scholarly journals INFLUENCE OF HYPOXIC HYPOXIA AND THE COURSE INTAKE OF MEXIDOL ON THE HEMOSTASIS SYSTEM RESPONSE AT SINGLE PHYSICAL LOADS OF VARIOUS DURATION

2021 ◽  
pp. 99-104
Author(s):  
S.V. Moskalenko ◽  
I.I. Shakhmatov ◽  
V.M. Vdovin ◽  
A.A. Blazhko
Keyword(s):  
Hypoxic Hypoxia ◽  
System Response ◽  
Hemostasis System

EFFECTS OF NICKEL CHLORIDE ON INDICES OF HEMOCOAGULATION AND LIPID PEROXIDATION IN RATS

2019 ◽  
pp. 83-90
Author(s):  
Э.М. Гаглоева ◽  
В.Б. Брин ◽  
С.В. Скупневский ◽  
Н.В. Боциева ◽  
Т.В. Молдован
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Platelet Aggregation ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Nickel Chloride ◽  
Activated Partial Thromboplastin Time ◽  
Fibrinogen Concentration ◽  
Thrombin Time ◽  
Hemostasis System

Цель исследования - изучить состояние системы гемостаза при хронической интоксикации хлоридом никеля, исследовать взаимосвязь показателей гемокоагуляции с процессами липопероксидации у крыс в эксперименте. Методика. Опыты проводили на крысах-самцах Вистар (n=50, 230-250 г). Раствор NiCl2 (5 мг/кг) вводили внутрижелудочно ежедневно в течение 2 нед, 1 и 2 мес. По завершении эксперимента исследовали состояние тромбоцитарного и коагуляционного звеньев гемостаза, антикоагулянтную и фибринолитическую активность крови, а также определяли активность процессов перекисного окисления липидов и антиоксидантных ферментов. Результаты. Установлено, что через 2 нед и 1 мес интоксикации у крыс отмечались гиперкоагуляционные изменения показателей свертывающей системы крови: повышение агрегационной активности тромбоцитов, увеличение концентрации фибриногена, снижение активированного частичного тромбопластинового времени (АЧТВ) и протромбинового времени. В этот период регистрировалось увеличение антитромбиновой и фибринолитической активности крови. Через 2 мес наблюдалось подавление активности клеточного звена гемостаза - тромбоцитопения, ослабление степени АДФ-индуцируемой агрегации тромбоцитов. Выявлялась тенденция к уменьшению концентрации фибриногена. На фоне снижения АЧТВ и тромбинового времени отмечалось увеличение протромбинового времени. В то же время регистрировалось угнетение противосвертывающего звена системы гемостаза (снижалась активность антитромбина III), наблюдалось истощение резервных возможностей фибринолитического звена (замедление фXIIа-зависимого эуглобулинового лизиса) и увеличение содержания растворимых фибрин мономерных комплексов, что свидетельствует о наличии тромбинемии. Через 2 нед, один и два месяца интоксикации у животных выявлялись корреляционные связи между основными показателями системы гемостаза и активностью процессов перекисного окисления липидов и антиоксидантных ферментов. Заключение. Полученные данные подтверждают наличие взаимосвязи активности процессов липопероксидации и системы гемостаза, в том числе при хронической никелевой интоксикации. Результаты исследования позволяют рекомендовать применение антиоксидантов для разработки способов коррекции гемостатических сдвигов при воздействии на организм тяжелых металлов. The aim. To study the state of the hemostasis system in chronic nickel intoxication and to investigate the relationship between hemocoagulation indices and lipoperoxidation processes in rats. Methods. Experiments were carried out on male Wistar rats (n=50, 230-250 g). A solution of nickel chloride (5 mg/kg) was administered daily intragastrically for two weeks, one and two months. At the end of the experiments, indices of platelet and coagulation hemostasis systems, anticoagulant and fibrinolytic activity of blood plasma, and activities of lipid peroxidation and antioxidant enzymes were studied. Results. Hypercoagulative changes in indices of the coagulation system were observed in rats after two weeks and one month of intoxication, including increased platelet aggregation and fibrinogen concentration and shortened activated partial thromboplastin time and prothrombin time. During the same period, increased antithrombin and fibrinolytic activities were observed. The depressed activity of the cellular component of hemostasis evident as thrombocytopenia and impaired ADP-induced platelet aggregation was detected after two months of intoxication. A tendency to decrease in fibrinogen concentration was observed. The shortened activated partial thromboplastin time and thrombin time were associated with prolonged prothrombin time. At the same time, inhibition of the anticoagulant component of hemostasis (decreased antithrombin III activity), exhaustion of the fibrinolysis system reserve (delayed fXIIa-dependent euglobulin lysis), and a significant increase in soluble fibrin monomeric complexes indicative of thrombinemia were observed. After two weeks, one and two months of nickel intoxication, a correlation was found between the major indices of the hemostasis system and the activities of lipid peroxidation and antioxidant enzymes. Conclusion. The study confirmed a relationship between the lipid peroxidation activity and the hemostasis system, specifically in chronic nickel intoxication. This result allows to recommend the use of antioxidants in developing methods for correction of hemostatic induced affected by heavy metals.

