Familial intracranial aneurysms and cerebral vascular anomalies

1977 ◽  
Vol 46 (4) ◽  
pp. 419-427 ◽  
Author(s):  
Isao Hashimoto
Keyword(s):  
Intracranial Aneurysms ◽  
Associated Anomalies ◽  
Surgical Prophylaxis ◽  
Content Type ◽  
Multiple Aneurysms ◽  
The Family ◽  
High Incidence ◽  
Banding Analysis ◽  
Additional Member ◽  
Fine Print

✓ The author reports a family in which four members had intracranial aneurysms and one additional member was suspect. One member had multiple aneurysms that were successfully treated surgically. Elective angiography on five asymptomatic members of the family disclosed asymptomatic aneurysms in two. In addition, cerebrovascular anomalies were found in many of the family members. The parents of the family were consanguineous. High incidence of these associated anomalies and consanguinity in the parents tend to suggest the hereditary basis of the disease. Banding analysis of chromosomes in three siblings with aneurysms and three siblings without aneurysms was carried out. Elective investigation of the asymptomatic members should be considered where there are already two or more affected in a family. The indications for surgical prophylaxis on asymptomatic aneurysms in other members of the family are discussed.

Angiographic frequency of anterior circulation intracranial aneurysms

1989 ◽  
Vol 70 (4) ◽  
pp. 551-555 ◽  
Author(s):  
John L. D. Atkinson ◽  
Thoralf M. Sundt ◽  
O. Wayne Houser ◽  
Jack P. Whisnant
Keyword(s):  
Intracranial Aneurysms ◽  
Age Groups ◽  
Low Frequency ◽  
Anterior Circulation ◽  
Content Type ◽  
Clinical Series ◽  
High Incidence ◽  
Incidental Aneurysms ◽  
Minimal Bias ◽  
Fine Print

✓ A retrospective angiographic analysis was designed to extrapolate the frequency of angiographically defined asymptomatic intracranial aneurysms in the anterior circulation from a relatively unbiased clinical series. A total of 9295 angiograms were reviewed from January, 1980, to January, 1987, and, based on these, 278 patients with minimal bias for the presence of an aneurysm were selected. Three patients were found to have incidental aneurysms; thus, the angiographic frequency of patients with asymptomatic aneurysms in this series was 1%. This patient population is skewed toward the older age groups and probably over-represents the incidence of these aneurysms in the population at large. Comparing current subarachnoid hemorrhage statistics and the low frequency of asymptomatic aneurysms suggests that a larger percentage of these aneurysms than was previously thought subsequently rupture. This study contrasts sharply with previous reports quoting a high incidence of aneurysms, and significantly alters the concept and treatment of this disease.

Anosmia following operation for cerebral aneurysms in the anterior circulation

1990 ◽  
Vol 72 (6) ◽  
pp. 864-865 ◽  
Author(s):  
Kjeld Dons Eriksen ◽  
Torben Bøge-Rasmussen ◽  
Christian Kruse-Larsen
Keyword(s):  
Intracranial Aneurysms ◽  
Cerebral Aneurysms ◽  
Olfactory Nerve ◽  
Aneurysm Surgery ◽  
Anterior Circulation ◽  
Widespread Occurrence ◽  
Content Type ◽  
High Incidence ◽  
Ruptured Intracranial Aneurysms ◽  
Fine Print

✓ Damage to the olfactory nerve during frontotemporal approach to the basal cisternal region has not previously been investigated in a quantified manner. In this retrospective study of 25 patients operated on for ruptured intracranial aneurysms via the frontotemporal route, 22 patients suffered postoperatively from anosmia ipsilateral to the side of surgery. This complication most often goes unrecognized by the patient as well as the physician, and attention should be drawn to it because of its widespread occurrence. This investigation demonstrates a high incidence of anosmia (24 (88.9%) of 27 surgical sides) occurring ipsilateral to the frontotemporal approach in aneurysm surgery. Recovery after traumatic anosmia has been recorded up to 5 years after injury.1 Nevertheless, the authors believe that the damage is permanent when lasting 35 months or longer.

Ventral paraclinoid carotid aneurysms

1988 ◽  
Vol 69 (3) ◽  
pp. 340-344 ◽  
Author(s):  
Stephen L. Nutik
Keyword(s):  
Carotid Artery ◽  
Ophthalmic Artery ◽  
Ventral Surface ◽  
Posterior Communicating Artery ◽  
Anterior Clinoid Process ◽  
Content Type ◽  
Multiple Aneurysms ◽  
High Incidence ◽  
Carotid Aneurysms ◽  
Fine Print

✓ A series of 15 patients with 17 ventral paraclinoid carotid artery aneurysms is presented. With this type of aneurysm the neck is at or just distal to the level of the ophthalmic artery and proximal to the posterior communicating artery on the ventral surface of the carotid artery. There is a high incidence of female patients and multiple aneurysms. At surgery, the aneurysms are hidden by the anterior clinoid process and often have an intracavernous component. The neck of the aneurysm is usually intradural and can be clipped.

