scholarly journals Association of Nephropathy with the Thyroid Profile

2020 ◽  
Vol 2 (4) ◽  
pp. 24-33
Author(s):  
Ali Tahir ◽  
Fatima- Tuz-Zahra ◽  
Imran Tipu
Keyword(s):  
Uric Acid ◽  
Serum Creatinine ◽  
Thyroid Hormones ◽  
Venous Blood ◽  
Thyroid Stimulating Hormone ◽  
Kidney Morphology ◽  
Kinetic Phenomenon ◽  
Thyroid Profile ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

The thyroid gland produces two hormones: thyroxin (T4) and triiodothyronine (T3). The thyroid hormone affects both the kidney morphology and its functions. Kidneys are involved in the metabolism and elimination of the thyroid hormones. The current study was conducted on 100 nephropathy patients, of which 57 were female patients and 43 were male patients. Venous blood samples were collected for the estimation of hyperthyroidism in nephropathy patients. Thyroid stimulating hormone (TSH), thyroxin, and triiodothyronine were estimated using the chemilumeniscent techniques. Serum creatinine levels were estimated through the modified kinetic phenomenon (Jaffe’s reaction). Serum urea levels were estimated through the urease method and uric acid levels were recorded. The mean age of hypothyroid patients was 37.38 years. It was 34.13 years for patients with the hyperthyroid state, while for the normal patients it was 35.46 years. Women comprised 70% of the hypothyroid patients, whereas among the normal patients their percentage was 29%. Serum TSH level (7.11 ± 0.001 mIU/L) was significantly higher in hypothyroid patients, although it decreased in hyperthyroid patients (0.22 ± 0.001) as compared to the corresponding values in healthy patients (2.54 ± 0.001). The values of T3 (52.3 ± 0.05 ng/dl) and T4 (2.217 ± 0.001) decreased slightly in hypothyroid patients as compared to the healthy patients (104 ± 0.001 and 6.667 ±0.001 respectively), although they remained statistically significant. T3 (356.12 ± 0.001) and T4 (17.99 ± 0.001) significantly increased in hyperthyroid patients. The correlation between thyroid dysfunction and nephropathy was found to be significant. Gender and age proved to be the most important factors for these pathological conditions. Renal function biomarkers including GFR, serum creatinine, urea and uric acid were found to have an association with changes in the thyroid hormones.

scholarly journals Association of Nephropathy with the Thyroid Profile

2020 ◽  
Vol 2 (4) ◽  
pp. 24-33
Author(s):  
Ali Tahir ◽  
Fatima- Tuz-Zahra ◽  
Imran Tipu
Keyword(s):  
Uric Acid ◽  
Serum Creatinine ◽  
Thyroid Hormones ◽  
Venous Blood ◽  
Thyroid Stimulating Hormone ◽  
Kidney Morphology ◽  
Kinetic Phenomenon ◽  
Thyroid Profile ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

The thyroid gland produces two hormones: thyroxin (T4) and triiodothyronine (T3). The thyroid hormone affects both the kidney morphology and its functions. Kidneys are involved in the metabolism and elimination of the thyroid hormones. The current study was conducted on 100 nephropathy patients, of which 57 were female patients and 43 were male patients. Venous blood samples were collected for the estimation of hyperthyroidism in nephropathy patients. Thyroid stimulating hormone (TSH), thyroxin, and triiodothyronine were estimated using the chemilumeniscent techniques. Serum creatinine levels were estimated through the modified kinetic phenomenon (Jaffe’s reaction). Serum urea levels were estimated through the urease method and uric acid levels were recorded. The mean age of hypothyroid patients was 37.38 years. It was 34.13 years for patients with the hyperthyroid state, while for the normal patients it was 35.46 years. Women comprised 70% of the hypothyroid patients, whereas among the normal patients their percentage was 29%. Serum TSH level (7.11 ± 0.001 mIU/L) was significantly higher in hypothyroid patients, although it decreased in hyperthyroid patients (0.22 ± 0.001) as compared to the corresponding values in healthy patients (2.54 ± 0.001). The values of T3 (52.3 ± 0.05 ng/dl) and T4 (2.217 ± 0.001) decreased slightly in hypothyroid patients as compared to the healthy patients (104 ± 0.001 and 6.667 ±0.001 respectively), although they remained statistically significant. T3 (356.12 ± 0.001) and T4 (17.99 ± 0.001) significantly increased in hyperthyroid patients. The correlation between thyroid dysfunction and nephropathy was found to be significant. Gender and age proved to be the most important factors for these pathological conditions. Renal function biomarkers including GFR, serum creatinine, urea and uric acid were found to have an association with changes in the thyroid hormones.

