scholarly journals Tremor control after pallidotomy in patients with Parkinson's disease: correlation with microrecording findings

1997 ◽  
Vol 2 (3) ◽  
pp. E4 ◽  
Author(s):  
Jamal M. Taha ◽  
Jacques Favre ◽  
Thomas K. Baumann ◽  
Kim J. Burchiel
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Analog Scale ◽  
Tungsten Electrode ◽  
Drug Induced ◽  
Parkinsonian Tremor ◽  
Posteroventral Pallidotomy ◽  
Group A ◽  
The Difference ◽  
Group B

The goals of this study were to analyze the effect of pallidotomy on parkinsonian tremor and to ascertain whether an association exists between microrecording findings and tremor outcome. Forty-four patients with Parkinson's disease (PD) who had drug-induced dyskinesia, bradykinesia, rigidity, and tremor underwent posteroventral pallidotomy. Using a 1-μ-tip tungsten electrode, microrecordings were obtained through one to three tracts, starting 10 mm above the pallidal base. Tremor severity was measured on a patient-rated, 100-mm Visual Analog Scale (VAS), both preoperatively and 3 to 9 months (mean 6 months) postoperatively. Preoperatively, tremor was rated as 50 mm or greater in 24 patients (55%) and as less than 25 mm in 13 patients (30%). Postoperatively, tremor was rated as 50 mm or greater in five patients (11%) and less than 25 mm in 29 patients (66%). The difference was significant (p = 0.0001). Four patients (9%) had no postoperative tremor. Tremor improved by at least 50% in eight (80%) of 10 patients in whom tremor-synchronous cells were recorded (Group A) and in 12 (35%) of 34 patients in whom tremor-synchronous cells were not recorded (Group B). This difference was significant (p = 0.03). Tremor improved by at least 50 mm in all (100%) of the seven Group A patients with severe (>= 50 mm) preoperative tremor and in nine (53%) of 17 Group B patients with severe preoperative tremor. This difference was also significant (p = 0.05). The authors proffer two conclusions: 1) after pallidotomy, tremor improves by at least 50% in two-thirds of patients with PD who have severe (>= 50 mm on the VAS) preoperative tremor; and 2) better tremor control is obtained when tremor-synchronous cells are included in the lesion.

Tremor control after pallidotomy in patients with Parkinson's disease: correlation with microrecording findings

1997 ◽  
Vol 86 (4) ◽  
pp. 642-647 ◽  
Author(s):  
Jamal M. Taha ◽  
Jacques Favre ◽  
Thomas K. Baumann ◽  
Kim J. Burchiel
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Tungsten Electrode ◽  
Drug Induced ◽  
Content Type ◽  
Parkinsonian Tremor ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
Fine Print

✓ The goals of this study were to analyze the effect of pallidotomy on parkinsonian tremor and to ascertain whether an association exists between microrecording findings and tremor outcome. Forty-four patients with Parkinson's disease who had drug-induced dyskinesia, bradykinesia, rigidity, and tremor underwent posteroventral pallidotomy. Using a 1-µ-tip tungsten electrode, microrecordings were obtained through one to three tracts, starting 10 mm above the pallidal base. Tremor severity was measured on a patient-rated, 100-mm Visual Analog Scale (VAS), both preoperatively and 3 to 9 months (mean 6 months) postoperatively. Preoperatively, tremor was rated as 50 mm or greater in 24 patients (55%) and as less than 25 mm in 13 patients (30%). Postoperatively, tremor was rated as 50 mm or greater in five patients (11%) and less than 25 mm in 29 patients (66%). The difference was significant (p = 0.0001). Four patients (9%) had no postoperative tremor. Tremor improved by at least 50% in eight (80%) of 10 patients in whom tremor-synchronous cells were recorded (Group A) and in 12 (35%) of 34 patients in whom tremor-synchronous cells were not recorded (Group B). This difference was significant (p = 0.03). Tremor improved by at least 50 mm in all (100%) of the seven Group A patients with severe (≥ 50 mm) preoperative tremor and in nine (53%) of 17 Group B patients with severe preoperative tremor. This difference was also significant (p = 0.05). The authors proffer two conclusions: 1) after pallidotomy, tremor improves by at least 50% in two-thirds of patients with Parkinson's disease who have severe (≥ 50 mm on the VAS) preoperative tremor; and 2) better tremor control is obtained when tremor-synchronous cells are included in the lesion.

