014 after the approval by our constitution, the family code and medical ethics that egg donation began.

scholarly journals The obligate need for accuracy in reporting preclinical studies relevant to clinical trials: autologous germline mitochondrial supplementation for assisted human reproduction as a case study

2020 ◽  
Vol 14 ◽  
pp. 263349412091735
Author(s):  
Jonathan L. Tilly ◽  
Dori C. Woods
Keyword(s):  
Energy Transfer ◽  
In Vitro Fertilization ◽  
Clinical Studies ◽  
Human Reproduction ◽  
Fertility Treatment ◽  
Success Rates ◽  
Vitro Fertilization ◽  
Mouse Study ◽  
Mitochondrial Supplementation

A now large body of work has solidified the central role that mitochondria play in oocyte development, fertilization, and embryogenesis. From these studies, a new technology termed autologous germline mitochondrial energy transfer was developed for improving pregnancy success rates in assisted reproduction. Unlike prior clinical studies that relied on the use of donor, or nonautologous, mitochondria for microinjection into eggs of women with a history of repeated in vitro fertilization failure to enhance pregnancy success, autologous germline mitochondrial energy transfer uses autologous mitochondria collected from oogonial stem cells of the same woman undergoing the fertility treatment. Initial trials of autologous germline mitochondrial energy transfer during - in vitro fertilization at three different sites with a total of 104 patients indicated a benefit of the procedure for improving pregnancy success rates, with the birth of children conceived through the inclusion of autologous germline mitochondrial energy transfer during in vitro fertilization. However, a fourth clinical study, consisting of 57 patients, failed to show a benefit of autologous germline mitochondrial energy transfer– in vitro fertilization versus in vitro fertilization alone for improving cumulative live birth rates. Complicating this area of work further, a recent mouse study, which claimed to test the long-term safety of autologous mitochondrial supplementation during in vitro fertilization, raised concerns over the use of the procedure for reproduction. However, autologous mitochondria were not actually used for preclinical testing in this mouse study. The unwarranted fears that this new study’s erroneous conclusions could cause in women who have become pregnant through the use of autologous germline mitochondrial energy transfer during- in vitro fertilization highlight the critical need for accurate reporting of preclinical work that has immediate bearing on human clinical studies.

Editorial-SURROGACY

2016 ◽  
Vol 32 (2) ◽  
Author(s):  
O.S. Verma
Keyword(s):  
In Vitro Fertilization ◽  
Intrauterine Insemination ◽  
Natural Course ◽  
Assisted Reproductive Techniques ◽  
Egg Donation ◽  
Surrogate Mother ◽  
Vitro Fertilization ◽  
Reproductive Techniques

Worldwide, about 200 million couples are infertile. Almost 15 per cent of them require ART and IVF treatments. Couples who are unable to conceive even after years of trying could use procedure called Assisted Reproductive Techniques (ART) to get pregnant. These includes Intrauterine Insemination, In-Vitro Fertilization (IVF), Spern / Egg donation, and Gestational Carriers called “Surrogacy”. People join for Surrogacy when they want to have their genes in the child but can not make it happen in natural course. There are two types of Surrogacy: (1) The man’s sperm and the woman’s ova is injected in the uterus of the surrogate mother who rents out her womb for the child, (2) If the Egg of the mother is not good enough to produce a baby, an Egg is then rented out by donor mother. A tripartite agreement is duly signed according to the terms and conditions prevalent at that time. This Editorial viewed Surrogacy Industry through the lens of intent, efficacy, and its purview.

scholarly journals In vitro fertilization (IVF) centre at Dhaka Medical College Hospital - A New hope for Infertile couple!

