Association of long-term adherence to the mind diet with cognitive function and cognitive decline in American women

2017 ◽  
Vol 22 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Agnes M. Berendsen ◽  
J. H. Kang ◽  
E. J. M. Feskens ◽  
C. P. G. M. de Groot ◽  
F. Grodstein ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
American Women ◽  
The Mind ◽  
Mind Diet

MIND Diet and Cognitive Function over Eight Years in Puerto Rican Older Adults

2021 ◽  
Author(s):  
Tahani Boumenna ◽  
Tammy M Scott ◽  
Jong-Soo Lee ◽  
Xiyuan Zhang ◽  
David Kriebel ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Puerto Rican ◽  
Job Complexity ◽  
Cross Sectional ◽  
Cognitive Trajectory ◽  
Function Relationship ◽  
The Mind ◽  
Mind Diet

Abstract Background Healthy diets have been associated with better cognitive function. Socio-economic factors including education, poverty and job complexity may modify the relationship between diet and cognition. Methods We used adjusted linear mixed models to examine the association between long-term adherence to the Mediterranean-Dietary Approaches to Stop Hypertension - Intervention for Neurodegenerative Delay (MIND) diet and cognitive function over 8 years of follow-up in Puerto Rican adults residing in the Boston, MA area (aged 45 to 75 years at baseline). We also examined whether the MIND diet – cognition association was confounded or modified by socioeconomic measures. Results In both cross-sectional and longitudinal analyses the highest, vs lowest, MIND quintile was associated with better cognition function (ß = 0.093; 95% CI: 0.035, 0.152; P trend = 0.0019), but not with cognitive trajectory over 8 years. Education <=8 th grade (ß = -0.339; 95% CI: 0.394, -0.286; P < 0.0001) and income-to-poverty ratio <120% (ß = -0.049; 95% CI: -0.092, -0.007; P = 0.024) were significantly associated with lower cognitive function, while higher job complexity (ß = 0.008; 95% CI: 0.006, 0.011; P < 0.0001) was associated with better cognition function. These variables acted confounders, but not effect modifiers of the MIND-diet – cognitive function relationship. Conclusion Adherence to the MIND diet was associated with better cognitive function at baseline and over 8 years of follow-up, however MIND diet was not associated with 8-year cognitive trajectory. More studies are needed to better understand whether the MIND diet is protective against long-term cognitive decline.

Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study

2021 ◽  
pp. 1-13
Author(s):  
Debora Melo van Lent ◽  
Adrienne O’Donnell ◽  
Alexa S. Beiser ◽  
Ramachandran S. Vasan ◽  
Charles S. DeCarli ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Framingham Heart Study ◽  
Visual Memory ◽  
Brain Volume ◽  
Brain Mri ◽  
Heart Study ◽  
The Mind ◽  
Mind Diet

Background: Adherence to the Mediterranean-DASH for Neurodegenerative Delay (MIND) diet has previously been associated with cognitive decline and dementia. To our knowledge, no prior study has investigated the association between the MIND diet and measures of brain volume, silent brain infarcts (SBIs), or brain atrophy. Objective: We evaluated whether adherence to the MIND diet associated with superior cognitive function, larger brain volumes, fewer SBIs, and less cognitive decline in the community-based Framingham Heart Study. Methods: 2,092 participants (mean±SD, age 61±9) completed Food Frequency Questionnaires, averaged across a maximum of 3-time points (examination cycles 5, 6, and 7), cognitive testing at examination cycle 7 (present study baseline: 1998–2001) and after a mean±SD of 6.6±1.1 years from baseline (n = 1,584). A subset of participants also completed brain magnetic resonance imaging (MRI) at examination cycle 7 (n = 1,904). In addition, participants with dementia, stroke, and other relevant neurological diseases such as significant head trauma, subdural hematoma, or multiple sclerosis were excluded from the analyses. Results: Higher MIND diet scores were associated with better global cognitive function (β±SE,+0.03SD±0.01; p = 0.004), verbal memory, visual memory, processing speed, verbal comprehension/reasoning, and with larger total brain volume (TBV) following adjustments for clinical, lifestyle and demographic covariates, but not with other brain MRI measures (i.e., hippocampal volume, lateral ventricular volume, white matter hyperintensity volume, SBIs) or cognitive decline. Conclusion: Higher MIND diet scores associated with better cognitive performance and larger TBV at baseline, but not with cognitive decline. Clinical trials are needed to ascertain whether adopting the MIND diet affects trajectories of cognitive decline.

