scholarly journals A novel, reproducible, and objective method for volumetric magnetic resonance imaging assessment of enhancing glioblastoma

2014 ◽  
Vol 121 (3) ◽  
pp. 536-542 ◽  
Author(s):  
Charles W. Kanaly ◽  
Ankit I. Mehta ◽  
Dale Ding ◽  
Jenny K. Hoang ◽  
Peter G. Kranz ◽  
...  
Keyword(s):  
Interobserver Variability ◽  
Intraclass Correlation ◽  
Evaluation Criteria ◽  
Correlation Coefficients ◽  
Response Assessment ◽  
Volumetric Method ◽  
Kappa Statistics ◽  
Macdonald Criteria ◽  
Automated Method ◽  
Radiological Response

Object Robust methodology that allows objective, automated, and observer-independent measurements of brain tumor volume, especially after resection, is lacking. Thus, determination of tumor response and progression in neurooncology is unreliable. The objective of this study was to determine if a semi-automated volumetric method for quantifying enhancing tissue would perform with high reproducibility and low interobserver variability. Methods Fifty-seven MR images from 13 patients with glioblastoma were assessed using our method, by 2 neuroradiologists, 1 neurosurgeon, 1 neurosurgical resident, 1 nurse practitioner, and 1 medical student. The 2 neuroradiologists also performed traditional 1-dimensional (1D) and 2-dimensional (2D) measurements. Intraclass correlation coefficients (ICCs) assessed interobserver variability between measurements. Radiological response was determined using Response Evaluation Criteria In Solid Tumors (RECIST) guidelines and Macdonald criteria. Kappa statistics described interobserver variability of volumetric radiological response determinations. Results There was strong agreement for 1D (RECIST) and 2D (Macdonald) measurements between neuroradiologists (ICC = 0.42 and 0.61, respectively), but the agreement using the authors' novel automated approach was significantly stronger (ICC = 0.97). The volumetric method had the strongest agreement with regard to radiological response (κ = 0.96) when compared with 2D (κ = 0.54) or 1D (κ = 0.46) methods. Despite diverse levels of experience of the users of the volumetric method, measurements using the volumetric program remained remarkably consistent in all users (0.94). Conclusions Interobserver variability using this new semi-automated method is less than the variability with traditional methods of tumor measurement. This new method is objective, quick, and highly reproducible among operators with varying levels of expertise. This approach should be further evaluated as a potential standard for response assessment based on contrast enhancement in brain tumors.

Linear Mandibular Measurements: Comparison between Orthopantomograms and Lateral Cephalograms

2009 ◽  
Vol 46 (2) ◽  
pp. 147-153 ◽  
Author(s):  
E. M. Ongkosuwito ◽  
M. M. J. Dieleman ◽  
A. M. Kuijpers-Jagtman ◽  
P. G. H. Mulder ◽  
J. W. van Neck
Keyword(s):  
Interobserver Variability ◽  
Intraclass Correlation ◽  
Kappa Statistics ◽  
Magnification Factor ◽  
Linear Measurements ◽  
Lateral Cephalogram ◽  
X Ray ◽  
Lateral Cephalograms ◽  
Left And Right ◽  
Cephalometric Measurements

Objective: To investigate the reliability of length measurements of the mandible by comparing orthopantomograms (OPTs) with lateral cephalograms. Design: Observational study. Setting: OPTs and lateral cephalograms were taken of 20 human dry skulls. Four orthodontists and four maxillofacial surgeons located landmarks on all radiographs using a computer program for cephalometric measurements. Intraobserver and interobserver variability in locating landmarks was assessed, as well as positioning of the skulls prior to radiography between the x-ray assistants. Magnification differences between the left and right side of the mandible on the OPT were determined for five skulls. Kappa statistics were used to calculate the intraclass correlation coefficient for intraobserver and interobserver differences. An F test was used to assess differences between methods and between type of observer. Results: No significant differences were found in the magnification factor of the left and right side of the mandible. Compared with a lateral cephalogram, the OPT had comparable reliability in measuring mandibular distances condylion-gonion, gonion-menton, and condylion-menton. No significant differences were observed between the x-ray assistants in taking the OPTs and lateral cephalograms or in repositioning the skulls. Significant differences were found between orthodontists and maxillofacial surgeons for landmark measurements. Conclusion: An OPT is as reliable as a lateral cephalogram for linear measurements of the mandible (condylion-gonion, gonion-menton, and condylion-menton).

