Primary Bilateral Papilledema Due Myxedema

2021 ◽  
Vol 4 (1) ◽  
pp. 01-03
Author(s):  
Himmatrao Saluba Bawaskar
Keyword(s):  
Thyroid Hormone ◽  
Well Being ◽  
Thyroid Stimulating Hormone ◽  
Hormone Concentration ◽  
Target Zone ◽  
Insidious Onset ◽  
Optimal Target ◽  
Stimulating Hormone

Hypothyroidism is a highly prevalent disorder and can substantially impact the well-being of an individual. Till date there is no single accurate optimal target zone for thyroid stimulating hormone concentration that exists in the context of replacement of thyroid hormone. Due to the gradually progressive nature and insidious onset of disease, it often remains unrecognized

Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data

2021 ◽  
Vol 53 (04) ◽  
pp. 272-279
Author(s):  
Chaochao Ma ◽  
Xiaoqi Li ◽  
Lixin Liu ◽  
Xinqi Cheng ◽  
Fang Xue ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Dynamic Change ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Stimulating Hormone

AbstractThyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidence interval method. The differences in thyroid stimulating hormone and free thyroxine between early pregnant and non-pregnant women were statistically significant (p<0.0001). The reference intervals of thyroid stimulating hormone, free thyroxine and free triiodothyronine for early pregnant women were 0.052–3.393 μIU/ml, 1.01–1.54 ng/dl, and 2.51–3.66 pg/ml, respectively. Results concerning thyroid stimulating hormone and free thyroxine reference intervals of early pregnancy are comparable with those from other studies using the same detection platform. Early pregnancy related thyroid hormones models showed various change patterns with gestational age for thyroid hormones. Early pregnancy related thyroid hormones models and reference intervals for pregnant women were established, so as to provide accurate and reliable reference basis for the diagnosing and monitoring of maternal thyroid disfunction in early pregnancy.

INFLUENCE OF HEMITHYROIDECTOMY ON ENDOGENOUSLY LABELLED THYROXINE AND TRI-IODOTHYRONINE IN RATS

1972 ◽  
Vol 55 (3) ◽  
pp. 479-487 ◽  
Author(s):  
D. EMRICH ◽  
A. von zur MÜHLEN ◽  
J. LINDNER ◽  
H. D. ZIMMERMANN ◽  
R. BECKMANN
Keyword(s):  
Oxygen Consumption ◽  
Thyroid Stimulating Hormone ◽  
Significant Alteration ◽  
Hormone Deficiency ◽  
Hormone Concentration ◽  
Regulatory Factor ◽  
Entire Study ◽  
Peripheral Cells ◽  
Stimulating Hormone

SUMMARY In order to investigate the influence of thyroid-stimulating hormone (TSH) on the ratio of newly synthesized thyroxine( T4):tri-iodothyronine (T3), hemithyroidectomy was performed on rats maintained on an iodinerich diet. One and two weeks after the operation the concentration of TSH increased in the plasma. As a result, the weight of the residual lobes and their thyroidal uptake of 131I/mg increased and significant histological signs of increased function in the remaining lobes were observed. The most prominent effect was a significant alteration of the ratio of newly synthesized T4:T3 in favour of T3, both in the thyroid and plasma. Four weeks after the operation, when the residual lobes weighed 57% more than those in the controls, the alterations decreased or returned to normal. The total hormone concentration in the plasma (measured as protein-bound 127I) and the oxygen consumption of the animals remained unchanged during the entire study. These findings support the hypothesis that alteration of the production and secretion ratio of T4:T3 induced by TSH might act as another regulatory factor, if a hormone deficiency originates in the peripheral cells. The results show also that changes of the T4:T3 ratio induced by TSH occur in animals on an iodine-rich diet.

scholarly journals Misleading results from immunoassays of serum free thyroxine in the presence of rheumatoid factor

1997 ◽  
Vol 43 (6) ◽  
pp. 957-962 ◽  
Author(s):  
Anthony G W Norden ◽  
Rodwin A Jackson ◽  
Lorraine E Norden ◽  
A Jane Griffin ◽  
Margaret A Barnes ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Rheumatoid Factor ◽  
Equilibrium Dialysis ◽  
Thyroid Stimulating Hormone ◽  
Normal Serum ◽  
Free Thyroxine ◽  
Free Triiodothyronine ◽  
Serum Free ◽  
Serum Free Thyroxine ◽  
Stimulating Hormone

Abstract A novel interference with measurements of serum free thyroxine (FT4) caused by rheumatoid factor (RhF) is described. We found misleading, sometimes gross, increases of FT4 results in 5 clinically euthyroid elderly female patients with high RhF concentrations. All 5 patients had high FT4 on Abbott AxSYM® or IMx® analyzers. “NETRIA” immunoassays gave misleading results in 4 of the 5 patients; Amerlex-MAB® in 2 of 4 patients; AutoDELFIA®in 2 of the 5; and Corning ACS-180® and Bayer Diagnostics Immuno 1® in 1 of the 5. BM-ES700® system results for FT4 in these women remained within the reference range. Results for serum T4, thyroid-stimulating hormone, free triiodothyronine, thyroid-hormone-binding globulin, and FT4 measured by equilibrium dialysis were normal in all 5 patients. Drugs, albumin-binding variants, and anti-thyroid-hormone antibodies were excluded as interferences. Addition to normal serum of the RhF isolated from each of the 5 patients increased the apparent FT4 (Abbott AxSYM). Screening of 83 unselected patients demonstrated a highly significant positive correlation between FT4 (Abbott AxSYM) and RhF concentrations. Discrepant, apparently increased FT4 with a normal result for thyroid-stimulating hormone should lead to measurement of the patient’s RhF concentration.

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