Rank-based risk target data analysis using digital twin on oil pipeline network based on manifold learning

Oil and Gas Pipeline (OGP) projects face a wide scope of wellbeing and security Risk Factors (RFs) all around the world, especially in the oil and gas delivering nations having influencing climate and unsampled data. Lacking data about the reasons for pipeline risk predictor and unstructured data about the security of the OGP prevent endeavors of moderating such dangers. This paper, subsequently, means to foster a risk analyzing framework in view of a comprehensive methodology of recognizing, dissecting and positioning the related RFs, and assessing the conceivable pipeline characteristics. Hazard Mitigation Methods (HMMs), which are the initial steps of this approach. A new methodology has been created to direct disappointment investigation of pinhole erosion in pipelines utilizing the typical pipeline risk strategy and erosion climate reenactments during a full life pattern of the pipeline. Hence in the proposed work, manifold learning with rank based clustering algorithm is incorporated with the cloud server for improved data analysis. The probability risk rate is identified from the burst pressure by clustering the normal and leak category to improve the accuracy of the prediction system experimented on the lab-scale oil pipeline system. The numerical results like auto-correlation, periodogram, Laplace transformed P-P Plot are utilized to estimate the datasets restructured by the manifold learning approach. The obtained experimental results shows that the cloud server datasets are clustered with rank prioritization to make proactive decision in faster manner by distinguishing labelled and unlabeled pressure attributes.

The Association of Toxoplasma gondii IgG Antibody and Chronic Kidney Disease Biomarkers

Background: Toxoplasma gondii (T. gondii) is a parasite that infects more than 40 million Americans and causes toxoplasmosis. Most cases of toxoplasmosis are asymptomatic; however, T. gondii is capable of invading organs like the kidney, causing chronic infections and cell destruction. Methods: This study focused on evaluating the association between T. gondii exposure and chronic kidney disease (CKD) using data from the 2009–2010 National Health and Nutrition Examination Survey (NHANES). T. gondii exposure was assessed using Toxoplasma gondii IgG antibody status, and the status of CKD was assessed using the CKD biomarkers. The evaluation of risk rate and population prevalence was performed. In addition, multivariable regression models were used to further investigate this association after adjusting for sociodemographic, anthropometric, behavioral, and clinical covariates commonly associated with kidney dysfunction. Results: The positive T. gondii IgG antibody participants had significantly higher levels of CKD biomarkers, including second albumin-to-creatinine ratio (p = 0.0376), second albuminuria (p = 0.0005), and persistent albuminuria (p < 0.0001) compared to the negative participants. Furthermore, there were statistical associations between T. gondii exposure and the status of CKD (negative vs. positive) (p = 0.0001), and between T. gondii exposure and the CKD stage (negative, stage 1, …, stage 5) (p = 0.0004). Without adjusting for age, the positive T. gondii participants had a significantly higher risk (27% higher) of having CKD than the negative participants (RRcrude = 1.27, 95% CI: 1.09–1.49). The age-adjusted prevalence of CKD was higher among Toxoplasma-positive participants compared to the Toxoplasma-negative participants (10.45 vs. 8.99). T. gondii infection was significantly associated with CKD (OR = 1.40, 95% CI = 1.06–1.84, p = 0.00447) after adjusting for age, gender, race/ethnicity, and BMI. Age was positively associated with CKD (OR = 8.89, 95% CI = 6.31–12.51, p < 0.0001) with the participants 45+ years old being 8.89 times more likely to have CKD than those who are <45 years old, after adjusting for T. gondii infection, gender, race/ethnicity, and BMI. Moreover, positive T. gondii increased the odds of CKD progression (OR = 1.41, 95% CI = 1.07–1.86, p = 0.0424). Conclusions: Positive T. gondii IgG antibody is associated with CKD and the progression of CKD stages. This association is more apparent among older people. Further investigations are needed to examine these findings in different geographical locations and among differentially exposed populations.

