Therapy for patients with asymptomatic and mild cases of COVID-19 in Indonesia

Background: Though coronavirus disease (COVID-19) has been designated as a global pandemic, its nature as a viral infection means that it is essentially a self-limiting disease. We studied the application of symptomatic, isolation, relaxation, nutrition and observation (SIRNO) therapy in patients with asymptomatic and mild symptoms of COVID-19 at a rescue hospital in Indonesia. Methods: This is a retrospective cohort study involving 2122 patients who were admitted to Indrapura Field Hospital in Surabaya from 28 May 2020 to 20 September 2020. We analyzed demographic data, clinical signs and symptoms, laboratory data, therapy and clinical outcomes. Result: The total sample of 2122 patients consisted of 1403 male patients (66.12%), and 719 female patients (33.88 %). The most common age range was 26-45 years, at 52.54% (1115 patients). The clinical symptoms of 1121 patients (52.8%) were asymptomatic, 977 patients (46%) had mild symptoms, and 24 patients (0.1%) had moderate symptoms. All patients received the SIRNO therapy method. From a total of 2122 patients, 1930 patients (90.9%) were cured, 181 patients (8.5%) are still being treated, seven patients (0.03%) were referred for indications of desaturation (SpO2 <94%), and four patients (0.01%) were moved to a referral hospital. Until 20 September 2020, the final date studied, there were no patient deaths. Conclusion: The SIRNO method provides excellent results in the management of COVID-19 at a rescue hospital for patients with asymptomatic and mild symptoms. Economic pharmacological research can initiate a follow-up study in order to objectively measure the effectiveness and efficiency of SIRNO treatment methods in patients with asymptomatic, mild symptoms of COVID-19, and the small number of 24 patients (0,.1%) with moderate symptoms.

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Clinical Features, Diagnosis and Management of Patients with Suspicion of Fascioliasis in Kohgiluyeh and Boyer-Ahmad Province, Southwestern Iran

Iranian Journal of Parasitology ◽

10.18502/ijpa.v15i1.2530 ◽

2020 ◽

Author(s):

Abdolali MOSHFE ◽

Arash ARIA ◽

Najme ERFANI ◽

Ali JAMSHIDI ◽

Bahador SARKARI ◽

...

Keyword(s):

Clinical Features ◽

Clinical Symptoms ◽

Epigastric Pain ◽

Serological Test ◽

Demographic Data ◽

Clinical Signs ◽

Signs And Symptoms ◽

Diagnosis And Management ◽

History Of ◽

Clinical Signs And Symptoms

Background: In the current study, we described the epidemiological features, clinical presentation, diagnosis and management of patients with suspicion of fascioliasis in Kohgiluyeh and Boyer-Ahmad Province in southwest of Iran. Methods: Overall, 56 patients with suspicion of fascioliasis, based on their clinical signs and symptoms that referred to Clinic of Internal Medicine in Yasuj city, from 2014 to 2016 were enrolled. Demographic data, history of eating aquatic local plants, the chief complains, and laboratory findings were recorded for each patient. Stool samples were obtained from each case for detection of Fasciola eggs. Moreover, blood samples were taken from each patient and evaluated for detection of anti-Fasciola antibodies by an indirect ELISA. Patients who defined as having fascioliasis were treated with triclabendazole and were followed for at least three months for clinical improvement. Results: Serological test was positive in 5 patients. Of these 5 cases, three cases had a history of ingesting raw aquatic vegetables. The main clinical signs and symptoms in positive cases were; abdominal pain (60%), epigastric pain (40%), anemia (60%), and dermal pruritus (20%). Hypereosinophilia was seen in all of 5 positive cases. No Fasciola egg was found in stool specimens of any of the patients. The fascioliasis cases were treated by triclabendazole and clinical symptoms disappeared in all of 5 cases. Conclusion: Our observation further confirmed Yasuj district as a human endemic area for fascioliasis in Iran. The study also highlighted the importance of clinical features together with eosinophilia, as key parameters, in the diagnosis of human fascioliasis. Clinicians need to be aware of this disease and should keep in mind fascioliasis when hypereosinophilia present in patients in such endemic areas.