Intracranial aneurysms

1979 ◽  
Vol 51 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Russell J. Andrews ◽  
Peter K. Spiegel
Keyword(s):  
Intracranial Aneurysms ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Male And Female ◽  
Content Type ◽  
Multiple Aneurysms ◽  
The Individual ◽  
Undetermined Etiology ◽  
Fine Print

✓ All cases of intracranial aneurysm, arteriovenous malformation, and subarachnoid hemorrhage of undetermined etiology seen at one hospital over a 13-year period were reviewed to assess relationships between age, sex, systolic and diastolic blood pressure, and number of aneurysms. There were 350 patients, of whom 212 had aneurysms. The major findings were as follows: 1) Hypertension was not significantly more prevalent in the aneurysm population than in the age-matched general population, except for females aged 18 to 54 years (systolic pressure elevation of 10 to 15 mm Hg). 2) Under 55 years of age, both male and female hypertensive patients were twice as likely to have multiple aneurysms as normotensive patients. 3) Females were more likely than males to have multiple aneurysms. 4) For females but not males, increasing age, higher systolic pressure, and higher diastolic pressure all correlated with an increasing number of aneurysms. Hypertension appears to be more prevalent in certain subgroups of the total aneurysm population, although the individual relationships between hypertension, atherosclerosis, and aneurysms cannot be determined from either the present or previous studies. The possible role of familial factors, as well as implications for both diagnosis and further research, are briefly noted.

Some observations on aneurysms of the proximal internal carotid artery

1979 ◽  
Vol 51 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Jonathan Punt
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Ophthalmic Artery ◽  
Internal Carotid ◽  
Content Type ◽  
Multiple Aneurysms ◽  
Proximal Internal Carotid Artery ◽  
High Incidence ◽  
Fine Print

✓ The author reports on 41 aneurysms of the proximal internal carotid artery (PICA) demonstrated in 36 patients with subarachnoid hemorrhage. The patients included a striking preponderance of women, and there was a high incidence of multiple aneurysms. In cases with multiple aneurysms the PICA aneurysm was usually found incidentally, a more distal aneurysm on the internal carotid artery being the source of hemorrhage. An infundibulum at the origin of a posterior communicating artery was unusually common in these patients. The origin of the ophthalmic artery is proposed as the angiographic landmark of the level at which the internal carotid artery penetrates the dura mater.

Risk factors for the formation of multiple intracranial aneurysms

2001 ◽  
Vol 94 (5) ◽  
pp. 728-732 ◽  
Author(s):  
Habib E. Ellamushi ◽  
Joan P. Grieve ◽  
H. Rolf Jäger ◽  
Neil D. Kitchen
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Cigarette Smoking ◽  
Cerebrovascular Disease ◽  
Intracranial Aneurysms ◽  
Content Type ◽  
Multiple Aneurysms ◽  
Female Patients ◽  
History Of ◽  
Fine Print

Object. Several factors are known to increase the risk of subarachnoid hemorrhage (SAH) and spontaneous intracerebral hematoma. However, information on the roles of these same factors in the formation of multiple aneurysms is less well defined. The purpose of this study was to examine factors associated with an increased risk of multiple aneurysm formation. Methods. A retrospective review of the medical records of all patients with a diagnosis of SAH and intracranial aneurysms who were admitted to a single institution between 1985 and 1997 was undertaken. The authors examined associations between risk factors (patient age and sex, menopausal state of female patients, hypertension, cigarette smoking, alcohol consumption, history of cardiovascular disease or diabetes mellitus, and family history of cerebrovascular disease) and the presence of multiple aneurysms by using the Fisher exact test and logistic regression analysis. Of 400 patients admitted with a diagnosis of cerebral aneurysms, 392 were included in the study (287 women and 105 men). Two hundred eighty-four patients harbored a single aneurysm and 108 harbored multiple aneurysms (2 aneurysms in 68 patients, three aneurysms in 22 patients, four aneurysms in 13 patients, and five aneurysms in five patients). Conclusions. Statistical analysis revealed that, as opposed to the occurrence of a single aneurysm, there was a significant association between the presence of multiple aneurysms and hypertension (p < 0.001), cigarette smoking (p < 0.001), family history of cerebrovascular disease (p < 0.001), female sex (p < 0.001), and postmenopausal state in female patients (p < 0.001).

