Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Pengfei Fu ◽  
Ken Kin Lam Yung
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
Meta Analysis ◽  
Positive Association ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Pollution Levels ◽  
Risk Rate

Background: Ambient air pollution has been associated with Alzheimer’s disease (AD) in the elderly. However, its effects on AD have not been meta-analyzed comprehensively. Objective: We conducted a systematic review and meta-analysis to assess the associations between air pollution and AD incidence. Methods: We searched PubMed and Web of Science for indexed publications up to March 2020. Odds risk (OR) and confidence intervals (CI) were estimated for particulate matter (PM)10 (PM10), PM2.5, ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO). The subgroup analysis was conducted based on the pollution levels. Results: Nine studies were included in the meta-analysis and review. The OR per 10 μg/m3 increase of PM2.5 was 1.95 (95% CI: 0.88–4.30). The corresponding values per 10 μg/m3 increment of other pollutants were 1.03 (95% CI: 0.68–1.57) for O3, 1.00 (95% CI: 0.89–1.13) for NO2, and 0.95 (95% CI: 0.91–0.99) for PM10 (only one study), respectively. Overall OR of the five air pollutants above with AD was 1.32 (95% CI: 1.09–1.61), suggesting a positive association between ambient air pollution and AD incidence. The sub-analysis indicated that the OR (2.20) in heavily polluted regions was notably higher than that in lightly polluted regions (1.06). Although AD risk rate data related to SO2 or CO exposure are still limited, the epidemiologic and toxicological evidence indicated that higher concentration of SO2 or CO exposure increased risks of dementia, implying that SO2 or CO might have a potential impact on AD. Conclusion: Air pollution exposure may exacerbate AD development.

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 77 (2) ◽  
pp. 701-714
Author(s):  
Pengfei Fu ◽  
Ken Kin Lam Yung
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
Meta Analysis ◽  
Positive Association ◽  
Ambient Air ◽  
The Elderly ◽  
Ambient Air Pollution ◽  
Pollution Levels

Background: Ambient air pollution has been associated with Alzheimer’s disease (AD) in the elderly. However, its effects on AD have not been meta-analyzed comprehensively. Objective: We conducted a systematic review and meta-analysis to assess the associations between air pollution and AD incidence. Methods: We searched PubMed and Web of Science for indexed publications up to March 2020. Odds risk (OR) and confidence intervals (CI) were estimated for particulate matter (PM)10 (PM10), PM2.5, ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO). The subgroup analysis was conducted based on the pollution levels. Results: Nine studies were included in the meta-analysis and review. The OR per 10μg/m3 increase of PM2.5 was 1.95 (95% CI: 0.88–4.30). The corresponding values per 10μg/m3 increment of other pollutants were 1.03 (95% CI: 0.68–1.57) for O3, 1.00 (95% CI: 0.89–1.13) for NO2, and 0.95 (95% CI: 0.91–0.99) for PM10 (only one study), respectively. Overall OR of the five air pollutants above with AD was 1.32 (95% CI: 1.09–1.61), suggesting a positive association between ambient air pollution and AD incidence. The sub-analysis indicated that the OR (2.20) in heavily polluted regions was notably higher than that in lightly polluted regions (1.06). Although AD risk rate data related to SO2 or CO exposure are still limited, the epidemiologic and toxicological evidence indicated that higher concentration of SO2 or CO exposure increased risks of dementia, implying that SO2 or CO might have a potential impact on AD. Conclusion: Air pollution exposure may exacerbate AD development.

Global association between ambient air pollution and blood pressure: A systematic review and meta-analysis

2018 ◽  
Vol 235 ◽  
pp. 576-588 ◽  
Author(s):  
Bo-Yi Yang ◽  
Zhengmin Qian ◽  
Steven W. Howard ◽  
Michael G. Vaughn ◽  
Shu-Jun Fan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Air Pollution ◽  
Meta Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution

Ambient air pollution and body weight status in adults: A systematic review and meta-analysis

2020 ◽  
Vol 265 ◽  
pp. 114999 ◽  
Author(s):  
Sihan Huang ◽  
Xinyu Zhang ◽  
Jianfeng Huang ◽  
Xiangfeng Lu ◽  
Fangchao Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Air Pollution ◽  
Body Weight ◽  
Weight Status ◽  
Meta Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Body Weight Status

scholarly journals Influence of Woodsmoke Exposure on Molecular Mechanisms Underlying Alzheimer’s Disease: Existing Literature and Gaps in Our Understanding