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ELECTRODIAGNOSTIC CRITERIA FOR DIAGNOSING CARPAL TUNNEL SYNDROME NEED TO BE REVISED IN HYPOTHYROID PATIENTS

Journal of Musculoskeletal Research ◽

10.1142/s0218957717500142 ◽

2017 ◽

Vol 20 (03) ◽

pp. 1750014

Author(s):

Mahdieh Asadi ◽

Sharareh Roshanzamir

Keyword(s):

Carpal Tunnel Syndrome ◽

Carpal Tunnel ◽

Clinical Symptoms ◽

Clinical Signs ◽

Signs And Symptoms ◽

Control Group ◽

Tunnel Syndrome ◽

Clinical Signs And Symptoms ◽

Relationship Of ◽

Hypothyroid Patients

Background: Previous studies do not agree with each other on the association between electrodiagnostic findings and clinical symptoms of Carpal tunnel syndrome (CTS). In most of these studies, many variables such as age, sex, obesity and hypothyroidism have not been taken into account. Material & methods: About 62 patients with hypothyroidism and 62 patients without hypothyroidism with sign and symptoms of CTS were included in this study. Electrodiagnostic tests were done for all patients. And relationship of the severity of CTS signs and symptoms with electrodiagnostic parameters was examined statistically in each group. Results: This study showed that distal motor latency in control group (without hypothyroidism) is significantly more prolonged than hypothyroid patients. Also there was significant correlation between clinical symptoms and electrodiagnostic findings in control group, but there was not such correlation in hypothyroid patients. In 62% of hypothyroid patients with clinical signs and symptoms of CTS, electrodiagnostic findings were normal and only in 38% of cases, electrodiagnostic findings were suggestive of CTS. Conclusion: Relationship of the severity of CTS signs and symptoms with electrodiagnostic parameters is very weak in hypothyroid patients. Many hypothyroid patients with clinical signs and symptoms of CTS have normal electrodiagnostic findings; so we need more studies for revising the para-clinic criteria of labeling patients having CTS in hypothyroid patients.

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Evaluate the Therapeutic Effect of Allicin (L-cysteine) on Clinical Presentation and Prognosis in Patients with COVID-19

European Journal of Translational Myology ◽

10.4081/ejtm.2021.9518 ◽

2021 ◽

Author(s):

Hosein Yaghoubian ◽

Hossein Niktale ◽

Arash Peivandi Yazdi ◽

Vahideh Ghorani ◽

Masoud Mahdavi Rashed ◽

...

Keyword(s):

Therapeutic Effect ◽

Clinical Presentation ◽

Clinical Symptoms ◽

Healing Process ◽

Clinical Signs ◽

Signs And Symptoms ◽

Blood Parameters ◽

Radiological Data ◽

Clinical Signs And Symptoms ◽

Chest Ct Scan

The antiviral effectiveness of allicin (L-cysteine) has been shown by numerous studies in both levels of clinical and animals. The aim of this study was to evaluate the therapeutic effect of allicin (L-cysteine) on clinical presentation and prognosis. In the current study, 66 patients with COVID-19 based on clinical, radiological presentations and RT-PCR results, were enrolled in two groups of placebo and allicin. In the both allicin (L-cysteine) and placebo groups (n=33 in each group), the capsules were prescribed two times a day for two weeks. Clinical signs and symptoms, blood parameters and chest CT scan were evaluated before and two weeks after treatment. The results showed that allicin (L-cysteine) could significantly impact on improvement of signs and symptoms of COVID-19 after two weeks of treatment in comparison to placebo. Allicin (L-cysteine) not only improve the clinical signs, but also ameliorate the lab and radiological data, which suggest a therapeutic effect for this agent in COVID-19. Our data suggest the therapeutic effect of allicin (L-cysteine) on COVID-19 through improvement of clinical symptoms and acceleration of the healing process.

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Clinical characteristics of COVID-19 in children compared with adults in Shandong, China

10.21203/rs.3.rs-17119/v1 ◽

2020 ◽

Author(s):

Wenjun Du ◽

Jinhong Yu ◽

Hui Wang ◽

Xiaoguo Zhang ◽

Shouwei Zhang ◽

...