Long-Term Cognitive Decline After Stroke: An Individual Participant Data Meta-Analysis

Stroke ◽  
2021 ◽  
Author(s):  
Jessica W. Lo ◽  
John D. Crawford ◽  
David W. Desmond ◽  
Hee-Joon Bae ◽  
Jae-Sung Lim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Recurrent Stroke ◽  
Meta Analysis ◽  
Older Age ◽  
Individual Participant Data ◽  
Individual Participant ◽  
Global Cognition

Background and Purpose: Poststroke cognitive impairment is common, but the trajectory and magnitude of cognitive decline after stroke is unclear. We examined the course and determinants of cognitive change after stroke using individual participant data from the Stroke and Cognition Consortium. Methods: Nine longitudinal hospital-based cohorts from 7 countries were included. Neuropsychological test scores and normative data were used to calculate standardized scores for global cognition and 5 cognitive domains. One-step individual participant data meta-analysis was used to examine the rate of change in cognitive function and risk factors for cognitive decline after stroke. Stroke-free controls were included to examine rate differences. Based on the literature and our own data that showed short-term improvement in cognitive function after stroke, key analyses were restricted to the period beginning 1-year poststroke to focus on its long-term effects. Results: A total of 1488 patients (mean age, 66.3 years; SD, 11.1; 98% ischemic stroke) were followed for a median of 2.68 years (25th–75th percentile: 1.21–4.14 years). After an initial period of improvement through up to 1-year poststroke, decline was seen in global cognition and all domains except executive function after adjusting for age, sex, education, vascular risk factors, and stroke characteristics (−0.053 SD/year [95% CI, −0.073 to −0.033]; P <0.001 for global cognition). Recurrent stroke and older age were associated with faster decline. Decline was significantly faster in patients with stroke compared with controls (difference=−0.078 SD/year [95% CI, −0.11 to −0.045]; P <0.001 for global cognition in a subgroup analysis). Conclusions: Patients with stroke experience cognitive decline that is faster than that of stroke-free controls from 1 to 3 years after onset. An increased rate of decline is associated with older age and recurrent stroke.

scholarly journals Long-term effects of alcohol consumption on cognitive function in seniors: a cohort study in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lizhen Han ◽  
Jinzhu Jia
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Cognitive Decline ◽  
Cox Model ◽  
The Elderly ◽  
Alcoholic Beverages ◽  
Rice Wine ◽  
Long Term Effects ◽  
Healthy Longevity

Abstract Background In the context of increasing global aging, the long-term effects of alcohol consumption on cognitive function in older adults were analyzed in order to provide rationalized health recommendations to the elderly population. Methods The study used the Chinese Longitudinal Healthy Longevity Survey (CLHLS) dataset, from which 5354 Chinese seniors aged 65–112 years were selected as the subjects, spanning the years 1998–2018. Data on alcohol, diet, activity, and cognition were collected by questionnaire and cognitive levels were judged by the Mini-Mental State Examination scale (also referenced to the Functional Assessment Staging Test). Data cleaning and preprocessing was implemented by R software. The dynamic Cox model was applied for model construction and data analysis. Results The results of the dynamic Cox model suggested that seniors who drank alcohol were at higher risk of cognitive decline compared to those who never drank (HR = 1.291, 95%CI: 1.175–1.419). The risk was similarly exacerbated by perennial drinking habits (i.e., longer drinking years, HR = 1.008, 95%CI: 1.004–1.013). Compared to non-alcoholic beverages, liquor (≥ 38°), liquor (< 38°), wine and rice wine all showed negative effects. Whereas, the risk of cognitive decline was relatively lower in seniors who consumed liquors (< 38°) and rice wine compared to the high-level liquor (HR: 0.672 (0.508, 0.887) and 0.732 (0.559, 0.957), respectively). Conclusions Alcohol consumption has a negative and long-term effects on cognitive function in seniors. For the elderly, we suggested that alcohol intake should be avoided as much as possible.

scholarly journals Does laparoscopic colorectal surgery result in short and long term post-operative cognitive decline (POCD)? (Preprint)