2020 ◽  
Vol 13 ◽  
pp. 251686572095487
Author(s):  
Adam Schuller ◽  
Luke Montrose
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
Molecular Mechanisms ◽  
Neurodegenerative Disorder ◽  
Ambient Air ◽  
The United States ◽  
Ambient Air Pollution ◽  
Current Status

Woodsmoke poses a significant health risk as a growing component of ambient air pollution in the United States. While there is a long history of association between woodsmoke exposure and diseases of the respiratory, circulatory, and cardiovascular systems, recent evidence has linked woodsmoke exposure to cognitive dysfunction, including Alzheimer’s disease dementia. Alzheimer’s disease is a progressive neurodegenerative disorder with largely idiopathic origins and no known cure. Here, we explore the growing body of literature which relates woodsmoke-generated and ambient air pollution particulate matter exposure to Alzheimer’s disease (AD) onset or exacerbation, in the context of an inflammation-centric view of AD. Epigenetic modifications, specifically changes in DNA methylation patterns, are well documented following woodsmoke exposure and have been shown to influence disease-favoring inflammatory cascades, induce oxidative stress, and modulate the immune response in vitro, in vivo, and in humans following exposure to air pollution. Though the current status of the literature does not allow us to draw definitive conclusions linking these events, this review highlights the need for additional work to fill gaps in our understanding of the directionality, causality, and susceptibility throughout the life course.

scholarly journals Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis

2020 ◽  
Vol 17 (22) ◽  
pp. 8658
Author(s):  
Sylvester Dodzi Nyadanu ◽  
Gizachew Assefa Tessema ◽  
Ben Mullins ◽  
Bernard Kumi-Boateng ◽  
Michelle Lee Bell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Air Pollution ◽  
Birth Outcomes ◽  
Meta Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Adverse Birth Outcomes ◽  
Extreme Temperatures ◽  
Umbrella Review ◽  
Review Systematic

Prenatal exposure to ambient air pollution and extreme temperatures are among the major risk factors of adverse birth outcomes and with potential long-term effects during the life course. Although low- and middle-income countries (LMICs) are most vulnerable, there is limited synthesis of evidence in such settings. This document describes a protocol for both an umbrella review (Systematic Review 1) and a focused systematic review and meta-analysis of studies from LMICs (Systematic Review 2). We will search from start date of each database to present, six major academic databases (PubMed, CINAHL, Scopus, MEDLINE/Ovid, EMBASE/Ovid and Web of Science Core Collection), systematic reviews repositories and references of eligible studies. Additional searches in grey literature will also be conducted. Eligibility criteria include studies of pregnant women exposed to ambient air pollutants and/or extreme temperatures during pregnancy with and without adverse birth outcomes. The umbrella review (Systematic Review 1) will include only previous systematic reviews while Systematic Review 2 will include quantitative observational studies in LMICs. Searches will be restricted to English language using comprehensive search terms to consecutively screen the titles, abstracts and full-texts to select eligible studies. Two independent authors will conduct the study screening and selection, risk of bias assessment and data extraction using JBI SUMARI web-based software. Narrative and semi-quantitative syntheses will be employed for the Systematic Review 1. For Systematic Review 2, we will perform meta-analysis with two alternative meta-analytical methods (quality effect and inverse variance heterogeneity) as well as the classic random effect model. If meta-analysis is infeasible, narrative synthesis will be presented. Confidence in cumulative evidence and the strength of the evidence will be assessed. This protocol is registered with PROSPERO (CRD42020200387).

scholarly journals Ambient Air Pollution and Risk of Congenital Anomalies: A Systematic Review and Meta-analysis

2011 ◽  
Vol 119 (5) ◽  
pp. 598-606 ◽  
Author(s):  
Martine Vrijheid ◽  
David Martinez ◽  
Sandra Manzanares ◽  
Payam Dadvand ◽  
Anna Schembari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Air Pollution ◽  
Congenital Anomalies ◽  
Meta Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution

Association between Ambient Air Pollution and Diabetes Mellitus: Systematic Review and Meta-Analysis

2014 ◽  
Vol 2014 (1) ◽  
pp. 1515
Author(s):  
Ikenna Eze* ◽  
Lars Hemkens ◽  
Heiner Bucher ◽  
Barbara Hoffmann ◽  
Christian Schindler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Air Pollution ◽  
Meta Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution
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