Unilateral posteroventral pallidotomy in the treatment of drug-induced dyskinesia in Parkinson's disease

2017 ◽  
Vol 81 (5) ◽  
pp. 69 ◽  
Author(s):  
V. M. Tyurnikov ◽  
D. M. Nizametdinova ◽  
A. O. Gushcha ◽  
E. Yu. Fedotova ◽  
V. V. Poleshchuk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Drug Induced ◽  
Posteroventral Pallidotomy

Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease

1992 ◽  
Vol 76 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Lauri V. Laitinen ◽  
A. Tommy Bergenheim ◽  
Marwan I. Hariz
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Movement Control ◽  
Complete Relief ◽  
Content Type ◽  
Parkinsonian Tremor ◽  
Main Complaint ◽  
Posteroventral Pallidotomy ◽  
Positive Effect ◽  
Fine Print

✓ Between 1985 and 1990, the authors performed stereotactic posteroventral pallidotomies on 38 patients with Parkinson's disease whose main complaint was hypokinesia. Upon re-examination 2 to 71 months after surgery (mean 28 months), complete or almost complete relief of rigidity and hypokinesia was observed in 92% of the patients. Of the 32 patients who before surgery also suffered from tremor, 26 (81%) had complete or almost complete relief of tremor. The L-dopa-induced dyskinesias and muscle pain had greatly improved or disappeared in most patients, and gait and speech volume also showed remarkable improvement. Complications were observed in seven patients: six had a permanent partial homonymous hemianopsia (one also had transient dysphasia and facial weakness) and one developed transitory hemiparesis 1 week after pallidotomy. The results presented here confirm the 1960 findings of Svennilson, et al., that parkinsonian tremor, rigidity, and hypokinesia can be effectively abolished by posteroventral pallidotomy, an approach developed in 1956 and 1957 by Lars Leksell. The positive effect of posteroventral pallidotomy is believed to be based on the interruption of some striopallidal or subthalamopallidal pathways, which results in disinhibition of medial pallidal activity necessary for movement control.

scholarly journals Neuroprotective Effect of Monosialotetrahexosylganglioside (GM1) on Patients with Parkinson’s Disease Anesthetized by Ketamine under Denoising Algorithm-Based Ultrasound Image Diagnosis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Weili Wang ◽  
Mingwei Huang ◽  
Tingting Lin ◽  
Chengzhi Lu ◽  
Jiandong Liu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuroprotective Effect ◽  
Lipid Level ◽  
Bilateral Filtering ◽  
Noise Elimination ◽  
Anesthesia Group ◽  
Ketamine Anesthesia ◽  
Group A ◽  
Group B

This study was to investigate the value of ultrasound technology based on the bilateral filtering noise elimination algorithm in evaluating the neuroprotective effect of monosialoganglioside in ketamine-anesthetized Parkinson’s disease patients. The research subjects were 75 patients with Parkinson’s disease admitted to the hospital. The patients were randomly divided into three groups according to different treatment methods: A (GM1 + ketamine anesthesia group), B (conventional treatment + ketamine anesthesia group), and C (GM1 + nonketamine anesthesia group), with 25 patients in each group. Twenty-five healthy people with similar general data in the three groups (groups A, B, and C) were also selected as the control group (group D). All patients underwent ultrasonography, and ultrasound images were processed using the bilateral filter noise elimination. Structural similarity (SSIM), mean absolute error (MAE), and peak signal to noise ratio (PSNR) were used to evaluate the treatment effect. Plasma phospholipids, the third part of the PD unified score scale, Montreal cognitive assessment scale, and other indicators were analyzed and compared among the four groups. The bilateral filtering image noise was effectively suppressed, and the edge details were kept well. Some of the weak edges and texture information in the image were eliminated, the visual effect was ideal, and the accuracy of the edges of the picture remained good. The serotonin lipid level in group A was greatly lower than the serum phospholipid level in group B after GM1 treatment (6.55 VS 7.84, P < 0.05 ). Compared with that before treatment, the serotonin lipid level of group A patients decreased after the treatment, and the difference was considerable (7.46 VS 6.55, P < 0.05 ). In short, GM1 had a protective effect on the nerves of patients with Parkinson’s disease anesthetized by ketamine.

scholarly journals Efficacy of the Osteopathic Treatment in Parkinson’s Disease

2021 ◽  
Vol 20 (2) ◽  
pp. 88-93
Author(s):  
Andrea Bergna ◽  
Elena Zanfagna ◽  
Alessia Ballabio ◽  
Andrea Vendramini ◽  
Livio Claudio Bressan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Disorder ◽  
Sham Treatment ◽  
Potential Efficacy ◽  
Osteopathic Treatment ◽  
Taking Charge ◽  
Group A ◽  
Group B

Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Several studies were carried out in time on osteopathic treatments in patients with PD, demonstrating an improved motor function, albeit short lived. Our trial was aimed at assessing the potential efficacy of the Osteopathic Manipulative treatment (OMT) on mobility, posture, and gait in patients with moderate PD, as well as the importance of “taking charge” of the patient for the Quality of Life (QoL) of individuals with PD. Material and methods. 32 subjects aged 76±7.284 were divided in two groups: group B (n=17) received the OMT, followed by the SHAM treatment; group A (n=15) received the SHAM treatment, then the OMt. the study was designed as a nine-week cross-over trial, with group cross-overperformed after a one-week wash-out. All the subjects underwent a baseline neurological blind evaluation at four weeks and post cross-over. the ADL, IADL, GDS, and GpE scales were also administered. Results. 16 subjects completed the study, 32 subjects participated in the first four weeks only. An improvement of the mean and standard deviation parameters was observed in the UpDRS and the tUG test in patients receiving the OMT. A decrease of the dysfunction degree was observed in both groups upon the osteopathic evaluation. Conclusions. The data show the potential usefulness of the OMT in PD with respect to stiffness, mobility, posture and where the patient is taken charge of. Further studies will be needed to disprove the goal of the trial.

NEUROPSYCHOLOGICAL EFFECTS AFTER CHRONIC SUBTHALAMIC STIMULATION AND THE TOPOGRAPHY OF THE NUCLEUS IN PARKINSON'S DISEASE

Neurosurgery ◽  
2007 ◽  
Vol 61 (5) ◽  
pp. E1024-E1030 ◽  
Author(s):  
Sheng-Tzung Tsai ◽  
Sheng-Huang Lin ◽  
Shinn-Zong Lin ◽  
Jen-Yeu Chen ◽  
Chi-Wei Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Side Effects ◽  
Clinical Outcomes ◽  
Neuropsychological Effects ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Stn Dbs

Abstract OBJECTIVE The neuropsychological effects of chronic subthalamic nucleus (STN)-deep brain stimulation (DBS) as a treatment for Parkinson's disease are variable. Whether these side effects result from the target per se or current diffusion into neighboring structures is uncertain. In this study, the relationship between clinical outcomes and coordinates of active contact are analyzed and compared between patients with and without neuropsychological sequelae. METHODS Thirty-eight Parkinsonian patients who underwent bilateral STN-DBS were enrolled in this retrospective cohort study. They were followed for at least 12 months. During the follow-up period, they were divided into two groups for comparison; Group A included patients with neuropsychological side effects and Group B was composed of patients without neuropsychological side effects. The position of the active contact of the electrode was defined with postoperative magnetic resonance imaging scans according to the midcommissural line. Active contact coordinates and clinical outcomes were compared for the two groups. RESULTS Among the 38 Parkinsonian patients who underwent STN-DBS, eight patients who had neuropsychological side effects were assigned to Group A; the other 30 patients were assigned to Group B. In Groups A and B, the mean follow-up periods were 13.9 and 12.1 months, respectively, the Unified Parkinson's Disease Rating Scale motor score was improved by 53.4 and 45.2% (P = 0.24), respectively, and the levodopa equivalent daily dosage was decreased by 68.4 and 46.4% (P = 0.16), respectively. The mean coordinates of active contact in both Groups A and B were x = 10.1 and 10.5 mm, respectively, y = −2.8 and −3.9 mm, respectively, and z = −6.3 and −6.2 mm, respectively, relative to the midcommissural point. A significant difference was observed on the y axis (P = 0.01). CONCLUSION When taking spatial influence into consideration, the neuropsychological effects of chronic STN-DBS were related to a significant anteriorly located active contact within the ventral STN in this preliminary study. This might suggest the existence of topography of STN in patients with Parkinson's disease concerning limbic and associative circuits.

Efficacy and Safety of Oral Ivermectin and Topical Permethrin in the Treatment of Scabies

2020 ◽  
Vol 33 (1) ◽  
pp. 41-47
Author(s):  
Mohsena Akhter ◽  
Ishrat Bhuiyan ◽  
Zulfiqer Hossain Khan ◽  
Mahfuza Akhter ◽  
Gulam Kazem Ali Ahmad ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Close Contact ◽  
Randomized Study ◽  
Sarcoptes Scabiei ◽  
Efficacy And Safety ◽  
Common Skin ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B

