Sensory evoked response to electrical stimulation of the trigeminal nerve in humans

1982 ◽  
Vol 56 (4) ◽  
pp. 545-549 ◽  
Author(s):  
Gideon Findler ◽  
Moshe Feinsod
Keyword(s):  
Electrical Stimulation ◽  
Normal Subjects ◽  
Evoked Response ◽  
Lower Lip ◽  
Content Type ◽  
Face Area ◽  
Lower Amplitude ◽  
The Face ◽  
Sensory Evoked ◽  
Stimulation Of

✓ Electrical stimulation of the upper and lower lips of normal subjects evoked a consistent response recorded from over the face area of the ipsi- and contralateral hemispheres. This response consisted of seven discrete waves. Peak latencies ranged from as early as 8 msec to 115 msec. Stimulation of the lower lip evoked a response of lower amplitude and reversed polarity, as compared to the upper lip stimulation response. The data support the validity of the trigeminal sensory evoked response in the evaluation of the trigeminal pathways. Previously reported methods are reviewed and compared.

Physiological and behavioral changes produced by cerebellar stimulation in the monkey

1980 ◽  
Vol 53 (4) ◽  
pp. 533-540 ◽  
Author(s):  
Lee T. Robertson ◽  
William L. Smith
Keyword(s):  
Electrical Stimulation ◽  
Cerebellar Cortex ◽  
High Speed ◽  
Evoked Response ◽  
Small Surface ◽  
Content Type ◽  
Lateral Cortex ◽  
Forelimb Movement ◽  
Time Required ◽  
Stimulation Of

✓ Small surface electrodes were placed bilaterally over the intermediate or lateral cerebellar cortex of cynomolgus monkeys to determine how electrical stimulation of different areas of the cerebellar cortex affected average evoked responses and a sequential forelimb movement. Biphase electrical stimulation was applied between various electrode combinations, and various intensities and frequencies were established for each combination. Transcortical stimulation between the right and left intermediate cerebellar cortex required the lowest intensity (1.5 µC/sq cm/ph) to elicit an average evoked response in the sensorimotor cortex; stimulation between the electrodes over the contralateral intermediate or lateral cortex required slightly higher levels (2.0 µC/sq cm/ph). No response could be elicited from stimulating the ipsilateral cortex. Likewise, 1 minute of transcortical stimulation was more effective than comparable stimulation of the contralateral intermediate or lateral cortex in altering the waveforms of a somatosensory evoked response. Transcortical stimulation also modified the forelimb movement, whereas contralateral stimulation of the intermediate or lateral cortex had little or no effect. Transcortical stimulation at 2.0 µC/sq cm/ph, with frequencies of 150 Hz or higher, increased the time required to execute the forelimb movement but did not affect the accuracy of the movement. High-speed motion pictures indicated that transcortical stimulation decreased the velocity of forelimb movement and in some cases also affected the limb trajectory. These results indicate that consideration should be given to the area of the cerebellum stimulated and to the mode of stimulation, in the hope of achieving optimum clinical benefit.

Localization of the face area of human sensorimotor cortex by intracranial recording of somatosensory evoked potentials

1993 ◽  
Vol 79 (6) ◽  
pp. 874-884 ◽  
Author(s):  
Gregory McCarthy ◽  
Truett Allison ◽  
Dennis D. Spencer
Keyword(s):  
Evoked Potentials ◽  
Median Nerve ◽  
Somatosensory Cortex ◽  
Somatosensory Evoked Potentials ◽  
Content Type ◽  
Face Area ◽  
The Face ◽  
Hand Area ◽  
Fine Print ◽  
Stimulation Of

