Cerebellar metastasis from a prolactinoma during treatment with bromocriptine

1981 ◽  
Vol 55 (4) ◽  
pp. 615-619 ◽  
Author(s):  
Neil A. Martin ◽  
Martha Hales ◽  
Charles B. Wilson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Adenoma ◽  
Pituitary Tumors ◽  
Metastatic Tumor ◽  
Metastatic Spread ◽  
Content Type ◽  
The Central Nervous System ◽  
Cerebellar Metastasis ◽  
Fine Print

✓ A 31-year-old woman developed a cerebellar metastasis from an invasive prolactin-secreting pituitary adenoma while undergoing treatment with bromocriptine. The metastatic tumor was totally excised. Metastatic spread of pituitary tumors within the central nervous system is reviewed briefly.

Multiple dural metastases from a pituitary adenoma

1994 ◽  
Vol 81 (4) ◽  
pp. 624-626 ◽  
Author(s):  
William A. S. Taylor ◽  
David Uttley ◽  
P. R. Wilkins
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Adenoma ◽  
Pituitary Tumors ◽  
Content Type ◽  
Original Tumor ◽  
The Central Nervous System ◽  
Dural Metastases ◽  
Fine Print

✓ Only 12 cases of pituitary tumors that metastasized within the central nervous system have been reported. A further case is presented in which the histology of the multiple dural metastases remained identical to that of the original tumor, a pituitary adenoma. The authors discuss management of these rare lesions that appear histologically benign.

Cerebral sparganosis

1990 ◽  
Vol 73 (1) ◽  
pp. 147-150 ◽  
Author(s):  
Andrew Mitchell ◽  
Bernd W. Scheithauer ◽  
Patrick J. Kelly ◽  
Glenn S. Forbes ◽  
Jon E. Rosenblatt
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Surgical Removal ◽  
Asian Countries ◽  
Content Type ◽  
Chronic Abscess ◽  
The Central Nervous System ◽  
Cerebral Sparganosis ◽  
Tapeworm Infection ◽  
Fine Print

✓ The tapeworm Spirometra mansonoides infects man worldwide, particularly in Asian countries. Rarely, the central nervous system is involved; such a case is presented here. In the total of 12 reported cases, including the case described, the worm presented clinically as a mass suspicious for neoplasm or chronic abscess cavity. Surgical removal was invariably curative in each case. Although infrequent, the possibility of tapeworm infection should be entertained in the evaluation of intracranial masses in patients who have visited exotic locales.

Central nervous system mesenchymal chondrosarcoma

1984 ◽  
Vol 61 (2) ◽  
pp. 375-381 ◽  
Author(s):  
Griffith R. Harsh ◽  
Charles B. Wilson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Vascular Tumor ◽  
Mesenchymal Chondrosarcoma ◽  
Content Type ◽  
Meningeal Tumor ◽  
The Central Nervous System ◽  
Initial Resection ◽  
Mesenchymal Chondrosarcomas ◽  
Fine Print

✓ Local recurrence developed 6 years after the initial resection of an intraspinal meningeal tumor that originally was thought to be an angioblastic meningioma. Histological review of the pathology led to a change of that diagnosis to one of mesenchymal chondrosarcoma. The recurrent vascular tumor was embolized, then totally excised. Because this tumor had malignant features, the patient received irradiation and chemotherapy. No evidence of regrowth has been observed during a period of more than 4 years. Mesenchymal chondrosarcomas of the central nervous system and their treatment are reviewed.

Epidermoid and dermoid cysts

1977 ◽  
Vol 47 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Beniamino Guidetti ◽  
Franco M. Gagliardi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Postoperative Complications ◽  
Clinical Data ◽  
Late Results ◽  
Content Type ◽  
Operating Technique ◽  
The Central Nervous System ◽  
Fine Print

✓ The authors report on the clinical data, operating technique, postoperative complications, and late results in a series of 31 epidermoid and 21 dermoid cysts of the central nervous system.

Cerebral hemangioma with glial neoplasia (angioglioma?)