scholarly journals The interobserver reliability of the diagnosis and classification of scaphoid fractures using high-resolution peripheral quantitative CT

2020 ◽  
Vol 102-B (4) ◽  
pp. 478-484 ◽  
Author(s):  
Anne M. Daniels ◽  
Caroline E. Wyers ◽  
Heinrich M. J. Janzing ◽  
Sander Sassen ◽  
Daan Loeffen ◽  
...  
Keyword(s):  
High Resolution ◽  
Interobserver Agreement ◽  
Interobserver Reliability ◽  
Scaphoid Fracture ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Kappa Statistics ◽  
Quantitative Ct ◽  
Scaphoid Fractures

Aims Besides conventional radiographs, the use of MRI, CT, and bone scintigraphy is frequent in the diagnosis of a fracture of the scaphoid. However, which techniques give the best results remain unknown. The investigation of a new imaging technique initially requires an analysis of its precision. The primary aim of this study was to investigate the interobserver agreement of high-resolution peripheral quantitative CT (HR-pQCT) in the diagnosis of a scaphoid fracture. A secondary aim was to investigate the interobserver agreement for the presence of other fractures and for the classification of scaphoid fracture. Methods Two radiologists and two orthopaedic trauma surgeons evaluated HR-pQCT scans of 31 patients with a clinically-suspected scaphoid fracture. The observers were asked to determine the presence of a scaphoid or other fracture and to classify the scaphoid fracture based on the Herbert classification system. Fleiss kappa statistics were used to calculate the interobserver agreement for the diagnosis of a fracture. Intraclass correlation coefficients (ICCs) were used to assess the agreement for the classification of scaphoid fracture. Results A total of nine (29%) scaphoid fractures and 12 (39%) other fractures were diagnosed in 20 patients (65%) using HR-pQCT across the four observers. The interobserver agreement was 91% for the identification of a scaphoid fracture (95% confidence interval (CI) 0.76 to 1.00) and 80% for other fractures (95% CI 0.72 to 0.87). The mean ICC for the classification of a scaphoid fracture in the seven patients diagnosed with scaphoid fracture by all four observers was 73% (95% CI 0.42 to 0.94). Conclusion We conclude that the diagnosis of scaphoid and other fractures is reliable when using HR-pQCT in patients with a clinically-suspected fracture. Cite this article: Bone Joint J 2020;102-B(4):478–484.

scholarly journals Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Paulo Linhares ◽  
Bruno Carvalho ◽  
Rita Figueiredo ◽  
Rui M. Reis ◽  
Rui Vaz
Keyword(s):  
Survival Data ◽  
Response Assessment ◽  
Rank Analysis ◽  
Rano Criteria ◽  
Macdonald Criteria ◽  
Kaplan Meier ◽  
Early Progression ◽  
Radiological Response ◽  
The Impact ◽  
True Progression

Introduction. The aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM) patients following radiotherapy/temozolomide (RT/TMZ) by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO) criteria. The impact on prognosis and survival analysis was also studied.Materials and Methods. All patients receiving RT/TMZ for newly diagnosed GBM from January 2005 to December 2009 were retrospectively evaluated, and demographic, clinical, radiographic, treatment, and survival data were reviewed. Updated RANO criteria were used for the evaluation of the pre-RT and post-RT MRI and compared to classic Macdonald criteria. Survival data was evaluated using the Kaplan-Meier and log-rank analysis.Results and Discussion. 70 patients were available for full radiological response assessment. Early progression was confirmed in 42 patients (60%) according to Macdonald criteria and 15 patients (21%) according to RANO criteria. Pseudoprogression was identified in 10 (23.8%) or 2 (13.3%) patients in Macdonald and RANO groups, respectively. Cumulative survival of pseudoprogression group was higher than that of true progression group and not statistically different from the non-progressive disease group.Conclusion. In this cohort, the frequency of pseudoprogression varied between 13% and 24%, being overdiagnosed by older Macdonald criteria, which emphasizes the importance of RANO criteria and new radiological biomarkers for correct response evaluation.