Keyword(s):

Clinical Laboratory ◽

Health Workers ◽

Clinical Symptoms ◽

Clinical Signs ◽

Clinical Manifestations ◽

Case Series ◽

Signs And Symptoms ◽

Asymptomatic Patients ◽

Positive Indicators ◽

Clinical Signs And Symptoms

Abstract Aims & Background: The COVID-19 outbreak spread in China and is a threat to the world. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment.Methods: Retrospectively, two research centers’ case series of 67 consecutive hospitalized cases including 14 children cases with COVID-19 between 23 Jan 2020 to 15 Feb 2020 from Jinan and Rizhao were enrolled in this study. Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared.Results: Most cases in children were mild(21.4%) and conventional cases(78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. Fever (35.7%) and dry cough(21.4%) were described as clinical manifestations in children cases. Dry cough and phlegm were not the most common symptoms in children compared with adults(p=0.03). In the early stages of the disease, lymphocyte counts did not significantly decline but neutrophils counts did in children compared with adults(p=0.00).There was an elevated level of LDH(p=0.01) and a lower level of CRP(p=0.00)and IL-6(p=0.01) in children compared with adults. There were 8 (57.1%)asymptomatic cases and 6 (42.9%)symptomatic cases among the 14 children cases. The age of asymptomatic patients was younger than that of symptomatic patients(p=0.03). Even among asymptomatic patients, 5(62.5%)cases had pneumonia including 3 (60%) cases with bilateral pneumonia, which was not different compared with that of asymptomatic cases(p=0.58, p=0.74).Conclusions: The clinical symptoms of children are mild, and the positive indicators of laboratory tests are rare, which may easily cause clinical misdiagnoses.

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ORAL MANIFESTATIONS OF COVID-19: EARLY DIAGNOSTIC AID?

10.36106/ijsr/7233891 ◽

2020 ◽

pp. 1-3

Author(s):

Pooja Katira ◽

Deep Shah ◽

Falguni Maniyar

Keyword(s):

Salivary Glands ◽

Oral Mucosa ◽

Clinical Signs ◽

Signs And Symptoms ◽

Healthcare Services ◽

Oral Lesions ◽

Oral Manifestations ◽

Global Pandemic ◽

Clinical Signs And Symptoms ◽

Taste And Smell

The outbreak of coronavirus disease which has rapidly escalated into a global pandemic continues to have disastrous health, economic and social effects on the human population. It has markedly affected the delivery of healthcare services all over the world. Early diagnosis of the disease is imperative to contain the spread of the viral infection. The main clinical signs and symptoms produced by SARS-CoV2 have been well described in the literature. However, there is emerging evidence on the oral lesions that may indicate the presence of COVID-19 infection. Since the virus has affinity for angiotensin converting enzyme (ACE2) receptors present in the respiratory tract, oral mucosa, tongue and salivary glands, the oral cavity serves as a major habitat for invasion of the virus. Thus, COVID-19 infection can affect the functioning of salivary glands, integrity of oral mucosa and can also cause alterations in sense of taste and smell. Good oral hygiene can decrease the incidence and severity of the main complications of COVID-19. The present review analyses the available evidence in relation to oral manifestations which are expressed in the course of the coronavirus disease and how it can aid in diagnosing the disease further.

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MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy

International Journal of Molecular Sciences ◽

10.3390/ijms20225600 ◽

2019 ◽

Vol 20 (22) ◽

pp. 5600 ◽

Cited By ~ 3

Author(s):

Arturo López Castel ◽

Sarah Joann Overby ◽

Rubén Artero

Keyword(s):