✓ The authors describe a method of localizing the sensory and motor peri-rolandic cortex representing the face and intraoral structures. Somatosensory evoked potentials (SEP's) to stimulation of the chin, lips, tongue, and palate were recorded in 37 patients studied intraoperatively under general anesthesia or following chronic implantation of cortical surface electrodes. Localization by trigeminal SEP recording was validated by SEP localization of the hand area with median nerve stimulation, and by cortical stimulation of the hand and face areas. The following conclusions were drawn regarding the implementation of face area localization: 1) in general agreement with the results of cortical stimulation in humans and single-unit recordings in monkeys, there is a medial-to-lateral representation in somatosensory cortex of the hand, chin, upper lip, lower lip, tongue, and palate; 2) the chin and lip representations overlap, are adjacent to the hand area, and provide little additional localizing information if the hand area has been identified; 3) stimulation of the tongue and palate evokes reliable, large-amplitude SEP's useful for localization; 4) palatal SEP's allow localization near the sylvian sulcus; 5) for any type of trigeminal stimulation, the largest SEP's are recorded from the somatosensory cortex and provide the most consistent criterion for its identification; and 6) polarity inversion of potentials across the sulcus (a reliable localizing criterion for median nerve SEP's) is a less reliable criterion for trigeminal SEP's.

The mechanism and effect of chronic electrical stimulation of the globus pallidus for treatment of Parkinson disease

2004 ◽  
Vol 100 (6) ◽  
pp. 997-1001 ◽  
Author(s):  
Mitsuhiro Ogura ◽  
Naoyuki Nakao ◽  
Ekini Nakai ◽  
Yuji Uematsu ◽  
Toru Itakura
Keyword(s):  
Electrical Stimulation ◽  
Parkinson Disease ◽  
Globus Pallidus ◽  
Rating Scale ◽  
Underlying Mechanism ◽  
Clinical Effects ◽  
Content Type ◽  
Chronic Electrical Stimulation ◽  
Fine Print ◽  
Stimulation Of

Object. Although chronic electrical stimulation of the globus pallidus (GP) has been shown to ameliorate motor disabilities in Parkinson disease (PD), the underlying mechanism remains to be clarified. In this study the authors explored the mechanism for the effects of deep brain stimulation of the GP by investigating the changes in neurotransmitter levels in the cerebrospinal fluid (CSF) during the stimulation. Methods. Thirty patients received chronic electrical stimulation of the GP internus (GPi). Clinical effects were assessed using the Unified PD Rating Scale (UPDRS) and the Hoehn and Yahr Staging Scale at 1 week before surgery and at 6 and 12 months after surgery. One day after surgery, CSF samples were collected through a ventricular tube before and 1 hour after GPi stimulation. The concentration of neurotransmitters such as γ-aminobutyric acid (GABA), noradrenaline, dopamine, and homovanillic acid (HVA) in the CSF was measured using high-performance liquid chromatography. The treatment was effective for tremors, rigidity, and drug-induced dyskinesia. The concentration of GABA in the CSF increased significantly during stimulation, although there were no significant changes in the level of noradrenaline, dopamine, and HVA. A comparison between an increased rate of GABA concentration and a lower UPDRS score 6 months postimplantation revealed that the increase in the GABA level correlated with the stimulation-induced clinical effects. Conclusions. Stimulation of the GPi substantially benefits patients with PD. The underlying mechanism of the treatment may involve activation of GABAergic afferents in the GP.

Involvement of trigeminal spinal nucleus in parasympathetic reflex vasodilatation in cat lower lip

2002 ◽  
Vol 282 (2) ◽  
pp. R492-R500 ◽  
Author(s):  
Kentaro Mizuta ◽  
Satoshi Kuchiiwa ◽  
Takashi Saito ◽  
Hideaki Mayanagi ◽  
Keishiro Karita ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Kainic Acid ◽  
Local Anesthesia ◽  
Similar Degree ◽  
Dependent Manner ◽  
Lower Lip ◽  
Arterial Blood ◽  
Blood Flow Increase ◽  
Spinal Nucleus ◽  
Stimulation Of