The association of intracranial aneurysms and arteriovenous malformation of the brain

1981 ◽  
Vol 55 (6) ◽  
pp. 971-975 ◽  
Author(s):  
Seiji Hayashi ◽  
Taira Arimoto ◽  
Toru Itakura ◽  
Toru Fujii ◽  
Takashi Nishiguchi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Arteriovenous Malformation ◽  
Cerebral Artery ◽  
Intracranial Aneurysms ◽  
Anterior Cerebral Artery ◽  
Cerebral Aneurysms ◽  
Content Type ◽  
Multiple Aneurysms ◽  
The Brain ◽  
Fine Print

✓ A case of intracranial multiple aneurysms associated with an arteriovenous malformation (AVM) is described. Three aneurysms were found arising from an enlarged anterior cerebral artery feeding an AVM. In spite of the fact that two of these aneurysms received no surgical treatment, they disappeared almost completely several months after excision of the AVM. Seventy-three previously reported cases of cerebral aneurysms associated with AVM's are reviewed, and the effect of hemodynamic stresses on the development of these aneurysms is summarized.

Cerebral angiography during operation for intracranial aneurysms and arteriovenous malformations

1971 ◽  
Vol 34 (5) ◽  
pp. 706-708 ◽  
Author(s):  
Martin L. Lazar ◽  
Clark C. Watts ◽  
Bassett Kilgore ◽  
Kemp Clark
Keyword(s):  
Cerebral Angiography ◽  
Arteriovenous Malformations ◽  
Intracranial Aneurysms ◽  
Operative Procedure ◽  
Superficial Temporal Artery ◽  
Technical Problem ◽  
Temporal Artery ◽  
Content Type ◽  
Actual Operation ◽  
Fine Print

✓ Angiography during the operative procedure is desirable, but is often difficult because of the problem of maintaining a needle or cannula in an artery for long periods of time. Cannulation of the superficial temporal artery avoids this technical problem. The artery is easily found, cannulation is simple, and obliteration of the artery is of no consequence. Cerebral angiography then provides a means for prompt evaluation of the surgical procedure at any time during the actual operation.

Surgical experiences with giant intracranial aneurysms

1984 ◽  
Vol 61 (6) ◽  
pp. 1009-1028 ◽  
Author(s):  
Lindsay Symon ◽  
Janos Vajda
Keyword(s):  
Blood Pressure ◽  
Subarachnoid Hemorrhage ◽  
Mortality Rate ◽  
Intracranial Aneurysms ◽  
Visual Loss ◽  
Considerable Improvement ◽  
Brain Circulation ◽  
Content Type ◽  
Space Occupying Lesion ◽  
Fine Print

✓ A series of 35 patients with 36 giant aneurysms is presented. Thirteen patients presented following subarachnoid hemorrhage (SAH) and 22 with evidence of a space-occupying lesion without recent SAH. The preferred technique of temporary trapping of the aneurysm, evacuation of the contained thrombus, and occlusion of the neck by a suitable clip is described. The danger of attempted ligation in atheromatous vessels is stressed. Intraoperatively, blood pressure was adjusted to keep the general brain circulation within autoregulatory limits. Direct occlusion of the aneurysm was possible in over 80% of the cases. The mortality rate was 8% in 36 operations. Six percent of patients had a poor result. Considerable improvement in visual loss was evident in six of seven patients in whom this was a presenting feature, and in four of seven with disturbed eye movements.

Ruptured intracranial aneurysms in the first two decades of life

1971 ◽  
Vol 35 (5) ◽  
pp. 571-576 ◽  
Author(s):  
Aneel N. Patel ◽  
Alan E. Richardson
Keyword(s):  
Carotid Artery ◽  
Intracranial Aneurysms ◽  
Postmortem Examination ◽  
Surgical Mortality ◽  
Terminal Portion ◽  
Good Tolerance ◽  
Content Type ◽  
Intracranial Operation ◽  
Ruptured Intracranial Aneurysms ◽  
Fine Print

✓ An analysis of 3000 ruptured intracranial aneurysms revealed 58 cases in patients under the age of 19 years. There was a striking incidence of aneurysms of the carotid termination and anterior cerebral complex, accounting for 43 of 58 cases, and of these 20 involved the terminal portion of the carotid artery. Vasospasm occurred slightly less often than in adults and infarction was only seen in one postmortem examination. The surgical mortality in alert patients was 7% whereas in a comparable bedrest group it was 38%. This good tolerance to surgery was evident whether intracranial operation or carotid ligation was used, but the surgical method was not randomly allocated.

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