scholarly journals Therapeutic Apheresis in Neurology

2020 ◽  
Vol 5 (5) ◽  
pp. 01-09
Author(s):  
Rolf Bambauer
Keyword(s):  
Neurological Disorders ◽  
Neurological Diseases ◽  
Blood Flow Rate ◽  
Complete Separation ◽  
Second Line Therapy ◽  
Line Therapy ◽  
The World ◽  
American Society ◽  
Increased Blood Flow ◽  
Apheresis Therapy

Therapeutic plasma exchange (TPE) remove harmful plasma constituents from patient’s blood and replacing the extracted plasma with replacement solutions. The advantages of TPE with hollow fiber membranes are a complete separation of the corpuscular components from the plasma and due to increased blood flow rate higher efficacy. Therapeutic apheresis (TA) is used more and more throughout the world. The development of new, more sophisticated membranes and new adsorption technologies allow the most selective separation of plasma components. TA has been successfully introduced in a variety of autoantibody-mediated diseases. TA is the first- or second-line therapy in the treatment of neurological disorders. The updated information on immunology and molecular biology of different neurological diseases are discussed in relation to the rationale for apheresis therapy and its place in combination with other modern treatments. The different neurological diseases can be treated by various apheresis methods. Pathogenetical aspects are demonstrated in these diseases, in which they are clarified. TA has been shown to effectively remove the autoantibodies, immune complexes, inflammatory moderators, paraproteins, and other toxins from blood and lead to rapid clinical improvement. For the neurological diseases, which can be treated with TA, the guidelines of the Apheresis Application Committee (AAC) of the American Society for Apheresis (ASFA) are cited.

scholarly journals Therapeutic Apheresis in Pediatrics with Neurological and Hematological Diseases

2020 ◽  
Vol 5 (4) ◽  
Keyword(s):  
Blood Flow ◽  
Molecular Biology ◽  
Pediatric Patients ◽  
Blood Flow Rate ◽  
Complete Separation ◽  
Hematological Diseases ◽  
Low Incidence ◽  
American Society ◽  
Increased Blood Flow ◽  
Apheresis Therapy

The advantages of therapeutic apheresis (TA) with hollow fiber membranes are a complete separation of the corpuscular components from the plasma and due to increased blood flow rate higher efficacy [1]. The use of therapeutic apheresis in pediatric patients, which increasing more and more, has always been restricted by technical difficulties and the low incidence of diseases requiring this kind of treatment. The development of new, more sophisticated membranes and new adsorption technologies allow the most selective separation of plasma components. TA has been successfully introduced in a variety of autoantibody-mediated diseases [2]. The updated information on immunology and molecular biology of different neurological and hematological diseases are discussed in relation to the rationale for apheresis therapy and its place in combination with other modern treatments. The different diseases can be treated by various apheresis methods. Pathogenetical aspects are demonstrated in these diseases, in which they are clarified. TA has been shown to effectively remove the autoantibodies from blood and lead to rapid clinical improvement. For the neurological and hematological diseases, which can be treated with TA, the guidelines of the Apheresis Application Committee (AAC) of the American Society for Apheresis (ASFA) are cited [3, 4].

scholarly journals Extracts and Essential Oils from Medicinal Plants and Their Neuroprotective Effect

2020 ◽  
Author(s):  
Ianara Mendonça da Costa ◽  
Elaine Cristina Gurgel Andrade Pedrosa ◽  
Ana Paula de Carvalho Bezerra ◽  
Luciana Cristina Borges Fernandes ◽  
José Rodolfo Lopes de Paiva Cavalcanti ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Essential Oils ◽  
Neurological Disorders ◽  
Clinical Symptoms ◽  
Neurological Diseases ◽  
Neuroprotective Effect ◽  
Therapeutic Strategies ◽  
The World ◽  
Current Therapies ◽  
The Subject