We examined whether the trigeminal spinal nucleus (Vsp) forms part of the central mechanism by which electrical stimulation of the central cut end of the lingual nerve (LN) evokes parasympathetic reflex vasodilatation in the lower lip in artificially ventilated, cervically vagosympathectomized cats deeply anesthetized with α-chloralose and urethane. For this purpose, we made microinjections within the brain stem to produce nonselective, reversible local anesthesia (lidocaine) or soma-selective, irreversible neurotoxic damage (kainic acid). Local anesthesia of Vsp by microinjection of lidocaine (2%; 1 μl/site) reversibly and significantly reduced the ipsilateral-LN-evoked parasympathetic reflex vasodilatation. Unilateral microinjection of kainic acid (10 mM/site; 1 μl) into Vsp ipsilateral to the stimulated LN led to an irreversible reduction in the reflex vasodilatation but had no effect on the vasodilatation elicited by stimulation of the contralateral LN. Such microinjection of kainic acid into Vsp had no effect on the vasodilatation evoked by electrical stimulation of the ipsilateral inferior salivatory nucleus. Electrical stimulation of Vsp elicited a blood flow increase in the lower lip in an intensity- and frequency-dependent manner, regardless of whether systemic arterial blood pressure rose or fell. Hexamethonium (1.0 mg/kg iv) significantly reduced the vasodilator responses elicited by electrical stimulation of the central cut end of LN or of Vsp, each to a similar degree. After hexamethonium, both vasodilator responses showed time-dependent recovery. These results strongly suggest that Vsp is an important bulbar relay for LN-evoked parasympathetic reflex vasodilatation in the cat lower lip.

Cerebral responses evoked by electrical stimulation of rectosigmoid in normal subjects

1989 ◽  
Vol 34 (2) ◽  
pp. 202-205 ◽  
Author(s):  
Thomas Frieling ◽  
Paul Enck ◽  
Martin Wienbeck
Keyword(s):  
Electrical Stimulation ◽  
Normal Subjects ◽  
Stimulation Of

Several days of muscle hyperalgesia facilitates cortical somatosensory excitability

2017 ◽  
Vol 16 (1) ◽  
pp. 169-169
Author(s):  
E. De Martino ◽  
L. Petrini ◽  
S. Schabrun ◽  
T. Graven-Nielsen
Keyword(s):  
Chronic Pain ◽  
Electrical Stimulation ◽  
Eccentric Exercise ◽  
Radial Nerve ◽  
Muscle Soreness ◽  
Neural Circuits ◽  
Pain Thresholds ◽  
Pressure Pain Thresholds ◽  
Sensory Evoked ◽  
Stimulation Of

Abstract Background and aims Maladaptive plasticity in neural circuits has been proposed in chronic musculoskeletal pain and has been discussed as a key component of the transition from acute to chronic pain. The induction of delayed onset muscle soreness (DOMS) in healthy individuals is one method that can be used to investigate the adaptations of neural circuits in response to several days of muscle hyperalgesia. The aim of this study was to determine the adaptations of the sensory cortex in response to muscle hyperalgesia induced by eccentric exercise of the wrist extensor muscles. It was hypothesized that muscle hyperalgesia would result in a facilitation of cortical somatosensory excitability, based on sensory evoked potentials evoked by electrical stimulation of the radial nerve. Methods Twelve healthy subjects performed eccentric exercise of the wrist extensors. Muscle soreness, pressure pain thresholds (PPTs) on the extensor carpi radialis (ECR) muscle, somatosensory evoked potentials (SEPs) based on 10 channel EEG recorded during electrical stimulation of the radial nerve were recorded before (Day0Pre), 2h (Day0Post), 2 days (Day2), and 6 days (Day6) after exercise. Results Compared to Day0Pre: (i) Muscle soreness increased at Day0Post and increased further at Day2 (both P < 0.05). (ii) Pressure pain thresholds decreased at Day2 (P < 0.05), (iii) the peak-to-peak N30-P45 and P45-N60 amplitude of the sensory evoked potential from the central-parietal recording sites were increased at Day2 (both P < 0.05); (iv) reduction in ECR PPTs was correlated with an increase of the post-central P45 wave. ConclusionsThese data demonstrate that hyperalgesia developing across several days is accompanied by an increase in sensory cortical excitability. In addition, sensory cortical adaptation followed a similar temporal profile to increased sensitivity to pressure (PPTs). This model may be relevant for further understanding neural adaptation in the transition from acute to chronic pain.