Background: Scabies is one of the most common skin diseases in our country. It is caused by the mite Sarcoptes scabiei var hominis, which is an ecto-parasite infesting the epidermis. Scabies is highly contagious. Prevalence is high in congested or densely populated areas. Individuals with close contact with an affected person should be treated with scabicidal which is available in both oral and topical formulations. The only oral but highly effective scabicidal known to date is Ivermectin. Amongst topical preparations, Permethrin 5 % cream is the treatment of choice. Objective: To evaluate the efficacy & safety of oral Ivermectin compared to topical Permethrin in the treatment of scabies. Methodology: This prospective, non-randomized study was conducted at the out-patient department of Dermatology and Venereology of Shaheed Suhrawardy Medical College & Hospital over a period of 6 months, from August 2016 to January 2017. The study population consisted of one hundred patients having scabies, enrolled according to inclusion criteria. They were divided into two groups. group A was subjected to oral Ivermectin and the group B to Permethrin 5% cream. Patients were followed up on day 7 and 14 for assessment of efficacy and safety. Result: The mean scoring with SD in group A (Ivermectin) and group B (Permethrin) were 8.26 ± 2.22 and 7.59 ± 2.01 respectively at the time of observation. The difference between the mean score of the two group is not significant (p=0.117) the mean scoring with SD in group A and group B were 4.54 ± 2.05 and 1.64 ± 1.84 respectively at 7thdays. The difference between the mean score of the two group is significant (p<0.001). The mean scoring with SD in group A and group B were 2.68± 2.35 and .36± 1.10 respectively at 14th day difference between the mean score of the group is significant (p<0.001). Conclusion: Topical application of permethrin 5% cream is more effective and safer than oral Ivermectin in the treatment of scabies. TAJ 2020; 33(1): 41-47

Effect of Sample Storage Conditions on Body Burden Analysis of Organic Contaminants in Unionid Mussels

1992 ◽  
Vol 27 (4) ◽  
pp. 833-844 ◽  
Author(s):  
Micheline Hanna
Keyword(s):  
Organic Contaminants ◽  
Body Burden ◽  
Storage Conditions ◽  
The Body ◽  
Sample Storage ◽  
Pcb Congeners ◽  
Unionid Mussels ◽  
Group A ◽  
The Difference ◽  
Group B

Abstract In order to quantitatively assess the effect of sample storage conditions on the body burden analysis of organic contaminants, a comparative analysis was carried out on the unionid mussel Elliptic complanata. The mussels were divided into two groups, each with distinct storage conditions, while Group A was kept in the freezer at −20°C, Group B was kept in the refrigerator for five days at 5°C. All the compounds present in the control were also present in Group B samples. Analysis of the organic contaminants in each of these two groups showed that for total PCB concentrations, the two treatments were not significantly different; however when compared individually 6 of the 13 PCB congeners showed significant differences. The observed differences were relatively small for individual PCB congeners (7.1 to 15.3%), higher for chlorobenzenes (10.5 to 36.4%), and yet higher for HCE (44.1%); the difference for HCE, although large is nevertheless not significant, even if only marginally so.

scholarly journals The Pandemic and Changes in the Self-Perception of Teacher Digital Competences of Infant Grade Students: A Cross Sectional Study

2021 ◽  
Vol 18 (9) ◽  
pp. 4756
Author(s):  
Rosalía Romero-Tena ◽  
Carmen Llorente-Cejudo ◽  
María Puig-Gutiérrez ◽  
Raquel Barragán-Sánchez
Keyword(s):  
Intervention Group ◽  
Cross Sectional Study ◽  
Self Perception ◽  
Digital Competence ◽  
Cross Sectional ◽  
Self Perceptions ◽  
Group A ◽  
Different Dimensions ◽  
The Difference ◽  
Group B

Without having a reaction time, the pandemic has caused an unprecedented transformation in universities around the world, leading to a revolution from structured models anchored in the conception of transmission of training towards a teaching approach-learning saved thanks to the incorporation of technology. This study aims to verify whether the pandemic situation has influenced the digital competence self-perception of students. Comparing two groups during the academic years 2019/2020 and 2020/2021, the instrument used is the questionnaire for digital competence “DigCompEdu Check-In” for future teachers. After the educational intervention, group A (before COVID-19) presented higher self-perceptions of competence than group B (during COVID-19); the pandemic situation caused by COVID-19 has negatively influenced students’ self-perception of their digital skills in the pretest in the different dimensions under study. Before receiving the training, the group that did not experience the pandemic enjoyed a higher self-perception of their competencies than the group that experienced the pandemic. The data obtained indicate that the difference exists, and that it is statistically significant, and may be a consequence of the clear relationship between self-perception and the way in which students face reality through their personal and subjective vision.

Effects of Onabotulinum Toxin A on Gait in Parkinson’s Disease Patients with Foot Dystonia

2021 ◽  
pp. 1-6
Author(s):  
Pei Huang ◽  
Yuan-Yuan Li ◽  
Jung E. Park ◽  
Ping Huang ◽  
Qin Xiao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Botulinum Toxin ◽  
Gait Analysis ◽  
Rating Scale ◽  
Analog Scale ◽  
Toxin A ◽  
Timed Up And Go ◽  
Balance Test ◽  
Onabotulinum Toxin A

ABSTRACT: We investigated the effects of botulinum toxin on gait in Parkinson’s disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin’s effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.

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