Spinal cord involvement with Schistosoma mansoni

1972 ◽  
Vol 36 (4) ◽  
pp. 494-498 ◽  
Author(s):  
Allan Herskowitz
Keyword(s):  
Spinal Cord ◽  
Schistosoma Mansoni ◽  
Laboratory Data ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Leg Pain ◽  
Low Back ◽  
Pertinent Literature ◽  
Content Type ◽  
Clinical Signs And Symptoms

✓ A case of Schistosoma mansoni involving the spinal cord is reported and the pertinent literature reviewed. The epidemiology, pathology, clinical signs and symptoms, and laboratory data that frequently occur in this disease are presented. Low back or leg pain associated with sphincter disturbance and eosinophilia in a patient from an endemic area should alert the physician to the diagnosis. Early institution of specific therapy and decompressive surgery are the major determinants for a favorable prognosis in this potentially curable neurological disease.

Spinal epidural cavernous hemangiomas

1998 ◽  
Vol 88 (5) ◽  
pp. 903-908 ◽  
Author(s):  
Dimitris Zevgaridis ◽  
Andreas Büttner ◽  
Serge Weis ◽  
Christoph Hamburger ◽  
Hans-Jürgen Reulen
Keyword(s):  
Spinal Cord ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Surgical Excision ◽  
Content Type ◽  
Complete Surgical Excision ◽  
Imaging Characteristics ◽  
Cavernous Hemangiomas ◽  
Clinical Signs And Symptoms ◽  
Spinal Epidural

✓ Epidural cavernous hemangiomas are increasingly identified as a cause of acute or chronic progressive spinal cord syndrome and local back pain or radiculopathy. The authors present three cases of spinal epidural cavernous hemangiomas manifesting as spinal cord syndrome, thoracic radiculopathy, and lumbar radiculopathy. Based on the imaging characteristics of these three cases and a review of the literature, the clinical signs and symptoms and their implications, the role of preoperative neuroradiological diagnosis, and the need for complete surgical resection are discussed. Epidural cavernous hemangiomas display consistent magnetic resonance imaging properties: T1-weighted images most commonly show a homogeneous signal intensity similar to those of spinal cord and muscle, and contrast enhancement is homogeneous or slightly heterogeneous. On T2-weighted images the signal of the lesion is consistently high and slightly less intense than that of cerebrospinal fluid. Frequently, the lesion is characterized by its extension through the intervertebral foramen. Awareness of these characteristics facilitates diagnosis and treatment of the lesions. Despite the risk of bleeding, in all three cases complete surgical excision was achieved.

scholarly journals Validity of selected clinical signs and symptoms in diagnosis of Schistosoma mansoni infection

1991 ◽  
Vol 33 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Maria Fernanda F. de Lima e Costa ◽  
Roberto S. Rocha ◽  
Daniel Colley ◽  
Giovanni Gazzenelli ◽  
Naftale Katz
Keyword(s):  
Schistosoma Mansoni ◽  
Endemic Area ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Predictive Values ◽  
Clinical Signs And Symptoms ◽  
Sensitivity Specificity

Sensitivity, specificity and positive predictive values of selected clinical signs and symptoms in the diagnosis of Schistosoma mansoni infection were evaluated in 403 individuals (69% of inhabitants over 1 year of age) in an endemic area in Brazil (Divino). Highest sensitivity (13%) was found for blood in stools. Specificity over 90% was found for blood in stools, palpable liver with normal consistency and palpable hardened liver at middle clavicular (MCL) or middle sternal lines (MSL). Hardened liver at MSL (83%) or MCL (75%), and blood in stools (78%) presented higher positive predictive values for S. mansoni infection, while palpable liver with normal consistency at MCL (45%) or MSL (48%) presented smaller values. Enlarged liver without specification of its consistency has been traditionally used as an indicator of the infection in areas where malaria or Kalazar are not endemic. Our results demonstrate that the probability that a person with blood in stools or hardened palpable liver is infected is higher than among those with palpable liver with normal consistency.

Detection of small trigeminal neurinomas

1976 ◽  
Vol 45 (5) ◽  
pp. 568-575 ◽  
Author(s):  
Robert Levinthal ◽  
John R. Bentson
Keyword(s):  
Lumbar Puncture ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Tumor Removal ◽  
Operative Morbidity ◽  
Content Type ◽  
Brain Scan ◽  
Trigeminal Neurinoma ◽  
Clinical Signs And Symptoms ◽  
Fine Print

✓ Four cases of trigeminal neurinoma are reviewed with particular attention to clinical signs and symptoms, lumbar puncture, electroencephalogram, brain scan, plain skull and tomographic radiographs, and angiographic and pneumoencephalographic findings. Pneumoencephalography, with special tomographic projections to identify various portions of the trigeminal nerve, delineated the tumor in all cases. Tumor removal was complete in three patients and nearly complete in the fourth. There was no operative morbidity or mortality.