Myotonic Dystrophy ◽

Rna Binding ◽

Clinical Symptoms ◽

Clinical Signs ◽

Neuromuscular Diseases ◽

Signs And Symptoms ◽

Disease Biomarkers ◽

Clinical Signs And Symptoms

Myotonic dystrophy involves two types of chronically debilitating rare neuromuscular diseases: type 1 (DM1) and type 2 (DM2). Both share similarities in molecular cause, clinical signs, and symptoms with DM2 patients usually displaying milder phenotypes. It is well documented that key clinical symptoms in DM are associated with a strong mis-regulation of RNA metabolism observed in patient’s cells. This mis-regulation is triggered by two leading DM-linked events: the sequestration of Muscleblind-like proteins (MBNL) and the mis-regulation of the CUGBP RNA-Binding Protein Elav-Like Family Member 1 (CELF1) that cause significant alterations to their important functions in RNA processing. It has been suggested that DM1 may be treatable through endogenous modulation of the expression of MBNL and CELF1 proteins. In this study, we analyzed the recent identification of the involvement of microRNA (miRNA) molecules in DM and focus on the modulation of these miRNAs to therapeutically restore normal MBNL or CELF1 function. We also discuss additional prospective miRNA targets, the use of miRNAs as disease biomarkers, and additional promising miRNA-based and miRNA-targeting drug development strategies. This review provides a unifying overview of the dispersed data on miRNA available in the context of DM.

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Role of Dentist in Diagnosis and Management of Mucormycosis in Association with COVID-19

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210722 ◽

2021 ◽

Vol 11 (7) ◽

pp. 159-163

Author(s):

Piyush Dongre ◽

Tanya Bansal

Keyword(s):

Early Diagnosis ◽

Fungal Infections ◽

Clinical Signs ◽

Signs And Symptoms ◽

Review Article ◽

The Novel ◽

Diagnosis And Management ◽

Global Pandemic ◽

Clinical Signs And Symptoms

In surge of the novel corona virus, there is increase in the frequency of fungal infections. Mucormycosis is one of the deep fungal infections which are increasing rapidly in this global pandemic period. Thus the early diagnosis and management is of utmost importance to decline the rate of this fatal infection. The clinical signs and symptoms and the culture reports are strictly considered in the management of oral fungal infection. This review article focuses on the importance of early diagnosis, prevention and management of mucormycosis and the role of the dentist in doing so. Key words: Mucormycosis, diagnosis, management, dentist.

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Black Quarter (BQ) Disease in Cattle and Diagnosis of BQ Septicaemia Based on Gross Lesions and Microscopic Examination

Bangladesh Journal of Microbiology ◽

10.3329/bjm.v25i1.4848 ◽

1970 ◽

Vol 25 (1) ◽

pp. 13-16 ◽

Cited By ~ 4

Author(s):

Mahmuda Sultana ◽

Abdul Ahad ◽

Paritosh Kumar Biswas ◽

M Ashiqur Rahman ◽

Himel Barua

Keyword(s):

Clinical Symptoms ◽

Body Condition Score ◽

Demographic Variable ◽

Clinical Signs ◽

Signs And Symptoms ◽

Body Part ◽

Condition Score ◽

Acute Infectious Disease ◽

Clinical Signs And Symptoms ◽

Clostridium Chauvoei

Black quarter (BQ) is an acute, infectious disease caused by Clostridium chauvoei - a Gram-positive, anaerobic organism. This disease is characterized by inflammation with gaseous oedema of skeletal muscle and severe toxaemia. This study was done in Upazilla Veterinary Hospital at Raozan in Chittagong from June to August 2006. During the study period, 25 cases of BQ in cattle were found in eight Unions. Among them the highest (32%) proportion of BQ was found in Raozan Union. Frequency of BQ according to demographic variable was: age incidence of >12 month (60%), male (60%), breed of Red Chittagong (44%), body condition score (BCS) of BCS-2 (88%), and affected body part involving hind quarter muscle (35%). Death was observed with 73% cases. In case of animals that were suffered from BQ, septicaemia developed after 12 h of onset of clinical signs and symptoms. Treatment was ineffective in advanced septicaemic stage. Antibiotic therapy was found to be effective when administered within 12 h of the clinical symptoms. Keywords: Black quarter; Clostridium chauvoei; Demographic variable; Septicaemia; Antibiotic therapyDOI: http://dx.doi.org/10.3329/bjm.v25i1.4848 Bangladesh J Microbiol, Volume 25, Number 1, June 2008, pp 13-16

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The Etiologies of Isolated Fourth Cranial Nerve Palsy: A 10-Year Review of 158 Cases

10.21203/rs.3.rs-323169/v1 ◽

2021 ◽

Author(s):

