scholarly journals The use of borehole inclinometry in determining basal sliding and internal deformation at Haut Glacier d’Arolla, Switzerland

1997 ◽  
Vol 24 ◽  
pp. 331-337 ◽  
Author(s):  
Luke Copland ◽  
Jon Harbor ◽  
Marie Minner ◽  
Martin Sharp
Keyword(s):  
Hot Water ◽  
Short Term ◽  
Digital Inclinometer ◽  
Basal Sliding ◽  
Internal Deformation ◽  
One Year ◽  
Annual Scale ◽  
Insight Into ◽  
Displacement Measurements

A series of boreholes were drilled with high-pressure hot water across a section of Haut Glacier d’Arolla, Switzerland, in summer 1995. Twenty-three of the boreholes were profiled with a digital inclinometer soon aller drilling, and 14 were re-profiled up to 6 weeks later to determine changes in the longitudinal shape of boreholes with time. In addition to the main surveys, three boreholes were surveyed 14 times each to assess the accuracy and reproducibility of inclinometry measurements. These repeat surveys suggest that caution is needed in the interpretation of short-term borehole displacement measurements, and that the reoccupation of boreholes from one year to the next may be a better way to determine patterns of internal deformation and basal sliding. The annual scale may also have advantages in providing more long-term insight into glaciological processes than short term (single season) measurements.

scholarly journals The use of borehole inclinometry in determining basal sliding and internal deformation at Haut Glacier d’Arolla, Switzerland

1997 ◽  
Vol 24 ◽  
pp. 331-337 ◽  
Author(s):  
Luke Copland ◽  
Jon Harbor ◽  
Marie Minner ◽  
Martin Sharp
Keyword(s):  
Hot Water ◽  
Short Term ◽  
Digital Inclinometer ◽  
Basal Sliding ◽  
Internal Deformation ◽  
One Year ◽  
Annual Scale ◽  
Insight Into ◽  
Displacement Measurements

A series of boreholes were drilled with high-pressure hot water across a section of Haut Glacier d’Arolla, Switzerland, in summer 1995. Twenty-three of the boreholes were profiled with a digital inclinometer soon aller drilling, and 14 were re-profiled up to 6 weeks later to determine changes in the longitudinal shape of boreholes with time. In addition to the main surveys, three boreholes were surveyed 14 times each to assess the accuracy and reproducibility of inclinometry measurements. These repeat surveys suggest that caution is needed in the interpretation of short-term borehole displacement measurements, and that the reoccupation of boreholes from one year to the next may be a better way to determine patterns of internal deformation and basal sliding. The annual scale may also have advantages in providing more long-term insight into glaciological processes than short term (single season) measurements.

Athletes Play Through Pain—What Does That Mean for Rehabilitation Specialists?

2020 ◽  
Vol 29 (5) ◽  
pp. 640-649 ◽  
Author(s):  
Amy Barrette ◽  
Katherine Harman
Keyword(s):  
Well Being ◽  
Short Term ◽  
Semistructured Interviews ◽  
Sport Organization ◽  
The University ◽  
E Mail ◽  
Competitive Nature ◽  
And Training ◽  
Insight Into

Context: Pain in sport has been normalized to the point where athletes are expected to ignore pain and remain in the game despite the possible detrimental consequences associated with playing through pain. While rehabilitation specialists may not have an influence on an athlete’s competitive nature or the culture of risk they operate in, understanding the consequences of those factors on an athlete’s physical well-being is definitely in their area of responsibility. Objective: To explore the factors associated with the experiences of subelite athletes who play through pain in gymnastics, rowing, and speed skating. Design: The authors conducted semistructured interviews with subelite athletes, coaches, and rehabilitation specialists. They recruited coach participants through their provincial sport organization. Athletes of the recruited coaches who were recovering from a musculoskeletal injury and training for a major competition were then recruited. They also recruited rehabilitation specialists who were known to treat subelite athletes independently by e-mail. Setting: An observation session was conducted at the athlete’s training facility. Interviews were then conducted either in a room at the university or at a preferred sound-attenuated location suggested by the participant. Participants: The authors studied 5 coaches, 4 subelite athletes, and 3 rehabilitation specialists. Interventions: The authors photographed athletes during a practice shortly before an important competition, and we interviewed all the participants after that competition. Our photographs were used during the interview to stimulate discussion. Results: The participant interviews revealed 3 main themes related to playing through pain. They are: Listening to your body, Decision making, and Who decides. Conclusion: When subelite athletes, striving to be the best in their sport continue to train with the pain of an injury, performance is affected in the short-term and long-term consequences are also possible. Our study provides some insight into the contrasting forces that athletes balance as they decide to continue or to stop.

scholarly journals Contrarian and Momentum Strategies in the Indian Capital Market

2002 ◽  
Vol 27 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Sanjay Sehgal ◽  
I Balakrishnan
Keyword(s):  
Stock Returns ◽  
Indian Market ◽  
Momentum Effect ◽  
Short Term ◽  
Momentum Strategy ◽  
Momentum Strategies ◽  
Holding Period ◽  
The Us ◽  
One Year

