The relevant psychological burden of having a benign brain tumor: a prospective study of patients undergoing surgical treatment of cranial meningiomas

OBJECTIVEMeningiomas are the most common intracranial neoplasm. Evidence concerning surgical management and outcome is abundant, while the implications for the quality of life (QOL) of a patient confronted with the diagnosis and undergoing surgery are unclear. The authors conducted a prospective study to evaluate QOL in relation to psychological comorbidities comorbidities.METHODSA prospective study of patients undergoing elective surgery for the removal of an intracranial meningioma was performed. The authors evaluated depression (Allgemeine Depressionsskala K score) and anxiety (Post-Traumatic Stress Scale–10 [PTSS-10]; State Trait Anxiety Inventory–State Anxiety and –Trait Anxiety [STAI-S and STAI-T]; and Anxiety Sensitivity Index–3 [ASI-3]) scores before surgery and at 3 and 12 months after surgery. The correlation between preoperative psychological burden and postoperative QOL as measured by the 36-Item Short Form Health Survey and EQ-5L questionnaires was analyzed. Incidence and influence of these psychiatric comorbidities on clinical outcome were examined.RESULTSA total of 78 patients undergoing resection of a meningioma between January 2013 and September 2017 participated in the preoperative psychological screening and 71 patients fully completed postoperative follow-up examination after 1 year of follow-up. At presentation, 48 patients (67.7%) had abnormal anxiety scores, which decreased to 29.6% (p = 0.003). On follow-up at 12 months, mean EQ-5L visual analog scale scores were significantly lower in patients with pathological scores on the PTSS-10 (0.84 vs 0.69; p = 0.004), STAI-S (0.86 vs 0.68; p = 0.001), and STAI-T (0.85 vs 0.71; p = 0.011). Neurological status (modified Rankin Scale) improved slightly and showed some correlation with psychological comorbidities QOL scores (p = 0.167). There was a nonsignificant increase of EQ-5L scores over the period of follow-up (p = 0.174) in the repeated-measures analysis. In the regression analysis, impaired QOL and physical disability on follow-up correlated with elevated preoperative anxiety and depression levels.CONCLUSIONSThe QOL and physical disability of patients undergoing resection of an intracranial meningioma highly depend on preoperative anxiety and depression levels. Stress and anxiety scores generally decrease after the resection, which leads us to conclude that there is a tremendous emotional burden caused by an upcoming surgery, necessitating close psychooncological support in order to uphold functional outcome and health-related QOL in the postoperative course.

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Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.757685 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hugo Bottemanne ◽

Clément Gouraud ◽

Jean-Sébastien Hulot ◽

Anne Blanchard ◽

Brigitte Ranque ◽

...

Keyword(s):

Prospective Study ◽

Acute Infection ◽

Depression Scale ◽

Physical Symptom ◽

Physical Symptoms ◽

Anxiety And Depression ◽

Increased Risk ◽

A Prospective Study ◽

Anxiety Depression

Background: Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the presence of fatigue, dyspnea, and pain complaints at 3-month follow-up.Methods: We conducted a prospective study in patients previously hospitalized for COVID-19 followed up for 3 months. The Hospital Anxiety and Depression Scale (HAD-S) was administered by physicians at 1-month follow-up, and the presence of fatigue, dyspnea, and pain complaints was assessed at both 1 month and 3 months. Multivariable logistic regressions explored the association between anxiety and depression subscores and the persistence of each of the physical symptom at 3 months.Results: A total of 84 patients were included in this study (Median age: 60 years, interquartile range: 50.5–67.5 years, 23 women). We did not find any significant interaction between anxiety and the presence of fatigue, dyspnea, or pain complaints at 1 month in predicting the persistence of these symptoms at 3 months (all p ≥ 0.36). In contrast, depression significantly interacted with the presence of pain at 1 month in predicting the persistence of pain at 3 months (OR: 1.60, 95% CI: 1.02–2.51, p = 0.039), with a similar trend for dyspnea (OR: 1.51, 95% CI: 0.99–2.28, p = 0.052).Discussion and Conclusion: Contrary to anxiety, depression after an acute COVID-19 episode may be associated with and increased risk of some persistent physical symptoms, including pain and dyspnea.

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The hidden burden of anxiety and depression in ovarian cancer: A prospective study from diagnosis.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.7_suppl.155 ◽

2018 ◽

Vol 36 (7_suppl) ◽

pp. 155-155

Author(s):

Penelope M Webb ◽

Vanessa Beesley ◽

Anna deFazio ◽

Andreas Obermair ◽

Peter T. Grant ◽

...