The Effects of Hypoxic Hypoxia on Cognitive Performance Decay

2015 ◽  
Author(s):  
Thomas Morgan ◽  
Elizabeth Combs ◽  
Megan Clayton ◽  
Todd S. Dart ◽  
Joseph Fischer ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Hypoxic Hypoxia

Detection of Metal Toxicity Using Natural Phytoplankton as Test Organisms in the Great Lakes

1993 ◽  
Vol 28 (1) ◽  
pp. 155-176
Author(s):  
Mohiddin Munawari ◽  
Milos Legner
Keyword(s):  
Great Lakes ◽  
Metal Toxicity ◽  
Structural Changes ◽  
System Response ◽  
Turnover Rates ◽  
High Turnover ◽  
Spectra Analysis ◽  
Test Organisms ◽  
Future Potential ◽  
Natural Phytoplankton

Abstract This paper presents an overview of techniques utilizing natural phytoplankton for the detection of metal-Induced stress in the Great Lakes. Both field and laboratory procedures are designed to evaluate either structural changes or functional response of test organisms. This up-to-date compendium provides a choice of techniques, which permits a holistic assessment of the stress caused by toxic metals. Recently introduced techniques, such as normalized size spectra analysis, flow cytometry, and the evaluation of a continuous-flow system response to metal toxicity, are discussed in more detail to explore their future potential. Owing to their key position in the food web, high turnover rates, abundance, and sensitivity to environmental perturbation, phytoplankton serve as reliable early warning indicators of ecosystem deterioration and its restoration.

Treatment system response to transient AOX (adsorbable organic halogen) loadings

1997 ◽  
Vol 35 (2-3) ◽  
pp. 85-91
Author(s):  
D. A. Barton ◽  
J. D. Woodruff ◽  
T. M. Bousquet ◽  
A. M. Parrish
Keyword(s):  
Paper Industry ◽  
Model Development ◽  
Operating Conditions ◽  
System Response ◽  
Additional Information ◽  
Organic Halogen ◽  
Aox Removal ◽  
Variable Operating Conditions ◽  
Plant Shutdown

If promulgated as proposed, effluent guidelines for the U.S. pulp and paper industry will impose average monthly and maximum daily numerical limits of discharged AOX (adsorbable organic halogen). At this time, it is unclear whether the maximum-day variability factor used to establish the proposed effluent guidelines will provide sufficient margin for mills to achieve compliance during periods of normal but variable operating conditions within the pulping and bleaching processes. Consequently, additional information is needed to relate transient AOX loadings with final AOX discharges. This paper presents a simplistic dynamic model of AOX decay during treatment. The model consists of hydraulic characterization of an activated sludge process and a first-order decay coefficient for AOX removal. Data for model development were acquired by frequent collection of influent and effluent samples at a bleach kraft mill during a bleach plant shutdown and startup sequence.

scholarly journals Assessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaoting Xia ◽  
Shunjin Zhang ◽  
Huaju Zhang ◽  
Zijing Zhang ◽  
Ningbo Chen ◽  
...  
Keyword(s):  
Population Structure ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Genomic Variation ◽  
Genomic Diversity ◽  
System Response ◽  
Whole Genome ◽  
Population Structure Analysis ◽  
Native Cattle ◽  
Genomic Regions