Burnt to a crisp? Understanding drivers of burnout amongst New Zealand workers

PurposeJob burnout is a popular topic for researchers and a pressing issue for employees and employers. However, the most popular measure has become widely critiqued, and a new construct – the Burnout Assessment Tool (BAT) – has been offered as a better way to assess burnout.Design/methodology/approachThe study uses data from 1,022 employees across a wide range of occupations, sectors and industries. Confirmatory factor analysis (CFA) and odds ratio calculations are explored.FindingsThe present psychometric properties of the BAT construct are supported. Overall, 11.1% of employees met the high burnt-out risk threshold. Determinants of burnt-out risk were explored, with significant findings from high perceptions of organizational support, large firm-size, young age and long work hours found. No gender differences. The odds ratio provides greater insights into the risks associated with factors, especially working 55+ hours/week, which resulted in 580% higher risk of burnt-out risk.Research limitations/implicationsThe findings highlight the danger of burnt-out risk and provide a useful benchmark for those exploring the burnt-out risk rate.Originality/valueThe BAT has not been tested in New Zealand across a sample of employees. Given the large size and breadth of employees, this provides useful generalizability to the BAT-NZ. The determinants tested here are all unique to the literature and provide new insights.

New Concepts about DOL-DFL Nexus: The Relationships with Market Sensitivities, Firm-Specific Risk and Other Issues

This paper investigates several issues related to the Degree of Operating Leverage (DOL) and the Degree of Financial Leverage (DFL) in the light of advanced concepts on the matter proposed by recent studies. In particular, the paper treats mainly the relationships between DOL and market sensitivities and the impact of the uncertainty on DOL and DFL volatility together with minor issues. We used the DOL function already developed to analyse what market conditions facilitate or hinder, with or without economies of scale, Revenue development or a profit-maximising policy. DOL records the reaction coming from the factor and product markets together with the management decision process. DOL highlights whether the current economic strategy is, or not, successful and why, so that management can perceive clues to evaluate both the policy and its implementation. The uncertainty related to six fundamental economic variables determining EBIT and Net Profit growth volatility eventually contaminates DOL and DFL. Not all such variables impact DOL and DFL volatility, but when it happens, the firm&rsquo;s risk is representable through the asymptotes of the DOL and DFL curves generated by each specific variable. Such a risk rate is independent of the chosen uncertainty range and is firm unique in any financial period. In normal economic conditions, DOL undervalues firm-specific risk while DFL carries out a containment function. The higher risk rate comes from the unit price change, that coupled with a sturdy quantity/mix growth, could induce negative economic and financial results.

Demographic and Epidemiological Contributions to Recent Trends in Cancer Incidence in Hong Kong

Background: Hong Kong has an ageing Chinese population with high life expectancy and a rising number of cancer cases. While population ageing could lead to higher incidence, we aim to quantify the demographic and epidemiological contributions to this trend by disentangling the effect of these factors. Methods: We analysed secular trends of cancer incidences of all cancer sites combined, including the five top cancers in men and women in Hong Kong in 1983–2017, by disentangling effects of demographics (ageing population and population growth) and cancer risk/rate change using the RiskDiff methodology. Results: Overall, age-standardised incidences of all cancers combined in women and in men declined over the study period (−5.3% for women, −30.2% for men), but total incident cancer case counts increased dramatically (156.5% for women, 96% for men). This increase was primarily due to ageing and increasing population (95% age, 66.1% growth for women, and 119.4% age, 25.4% growth for men), while disease risk for all cancers combined has a decreasing trend (−4.5% for women and −48.8% for men). For the site-specific risk changes among the most five common cancer types, there were increases in risks of prostate and colorectal cancers in men, and breast, endometrial, and thyroid cancers in women. Conclusion: Demographic changes and ageing in our Chinese population resulted in a marked increase in the number of cancer diagnoses in Hong Kong in past decades. The surge in incident case counts overall is expected to stress the healthcare system in terms of the increased demand of healthcare professionals. Cancer surveillance should be enhanced in view of the growing demand from older patients and the cancer types with fast-increasing incidence rates in our population.

Reduced capsular contracture with smooth and textured breast implants following submuscular mammoplasty: systematic literature review

Background: Capsular contracture is common in breast augmentation and reconstruction surgery. The present systematic review discusses the safety of textured and smooth implants in the submuscular position. Methods: A literature search was conducted on PubMed and EMBASE from inception until June 2020. The primary outcome was reduction of capsular contracture (Baker grade); others included time of capsular contracture onset, implant position/rupture rate/surface, hematoma/seroma risk, surgeon assessment and patient satisfaction. A total of 7731 patients were included from six publications. Results: The overall risk rate for capsular contracture increased from 7.6 to 25% in 10 years. The capsular contracture rates in textured and smooth implants were 3–14% and 6–20%, respectively, and no significant difference between implants was observed when the implants were placed submuscularly. Submuscular placement and textured implants also reduced the incidence of other complications. Conclusion: This systematic review suggests that appropriate placement reduces capsular contracture rate, irrespective of implant surface.