The study attempts to evaluate if there are any systematic patterns in stock returns for the Indian market. The empirical findings reveal that there is a reversal in long-term returns, once the short-term momentum effect has been controlled by maintaining a one year gap between portfolio formation period and the portfolio holding period. A contrarian strategy based on long-term past returns provides moderately positive returns. Further, there is a continuation in short-term returns and a momentum strategy based on it provides significantly positive payoffs. The results in general are in conformity with those for developed capital markets such as the US.

scholarly journals Effect of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients – a one-year follow-up

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Ana Isabel Penzlin ◽  
Kristian Barlinn ◽  
Ben Min-Woo Illigens ◽  
Kerstin Weidner ◽  
Martin Siepmann ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Short Term ◽  
Heart Rate Variability Biofeedback ◽  
One Year ◽  
Alcohol Dependent

scholarly journals Az etopozid szervezeten belüli eloszlásában és metabolizmusában szerepet játszó epigenetikai hatások

2018 ◽  
Vol 159 (32) ◽  
pp. 1295-1302
Author(s):  
Erika Rozália Kovács ◽  
Sára Tóth ◽  
Dániel János Erdélyi
Keyword(s):  
Topoisomerase Ii ◽  
Therapeutic Index ◽  
Antitumor Agent ◽  
Hematologic Malignancies ◽  
Short Term ◽  
Drug Dosing ◽  
And Personalized Medicine ◽  
Insight Into ◽  
Pharmacogenomic Studies

Abstract: Etoposide is a topoisomerase II inhibitor antitumor agent which is widely used in the treatment of several hematologic malignancies and solid tumors. The therapeutic index of etoposide is quite high, thus its application causes several short-term and long-term side effects which can decrease the chance to cure patients. Drug dosing is based on body surface area calculation; recommendations for individual dosing do not exist yet. The biotransformation and transportation of etoposide are carried out by enzymes and transporters as reported in pharmacogenomic studies published in this area. Nowadays pharmacoepigenetics research has come to the fore. The authors wish to give an insight into the research of the epigenetical changes of the etoposide pathways, especially focusing on published findings on enzymes and transporters with pharmacokinetic relevance. In the future, epigenetical changes of the etoposide pathway might have a great role in diagnostics, prognostics and personalized medicine. Orv Hetil. 2018; 159(32): 1295–1302.

Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis

2019 ◽  
Vol 11 (12) ◽  
pp. 1266-1272 ◽  
Author(s):  
Krishnan Ravindran ◽  
Lauren A Dalvin ◽  
Jose S Pulido ◽  
Waleed Brinjikji
Keyword(s):  
Metastatic Disease ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
First Line ◽  
Short Term ◽  
Systemic Complications ◽  
Substantial Heterogeneity ◽  
Insight Into

Background and purposeIntra-arterial chemotherapy for retinoblastoma has been adopted as a first-line treatment option by numerous tertiary centers. The effect of intra-arterial chemotherapy on future rates of metastatic disease as well as on globe salvage in advanced eyes remains relatively unknown.MethodsA search of PubMED, MEDLINE, EMBASE, and Web of Science electronic databases was conducted from inception until January 2019 for studies with a minimum of 10 patients reporting outcomes and complications following intra-arterial chemotherapy for retinoblastoma.ResultsA total of 20 studies met the inclusion criteria for analysis, comprising 873 patients and 1467 eyes. Only one study was comparative; there was substantial heterogeneity in reported outcomes and several overlapping patient cohorts that were published. Across all studies, 174 of 1467 eyes were enucleated (11.8%). Metastatic disease occurred in 8 of 513 patients (1.6%). Globe salvage was achieved in 318 of 906 (35.6%) cases of advanced retinoblastoma. The most common ocular complication was retinal detachment, occurring in 23% of eyes, and the most common systemic complications were transient fever and nausea/vomiting.ConclusionsThere is a paucity of higher-level evidence with adequate follow-up surrounding the long-term safety of intra-arterial chemotherapy and effect on metastasis in retinoblastoma. Studies to date have been limited by short-term follow-up. Longitudinal prospective studies could provide greater insight into the ability of intra-arterial chemotherapy to reduce the risk of retinoblastoma metastasis.

scholarly journals Mitochondrial and Oxidative Impacts of Short and Long-term Administration of HAART on HIV Patients

2020 ◽  
Vol 15 (2) ◽  
pp. 110-124
Author(s):  
Joy E. Ikekpeazu ◽  
Oliver C. Orji ◽  
Ikenna K. Uchendu ◽  
Lawrence U.S. Ezeanyika
Keyword(s):  
Treatment Group ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Hiv Patients ◽  
Long Term Treatment ◽  
Term Administration ◽  
Short And Long Term ◽  
One Year