scholarly journals 741. Ehrlichia chaffeensis Induced Hemophgocytic lymphohistiocytosis: A Descriptive Case Series

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S468-S469
Author(s):  
jeffrey lin ◽  
Hanine El Haddad ◽  
Ayman Qasrawi ◽  
Gerhard Hildebrandt
Keyword(s):  
Hemophagocytic Lymphohistiocytosis ◽  
Nk Cell ◽  
Spotted Fever ◽  
Immunosuppressive Treatment ◽  
Laboratory Data ◽  
Cell Activity ◽  
Clinical Signs ◽  
Case Series ◽  
Signs And Symptoms ◽  
Clinical Signs And Symptoms

Abstract Background Hemophagocytic lymphohistiocytosis (HLH) secondary to tick borne illnesses is rarely reported. Clinical signs and symptoms of tick borne illnesses and HLH might overlap with fever, cytopenias and increased liver enzymes being common. We describe findings from case series of ehrlichiosis induced HLH. Methods We reviewed patients with ICD-10 codes corresponding to a diagnosis of HLH or macrophage activation syndrome (MAS) at University of University of Kentucky Medical Center between January 2008 and April 2020. Inpatients who were >18 years of age without known immune compromise were included. 4 cases with confirmed underlying ehrlichiosis were identified at our institution. We searched PubMed for English-language articles containing the terms “ Hemophagocytic lymphohistiocytosis “ and “infection” or “tick borne” or “Ehrlichia”. Data on patient demographics, clinical signs and symptoms, laboratory data such as ferritin, platelet count, Il-2, NK cell activity, and outcomes were collected. Results We identified 16 cases of ehrlichiosis (1 had a coinfection with Rocky Mountain Spotted fever). Eleven out of 6 (68%) were male, median age was 58. All patients were febrile and thrombocytopenic on presentation and 8/14 (57%) were neutropenic. All had elevated ferritin (mean 36187 ng/mL, range 860 – more than 100000). CNS involvement was reported in 4 patients with a positive CSF Ehrlichia chaffensis PCR. All patients met at least 5 2004-HLH defining criteria and 10/14 (71%) patients had evidence of hemophagocytosis on bone marrow biopsy (table 1). Fourteen out of 15 (93%) patients received doxycycline and 9/15 (60%) received steroids +/- etoposide. Mortality for Ehrlichia induced HLH was 12.5%, significantly lower than that reported for all secondary HLH mortality (45%). Conclusion This review highlights the importance of considering Ehrilichiosis as a cause of HLH in endemic areas particularly as clinical signs and symptoms of the 2 entities overlap. While overall mortality rate due to HLH is elevated, Ehrlichia induced HLH seems to have a much favorable prognosis with prompt institution antimicrobial treatment. Additional prognostic factors that correlate with a more severe course dictate need for immunosuppressive treatment need to be further elucidated. Disclosures Gerhard Hildebrandt, MD, Bayer, Scotts-Miracle, Charlottes Webb CWBHF, Almmune Therapeutics Inc AIMT, Medical PPTYS TR Inc. MPW, Caretrust Reit Inc CTRE, ANGI Homeservices Inc (Shareholder)Bristil-Myers Squibb/Medarex, Crispr therapeutics, IDEXX Laboratories, Johnson & Johnson, Pfizer, Procter & Gamble, Vertex (Shareholder)Falk Foundation, Incyte, Takeda (Other Financial or Material Support, Travel, Accommodations, Expenses)Jazz Pharmaceuticals, Incyte, Morphosys, Alexion Pharmaceuticals, Karyopharm Therapeutics, Seattle Genetics (Consultant)Jazz Pharmaceuticals, Pharmacyclics, Incyte, AstraZeneca (Grant/Research Support)Novartis, Insys Therapeutics, Abbvie, GW Pharmaceuticals, Cardinal Health, Clovis Oncology, Cellectis, CVS Health, Celgene, Bluebird Bio (Shareholder)

scholarly journals Therapy for patients with asymptomatic and mild cases of COVID-19 in Indonesia

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 898
Author(s):  
Joni Wahyuhadi ◽  
Erwin Astha Triyono ◽  
Christijogo Soemartono Waloejo ◽  
Agus Harianto ◽  
Halim Priyahau Jaya ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Demographic Data ◽  
Laboratory Data ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Total Sample ◽  
Field Hospital ◽  
Global Pandemic ◽  
Clinical Signs And Symptoms ◽  
Age Range