2021 ◽  
Vol 28 (2) ◽  
pp. 129-130
Author(s):  
Nilufar Sultana
Keyword(s):  
In Vitro Fertilization ◽  
Medical College Hospital ◽  
Infertile Couple ◽  
College Hospital ◽  
Vitro Fertilization ◽  
Medical College

Abstract not available J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 129-130

scholarly journals The unknown face of in vitro fertilization

2012 ◽  
Vol 61 (1) ◽  
Author(s):  
José María Pardo Sáenz
Keyword(s):  
In Vitro Fertilization ◽  
Human Reproduction ◽  
Ethical Aspect ◽  
Vitro Fertilization ◽  
Ethical Concerns ◽  
Embryo Freezing ◽  
Human Fertilization ◽  
Attractive Face ◽  
A La Carte

Lo scopo di questo articolo è quello di mostrare il volto sconosciuto dei metodi artificiali di riproduzione umana. In generale, le cliniche per la fecondazione umana mostrano solo il volto più attraente della fecondazione in vitro: il neonato. Eppure, non hanno mai mostrato l’altra faccia di essa: la procedura lunga e drammatica che sta dietro. Dopo aver fatto un breve cenno alla attribuzione del Premio Nobel per la Medicina 2010 Robert Edwards, padre della fecondazione in vitro, analizziamo le due radici che sostengono il grande albero di metodi artificiali di riproduzione umana: lo scientismo e il sentimentalismo. Poi si studia l’aspetto etico di queste procedure. Siamo giunti ad un giudizio eticamente negativo su queste tecniche, dal momento che snaturano il significato della sessualità umana e l’atto coniugale. Subito dopo, analizziamo alcune delle conseguenze più frequenti di tali metodi: “la mortalità embrionale” associata con tali tecniche; “il congelamento degli embrioni in eccesso”; “i rischi per la salute”, sia del neonato così come quella della donna. Tutti questi sono elementi che la coppia deve prendere in considerazione al fine di prendere la decisione più libera e più responsabile possibile. Infine, spieghiamo il “pendio scivoloso” relativo all’uso di queste tecniche (il bambino medicalizzato, i bambini à la carte, la maternità surrogata e il mercantilismo riproduttivo): ciò che è stato sviluppato con uno intento ben preciso, per risolvere il problema di infertilità, ha sicuramente aperto nuove importanti questioni etiche. ---------- The purpose of this article is to show the unknown face of artificial human reproduction methods. Generally, human fertilization clinics only show the most attractive face of in vitro fertilization: the newborn. Yet, they never show the other face of it: the long and dramatic procedure behind it. After briefly mentioning the 2010 Nobel Medicine Award granted to Robert Edwards, the father of in vitro fertilization, we analyze the two roots that support the big tree of artificial human reproduction methods: scientism and sentimentalism. Then we study the ethical aspect of these procedures. We come to the conclusion that these techniques are ethically negative since they denaturalize the meaning of human sexuality and the conjugal act. Right after that, we analyze some of the most frequent consequences of such methods: “embryonic mortality” and directly related to it exceeding “embryo freezing”; “the risks for the health”, both of the newborn as well as that of the woman. All those are elements that the couple must take into consideration in order to make the freest and most responsible decision possible. Finally, we explain the “slippery slope” effect in the use of these techniques (medicine babies, babies a la carte, surrogate maternity and reproductive mercantilism): what was developed with a very specific aim in mind, to remedy the infertility problem, has definitely open new and important ethical concerns.

scholarly journals The Methodology and Stylistic Approach of Imam Tahavi in Tafseer “Ahkam ul Quran

2019 ◽  
pp. 1-19
Author(s):  
dr. hafiz muhammad sani
Keyword(s):  
In Vitro Fertilization ◽  
Infertility Treatment ◽  
Reproductive Technology ◽  
Sex Selection ◽  
Human Reproduction ◽  
Religious Values ◽  
Vitro Fertilization ◽  
Minimum Number ◽  
Natural Way

In Vitro Fertilization (IVF) has emerged as one of the most popular byproduct of Assistant Reproductive Technology (ART) in our time. It has proven attractive to people across the globe for variety of reasons including infertility treatment and pre-natal sex selection. People of various cultures have reacted to its use in line with their own code of morality and religious values on human procreation, sexual purity and lineage exactitude. In the case of Muslims, its application for overcoming infertility has received general juridical approval with minimum number of caveats. A cursory of the existing fatwas, however reveals that the juristic deliberation on the implications of IVF in terms of destroying the excess embryos generated in the process is scanty. Accordingly, this study argues that if we equate legitimate use of IVF with natural way of human reproduction, then the ethicality of its casualties in terms of surplus embryo destruction should not be trivialized.