scholarly journals Serum Creatinine and Uric Acid Levels of Hypothyroid Patients

2013 ◽  
Vol 3 (2) ◽  
pp. 61-63 ◽  
Author(s):  
A Haque Khan ◽  
I Majumder
Keyword(s):  
Uric Acid ◽  
Serum Creatinine ◽  
Thyroid Hormones ◽  
Kidney Diseases ◽  
Clinical Syndrome ◽  
Chronic Kidney Diseases ◽  
Slowing Down ◽  
Hypothyroid Patients ◽  
Good Number ◽  
Biochemical Abnormalities

Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones which, in turn, results in a generalized slowing down of metabolic processes. It is associated with many biochemical abnormalities including increased serum creatinine and uric acid levels. We reviewed more than 30 articles and a good number of textbooks to evaluate serum creatinine and uric acid levels in hypothyroid patients. We found both these parameters are significantly higher in hypothyroid patients. Chronic kidney diseases (CKDs) also affect thyroid function in many ways leading to decreased T3 and T4. So, it is important for clinicians to differentiate between chronic kidney diseases and hypothyroidism with respect to their causal and consequential entities. DOI: http://dx.doi.org/10.3329/bjmb.v3i2.13814 Bangladesh J Med Biochem 2010; 3(2): 61-63

scholarly journals Renal insufficiency in overt hypothyroidism

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 13-15
Author(s):  
Monisha M ◽  
Merriwin D
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Renal Plasma Flow ◽  
Significant Negative Correlation ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Thyroid State ◽  
Thyroid Profile ◽  
Hypothyroid Patients

Hypothyroidism is a common endocrine disorder worldwide. In hypothyroidism, there is altered regulation of renal hemodynamics and basal metabolic rate. This hospital-based case-control study was done to evaluate the changes in uric acid level in hypothyroid subjects. This study includes 25 hypothyroid cases with age and sex-matched controls. Serum total thyroid profile was estimated by ChemiluminiscenceImmunoassay (CLIA) and uric acid by the Uricase method in fully automated Vitros 5600. The mean uric acid level is increased in hypothyroid. Triiodothyronine(T3)&Thyroxine(T4)levelof hypothyroid patients showed a significant negative correlation with uric acid with 'r' values of 0.45 and 0.51, respectively. A positive correlation was observed between Thyroid-stimulating hormone (TSH) and uric acid (p=0.22) in hypothyroid subjects. The raise in uric acid is hypothyroid subjects is due to hemodynamic changes like reduction in renal plasma flow and disordered thyroid state affects purine metabolism, leading to hyperuricemia and gout. Hence, these parameters should be monitored regularly in hypothyroid patients.

scholarly journals Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

2013 ◽  
Vol 3 (2) ◽  
pp. 84-87
Author(s):  
Md. Aminul Haque Khan ◽  
Md. Ishaque Majumder ◽  
Md. Mozammel Hoque ◽  
Md. Fariduddin ◽  
Forhadul Hoque Mollah ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Medical University ◽  
Relationship Of ◽  
Hypothyroid Patients ◽  
Biochemical Abnormalities

Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum creatinine and uric acid levels. Many studies were done abroad regarding serum creatinine and uric acid levels in hypothyroid patients. We designed this study in our population for evaluation of serum creatinine and uric acid levels in hypothyroid patients. Objective: To assess serum creatinine and uric acid levels in hypothyroid patients and to find out relationship of creatinine and uric acid levels with severity of hypothyroidism. Materials and Methods: This retrospective cross sectional study to evaluate the serum creatinine and uric acid levels of hypothyroid patients and to find out relationship of hyperuricemia and hypercreatininemia with severity of hypothyroidism was done in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka. Results were compared with that of age and sex matched healthy euthyroid controls. Statistical analyses were performed by using SPSS for Windows version 10.0. ANOVA and unpaired ‘t’ tests were done to see the significance among the groups and between groups respectively. Pearson’s correlation coefficient test was done to see the correlation of serum creatinine and uric acid levels with the severity of hypothyroidism. Results: Mean serum creatinine and uric acid levels in cases were 1.38 ± 0.53 and 7.00 ± 2.54 mg/dL respectively compared to 1.01 ± 0.17 and 5.21 ± 1.35 mg/dL in controls. Conclusion: Mean serum creatinine and uric acid levels were found significantly higher in hypothyroid patients compared to controls. These findings suggest that hyperuricemia and hypercreatininemia are associated with hypothyroidism. Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated to explore hypothyroidism. Journal of Enam Medical College; Vol 3 No 2 July 2013; Page 84-87 DOI: http://dx.doi.org/10.3329/jemc.v3i2.16129

scholarly journals Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrations in Human Subcutaneous Abdominal Adipose Tissue Assessed with Microdialysis

2003 ◽  
Vol 88 (12) ◽  
pp. 5605-5608 ◽  
Author(s):  
Martin Haluzik ◽  
Jara Nedvidkova ◽  
Vladimir Bartak ◽  
Ivana Dostalova ◽  
Petr Vlcek ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormones ◽  
Relative Magnitude ◽  
In Vivo Microdialysis ◽  
Abdominal Adipose Tissue ◽  
Subcutaneous Abdominal Adipose Tissue ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
Tissue Norepinephrine

Abstract Thyroid hormones play a major role in lipid metabolism. However, whether they directly affect lipolysis locally in the adipose tissue remains unknown. Therefore, we measured abdominal sc adipose tissue norepinephrine (NE), basal, and isoprenaline-stimulated lipolysis in 12 hypothyroid patients (HYPO), six hyperthyroid patients (HYPER), and 12 healthy controls by in vivo microdialysis. Adipose tissue NE was decreased in HYPO and increased in HYPER compared with controls (90.4 ± 2.9 and 458.0 ± 69.1 vs. 294.9 ± 19.5 pmol/liter, P < 0.01). Similarly, basal lipolysis, assessed by glycerol assay, was lower in HYPO and higher in HYPER than in controls (88.2 ± 9.9 and 566.0 ± 42.0 vs. 214.3 ± 5.1 μmol/liter P < 0.01). The relative magnitude of isoprenaline-induced glycerol increase was smaller in HYPO (39 ± 19.4%, P < 0.05 vs. basal) and higher in HYPER (277 ± 30.4%, P < 0.01) than in controls (117 ± 5.6%, P < 0.01). The corresponding changes in NE after isoprenaline stimulation were as follows: 120 ± 9.2% (P < 0.05), 503 ± 113% (P < 0.01), and 267 ± 17.2 (P < 0.01). In summary, by affecting local NE levels and adrenergic postreceptor signaling, thyroid hormones may influence the lipolysis rate in the abdominal sc adipose tissue.

THYROID FUNCTION AND PLASMA CYCLIC AMP RESPONSE TO INTRAVENOUS GLUCAGON

1977 ◽  
Vol 85 (4) ◽  
pp. 760-768 ◽  
Author(s):  
S. Nistrup Madsen
Keyword(s):  
Cyclic Amp ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Healthy Subjects ◽  
Blood Levels ◽  
Sensitive Test ◽  
Normal Response ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

ABSTRACT The glucagon stimulated increase in plasma cyclic AMP has been studied in 17 healthy subjects, in 13 hyperthyroid and in 14 hypothyroid patients. Six hyperthyroid and 2 hypothyroid patients were re-investigated after at least 15 months of treatment. The results show: 1) The glucagon stimulated cyclic AMP response is significantly increased in hyperthyroid patients considered as a group, and is reduced in patients with hypothyroidism. 2) Three hyperthyroid and 4 hypothyroid patients showed a normal response to iv glucagon, indicating that the plasma cyclic AMP response to iv glucagon is not a sensitive test for the evaluation of peripheral thyroid states. This suggests that the effects of thyroid hormones in the liver does not necessarily follow the effects in other tissues. 3) Re-investigation of treated patients showed that the cyclic AMP response can be normalized by treatment, both in hyperthyroidism and in hypothyroidism. However, in patients treated for hyperthyroidism a hyper-response to glucagon can continue after blood levels of thyroid hormones are reduced to normal. This suggests an inertia in the loss of the hyper-response to glucagon, once a hyperfunction has been induced. A similar inertia in the loss of glucagon sensitivity in hypothyroidism could explain the large number of normal tests in hypothyroid patients.