Background: Though coronavirus disease (COVID-19) has been designated as a global pandemic, its nature as a viral infection means that it is essentially a self-limiting disease. We studied the application of symptomatic, isolation, relaxation, nutrition and observation (SIRNO) therapy in patients with asymptomatic and mild symptoms of COVID-19 at a rescue hospital in Indonesia. Methods: This is a retrospective cohort study involving 2122 patients who were admitted to Indrapura Field Hospital in Surabaya from 28 May 2020 to 20 September 2020. We analyzed demographic data, clinical signs and symptoms, laboratory data, therapy and clinical outcomes. Result: The total sample of 2122 patients consisted of 1403 male patients (66.12%), and 719 female patients (33.88 %). The most common age range was 26-45 years, at 52.54% (1115 patients). The clinical symptoms of 1121 patients (52.8%) were asymptomatic, 977 patients (46%) had mild symptoms, and 24 patients (0.1%) had moderate symptoms. All patients received the SIRNO therapy method. From a total of 2122 patients, 1930 patients (90.9%) were cured, 181 patients (8.5%) are still being treated, seven patients (0.03%) were referred for indications of desaturation (SpO2 <94%), and four patients (0.01%) were moved to a referral hospital. Until 20 September 2020, the final date studied, there were no patient deaths. Conclusion: The SIRNO method provides excellent results in the management of COVID-19 at a rescue hospital for patients with asymptomatic and mild symptoms. Economic pharmacological research can initiate a follow-up study in order to objectively measure the effectiveness and efficiency of SIRNO treatment methods in patients with asymptomatic, mild symptoms of COVID-19, and the small number of 24 patients (0,.1%) with moderate symptoms.

Cruciate paralysis: a clinical and radiographic analysis of injuries to the cervicomedullary junction

1990 ◽  
Vol 73 (6) ◽  
pp. 850-858 ◽  
Author(s):  
Curtis A. Dickman ◽  
Mark N. Hadley ◽  
Conrad T. E. Pappas ◽  
Volker K. H. Sonntag ◽  
Fred H. Geisler
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injuries ◽  
Cervical Spinal Cord ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Lower Extremity Function ◽  
Rare Injury ◽  
Radiographic Findings ◽  
Content Type ◽  
Cervicomedullary Junction

✓ Fourteen patients with superior cervical spinal cord injuries and the clinical signs and symptoms of cruciate paralysis are presented. This rare injury pattern is characterized by weakness of the upper extremities with little or no compromise of lower-extremity function following trauma to the superior spinal cord. Anatomically, cruciate paralysis is thought to represent selective injury to descending corticospinal tracts as they decussate at the cervicomedullary junction. The clinical and radiographic findings of each patient are outlined and the incidence and natural history of the injury syndrome, including a review of the literature, are presented.

scholarly journals Epidemiology of Schistosoma mansoni infection in a low-endemic area in Brazil: clinical and nutritional characteristics

1992 ◽  
Vol 34 (5) ◽  
pp. 409-419 ◽  
Author(s):  
Fernando A. Proietti ◽  
Urquisa H. M. Paulino ◽  
Clea A. Chiari ◽  
Anna B. F. C. Proietti ◽  
Carlos M. F. Antunes
Keyword(s):  
Schistosoma Mansoni ◽  
Linear Trend ◽  
Clinical Signs ◽  
Low Frequency ◽  
Signs And Symptoms ◽  
Stool Examination ◽  
Cross Sectional ◽  
Positive Stool ◽  
Geometrical Mean ◽  
Clinical Signs And Symptoms

A cross-sectional case-control study designed to evaluate the role of malnutrition in the association between the intensity of Schistosoma mansoni infection and clinical schistosomiasis, was conducted in an area with both low frequency of infection and low morbidity of schistosomiasis in Brazil. Cases (256) were patients with a positive stool examination for S. mansoni; their geometrical mean number of eggs/gram of feces was 90. Controls (256) were a random sample of the negative participants paired to the cases by age, sex and length of residence in the area. The clinical signs and symptoms found to be associated with S. mansoni infection, comparing cases and controls, were blood in stools and presence of a palpable liver. A linear trend in the relative odds of these signs and symptoms with increasing levels of infection was detected. Adjusting by the level of egg excretion, the existence of an interaction between palpable liver and ethnic group (white) was suggested. No differences in the nutritional status of infected and non-infected participants were found.

scholarly journals Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 5
Author(s):  
Donatella Rita Petretto ◽  
Gian Pietro Carrogu ◽  
Luca Gaviano ◽  
Lorenzo Pili ◽  
Roberto Pili
Keyword(s):  
Young Woman ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neurocognitive Disorders ◽  
Lessons Learned ◽  
Alzheimer Dementia ◽  
Clinical Notes ◽  
Alois Alzheimer ◽  
Clinical Signs And Symptoms

Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

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