Background and Objective: There may be a possible link between the use of HAART and oxidative stress-related mitochondrial dysfunction in HIV patients. We evaluated the mitochondrial and oxidative impacts of short and long-term administration of HAART on HIV patients attending the Enugu State University Teaching (ESUT) Hospital, Enugu, Nigeria following short and long-term therapy. Methods: 96 patients categorized into four groups of 24 individuals were recruited for the study. Group 1 comprised of age-matched, apparently healthy, sero-negative individuals (the No HIV group); group 2 consisted of HIV sero-positive individuals who had not started any form of treatment (the Treatment naïve group). Individuals in group 3 were known HIV patients on HAART for less than one year (Short-term treatment group), while group 4 comprised of HIV patients on HAART for more than one year (Long-term treatment group). All patients were aged between 18 to 60 years and attended the HIV clinic at the time of the study. Determination of total antioxidant status (TAS in nmol/l), malondialdehyde (MDA in mmol/l), CD4+ count in cells/μl, and genomic studies were all done using standard operative procedures. Results: We found that the long-term treatment group had significantly raised the levels of MDA, as well as significantly diminished TAS compared to the Short-term treatment and No HIV groups (P<0.05). In addition, there was significantly elevated variation in the copy number of mitochondrial genes (mtDNA: D-loop, ATPase 8, TRNALEU uur) in the long-term treatment group. Interpretation and Conclusion: Long-term treatment with HAART increases oxidative stress and causes mitochondrial alterations in HIV patients.

scholarly journals General Assessment of the Operational Utility of National Water Model Reservoir Inflows for the Bureau of Reclamation Facilities

Water ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2897
Author(s):  
Francesca Viterbo ◽  
Laura Read ◽  
Kenneth Nowak ◽  
Andrew W. Wood ◽  
David Gochis ◽  
...  
Keyword(s):  
Water Model ◽  
Short Term ◽  
Bureau Of Reclamation ◽  
Hydrologic Processes ◽  
One Year ◽  
Inflow Performance ◽  
Basin Area ◽  
National Water ◽  
Total Inflow

This work investigates the utility of the National Oceanic and Atmospheric Administration’s National Water Model (NWM) for water management operations by assessing the total inflow into a select number of reservoirs across the Central and Western U.S. Total inflow is generally an unmeasured quantity, though critically important for anticipating both floods and shortages in supply over a short-term (hourly) to sub-seasonal (monthly) time horizon. The NWM offers such information at over 5000 reservoirs across the U.S., however, its skill at representing inflow processes is largely unknown. The goal of this work is to understand the drivers for both well performing and poor performing NWM inflows such that managers can get a sense of the capability of NWM to capture natural hydrologic processes and in some cases, the effects of upstream management. We analyzed the inflows for a subset of Bureau of Reclamation (BoR) reservoirs within the NWM over the long-term simulations (retrospectively, seven years) and for short, medium and long-range operational forecast cycles over a one-year period. We utilize ancillary reservoir characteristics (e.g., physical and operational) to explain variation in inflow performance across the selected reservoirs. In general, we find that NWM inflows in snow-driven basins outperform those in rain-driven, and that assimilated basin area, upstream management, and calibrated basin area all influence the NWM’s ability to reproduce daily reservoir inflows. The final outcome of this work proposes a framework for how the NWM reservoir inflows can be useful for reservoir management, linking reservoir purposes with the forecast cycles and retrospective simulations.

scholarly journals Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis

Open Heart ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. e000901
Author(s):  
Anette Borger Kvaslerud ◽  
Amjad Iqbal Hussain ◽  
Andreas Auensen ◽  
Thor Ueland ◽  
Annika E Michelsen ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Short Term ◽  
Prognostic Implication ◽  
Wide Range ◽  
One Year

ObjectiveThe aim of this study was to evaluate the prevalence and prognostic implication of iron deficiency (ID) and anaemia in patients with severe aortic stenosis (AS).MethodsIn an observational study of consecutive patients referred for aortic valve replacement (AVR), we assessed a wide range of biomarkers of iron status, including the definition of ID commonly applied in patients with chronic heart failure (ferritin <100 µg/L or ferritin 100–299 µg/L with a transferrin saturation <20%). The endpoints were short-term (one-year) and long-term (median 4.7 years, IQR: 3.8–5.5) mortality and major adverse cardiovascular events (MACE) within the first year after inclusion.Results464 patients were included in this substudy. 91 patients (20%) received conservative treatment and 373 patients (80%) received AVR. ID was detected in 246 patients (53%). 94 patients (20%) had anaemia. Patients with ID had an overall worse clinical profile than patients without ID. During follow-up, 129 patients (28%) died. Neither ID as defined above, soluble transferrin receptor nor hepcidin were associated with short-term or long-term mortality or MACE independent on treatment allocation. Anaemia was associated with one-year mortality in conservatively treated patients.ConclusionsID and anaemia are prevalent in patients with severe AS. In our cohort, ID did not provide independent prognostic information on top of conventional risk factors. More studies are required to determine how to correctly diagnose ID in patients with AS.Trial registration numberNCT01794832.

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