1982 ◽  
Vol 56 (3) ◽  
pp. 430-434 ◽  
Author(s):  
Edwin G. Fischer ◽  
Ana Sotrel ◽  
Keasley Welch
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Other ◽  
Content Type ◽  
Growth Reference ◽  
Biological Potential ◽  
Cavernous Hemangiomas ◽  
The Central Nervous System ◽  
Mass Lesions ◽  
Fine Print

✓ Two patients are reported who had intracerebral mass lesions composed of hemangioma and glial neoplasm. After excision, one recurred as an oligodendroglioma, and the remnant of the other remained static over a 5-year period. These lesions may represent a subgroup of cerebral hemangiomas that have the biological potential for future glial neoplastic growth. Reference is made to experimental work with polyoma virus which can induce cavernous hemangiomas in the central nervous system in mice, and which is a papovavirus. Other papovaviruses can induce ependymomas in hamsters.

Superficial siderosis of the central nervous system after brachial plexus injury

1994 ◽  
Vol 80 (5) ◽  
pp. 931-934 ◽  
Author(s):  
Virginio Bonito ◽  
Cristina Agostinis ◽  
Stefano Ferraresi ◽  
Carlo Alberto Defanti
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hearing Loss ◽  
Brachial Plexus ◽  
Brachial Plexus Injury ◽  
Superficial Siderosis ◽  
Content Type ◽  
Initial Symptoms ◽  
The Central Nervous System ◽  
Fine Print

✓ Superficial siderosis is a rare condition characterized by deposition of hemosiderin in the leptomeninges and in the subpial layers of the brain and spinal cord. It is associated with cerebrospinal fluid abnormalities consistent with recurrent bleeding into the subarachnoid space. The usual symptoms are hearing loss, ataxia, spastic paraparesis, sensory and sphincter deficits, and mental deterioration. A case is presented of severe superficial siderosis of the central nervous system in a 51-year-old man who had suffered a brachial plexus injury at the age of 20 years. The diagnosis was made by means of magnetic resonance imaging 16 years after the initial symptoms, which comprised bilateral hearing loss and anosmia. Subarachnoid bleeding was due to traumatic pseudomeningocele of the brachial plexus, a very unusual cause of superficial siderosis. This case is interesting insofar as the surgical treatment prevented further bleeding and possibly progression of the disease.

Actinomycotic granuloma of the Gasserian ganglion with primary site in a dental root

1981 ◽  
Vol 54 (4) ◽  
pp. 553-555 ◽  
Author(s):  
Enrico Perna ◽  
R. Liguori ◽  
G. Petrone ◽  
E. Mannarino
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Special Reference ◽  
Unusual Case ◽  
Primary Site ◽  
Pathological Diagnosis ◽  
Gasserian Ganglion ◽  
Content Type ◽  
The Central Nervous System ◽  
Fine Print

✓ An unusual case of cerebral actinomycosis of the Gasserian ganglion is reported. The location and the pathological diagnosis of granuloma are both extremely rare. The literature is briefly reviewed with special reference to similar reports. The manner of spread and the course of the disease are described. The present case tends to confirm the opinion that primary cerebral actinomycosis is extremely rare and probably does not exist. The case also definitely indicates that the organism reaches the central nervous system by way of nerve or perineural pathways.

Primary malignant lymphoma of the central nervous system

1986 ◽  
Vol 65 (5) ◽  
pp. 600-607 ◽  
Author(s):  
Kevin Murray ◽  
Larry Kun ◽  
James Cox
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Lymphoma ◽  
Primary Tumor ◽  
Craniospinal Irradiation ◽  
Late Relapse ◽  
Prior History ◽  
Content Type ◽  
The Central Nervous System ◽  
Fine Print