Keyword(s):

Ovarian Cancer ◽

Prospective Study ◽

Depression Scale ◽

Cancer Prognosis ◽

Anxiety And Depression ◽

Prior History ◽

Persistent Symptoms ◽

A Prospective Study ◽

Time Point

155 Background: Women with ovarian cancer (OC) report high rates of anxiety (A) and depression (D), but most studies have used a cross-sectional design at a single time-point, not considered prior history and not included affected women who are symptom-free due to medication. Our goals were to quantify (i) the total burden of A and D among women with newly diagnosed OC; the proportions who (ii) experience symptoms only after their OC diagnosis and (iii) with persistent symptoms; and (iv) use of appropriate medication/services by those affected. Methods: The OPAL (Ovarian Cancer Prognosis & Lifestyle) Study is a prospective study of Australian women diagnosed with OC from 2012-15 who agreed to complete questionnaires at baseline, 3, 6, 9, 12, 24, 36 & 48 months after diagnosis. At baseline, they were asked if they had ever been diagnosed with A or D and if they took medication for this in the year before their OC diagnosis. At follow-up they completed the Hospital Anxiety and Depression Scale (HADS) and were asked about current medication use. Results: Of 893 women with data for ≥1 time point, 216 (24%) reported clinical levels (HADS > 10) of anxiety (18%) and/or depression (15%) on at least one occasion during the first 3 years after diagnosis, with another 157 (18%) reporting use of anxiolytic or antidepressant medications. A further 167 (19%) reported subclinical (HADS 8-10) A or D. Of those with clinical levels of A/D and/or taking medication, 225 (60%) reported this at ≥3 time-points, 216 (58%) reported no prior history of A or D, and 271 (73%) reported no use of anxiolytic/antidepressant medication in the year before diagnosis. When women reported clinical levels of A or D, only 45% reported taking medication (37%) and/or seeing a psychiatrist or psychologist (19%). Conclusions: More than 40% of women with OC experienced clinical levels of A or D during treatment or the first 3 years of follow-up, for 25% this persisted. For 24% this was their first experience of distress and > 50% of those affected did not receive appropriate medication or psychological support. The hidden burden of anxiety and depression in this population is much greater than previously reported but is amenable to effective intervention if recognized.

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Uni- and Bilateral Instrumented Posterolateral Fusion of the Lumbar Spine With Local Bone Grafting: A Prospective Study With a 2-Year Follow-up

Yearbook of Neurology and Neurosurgery ◽

10.1016/j.yneu.2012.04.003 ◽

2012 ◽

Vol 2012 ◽

pp. 299-301

Author(s):

R. Riesenburger

Keyword(s):

Lumbar Spine ◽

Prospective Study ◽

Bone Grafting ◽

Posterolateral Fusion ◽

Local Bone ◽

A Prospective Study

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Spinal Cord Stimulator Improves Pain in Patients with Failed Back Surgery Syndrome: A Prospective Study with up to 2 Years of Follow-up

10.1055/s-0040-1717411 ◽

2020 ◽

Author(s):

S Weidert ◽

R Ibrahim ◽

D Habersatter ◽

Becker CA ◽

A Greiner ◽

...

Keyword(s):

Spinal Cord ◽

Prospective Study ◽

Failed Back Surgery Syndrome ◽

Spinal Cord Stimulator ◽

Failed Back Surgery ◽

Back Surgery ◽

A Prospective Study

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Faculty Opinions recommendation of Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9701956.10381054 ◽

2011 ◽

Author(s):

Sebastiano Filetti ◽

Cosimo Durante

Keyword(s):

Thyroid Cancer ◽

Prospective Study ◽

Follicular Thyroid Cancer ◽

Long Term Follow Up ◽

A Prospective Study

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A Prospective Study of Posterior (Transpedicular) Approach versus Anterior (Transthoracic/Thoracoabdominal) Approach for Posttraumatic Compression Fracture of Thoracolumbar Vertebra in a Tertiary Care Center: Comparison of Clinical and Radiological Outcomes

Indian Journal of Neurotrauma ◽

10.1055/s-0040-1714188 ◽

2020 ◽

Author(s):

Rahul Varshney ◽

Parthasarathi Datta ◽

Pulak Deb ◽

Santanu Ghosh

Keyword(s):