Current therapies for neurodegenerative diseases offer only limited benefits to their clinical symptoms and do not prevent the degeneration of neuronal cells. Neurological diseases affect millions of people around the world, and the economic impact of treatment is high, given that health care resources are scarce. Thus, many therapeutic strategies to delay or prevent neurodegeneration have been the subject of research for treatment. One strategy for this is the use of herbal and essential oils of different species of medicinal plants because they have several bioactive compounds and phytochemicals with neuroprotective capacity. In addition, they respond positively to neurological disorders, such as dementia, oxidative stress, anxiety, cerebral ischemia, and oxidative toxicity, suggesting their use as complementary treatment agents in the treatment of neurological disorders.

scholarly journals Immunoglobulins in neurological practice: a review of the literature

2019 ◽  
Vol 9 (1) ◽  
pp. 32-51
Author(s):  
S. S. Nikitin ◽  
L. M. Boriskina
Keyword(s):  
Neurological Disorders ◽  
Multifocal Motor Neuropathy ◽  
Intravenous Immunoglobulins ◽  
High Dose ◽  
Motor Neuropathy ◽  
Review Of The Literature ◽  
Second Line Therapy ◽  
Randomized Controlled ◽  
Line Therapy ◽  
Neurological Conditions

Today intravenous immunoglobulins are used increasingly in the management of patients with neurological conditions. The efficacy and safety of intravenous immunoglobulins treatment in chronic inflammatory demyelinating polyradiculoneuropathy, Guillain–Barre syndrome and multifocal motor neuropathy have been established in randomized controlled trials and declared in systematic reviews. There are discussions about the dose, timing, duration and necessity of repeated infusions in these disorders. The intravenous immunoglobulins treatment is an option in myasthenia gravis crisis and exacerbations the disease, stiff-person syndrome, a second-line therapy in dermatomyositis and some patients with polymyositis. The use of intravenous immunoglobulins in patients with multiple sclerosis, inclusion body myositis, resistant epilepsy is not finally proved. The review discussed the data of immunoglobulins efficacy in neurological disorders based on informative studies with an emphasis on the main criteria for choosing a drug for effective high-dose intravenous immunotherapy.

Individualized HbA1c Targets in People with Type 2 Diabetes Initiating Second-Line Therapy—The Global DISCOVER Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1629-P
Author(s):  
KAMLESH KHUNTI ◽  
HUNGTA CHEN ◽  
JAVIER CID-RUZAFA ◽  
PETER FENICI ◽  
MARILIA B. GOMES ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Second Line ◽  
Second Line Therapy ◽  
Line Therapy

The 1970s

2011 ◽  
Author(s):  
Thomas Borstelmann
Keyword(s):  
Civil Rights ◽  
Free Market ◽  
The United States ◽  
Global Perspective ◽  
Retirement Plans ◽  
Free Agency ◽  
The World ◽  
The Disabled ◽  
Oil Crisis ◽  
American Society

This book looks at an iconic decade when the cultural left and economic right came to the fore in American society and the world at large. While many have seen the 1970s as simply a period of failures epitomized by Watergate, inflation, the oil crisis, global unrest, and disillusionment with military efforts in Vietnam, this book creates a new framework for understanding the period and its legacy. It demonstrates how the 1970s increased social inclusiveness and, at the same time, encouraged commitments to the free market and wariness of government. As a result, American culture and much of the rest of the world became more—and less—equal. This book explores how the 1970s forged the contours of contemporary America. Military, political, and economic crises undercut citizens' confidence in government. Free market enthusiasm led to lower taxes, a volunteer army, individual 401(k) retirement plans, free agency in sports, deregulated airlines, and expansions in gambling and pornography. At the same time, the movement for civil rights grew, promoting changes for women, gays, immigrants, and the disabled. And developments were not limited to the United States. Many countries gave up colonial and racial hierarchies to develop a new formal commitment to human rights, while economic deregulation spread to other parts of the world, from Chile and the United Kingdom to China. Placing a tempestuous political culture within a global perspective, this book shows that the decade wrought irrevocable transformations upon American society and the broader world that continue to resonate today.

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