Validity and Reliability of the Comfort Behavior Scale in Children Undergoing Wound Dressing Replacement in Vietnam

MedPharmRes ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 24-31
Author(s):  
Huong Lan Thi Tran ◽  
Katrina Einhellig ◽  
Linh Thuy Khanh Tran ◽  
Oanh Hoang Thi Pham ◽  
Cuc Thu Thi Tran ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
World Health ◽  
Kappa Statistics ◽  
Validity And Reliability ◽  
Rater Reliability ◽  
Behavior Scale ◽  
Health Organization ◽  
Children's Pain

Background: This study translated and culturally adapted the Comfort Behavior Scale (Comfort-B) into Vietnamese using a standard protocol guided by the World Health Organization. Methods: The Comfort-B was translated into Vietnamese and then English back-translated by independent translators. These versions were reviewed and assessed by a Vietnamese expert’s panel and an English expert’s panel. Thirty-four nurses of the Nhi Dong 1 Hospital were invited to use the Vietnamese Comfort-B to assess pain while watching five videos recorded before, during and after wound dressing replacement. The eight characteristics of the Vietnamese Comfort-B were assessed by 34 nurses. Fifteen nurses agreed to do the second assessment two weeks from the first assessment. The content validity index was used to assess the relevance and clarity of all items and the whole scale. Agreements between raters were explored using Kappa statistics. Intraclass correlation coefficients (ICC) were used to assess intra-rater and inter-rater reliability. Multi-level linear regression was used to assess changes in the Vietnamese Comfort-B before, during and after wound dressing replacement between two assessments. Results: The Vietnamese Comfort-B was accredited by the Vietnamese expert’s panel. The English-back translated version was approved by the English expert’s panel. The nurses agreed that the Vietnamese Comfort-B can be used in clinical practice and research. Kappas of all items were ≥0.96 indicating excellent agreement between raters. Alpha coefficients of two assessments were ≥0.97 indicating excellent internal consistency. All ICCs ≥ 0.79 indicated good intra-rater and inter-rater reliability. Conclusions: The study suggested that the Vietnamese Comfort-B can be used for future studies assessing children’s pain in the local hospital context.

Nerve ultrasound

Neurology ◽  
2018 ◽  
Vol 92 (5) ◽  
pp. e443-e450 ◽  
Author(s):  
Johan A. Telleman ◽  
Ingrid J.T. Herraets ◽  
H. Stephan Goedee ◽  
Camiel Verhamme ◽  
Stavros Nikolakopoulos ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Random Effects ◽  
Interobserver Variability ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Random Effects Model ◽  
Nerve Ultrasound ◽  
Cross Sectional ◽  
Intraclass Correlation Coefficients ◽  
Time Image

ObjectiveTo determine interobserver variability of nerve ultrasound in peripheral neuropathy in a prospective, systematic, multicenter study.MethodsWe enrolled 20 patients with an acquired chronic demyelinating or axonal polyneuropathy and 10 healthy controls in 3 different centers. All participants underwent an extensive nerve ultrasound protocol, including cross-sectional area measurements of median, ulnar, fibular, tibial, and sural nerves, and brachial plexus. Real-time image acquisition was performed blind by a local and a visiting investigator (reference). Five patients were investigated using different types of sonographic devices. Intraclass correlation coefficients were calculated, and a random-effects model was fitted to identify factors with significant effect on interobserver variability.ResultsSystematic differences between measurements made by different investigators were small (mean difference 0.11 mm2 [95% confidence interval 0.00–0.23 mm2]). Intraclass correlation coefficients were generally higher in arm nerves (0.48–0.96) than leg nerves (0.46–0.61). The hospital site and sonographic device did not contribute significantly to interobserver variability in the random-effects model.ConclusionsInterobserver variability of nerve ultrasound in peripheral neuropathy is generally limited, especially in arm nerves. Different devices and a multicenter setting have no effect on interobserver variability. Therefore, nerve ultrasound is a reproducible tool for diagnostics in routine clinical practice and (multicenter) research.