Apatsa Lekskul ◽

Wadakarn Wuthisiri ◽

Phantaraporn Tangtammaruk

Keyword(s):

Nerve Palsy ◽

Demographic Data ◽

Closed Head Injury ◽

Clinical Signs ◽

Case Series ◽

Signs And Symptoms ◽

Rapid Progression ◽

Clinical Signs And Symptoms ◽

Atypical Presentations ◽

Fourth Nerve Palsy

Abstract MethodsPatients diagnosed with isolated fourth nerve palsy from January 1, 2009, through July 31, 2020 in Ramathibodi Hospital, were included in this retrospective, observational case series. The demographic data of patients, age at presentation, the etiologies of isolated fourth nerve palsy and neuroimaging results (if indicated) were recorded.ResultsWe identified 153 unilateral and 5 bilateral cases of isolated fourth nerve palsy. Mean age at presentation was 38.89 ± 25.71 years old. Most of the unilateral cases were congenital (58.17%), with vasculopathy (27.45%), intracranial neoplasm (8.5%) and other etiologies. Trauma with closed head injury was the most common etiology of bilateral cases (60%), followed by ruptured arterovenous malformation (20%) and vasculopathy (20%). Twenty-one of the 43 (48.84%) patients with vasculopathy-associated fourth nerve palsy underwent neuroimaging, with normal findings, and all patients’ symptoms resolved within 6 months of symptom onset.ConclusionsIn our series, most of the isolated fourth nerve palsy cases were congenital, followed in frequency by vasculopathy and intracranial tumor, as in many studies. In cases of vasculopathy, the clinical signs and symptoms resolved within 6 months in all cases: observation was sufficient, with no necessity for neuroimaging. However, neuroimaging should be considered in cases with atypical presentations, such as headache, periorbital pain, ataxia with positive cerebellar signs, or if there is rapid progression or no recovery.

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A scoping review protocol to identify clinical signs, symptoms and biomarkers indicative of biofilm presence in chronic wounds

HRB Open Research ◽

10.12688/hrbopenres.13300.1 ◽

2021 ◽

Vol 4 ◽

pp. 71

Author(s):

John D. Ivory ◽

Akke Vellinga ◽

James O'Gara ◽

Georgina Gethin

Keyword(s):

Chronic Wounds ◽

Evidence Synthesis ◽

Demographic Data ◽

Clinical Signs ◽

Signs And Symptoms ◽

Third Party ◽

Scoping Reviews ◽

Clinical Signs And Symptoms ◽

High Level

Introduction: Wound healing is characterised by haemostatic, inflammatory, proliferative and remodelling phases. In the presence of comorbidities such as diabetes, healing can stall and chronic wounds may result. Infection is detrimental to these wounds and associated with poor outcomes. Wounds are contaminated with microbes and debris, and factors such as host resistance, bacterial virulence, species synergy and bioburden determine whether a wound will deteriorate to critically colonised/infected states. Biofilms are sessile microbial communities, exhibiting high-level antibiotic tolerance and resistance to host defences. Biofilm in critically colonised wounds can contribute to delayed healing. Little is known about clinical presentation and diagnosis of wound biofilms. Objective: To identify from the literature clinical signs, symptoms and biomarkers that may indicate biofilm in chronic wounds. Methods: This review will be guided by the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR), and the Joanna Briggs Institute Manual for Evidence Synthesis. Studies of any design in any language recruiting adult patients with venous, diabetic, pressure or mixed arterial-venous ulcers and reporting data on clinical signs/symptoms of biofilm are eligible. Searches of Medline, Embase, CINAHL, Cochrane Central, Scopus, Web of Science, Google scholar and BASE will be conducted from inception to present. Reference scanning and contact with content experts will be employed. Title/abstract screening and full text selection will be executed by two reviewers independently. Discrepancies will be resolved by discussion between reviewers or through third party intervention. Data will be extracted by a single reviewer and verified by a second. Clinical signs and symptoms data will be presented in terms of study design, setting and participant demographic data. Discussion: Understanding biofilm impact on chronic wounds is inconsistent and based largely on in vitro research. This work will consolidate clinical signs, symptoms and biomarkers of biofilm in chronic wounds reported in the literature.

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