Prospective Study ◽

Posterior Approach ◽

Spinal Injuries ◽

Anterolateral Approach ◽

Kyphotic Angle ◽

Posterior Group ◽

Thoracoabdominal Approach ◽

A Prospective Study ◽

Anterior Group

Abstract Objective The aim of this article was to analyze the clinical and radiological outcomes of transpedicular decompression (posterior approach) and anterolateral approach in patients with traumatic thoracolumbar spinal injuries. Methods It was a prospective study of patients with fractures of dorsolumbar spine from December 2011 to December 2013. A total of 60 patients with traumatic spinal injuries were admitted during the study period (December 2011–2013), of which 51 cases were finally selected and taken for operations while 3 were eventually lost in follow-up. Twenty patients were operated by anterolateral approach, titanium mesh cage, and fixation with bicortical screws. Twenty-eight patients were treated with posterior approach and transpedicular screw fixation. Clinical and radiographic evaluations were performed on all 48 patients before and after surgery. Results There were 48 patients of thoracolumbar burst fractures with 40 male and 8 female patients. Range of follow-up was from 1 month to 20 months, with a mean of 7.4. Preoperatively in anterior group, 65% of the patients were bed ridden, 20% patients were able to walk with support, and 15% of the patients were able to walk without support. In posterior group, 78.57% patients were bed ridden, 10.71% were able to walk with support, and 10.71% patients were able to walk without support. Kyphotic angle changes were seen in 16 patients out of 18 in anterior group and 20 patients in posterior group out of 25. Out of 18 patients in anterior group, 14 showed reduction in kyphotic angle of 10 to 100 (improvement), with mean improvement of 4.070. In posterior group, 7 patients showed improvement of 10 to 80 (reduction in kyphotic angle) whereas 13 patients showed deterioration of 1 to 120. The mean improvement was 2.140 in 7 patients and mean deterioration was 4.920. No statistical difference was found (p > 0.05) regarding improvement in urinary incontinence during the follow-up period. Conclusion There are significant differences in anterior and posterior approaches in terms of clinical improvement. Compared with posterior approach, the anterolateral approach can reduce fusion segment and well maintain the kyphosis correction. The selection of treatment should be based on clinical and radiological findings, including neurological deficit.

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326 Effects of local laser treatment on vulvovaginal atrophy for women with breast cancer: a prospective study with long-term follow-up

10.1136/ijgc-2020-esgo.166 ◽

2020 ◽

Author(s):

Lucie Veron ◽

Delphine Wehrer ◽

Gisèle Annerose-Zephir ◽

Dan Chaltiel ◽

Suzette Delaloge ◽

...

Keyword(s):

Breast Cancer ◽

Prospective Study ◽

Laser Treatment ◽

Vulvovaginal Atrophy ◽

Long Term Follow Up ◽

A Prospective Study

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Customised gold weight eyelid implantation in paralytic lagophthalmos

The Journal of Laryngology & Otology ◽

10.1017/s0022215108001886 ◽

2008 ◽

Vol 122 (10) ◽

pp. 1088-1091 ◽

Cited By ~ 7

Author(s):

N Jayashankar ◽

K P Morwani ◽

M J Shaan ◽

S R Bhatia ◽

K T Patil

Keyword(s):

Visual Acuity ◽

Prospective Study ◽

Study Design ◽

Study Group ◽

Upper Eyelid ◽

Eyelid Closure ◽

Gold Weight ◽

One Year ◽

A Prospective Study

AbstractGold eyelid implantation is widely considered the procedure of choice to reanimate the upper eyelid in paralytic lagophthalmos. Commercially supplied implants are not readily available in all places and are sometimes cumbersome to import.Objective:We aimed to devise a method whereby every surgeon performing gold eyelid implantation could have easy and quick access to the implant. Furthermore, we aimed to develop a means of creating an implant of the exact weight required for complete eyelid closure.Study design and setting:A prospective study was performed from 1997 to 2005 in a tertiary research hospital, involving 50 subjects requiring gold upper eyelid implantation and using the technique in question.Results:Only patients with a minimum follow up of one year were included in the study group. Symptoms improved in 96 per cent of subjects, who were able to dispense with eyedrops and eye ointments. Visual acuity improved in 92 per cent of patients. There were two extrusions amongst the early cases.Conclusion and significance:Customised gold eyelid implantation offers an alternative in regions where commercial implants are not easily obtained.

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