A Quantitative Food Frequency Questionnaire for Women in Southeast China: Development and Reproducibility

2005 ◽  
Vol 17 (1) ◽  
pp. 29-35 ◽  
Author(s):  
M. Zhang ◽  
CW Binns ◽  
AH Lee
Keyword(s):  
Food Frequency Questionnaire ◽  
Eating Habits ◽  
Chinese Women ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Food Group ◽  
Kappa Statistics ◽  
Food Frequency ◽  
Southeast China ◽  
Intraclass Correlation Coefficients

This study describes the development and reproducibility of a 128-item quantitative food frequency questionnaire (FFQ) to measure usual food consumption for women in southeast China. The FFQ was pre-tested using 51 Chinese women who recently migrated to Australia. Cronbach's alpha coefficient was 0.81 for internal consistency. The reliability of the FFQ was then assessed by another test-retest study. A sample of 41 women residing in southeast China was interviewed twice within 12 weeks. Intraclass correlation coefficients were moderate to high for mean food group consumption (0.43-0.96) and mean daily nutrient intakes (0.47-0.89). Kappa statistics for eating habits ranged from 0.27 to 0.89 in the test-retest. The mean ratio of energy intake to basal metabolic rate was 1.73 (S.D. 0.39) in both test and retest samples. The study confirmed that the FFQ method using standard containers is appropriate to assess dietary intake for women in southeast China. Asia Pac J Public Health 2005: 17(1): 29-35.

scholarly journals Reliability and clinical applicability of a novel tear film imaging tool

2021 ◽  
Author(s):  
Noémi Tóth ◽  
Eszter Szalai ◽  
Tibor Rák ◽  
Veronika Lillik ◽  
Attila Nagy ◽  
...  
Keyword(s):  
Intraclass Correlation ◽  
Tear Film ◽  
Correlation Coefficients ◽  
Kappa Statistics ◽  
Ophthalmological Examination ◽  
Non Invasive ◽  
Imaging Tool ◽  
Clinical Applicability ◽  
Break Up

Abstract Purpose The aim of our research was to investigate the reliability and clinical applicability of a modern tear film imaging tool by comparing the inter- and intragrader difference. The further goal was to compare the non-invasive tear break-up time (NIBUT) measured with the LacryDiag® device with traditional tear film break-up time (TBUT). Methods Comprehensive ophthalmological examination was performed, including LacryDiag® (Quantel Medical, France) (lower tear meniscus height measuring (LTMH), superior and inferior eyelid meibography (MeibS MeibI), interferometry (INT), NIBUT), slit lamp examination, and TBUT. Two independent, well-trained graders selected and analyzed the LTMH, MeibI, MeibS, and INT. The second grader reanalyzed the data 1 month later. Intra- and inter-examiner reliabilities were evaluated using intraclass correlation coefficients (ICC), while for categorical variable, Cohen’s kappa statistics were provided. The Bland-Altman plot was used for visualization of the agreement between measurements. Results Fifty healthy volunteers were examined. For LTMH both the inter- and intragrader variabilities were excellent. Between two graders, the ICC of MeibI was poor; however, between two graders, the ICC of MeibS was good, and the intragrader variability in MeibI and MeibS was excellent. For the INT, both intra- and intergrading were in fair and moderate agreement, although the intragrader agreement was higher. Comparing the NIBUT and TBUT, the agreement was slight. Conclusion Based on our results, examination of a patient during follow-up should be performed by the same examiner, because of the slight agreement. The LacryDiag® is a non-invasive, easy-to-use device, which can examine the tear film and save the recordings for easier follow-up.