Vasodilator system for the face

1975 ◽  
Vol 42 (6) ◽  
pp. 696-703 ◽  
Author(s):  
Guillermo Gonzalez ◽  
Burton M. Onofrio ◽  
Frederick W. L. Kerr
Keyword(s):  
Brain Stem ◽  
Trigeminal Ganglion ◽  
Content Type ◽  
Moderate Number ◽  
Trigeminal Nuclei ◽  
The Face ◽  
Greater Superficial Petrosal Nerve ◽  
Radiofrequency Coagulation ◽  
The Brain ◽  
Stimulation Of

✓ The authors describe investigations in cats to delineate a vasodilator system to the face, which they undertook after a previous study showed that radiofrequency coagulation of the trigeminal ganglion produced a pronounced flush in the skin of the corresponding division. Results demonstrate a vasodilator system emerging from the brain stem with the facial nerve which, by way of the greater superficial petrosal nerve, reaches the trigeminal ganglion. There the fibers are distributed to each of the divisions of the fifth nerve; in addition, a moderate number of vasodilator fibers also appear to leave the brain stem directly with the trigeminal nerve. Vasodilator effects were elicited by stereotaxic stimulation of the facial and trigeminal nuclei in the brain stem. There is, therefore, a dual vasomotor control of the facial cutaneous vascular bed; the classical sympathetic vasoconstrictor system of the face is complemented by a vasodilator system capable of producing changes of equal but opposite amplitude in vessel caliber.

Functional magnetic resonance imaging of somatosensory cortex activity produced by electrical stimulation of the median nerve or tactile stimulation of the index finger

2000 ◽  
Vol 93 (5) ◽  
pp. 774-783 ◽  
Author(s):  
Maxwell Boakye ◽  
Sean C. Huckins ◽  
Nikolaus M. Szeverenyi ◽  
Bobby I. Taskey ◽  
Charles J. Hodge
Keyword(s):  
Electrical Stimulation ◽  
Median Nerve ◽  
Somatosensory Cortex ◽  
Tactile Stimulation ◽  
Index Finger ◽  
Functional Magnetic Resonance ◽  
Content Type ◽  
The Right ◽  
Fine Print ◽  
Stimulation Of

Object. Functional magnetic resonance (fMR) imaging was used to determine patterns of cerebral blood flow changes in the somatosensory cortex that result from median nerve stimulation (MNS).Methods. Ten healthy volunteers underwent stimulation of the right median nerve at frequencies of 5.1 Hz (five volunteers) and 50 Hz (five volunteers). The left median nerve was stimulated at frequencies of 5.1 Hz (two volunteers) and 50 Hz (five volunteers). Tactile stimulation (with a soft brush) of the right index finger was also applied (three volunteers). Functional MR imaging data were transformed into Talairach space coordinates and averaged by group. Results showed significant activation (p < 0.001) in the following regions: primary sensorimotor cortex (SMI), secondary somatosensory cortex (SII), parietal operculum, insula, frontal cortex, supplementary motor area, and posterior parietal cortices (Brodmann's Areas 7 and 40). Further analysis revealed no statistically significant difference (p > 0.05) between volumes of cortical activation in the SMI or SII resulting from electrical stimuli at 5.1 Hz and 50 Hz. There existed no significant differences (p > 0.05) in cortical activity in either the SMI or SII resulting from either left- or right-sided MNS. With the exception of the frontal cortex, areas of cortical activity in response to tactile stimulation were anatomically identical to those regions activated by electrical stimulation. In the SMI and SII, activation resulting from tactile stimulation was not significantly different (p > 0.05) from that resulting from electrical stimulation.Conclusions. Electrical stimulation of the median nerve is a reproducible and effective means of activating multiple somatosensory cortical areas, and fMR imaging can be used to investigate the complex network that exists between these areas.

Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus

2004 ◽  
Vol 100 (3) ◽  
pp. 560-564 ◽  
Author(s):  
Dirk De Ridder ◽  
Gert De Mulder ◽  
Vincent Walsh ◽  
Neil Muggleton ◽  
Stefan Sunaert ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Transcranial Magnetic Stimulation ◽  
Auditory Cortex ◽  
Magnetic Stimulation ◽  
Cortical Plasticity ◽  
Cortical Reorganization ◽  
Complete Suppression ◽  
Content Type ◽  
Fine Print ◽  
Stimulation Of

✓ Tinnitus is a distressing symptom that affects up to 15% of the population for whom no satisfactory treatment exists. The authors present a novel surgical approach for the treatment of intractable tinnitus, based on cortical stimulation of the auditory cortex. Tinnitus can be considered an auditory phantom phenomenon similar to deafferentation pain, which is observed in the somatosensory system. Tinnitus is accompanied by a change in the tonotopic map of the auditory cortex. Furthermore, there is a highly positive association between the subjective intensity of the tinnitus and the amount of shift in tinnitus frequency in the auditory cortex, that is, the amount of cortical reorganization. This cortical reorganization can be demonstrated by functional magnetic resonance (fMR) imaging. Transcranial magnetic stimulation (TMS) is a noninvasive method of activating or deactivating focal areas of the human brain. Linked to a navigation system that is guided by fMR images of the auditory system, TMS can suppress areas of cortical plasticity. If it is successful in suppressing a patient's tinnitus, this focal and temporary effect can be perpetualized by implanting a cortical electrode. A neuronavigation-based auditory fMR imaging-guided TMS session was performed in a patient who suffered from tinnitus due to a cochlear nerve lesion. Complete suppression of the tinnitus was obtained. At a later time an extradural electrode was implanted with the guidance of auditory fMR imaging navigation. Postoperatively, the patient's tinnitus disappeared and remains absent 10 months later. Focal extradural electrical stimulation of the primary auditory cortex at the area of cortical plasticity is capable of suppressing contralateral tinnitus completely. Transcranial magnetic stimulation may be an ideal method for noninvasive studies of surgical candidates in whom stimulating electrodes might be implanted for tinnitus suppression.

scholarly journals Sensory and motor electrophysiological mapping of the cerebellum in humans

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Reiko Ashida ◽  
Peter Walsh ◽  
Jonathan C. W. Brooks ◽  
Nadia L. Cerminara ◽  
Richard Apps ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Posterior Fossa ◽  
Functional Organization ◽  
Posterior Lobe ◽  
Posterior Fossa Surgery ◽  
Motor Mapping ◽  
Human Cerebellum ◽  
The Right ◽  
Sensory Evoked ◽  
Stimulation Of

AbstractCerebellar damage during posterior fossa surgery in children can lead to ataxia and risk of cerebellar mutism syndrome. Compartmentalisation of sensorimotor and cognitive functions within the cerebellum have been demonstrated in animal electrophysiology and human imaging studies. Electrophysiological monitoring was carried out under general anaesthesia to assess the limb sensorimotor representation within the human cerebellum for assessment of neurophysiological integrity to reduce the incidence of surgical morbidities. Thirteen adult and paediatric patients undergoing posterior fossa surgery were recruited. Sensory evoked field potentials were recorded in response to mapping (n = 8) to electrical stimulation of limb nerves or muscles. For motor mapping (n = 5), electrical stimulation was applied to the surface of the cerebellum and evoked EMG responses were sought in facial and limb muscles. Sensory evoked potentials were found in two patients (25%). Responses were located on the surface of the right inferior posterior cerebellum to stimulation of the right leg in one patient, and on the left inferior posterior lobe in another patient to stimulation of left forearm. No evoked EMG responses were found for the motor mapping. The present study identifies challenges with using neurophysiological methods to map functional organization within the human cerebellum and considers ways to improve success.

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