Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study

2021 ◽  
pp. 1-13
Author(s):  
Debora Melo van Lent ◽  
Adrienne O’Donnell ◽  
Alexa S. Beiser ◽  
Ramachandran S. Vasan ◽  
Charles S. DeCarli ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Framingham Heart Study ◽  
Visual Memory ◽  
Brain Volume ◽  
Brain Mri ◽  
Heart Study ◽  
The Mind ◽  
Mind Diet

Background: Adherence to the Mediterranean-DASH for Neurodegenerative Delay (MIND) diet has previously been associated with cognitive decline and dementia. To our knowledge, no prior study has investigated the association between the MIND diet and measures of brain volume, silent brain infarcts (SBIs), or brain atrophy. Objective: We evaluated whether adherence to the MIND diet associated with superior cognitive function, larger brain volumes, fewer SBIs, and less cognitive decline in the community-based Framingham Heart Study. Methods: 2,092 participants (mean±SD, age 61±9) completed Food Frequency Questionnaires, averaged across a maximum of 3-time points (examination cycles 5, 6, and 7), cognitive testing at examination cycle 7 (present study baseline: 1998–2001) and after a mean±SD of 6.6±1.1 years from baseline (n = 1,584). A subset of participants also completed brain magnetic resonance imaging (MRI) at examination cycle 7 (n = 1,904). In addition, participants with dementia, stroke, and other relevant neurological diseases such as significant head trauma, subdural hematoma, or multiple sclerosis were excluded from the analyses. Results: Higher MIND diet scores were associated with better global cognitive function (β±SE,+0.03SD±0.01; p = 0.004), verbal memory, visual memory, processing speed, verbal comprehension/reasoning, and with larger total brain volume (TBV) following adjustments for clinical, lifestyle and demographic covariates, but not with other brain MRI measures (i.e., hippocampal volume, lateral ventricular volume, white matter hyperintensity volume, SBIs) or cognitive decline. Conclusion: Higher MIND diet scores associated with better cognitive performance and larger TBV at baseline, but not with cognitive decline. Clinical trials are needed to ascertain whether adopting the MIND diet affects trajectories of cognitive decline.

P3-561: ADHERENCE TO THE MIND DIET IS ASSOCIATED WITH BETTER COGNITION IN THE FRAMINGHAM HEART STUDY

2006 ◽  
Vol 14 (7S_Part_25) ◽  
pp. P1338-P1339
Author(s):  
Jayandra J. Himali ◽  
Debora Melo van Lent ◽  
Adrienne O'Donnell ◽  
Paul F. Jacques ◽  
Michael Wagner ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Heart Study ◽  
The Mind ◽  
Mind Diet

Association of long-term adherence to the mind diet with cognitive function and cognitive decline in American women

2017 ◽  
Vol 22 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Agnes M. Berendsen ◽  
J. H. Kang ◽  
E. J. M. Feskens ◽  
C. P. G. M. de Groot ◽  
F. Grodstein ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
American Women ◽  
The Mind ◽  
Mind Diet

scholarly journals P2-568: ADHERENCE TO THE MIND DIET PREDICTS A LOWER RISK OF DEMENTIA IN THE FRAMINGHAM HEART STUDY

2019 ◽  
Vol 15 ◽  
pp. P840-P841
Author(s):  
Jayandra J. Himali ◽  
Alexa S. Beiser ◽  
Debora Melo van Lent ◽  
Adrienne O'Donnell ◽  
Paul F. Jacques ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Lower Risk ◽  
Heart Study ◽  
The Mind ◽  
Mind Diet

Abstract MP39: Association of MIND Diet Adherence With Brain Volume, Silent Brain Infarcts and Brain Atrophy in the Framingham Heart Study

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Debora Melo van Lent ◽  
Adrienne O’Donnell ◽  
Paul Jacques ◽  
Charles DeCarli ◽  
Michael Wagner ◽  
...  
Keyword(s):  
Brain Atrophy ◽  
Framingham Heart Study ◽  
Brain Volume ◽  
Diet Adherence ◽  
Brain Infarcts ◽  
Heart Study ◽  
Mind Diet

O2-10-01: OMEGA-3 FATTY ACID LEVELS ARE ASSOCIATED WITH BRAIN MRI MEASURES IN MIDDLE-AGED ADULTS FROM THE FRAMINGHAM HEART STUDY

