Assessing the efficiency of Honeybee venom as an antimicrobial pathogenic agent

The article discusses the tuberculosis care system for the Samara Province population in the 19th – mid-20th century based on archive documents, it also provides the historical reconstruction of Postnikov N.V., MD, Kumis Treatment Facility, studies V.Yu. Maslovskiy's contribution to the tuberculosis care system establishment. Kumis treatment was one of the most common methods that advanced on the cusp of the 19th and 20th centuries thanks to the works by Postnikov N.V., MD, a graduate of the Medical Faculty, the Moscow University. Samara Governor Grot K.K. assisted Postnikov N.V. in the Kumis Treatment Facility establishment. The Kumis Treatment Facility opened on May 5, 1858. Based on N.V. Postnikov's records, kumis can be regarded as a pathogenic agent in TB treatment. Kumis was the main, but not the only, treatment method: Postnikov N.V. reports names and dosages of many drugs known to physicians in the 19th century. No less significant is the contribution made by Viktor Maslovskiy, one of the founders of the Samara branch of the AllRussian League Against Tuberculosis.

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Faculty Opinions recommendation of A beneficial role for immunoglobulin E in host defense against honeybee venom.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718170948.793487951 ◽

2013 ◽

Author(s):

David Voehringer

Keyword(s):

Host Defense ◽

Immunoglobulin E ◽

Honeybee Venom ◽

Beneficial Role

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Hazards associated with municipal waste storage Vol. II

MATEC Web of Conferences ◽

10.1051/matecconf/201824700033 ◽

2018 ◽

Vol 247 ◽

pp. 00033 ◽

Cited By ~ 1

Author(s):

Anna Dmochowska

Keyword(s):

Heavy Metals ◽

Gas Exchange ◽

Allergic Diseases ◽

Municipal Waste ◽

Larynx Cancer ◽

Pathogenic Agent ◽

Waste Storage ◽

Mucous Membranes ◽

Upper Respiratory ◽

Suspended Dust

Municipal waste storage leads to many threats to all elements of the environment. Among other things, are suspended dusts. Before closing the plot designated for storing a given portion of waste, the unprotected volatile parts contained in it are emitted, including dusts. They can be a serious pathogenic agent, transferring microtoxins, heavy metals and other pollutants. Depending on the size, they settle on the walls of the alveoli, making gas exchange difficult, causing irritation to the epidermis and mucous membranes, inflammation of the upper respiratory tracts and cause allergic diseases such as asthma. They can also cause lung, throat and larynx cancer. The aim of the research was to measure the concentration of suspended dust in the areas adjacent to the landfill. The DustTrak II dust meter was used for the tests. Dust concentrations measurements were made for orientation purposes (to plan measurements in subsequent years). The obtained results indicate that the permissible dust concentrations are exceeded even though the landfill is already closed, and the landfill top and side escarpments were being reclamation.

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IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells

Allergy ◽

10.1111/all.14852 ◽

2021 ◽

Author(s):

Philipp Starkl ◽

Nicolas Gaudenzio ◽

Thomas Marichal ◽

Laurent L. Reber ◽

Riccardo Sibilano ◽

...

Keyword(s):

Mast Cells ◽

Ige Antibodies ◽

Honeybee Venom

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Melittin, a honeybee venom derived peptide for the treatment of chemotherapy-induced peripheral neuropathy

Medical Oncology ◽

10.1007/s12032-021-01496-9 ◽

2021 ◽

Vol 38 (5) ◽

Author(s):

Tenzin Tender ◽

Rakesh Ravishankar Rahangdale ◽

Sridevi Balireddy ◽

Madhavan Nampoothiri ◽

K. Krishna Sharma ◽

...

Keyword(s):

Peripheral Neuropathy ◽

Motor Nerve ◽

Symptomatic Relief ◽

Neurological Complication ◽

Treatment Protocol ◽

Chemotherapeutic Agents ◽

Lens Protein ◽

Active Constituent ◽

Honeybee Venom ◽

Eye Lens Protein

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of cancer treatment which involves sensory and motor nerve dysfunction. Severe CIPN has been reported in around 5% of patients treated with single and up to 38% of patients treated with multiple chemotherapeutic agents. Present medications available for CIPN are the use of opioids, nonsteroidal anti-inflammatory agents, and tricyclic antidepressants, which are only marginally effective in treating neuropathic symptoms. In reality, symptom reappears after these drugs are discontinued. The pathogenesis of CIPN has not been sufficiently recognized and methods for the prevention and treatment of CIPN remain vulnerable to therapeutic problems. It has witnessed that the present medicines available for the disease offer only symptomatic relief for the short term and have severe adverse side effects. There is no standard treatment protocol for preventing, reducing, and treating CIPN. Therefore, there is a need to develop curative therapy that can be used to treat this complication. Melittin is the main pharmacological active constituent of honeybee venom and has therapeutic values including in chemotherapeutic-induced peripheral neuropathy. It has been shown that melittin and whole honey bee venom are effective in treating paclitaxel and oxaliplatin-induced peripheral neuropathy. The use of melittin against peripheral neuropathy caused by chemotherapy has been limited despite having strong therapeutic efficacy against the disease. Melittin mediated haemolysis is the key reason to restrict its use. In our study, it is found that α-Crystallin (an eye lens protein) is capable of inhibiting melittin-induced haemolysis which gives hope of using an appropriate combination of melittin and α-Crystallin in the treatment of CIPN. The review summarizes the efforts made by different research groups to address the concern with melittin in the treatment of chemotherapeutic-induced neuropathy. It also focuses on the possible approaches to overcome melittin-induced haemolysis. Graphic Abstract

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A Synergic Potential of Antimicrobial Peptides against Pseudomonas syringae pv. actinidiae

Molecules ◽

10.3390/molecules26051461 ◽

2021 ◽

Vol 26 (5) ◽

pp. 1461

Author(s):

Nuno Mariz-Ponte ◽

Laura Regalado ◽

Emil Gimranov ◽

Natália Tassi ◽

Luísa Moura ◽

...

Keyword(s):

Flow Cytometry ◽

Antimicrobial Peptides ◽

Pseudomonas Syringae ◽

Pathogenic Bacteria ◽

High Efficiency ◽

Bacterial Canker ◽

Membrane Permeation ◽

Flow Cytometry Analysis ◽

Pathogenic Agent ◽

Peptide Mixtures

Pseudomonas syringae pv. actinidiae (Psa) is the pathogenic agent responsible for the bacterial canker of kiwifruit (BCK) leading to major losses in kiwifruit productions. No effective treatments and measures have yet been found to control this disease. Despite antimicrobial peptides (AMPs) having been successfully used for the control of several pathogenic bacteria, few studies have focused on the use of AMPs against Psa. In this study, the potential of six AMPs (BP100, RW-BP100, CA-M, 3.1, D4E1, and Dhvar-5) to control Psa was investigated. The minimal inhibitory and bactericidal concentrations (MIC and MBC) were determined and membrane damaging capacity was evaluated by flow cytometry analysis. Among the tested AMPs, the higher inhibitory and bactericidal capacity was observed for BP100 and CA-M with MIC of 3.4 and 3.4–6.2 µM, respectively and MBC 3.4–10 µM for both. Flow cytometry assays suggested a faster membrane permeation for peptide 3.1, in comparison with the other AMPs studied. Peptide mixtures were also tested, disclosing the high efficiency of BP100:3.1 at low concentration to reduce Psa viability. These results highlight the potential interest of AMP mixtures against Psa, and 3.1 as an antimicrobial molecule that can improve other treatments in synergic action.

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