Abstract Background Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese native cattle breed, is reported to have originated from crossbreeding between taurine and indicine cattle; their history as a draft and meat animal dates back at least 30 years. Using whole-genome sequencing (WGS) data of 30 animals from the core breeding farm, we investigated the genetic diversity, population structure and genomic regions under selection of Jiaxian Red cattle. Furthermore, we used 131 published genomes of world-wide cattle to characterize the genomic variation of Jiaxian Red cattle. Results The population structure analysis revealed that Jiaxian Red cattle harboured the ancestry with East Asian taurine (0.493), Chinese indicine (0.379), European taurine (0.095) and Indian indicine (0.033). Three methods (nucleotide diversity, linkage disequilibrium decay and runs of homozygosity) implied the relatively high genomic diversity in Jiaxian Red cattle. We used θπ, CLR, FST and XP-EHH methods to look for the candidate signatures of positive selection in Jiaxian Red cattle. A total number of 171 (θπ and CLR) and 17 (FST and XP-EHH) shared genes were identified using different detection strategies. Functional annotation analysis revealed that these genes are potentially responsible for growth and feed efficiency (CCSER1), meat quality traits (ROCK2, PPP1R12A, CYB5R4, EYA3, PHACTR1), fertility (RFX4, SRD5A2) and immune system response (SLAMF1, CD84 and SLAMF6). Conclusion We provide a comprehensive overview of sequence variations in Jiaxian Red cattle genomes. Selection signatures were detected in genomic regions that are possibly related to economically important traits in Jiaxian Red cattle. We observed a high level of genomic diversity and low inbreeding in Jiaxian Red cattle. These results provide a basis for further resource protection and breeding improvement of this breed.

scholarly journals Vibration characteristics of triple-gear-rotor system in compressed air energy storage under variable torque load

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042098705
Author(s):  
Xinran Wang ◽  
Yangli Zhu ◽  
Wen Li ◽  
Dongxu Hu ◽  
Xuehui Zhang ◽  
...  
Keyword(s):  
Large Scale ◽  
Three Dimensional ◽  
Element Model ◽  
Rotor System ◽  
Dynamic Responses ◽  
System Response ◽  
Rotating Speed ◽  
Torque Load ◽  
Set Up ◽  
Two Stages

This paper focuses on the effects of the off-design operation of CAES on the dynamic characteristics of the triple-gear-rotor system. A finite element model of the system is set up with unbalanced excitations, torque load excitations, and backlash which lead to variations of tooth contact status. An experiment is carried out to verify the accuracy of the mathematical model. The results show that when the system is subjected to large-scale torque load lifting at a high rotating speed, it has two stages of relatively strong periodicity when the torque load is light, and of chaotic when the torque load is heavy, with the transition between the two states being relatively quick and violent. The analysis of the three-dimensional acceleration spectrum and the meshing force shows that the variation in the meshing state and the fluctuation of the meshing force is the basic reasons for the variation in the system response with the torque load. In addition, the three rotors in the triple-gear-rotor system studied show a strong similarity in the meshing states and meshing force fluctuations, which result in the similarity in the dynamic responses of the three rotors.

scholarly journals What Solar–Terrestrial Link Researchers Should Know about Interplanetary Drivers

Universe ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. 138
Author(s):  
Yuri I. Yermolaev ◽  
Irina G. Lodkina ◽  
Lidia A. Dremukhina ◽  
Michael Y. Yermolaev ◽  
Alexander A. Khokhlachev
Keyword(s):  
Interplanetary Shock ◽  
Magnetic Storms ◽  
System Response ◽  
Ionospheric Disturbances ◽  
Atmosphere System ◽  
Compression Region ◽  
Different Types ◽  
Methodological Approaches ◽  
Composite Nature ◽  
Incorrect Data

One of the most promising methods of research in solar–terrestrial physics is the comparison of the responses of the magnetosphere–ionosphere–atmosphere system to various types of interplanetary disturbances (so-called “interplanetary drivers”). Numerous studies have shown that different types of drivers result in different reactions of the system for identical variations in the interplanetary magnetic field. In particular, the sheaths—compression regions before fast interplanetary CMEs (ICMEs)—have higher efficiency in terms of the generation of magnetic storms than ICMEs. The growing popularity of this method of research is accompanied by the growth of incorrect methodological approaches in such studies. These errors can be divided into four main classes: (i) using incorrect data with the identification of driver types published in other studies; (ii) using incorrect methods to identify the types of drivers and, as a result, misclassify the causes of magnetospheric-ionospheric disturbances; (iii) ignoring a frequent case with a complex, composite, nature of the driver (the presence of a sequence of several simple drivers) and matching the system response with only one of the drivers; for example, a magnetic storm is often generated by a sheath in front of ICME, although the authors consider these events to be a so-called “CME-induced” storm, rather than a “sheath-induced” storm; (iv) ignoring the compression regions before the fast CME in the case when there is no interplanetary shock (IS) in front of the compression region (“sheath without IS” or the so-called “lost driver”), although this type of driver generates about 10% of moderate and large magnetic storms. Possible ways of solving this problem are discussed.

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