Estimate risks rate for Android applications using Android Permissions

In recent years, Android becomes the first target for hackers and malware developers, due to his inefficient permission model. In this article, we introduce our tool called PerUpSecure to manage permissions requested by Android applications, calculate the risk rates and display the results to the user, in order to help him to make a better decision. Thanks to our PerUpSecure, user will be able to install only the trusted application. As far as we know, the other existing tools focus only on measuring app risk after being installed, and not before as our tool does. Therefore, to evaluate our tool, we selected two different applications sets. The results show that our tool can produce the most trustworthy risk rate to prevent and detect potential malicious activities performed by malware.

Trend Observations in Home Parenteral Nutrition. Prevalence, Hospitalizations and Costs: Results from a Nationwide Analysis of Health Care Provider Data

Background: The population of patients on home parenteral nutrition (HPN) worldwide is growing. Since only a few counties provide data from national registries long-term observations are valuable to address this specific area of nutrition support. This study is a nationwide analysis determining the trends in the epidemiology of HPN (prevalence, age distribution, death rates), indications for HPN, causes for hospitalizations, and cost analysis of HPN reimbursement in Poland between 2010–2020. Methods: A retrospective analysis of data obtained from the national health fund (NHF) of Poland on adult patients on HPN. Results: The prevalence of adult patients on HPN in Poland in 2020 was 53.26 per million citizens with a 2.99-fold increase and a growing trend observed from 2010. Significant decrease in the percentage of patients between 18–34, 45–54 and an increase in patients between 65–74 and patients over 75 years old was observed. Trend analysis showed an increase in new patients between 65–74 and a decrease between 35–54. Malnutrition (34.28%), postprocedural disorders of the GI tract (19.61%), intestinal malabsorption/other intestinal diseases (20.41%) and GI obstruction due to cancer (17.36% as primary and 23.16% as secondary diagnosis) were mostly reported as the primary indications for HPN. Cancer patients were mostly gastric, ovarian and colon cancer (34.74%, 17.83% and 12.3%). HPN and total health cost reimbursement increase was 2.6 and 2.57—fold respectively. Costs of HPN and total health care costs in 2020 per patient were € 10,015 and € 16,038, respectively. Overall death risk rate during the first year of nutrition was 0.59 with a significant increase in the observation period p-trend < 0.004. A significant increase in the death rate was observed in patients above 75 years old (estimate 1.629, p-trend < 0.030). Cancer, infection, malnutrition and GI symptoms were the most common indications for hospitalizations of HPN patients. The rate of patients with a maximal length of HPN of 5 months in 2010 was 54.9% and was growing up to 78.1% in 2020. Conclusions: The prevalence of HPN in Poland is growing. Trends of age distribution show increasing numbers of patients with more advanced age and shorter survival. Costs of HPN are comparable with other European data.

Should We Quantify Valvular Calcifications on Cardiac CT in Patients with Infective Endocarditis?

Background: Evaluate the impact of valvular calcifications measured on cardiac computed tomography (CCT) in patients with infective endocarditis (IE). Methods: Seventy patients with native IE (36 aortic IE, 31 mitral IE, 3 bivalvular IE) were included and explored with CCT between January 2016 and April 2018. Mitral and aortic valvular calcium score (VCS) were measured on unenhanced calcium scoring images, and correlated with clinical, surgical data, and 1-year death rate. Results: VCS of patients with mitral IE and no peripheral embolism was higher than those with peripheral embolism (868 (25–1725) vs. 6 (0–95), p < 0.05). Patients with high calcified mitral IE (mitral VCS > 100; n = 15) had a lower rate of surgery (40.0% vs.78.9%; p = 0.03) and a higher 1-year-death risk (53.3% vs. 10.5%, p = 0.04; OR = 8.5 (2.75–16.40) than patients with low mitral VCS (n = 19). Patients with aortic IE and high aortic calcifications (aortic VCS > 100; n = 18) present more frequently atypical bacteria on blood cultures (33.3% vs. 4.8%; p = 0.03) than patients with low aortic VCS (n = 21). Conclusion: The amount of valvular calcifications on CT was associated with embolism risk, rate of surgery and 1-year risk of death in patients with mitral IE, and germ’s type in aortic IE raising the question of their systematic quantification in native IE.