2018 ◽  
Author(s):  
Parveen Vitish-Sharma ◽  
Rosemary Van Oss ◽  
Boliang Guo ◽  
Charles Maxwell-Armstrong ◽  
Austin G Acheson
Keyword(s):  
Decision Making ◽  
Cognitive Function ◽  
Colorectal Surgery ◽  
Lexical Decision ◽  
Cognitive Decline ◽  
Laparoscopic Colorectal Surgery ◽  
Z Score ◽  
Number Of Patients ◽  
Postoperative Cognitive Decline

BACKGROUND Postoperative cognitive decline (POCD) is defined as a new cognitive impairment arising after surgical intervention. Cognitive function can be assessed using validated tests including: N Back, Stroop; and Lexical Decision Making Task. There is some concern that prolonged Trendelenburg positioning during laparoscopic colorectal surgery may cause POCD. Patients with POCD may experience prolonged hospitalisation and take longer returning to their normal level of functioning. OBJECTIVE To assess percentage of short or long-term POCD following laparoscopic colorectal surgery. METHODS Methods Patients undergoing laparoscopic colorectal surgery were recruited. Cognitive tests including: 1, 2 and 3 back, lexical decision making task and stroop task were carried out pre-operatively and repeated Day 1, and minimum 3 months post-operatively. For assessment of POCD, Day 1 the baseline was subtracted from Day 1 results for each test. This result was then divided by the standard deviation of the control group to give a Z score. A large positive Z score (>1.96) showed a deterioration in cognitive function from baseline for accuracy, and a large negative Z score (> -1.96) for response time.[1] An individual Z score of 1.96 or more was defined as cognitive dysfunction. RESULTS Forty-six patients were recruited (26 males, 24 female), mean age 66years (SD± 5.18). Of which 55% had POCD on Day 1; and 37 patients completed long-term follow up of which 32% had POCD. CONCLUSIONS Our study does show a significant number of patients develop both long and short term POCD following laparoscopic colorectal surgery.

scholarly journals Cross cultural “behavioural diagnosis” examining the uptake of the MIND diet, using the COM-B model to inform an intervention.

2020 ◽  
Author(s):  
Deirdre Timlin ◽  
Barbara Giannantoni ◽  
Jacqueline McCormack ◽  
Angela Polito Polito ◽  
Donatella Ciarapica Ciarapica ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Behaviour Change ◽  
Theoretical Domains Framework ◽  
Later Life ◽  
Behaviour Change Techniques ◽  
Valuable Insight ◽  
Two Samples ◽  
The Mind ◽  
Italian Sample ◽  
Mind Diet

Abstract Background: The aim of this study was to develop a “behavioural diagnosis” of factors influencing the uptake of the MIND diet in 40-55-year olds according to the COM-B model, in order to reduce the risk of cognitive decline in later life. Comparing a Mediterranean (Italy) and non-Mediterranean (Northern Ireland) country to inform an intervention. This study also sought to identify intervention functions and behaviour change techniques (BCTs) that are likely to be effective in changing MIND diet behaviour. Methods: This was a qualitative study that was used to elicit beliefs surrounding Capability, Opportunity, Motivation and Behaviour (COM-B) with adhering to a diet associated with a reduced risk of cognitive decline, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND diet). This study further elaborated the COM-B components into the 14 domains of the Theoretical Domains Framework (TDF) to further understand behaviour. Twenty-five Northern Irish (NI) and Italian participants were recruited onto the study, to take part in either a focus group or an interview. Participants were both male and female aged between 40-55 years. Results: Thematic analysis revealed that the main barriers to the uptake of the MIND diet were; time, work environment (opportunity), taste preference and convenience (motivation). Culture (motivation), seasonal foods and lack of family support (opportunity) to be a barrier to the Italian sample only. The main facilitators reported were; improved health, memory, planning and organisation (motivation) and access to good quality food (opportunity). Cooking skills, knowledge (capability) and heathy work lunch (opportunity) being a facilitator to the Italian sample only. Five intervention functions and fifteen BCTs were identified for possible inclusion in intervention development. Conclusions: The “behavioural diagnosis” provides comparisons and valuable insight into the personal, social and environmental factors that participants report as barriers and facilitators to the uptake of the MIND diet in the two samples. More barriers to healthy dietary change were found than facilitators. There is a need for interventions that increase capability, opportunity and motivation to aid behaviour change. The “behavioural diagnosis” from this study will be used to design a behaviour change intervention using the subsequent steps from the Behaviour Change Wheel (BCW).