scholarly journals Assessment of Psycho-Education of Carers Questionnaire: APEC-U” translation and cross cultural adaptation of an Urdu Version

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Imran Ijaz Haider ◽  
Farah Tiwana ◽  
Noor Zohra ◽  
Khaleeq Ur Rehman
Keyword(s):  
Internal Consistency ◽  
Cultural Adaptation ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Internal Consistency Reliability ◽  
Cross Cultural ◽  
Kappa Statistics ◽  
Cross Cultural Adaptation ◽  
Creative Commons ◽  
Good Mental Health

Background and Objective: Psycho-education of carers is a part of good mental health practice. Our objective was to translate and validate the English questionnaire “Assessment of Psycho-Education of Carers” (APEC) into Urdu (APEC-U), for use in Pakistan. Methods: Following development and validation of APEC, it was translated into Urdu after consultation with experts and translators. After pretesting, one hundred and twenty bilingual male 67(55.8%) and female 53(44.2%) primary carers, who could understand both Urdu and English, and were carers for more than three months, were asked to fill in the self reporting Urdu questionnaire at the Fatima Memorial Hospital Psychiatry Out-Patient Department. The data were collected over a period of three months from September, 2018 to November, 2018. Main outcome measures: Responses were analyzed for internal consistency, reliability, Intraclass correlation coefficients and kappa statistics. Results: APEC-U was understandable and capable of assessing psycho-education in Urdu. High internal consistency was demonstrated on the full scale as 0.859. Degree of agreement (<0.001) between the Urdu and the originally developed English version was evaluated by Cohen’s Kappa, and a high degree of agreement was demonstrated. Conclusion: The Urdu questionnaire can adequately assess psycho-education of carers in psychiatric settings. doi: https://doi.org/10.12669/pjms.35.4.661 How to cite this:Haider II, Tiwana F, Zohra N, Khaleeq Ur Rehman. Assessment of Psycho-Education of Carers Questionnaire: APEC-U” translation and cross cultural adaptation of an Urdu Version. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.661 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Lesion measurement on a combined “all-in-one” window for chest CT: effect on intra- and interobserver variability

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Annemiek Snoeckx ◽  
Jeroen Cant ◽  
Caro Franck ◽  
Elisa Luyckx ◽  
Ken Carpentier ◽  
...  
Keyword(s):  
Interobserver Agreement ◽  
Interobserver Variability ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Lesion Size ◽  
Processing Technique ◽  
Observer Agreement ◽  
Image Processing Technique ◽  
Measurement Variability ◽  
Intraclass Correlation Coefficients

Abstract Purpose A newly developed image processing technique fuses conventional windows into a single ‘All-In-One’ (AIO) window. This study aims to evaluate variability of CT measurement of lesions in thoracic oncology patients on this novel AIO-window. Methods Six radiologists with different levels of expertise measured 368 lesions of various size, origin and sharpness. All lesions were measured twice on the AIO-window and twice on the conventional window settings. Intraclass correlation coefficients and Bland-Altman plots were used to assess intra- and interobserver variability. Results Overall intra-observer agreement for lesion diameters on the AIO-window and conventional window settings was 0.986 (95% Confidence interval (CI): 0.983–0.989) and 0.991 (95% CI 0.989–0.993) respectively. For interobserver agreement this was 0.982 (95% CI 0.979–0.985) (AIO) and 0.979 (95% CI 0.957–0.982) (conventional). For both the AIO and conventional windows, intra- and interobserver agreement were dependent on size, sharpness and reader experience. Measurement variability decreased with increasing lesion size. Regarding sharpness, inter- and intra-observer agreement ranged from 0.986–0.989 (AIO) and 0.985–0.992 (conventional) for well-defined lesions and from 0.978–0.983 (AIO) and 0.974–0.991 (conventional) for ill-defined lesions. Conclusions Lesion diameters were consistently smaller on the AIO-window compared to conventional window settings. Overall intra- and interobserver variability rates were similar for the AIO-window and conventional window settings. We conclude that the AIO-window offers a reliable and reproducible alternative for measurement of thoracic lesions.

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