2006 ◽  
Vol 14 (7S_Part_11) ◽  
pp. P644-P644
Author(s):  
Claudia L. Satizabal ◽  
Jayandra J. Himali ◽  
Alexa S. Beiser ◽  
Ramachandran S. Vasan ◽  
Charlie S. DeCarli ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Framingham Heart Study ◽  
Brain Mri ◽  
Omega 3 ◽  
Middle Aged ◽  
Omega 3 Fatty Acid ◽  
Heart Study ◽  
Middle Aged Adults

scholarly journals Hypertension, Prehypertension, and Hypertension Control

Hypertension ◽  
2021 ◽  
Vol 77 (2) ◽  
pp. 672-681
Author(s):  
Sara Teles de Menezes ◽  
Luana Giatti ◽  
Luisa Campos Caldeira Brant ◽  
Rosane Harter Griep ◽  
Maria Inês Schmidt ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Blood Pressure Control ◽  
Test Scores ◽  
Pressure Control ◽  
Memory Test ◽  
Young Cohort ◽  
Cognitive Score

Hypertension, particularly in middle age, has been associated with worse cognitive function, but evidence is inconclusive. This study investigated whether hypertension, prehypertension, age, and duration of diagnosis, as well as blood pressure control, are associated with a decline in cognitive performance in ELSA-Brasil participants. This longitudinal study included 7063 participants, mean age 58.9 years at baseline (2008–2010), who attended visit 2 (2012–2014). Cognitive performance was measured in both visits and evaluated by the standardized scores of the memory, verbal fluency, trail B tests, and global cognitive score. The associations were investigated using linear mixed models. Hypertension and prehypertension at baseline were associated with decline in global cognitive score; being hypertension associated with reduction in memory test; and prehypertension with reduction in fluency test. Hypertension diagnose ≥55 years was associated with lower global cognitive and memory test scores, and hypertension diagnose <55 years with lower memory test scores. Duration of hypertension diagnoses was not associated with any marker of cognitive function decline. Among treated individuals, blood pressure control at baseline was inversely associated with the decline in both global cognitive and memory test scores. In this relatively young cohort, hypertension, prehypertension, and blood pressure control were independent predictors of cognitive decline in distinct abilities. Our findings suggest that both lower and older age of hypertension, but not duration of diagnosis, were associated with cognitive decline in different abilities. In addition to hypertension, prehypertension and pressure control might be critical for the preservation of cognitive function.

scholarly journals Cross cultural “behavioural diagnosis” examining the uptake of the MIND diet, using the COM-B model to inform an intervention.

2020 ◽  
Author(s):  
Deirdre Timlin ◽  
Barbara Giannantoni ◽  
Jacqueline McCormack ◽  
Angela Polito Polito ◽  
Donatella Ciarapica Ciarapica ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Behaviour Change ◽  
Theoretical Domains Framework ◽  
Later Life ◽  
Behaviour Change Techniques ◽  
Valuable Insight ◽  
Two Samples ◽  
The Mind ◽  
Italian Sample ◽  
Mind Diet

Abstract Background: The aim of this study was to develop a “behavioural diagnosis” of factors influencing the uptake of the MIND diet in 40-55-year olds according to the COM-B model, in order to reduce the risk of cognitive decline in later life. Comparing a Mediterranean (Italy) and non-Mediterranean (Northern Ireland) country to inform an intervention. This study also sought to identify intervention functions and behaviour change techniques (BCTs) that are likely to be effective in changing MIND diet behaviour. Methods: This was a qualitative study that was used to elicit beliefs surrounding Capability, Opportunity, Motivation and Behaviour (COM-B) with adhering to a diet associated with a reduced risk of cognitive decline, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND diet). This study further elaborated the COM-B components into the 14 domains of the Theoretical Domains Framework (TDF) to further understand behaviour. Twenty-five Northern Irish (NI) and Italian participants were recruited onto the study, to take part in either a focus group or an interview. Participants were both male and female aged between 40-55 years. Results: Thematic analysis revealed that the main barriers to the uptake of the MIND diet were; time, work environment (opportunity), taste preference and convenience (motivation). Culture (motivation), seasonal foods and lack of family support (opportunity) to be a barrier to the Italian sample only. The main facilitators reported were; improved health, memory, planning and organisation (motivation) and access to good quality food (opportunity). Cooking skills, knowledge (capability) and heathy work lunch (opportunity) being a facilitator to the Italian sample only. Five intervention functions and fifteen BCTs were identified for possible inclusion in intervention development. Conclusions: The “behavioural diagnosis” provides comparisons and valuable insight into the personal, social and environmental factors that participants report as barriers and facilitators to the uptake of the MIND diet in the two samples. More barriers to healthy dietary change were found than facilitators. There is a need for interventions that increase capability, opportunity and motivation to aid behaviour change. The “behavioural diagnosis” from this study will be used to design a behaviour change intervention using the subsequent steps from the Behaviour Change Wheel (BCW).