scholarly journals Long-Term Increase in Cholesterol Is Associated With Better Cognitive Function: Evidence From a Longitudinal Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Huamin Liu ◽  
Lianwu Zou ◽  
Rui Zhou ◽  
Minyi Zhang ◽  
Shanyuan Gu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Function ◽  
High Density Lipoprotein ◽  
Cognitive Decline ◽  
High Density Lipoprotein Cholesterol ◽  
Memory Function ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol

Background: Higher visit-to-visit cholesterol has been associated with cognitive decline. However, the association between long-term increase or decrease in cholesterol and cognitive decline remains unclear.Methods: A total of 4,915 participants aged ≥45 years with normal cognition in baseline were included. The participants were divided into four groups, namely low–low, low–high, high–low, and high–high, according to the diagnostic thresholds of total cholesterol (TC), non-high-density lipoprotein cholesterol (NHDL-C), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) after 4 years of follow-up. Cognitive function was assessed by episodic memory and mental intactness. Binary logistic regression was used to analyse the association of cholesterol variation with cognitive decline.Results: Among the participants, 979 (19.9%) experienced global cognitive decline. The odds ratio (OR) of global cognitive and memory function decline were remarkably lower in participants in the low–high NHDL-C group than those in the low–low group [OR and 95% confidence interval (CI): 0.50 [0.26–0.95] for global cognitive decline, 0.45 [0.25–0.82] for memory function decline]. The lower OR was also significant in females (OR [95% CI]: 0.38 [0.17–0.87] for global cognitive decline; 0.44 [0.19–0.97] for memory function decline) and participants without cardiovascular disease (OR [95% CI]: 0.31 [0.11–0.87] for global cognitive decline; 0.34 [0.14–0.83] for memory function decline). The increases in other cholesterol were also negatively associated with the risk of cognitive decline although not significantly.Conclusions: A longitudinal increase in NHDL-C may be protective for cognition in females or individuals without cardiovascular disease.

scholarly journals Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants

2021 ◽  
Vol 10 ◽  
Author(s):  
Xiaoran Liu ◽  
Klodian Dhana ◽  
Jeremy D. Furtado ◽  
Puja Agarwal ◽  
Neelum T. Aggarwal ◽  
...  
Keyword(s):  
At Risk ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Semantic Memory ◽  
Sex Education ◽  
Dietary Intervention ◽  
Vegetable Consumption ◽  
Population At Risk ◽  
Global Cognition ◽  
The Mind

Abstract There is emerging evidence linking fruit and vegetable consumption and cognitive function. However, studies focusing on the nutrients underlying this relationship are lacking. We aim to examine the association between plasma nutrients and cognition in a population at risk for cognitive decline with a suboptimal diet. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) trial is a randomized controlled intervention that examines the effects of the MIND diet to prevent cognitive decline. The primary outcome is global cognition. A multivariate linear model was used to investigate the association between blood nutrients and global and/or domain-specific cognition. The model was adjusted for age, sex, education, study site, smoking status, cognitive activities and physical activities. High plasma α-carotene was associated with better global cognition. Participants in the highest tertile of plasma α-carotene had a higher global cognition z score of 0⋅17 when compared with individuals in the lowest tertile (P 0⋅002). Circulating α-carotene levels were also associated with higher semantic memory scores (P for trend 0⋅007). Lutein and zeaxanthin (combined) was positively associated with higher semantic memory scores (P for trend 0⋅009). Our study demonstrated that higher α-carotene levels in blood were associated with higher global cognition scores in a US population at risk for cognitive decline. The higher α-carotene levels in blood reflected greater intakes of fruits, other types of vegetables and lesser intakes of butter and margarine and meat. The higher circulating levels of lutein plus zeaxanthin reflected a dietary pattern with high intakes of fruits, green leafy, other vegetables and cheese, and low consumption of fried foods. Objective nutrient markers in the blood can better characterize dietary intake, which may facilitate the implementation of a tailored dietary intervention for the prevention of cognitive decline.

scholarly journals The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease—A Review