✓ Eleven patients with primary malignant lymphoma of the central nervous system (CNS) were treated at the Medical College of Wisconsin Affiliated Hospitals between 1964 and 1984. Three patients had a prior history of immunosuppressive therapy following renal transplantation. All patients had biopsy-proven disease and 10 of the 11 were treated with external radiation therapy. The doses to the primary tumor ranged from 34 to 59.4 Gray (Gy). Actuarial (life-table) survival rate was 82% at 1 year and 43% at 3 years. No recurrence was seen after 13 months. Eighty-six reports totaling 693 cases of primary malignant lymphoma of the CNS were found in the literature. Of these, 308 cases were treated with a combination of surgery and irradiation. Overall survival at 5 years for those patients who received more than 50 Gy compared with less than 50 Gy to the primary tumor was 42.3% versus 12.8% (p < 0.05). Twenty-one patients survived longer than 5 years. Late relapse was notable, with 10 (47.6%) of 21 tumors recurring between 5 and 12.5 years after diagnosis. Based on this review, a minimum of 50 Gy radiation to the primary tumor is recommended. While no statement regarding the efficacy of craniospinal irradiation or chemotherapy can be made in view of the small numbers, the use of craniospinal irradiation and/or systemic chemotherapy should be considered for future trials.

Value of cerebrospinal fluid cytology for the diagnosis of malignancies in the central nervous system

1978 ◽  
Vol 48 (5) ◽  
pp. 747-753 ◽  
Author(s):  
J. Chris Balhuizen ◽  
Gerard Th. A. M. Bots ◽  
Aart Schaberg ◽  
Fré T. Bosman
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Retrospective Analysis ◽  
Content Type ◽  
Secondary Tumors ◽  
Cerebral Tumors ◽  
The Central Nervous System ◽  
Fine Print ◽  
Fluid Cytology

✓ The authors present a retrospective analysis of the results of the cytological examinations of cerebrospinal fluid (CSF) samples and tumor-cyst aspirates deriving from 262 patients treated for malignant intracranial primary and secondary tumors, and vertebral and peridural metastastic processes. Positive preoperative CSF samples were found in 15.3% of all cases of primary cerebral malignancies (13.9% of all gliomas) and positive postoperative CSF samples were found in 40% (91% of the medulloblastoma cases). In all cases of single or multiple secondary cerebral tumors, positive preoperative CSF samples were found in 20%.

Neoadjuvant chemotherapy for newly diagnosed germ-cell tumors of the central nervous system

1987 ◽  
Vol 67 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Jeffrey C. Allen ◽  
Jae Ho Kim ◽  
Roger J. Packer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neoadjuvant Chemotherapy ◽  
Partial Response ◽  
Germ Cell Tumors ◽  
Newly Diagnosed ◽  
Content Type ◽  
The Central Nervous System ◽  
Radiotherapy Dose ◽  
Fine Print

✓ A neoadjuvant (preradiotherapy) chemotherapy regimen consisting of either cyclophosphamide alone (60 to 80 mg/kg) or a modified multidrug regimen (vinblastine, bleomycin, cyclophosphamide, and cisplatin) was administered to 15 newly diagnosed patients with histologically confirmed, fully staged, primary germ-cell tumors (GCT's) of the central nervous system (CNS). There were 11 patients with germinomas and four with non-germinoma malignant GCT's. There were six females and nine males, whose median age was 13 years (range 4 months to 24 years). Seven germinoma patients (64%) had disseminated disease. For the germinoma patients, the subsequent radiotherapy dose was modified based on the response to the neoadjuvant chemotherapy, and craniospinal radiotherapy was given only to those with disseminated CNS disease at diagnosis. Ten of the 11 germinoma patients had complete disappearance of all evaluable disease after two courses of chemotherapy (cyclophosphamide in eight and multidrug in three) and one had a partial response. The planned dose of radiotherapy to the primary tumor was reduced from 5500 to 3000 rads, and the craniospinal dose was lowered from 3600 to 2000 rads. Ten patients remain in continuous disease-free remission 20+ to 89+ months after diagnosis (median follow-up period 47 months). All four patients with non-germinoma GCT's received the multidrug regimen, and two of three patients with evaluable disease had a partial response. High-dose regional and craniospinal radiotherapy was administered thereafter, but only two patients remain in their first remission. Previously untreated germinoma is a highly chemosensitive disease and the neoadjuvant treatment strategy permits the identification of active chemotherapy regimens in newly diagnosed patients. Patients who have complete responses to neoadjuvant chemotherapy tolerate a significant radiotherapy dose reduction without compromising long-term survival, thereby allowing a reduction of some of the late effects of therapeutic radiation. Germinomas tend to disseminate early in the course of the disease and a pre-therapy staging evaluation permits individualized radiotherapy treatment planning.

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