P–653 The levels and ratios of adipokines in the follicular fluid as promising prognostic factors for in vitro fertilization outcomes

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
J Ryzhov ◽  
A Shpakov ◽  
N Tkachenko ◽  
M Mahmadalieva ◽  
I Kogan ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
In Vitro Fertilization ◽  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Uterine Cavity ◽  
Normal Body Mass Index ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Number Of Patients

Abstract Study question Can the adipokines levels and ratios in the follicular fluid (FF) be used to predict in vitro fertilization (IVF) outcomes? Summary answer The leptin level and ratios leptin/ghrelin and leptin/adiponectin in FF are reliable prognostic factors for IVF outcomes in women with normal body mass index (BMI). What is known already The adipose tissue serves not a simple fat storage, rather an important endocrine organ, producing adipokines, such as leptin, adiponectin, ghrelin and others. Adipokines have been shown to regulate the cardiovascular system, food intake, metabolism, inflammation, metastatic spread of tumors,and also reproduction, affecting the activity of the hypothalamo-pituitary-gonadal axis. The plasma and FF adipokines have been used as prognostic factors for IVF outcomes, but the obtained results are controversial. The most promising in this case may be the distribution of patients into groups in accordance with their BMI and a separate study of adipokine ratios in them. Study design, size, duration Women (n = 53), who undergo IVF, were divided on two groups, according to their BMI: normal BMI (18.5–24.9 kg/m2, n = 25) and increased BMI (>25.0 kg/m2, n = 28). Depending on IVF outcomes after the antagonist protocol, the groups formed were subsequently subdivided into two groups each: non-pregnant with normal BMI (nPN, n = 16), pregnant with normal BMI (PN, n = 9), non-pregnant with increased BMI (nPI, n = 21), pregnant with increased BMI (PI, n = 7). Participants/materials, setting, methods: Inclusion criteria for participants were: age 18–45 years and infertility due to male/tubal factor. Exclusion criteria were: polycystic ovarian syndrome (PCOS), diabetes mellitus, or plasma level of anti-Müllerian hormone <1.0 ng/mL. The FF from the first punctated follicle was collected and tested for leptin, adiponectin and ghrelin levels using ELISA kits. If gestational sac was seen in uterine cavity using ultrasound on day 21–25 after embryo transfer, pregnancy was diagnosed. Main results and the role of chance Women with increased BMI had, as a rule, higher FF levels of leptin and the leptin/ghrelin and leptin/adiponectin ratios, compared with women with normal BMI. Furthermore, leptin level was higher in PN as compared to nPN (21.61±2.55 vs 10.54±1.16, p < 0.05), but did not differ in the PI and nPI groups. The same pattern was obtained for the leptin/ghrelin and leptin/adiponectin ratios. The ghrelin level showed an inverse pattern. It was higher in nPN as compared to PN (3.80±0.78 vs 1.39±0.19, p < 0.05), but did not differ in women with increased BMI. The obtained data demonstrate that the association between the adipokine levels in FF and the IVF outcomes is better in women with normal BMI than in women with increased BMI. Adipokines, which differed among the study groups, were evaluated as prognostic factors in women with normal BMI.The values were calculated at which pregnancy became unlikely: leptin level <15 ng/mL, leptin/ghrelin ratio <9, and leptin/adiponectin ratio <5. For each indicators, the sensitivity and specificity were >88%. The predictive power of these indicators in the clinic using the odds ratio (95% confidence interval) was: leptin level 7.11 (1.23–40.99, p < 0.05), leptin/ghrelin 29.53 (1.53–570.83, p < 0.05), and leptin/adiponectin 7.11 (1.23–40.99, p < 0.05). Limitations, reasons for caution The main limitation of the study is a relative small number of patients, although the differences between the investigated groups were significant. Furthermore, women with low ovarian reserve, age > 40 years, endometriosis or PCOS were not included in the study. Wider implications of the findings: The obtained results indicate the good prospects for using such indicators as the adipokines levels and their ratio in FF to predict IVF outcomes in women with low ovarian reserve, endometriosis and PCOS, but with normal BMI. Trial registration number Not applicable

Sign in / Sign up

Export Citation Format

Share Document