2019 ◽  
Vol 10 (6) ◽  
pp. 1040-1065 ◽  
Author(s):  
Annelien C van den Brink ◽  
Elske M Brouwer-Brolsma ◽  
Agnes A M Berendsen ◽  
Ondine van de Rest
Keyword(s):  
Cognitive Decline ◽  
Longitudinal Studies ◽  
Dietary Patterns ◽  
Lower Risk ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mediterranean ◽  
The Mind ◽  
Mind Diet

ABSTRACT As there is currently no cure for dementia, there is an urgent need for preventive strategies. The current review provides an overview of the existing evidence examining the associations of the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets and their dietary components with cognitive decline, dementia, and Alzheimer's disease (AD). A systematic search was conducted within Ovid Medline for studies published up to 27 March 2019 and reference lists from existing reviews and select articles were examined to supplement the electronic search results. In total, 56 articles were included. Higher adherence to the Mediterranean diet was associated with better cognitive scores in 9 of 12 cross-sectional studies, 17 of 25 longitudinal studies, and 1 of 3 trials. Higher adherence to the DASH diet was associated with better cognitive function in 1 cross-sectional study, 2 of 5 longitudinal studies, and 1 trial. Higher adherence to the MIND diet was associated with better cognitive scores in 1 cross-sectional study and 2 of 3 longitudinal studies. Evidence on the association of these dietary patterns with dementia in general was limited. However, higher adherence to the Mediterranean diet was associated with a lower risk of AD in 1 case-control study and 6 of 8 longitudinal studies. Moreover, higher adherence to the DASH or MIND diets was associated with a lower AD risk in 1 longitudinal study. With respect to the components of these dietary patterns, olive oil may be associated with less cognitive decline. In conclusion, current scientific evidence suggests that higher adherence to the Mediterranean, DASH, or MIND diets is associated with less cognitive decline and a lower risk of AD, where the strongest associations are observed for the MIND diet.

scholarly journals Higher Plasma α-Carotene Was Associated With Better Cognitive Function: A Cross-Sectional Evaluation Among the MIND Trial Participants

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 32-32
Author(s):  
Xiaoran Liu ◽  
Klodian Dhana ◽  
Jeremy Furtado ◽  
Puja Agarwal ◽  
Neelum Aggarwal ◽  
...  
Keyword(s):  
At Risk ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Vegetable Consumption ◽  
High Plasma ◽  
Leafy Vegetables ◽  
Population At Risk ◽  
Domain Specific ◽  
Global Cognition ◽  
The Mind

Abstract Objectives There is emerging evidence linking fruit and vegetable consumption and cognitive function. However, mechanistic evidence underlying this relationship is lacking. We aim to examine the association between plasma carotenoids and cognition in a population at risk for cognitive decline. Methods The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) trial (R01 AG052583) is an ongoing randomized controlled intervention on the effects of the MIND diet in preventing cognitive decline. The primary outcome is global cognition assessed using a battery of 12 cognitive tests. Plasma carotenoid levels were measured in 295 participants. Multivariate linear regression models were used to examine the association between blood nutrients and global and domain-specific cognition. Model was adjusted for age, sex, education, study site, smoking status, and frequency of cognitive and physical activities. The Benjamini-Hochberg method with a false discovery rate of 0.25 was used for multiple testing. Results Participants are predominantly Caucasian females (68%) with obesity (BMI 33.6) and a mean age of 69.8 years. High plasma α-carotene was associated with higher average scores for a global measure of cognition. Individuals in the highest tertile of plasma α-carotene levels (tertile median: 155.8 mcg/L) had a higher average score of 0.17 for global cognition compared to those in the lowest tertile (tertile median: 34.9 mcg/L, P = 0.002). Individuals with high plasma α-carotene levels had a dietary pattern that featured high consumption of vegetables other than green leafy vegetables (i.e., carrots, corn, beets, green beans, and onions), and fruits, as well as, lower consumption of butter, margarine, and fried foods. Plasma levels of α-carotene (p for trend 0.007) and lutein plus zeaxanthin (p for trend 0.009) were also associated with higher mean scores for semantic memory. Conclusions Higher circulating levels of specific forms of carotenoids i.e., α-carotene, lutein plus zeaxanthin was associated with higher scores of global and domain-specific cognitive function in a US population at risk for cognitive decline. Funding Sources Funding: R01 AG052583

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