scholarly journals Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants

2021 ◽  
Vol 10 ◽  
Author(s):  
Xiaoran Liu ◽  
Klodian Dhana ◽  
Jeremy D. Furtado ◽  
Puja Agarwal ◽  
Neelum T. Aggarwal ◽  
...  
Keyword(s):  
At Risk ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Semantic Memory ◽  
Sex Education ◽  
Dietary Intervention ◽  
Vegetable Consumption ◽  
Population At Risk ◽  
Global Cognition ◽  
The Mind

Abstract There is emerging evidence linking fruit and vegetable consumption and cognitive function. However, studies focusing on the nutrients underlying this relationship are lacking. We aim to examine the association between plasma nutrients and cognition in a population at risk for cognitive decline with a suboptimal diet. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) trial is a randomized controlled intervention that examines the effects of the MIND diet to prevent cognitive decline. The primary outcome is global cognition. A multivariate linear model was used to investigate the association between blood nutrients and global and/or domain-specific cognition. The model was adjusted for age, sex, education, study site, smoking status, cognitive activities and physical activities. High plasma α-carotene was associated with better global cognition. Participants in the highest tertile of plasma α-carotene had a higher global cognition z score of 0⋅17 when compared with individuals in the lowest tertile (P 0⋅002). Circulating α-carotene levels were also associated with higher semantic memory scores (P for trend 0⋅007). Lutein and zeaxanthin (combined) was positively associated with higher semantic memory scores (P for trend 0⋅009). Our study demonstrated that higher α-carotene levels in blood were associated with higher global cognition scores in a US population at risk for cognitive decline. The higher α-carotene levels in blood reflected greater intakes of fruits, other types of vegetables and lesser intakes of butter and margarine and meat. The higher circulating levels of lutein plus zeaxanthin reflected a dietary pattern with high intakes of fruits, green leafy, other vegetables and cheese, and low consumption of fried foods. Objective nutrient markers in the blood can better characterize dietary intake, which may facilitate the implementation of a tailored dietary intervention for the prevention of cognitive decline.

scholarly journals Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices

2018 ◽  
Vol 47 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Kristen L. Nowak ◽  
Linda Fried ◽  
Anna Jovanovich ◽  
Joachim Ix ◽  
Kristine Yaffe ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Sodium Intake ◽  
Brain Mri ◽  
Community Dwelling ◽  
Dietary Sodium ◽  
Potassium Intake ◽  
Community Dwelling Older Adults ◽  
Structural Brain

Background: Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow. Methods: The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of dietary potassium and sodium:potassium intake with cognitive decline, and associations of these nutrients with micro- and macro-structural brain magnetic resonance imaging (MRI) indices. In all, 1,194 participants in the Health Aging and Body Composition study with measurements of dietary sodium intake (food frequency questionnaire [FFQ]) and change in the modified Mini Mental State Exam (3MS) were included. Results: The age of participants was 74 ± 3 years with a mean dietary sodium intake of 2,677 ± 1,060 mg/day. During follow-up (6.9 ± 0.1 years), 340 (28%) had a clinically significant decline in 3MS score (≥1.5 SD of mean decline). After adjustment, dietary sodium intake was not associated with odds of cognitive decline (OR 0.96, 95% CI 0.50–1.84 per doubling of sodium). Similarly, potassium was not associated with cognitive decline; however, higher sodium:potassium intake was associated with increased odds of cognitive decline (OR 2.02 [95% CI 1.01–4.03] per unit increase). Neither sodium or potassium alone nor sodium:potassium were associated with micro- or macro-structural brain MRI indices. These results are limited by the use of FFQ. Conclusions: In community-dwelling older adults, higher sodium:potassium, but not sodium or potassium intake alone, was associated with decline in cognitive function, with no associations observed with micro- and macro-structural brain MRI indices. These findings do not support reduction dietary sodium/increased potassium intake to prevent cognitive decline with aging.

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