Chemiluminescent third-generation assay (Amerlite TSH-30) of thyroid-stimulating hormone in serum or plasma assessed

1993 ◽  
Vol 39 (10) ◽  
pp. 2167-2173 ◽  
Author(s):  
E Wilkinson ◽  
P W Rae ◽  
K J Thomson ◽  
A D Toft ◽  
C A Spencer ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Third Generation ◽  
Serum Samples ◽  
Nonthyroidal Illness ◽  
Ambulatory Patients ◽  
Stimulation Tests ◽  
Reference Preparation ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
Stimulating Hormone

Abstract We assessed the laboratory performance and clinical utility of a new commercial third-generation assay of thyroid-stimulating hormone (TSH), Amerlite TSH-30. The interassay CV was 6% at TSH concentrations of approximately 0.08 mIU/L, and the analytical and functional detection limits of the assay were 0.005 and 0.0125 mIU/L, respectively. Although the assay recovered approximately 96% of TSH International Reference Preparation (TSH-IRP) 80/558 added to serum samples, the endogenous TSH concentrations in basal samples were significantly lower than those found by using two other TSH assays; bias data obtained from thyroliberin stimulation tests suggested that the negative bias found with TSH-30 may be due to the heterogeneity of TSH in basal samples. TSH-30 completely discriminated hyperthyroid and hypothyroid patients from euthyroid ambulatory patients but also detected TSH (> 0.0125 mIU/L) in 3 of 46 untreated hyperthyroid patients. Compared with two second-generation assays, TSH-30 better discriminated between patients with subnormal TSH due to hyperthyroidism, thyroxine overreplacement, and nonthyroidal illness but there was still significant overlap between results for these groups.

Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans

1995 ◽  
Vol 132 (5) ◽  
pp. 594-598 ◽  
Author(s):  
Sonia C Dumoulin ◽  
Bertrand P Perret ◽  
Antoine P Bennet ◽  
Philippe J Caron
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Steroid Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Thyroid Status ◽  
Corticosteroid Binding Globulin ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

Dumoulin SC, Perret BP, Bennet AP, Caron PJ. Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans. Eur J Endocrinol 1995;132:594–8. ISSN 0804–4643 Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). The SHBG levels are increased in hyper- and decreased in hypothyroid patients, whereas CBG levels are increased in hypo- and decreased in hyperthyroid patients. The SHBG levels are higher in women than in men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients, SHBG concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In hyperthyroid patients, SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01) during antithyroid treatment. The SHBG and CBG concentrations in treated hypo- and hyperthyroid patients were not significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid status. Corticosteroid-binding globulin is an index of thyroid hormone action at the liver level whose changes are opposite to those of SHBG in hyper- and hypothyroidism. Philippe Caron, Service d'Endocrinologie et Maladies Métaboliques, CHU Rangueil, 1 Avenue J Poulhès, 31054 Toulouse Cedex, France

Thyroid hormones and atrial natriuretic hormone secretion: study in hyper- and hypothyroid patients

1992 ◽  
Vol 127 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Ermanno Rolandi ◽  
Bruno Santaniello ◽  
Marcello Bagnasco ◽  
Angelo Cataldi ◽  
Cristina Garibaldi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Thyroid Hormones ◽  
Hormone Secretion ◽  
Normal Range ◽  
Natriuretic Hormone ◽  
Atrial Natriuretic Hormone ◽  
Thyroxine Replacement ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
Atrial Natriuretic

Plasma atrial natriuretic hormone (ANH) values were evaluated in 28 hyperthyroid patients and in 11 hypothyroid patients and compared with 20 healthy subjects. In hyperthyroid patients plasma ANH basal levels were significantly (p<0.01) higher (14.2±1.6 pmol/l) than in controls (7.8±0.4 pmol/l) and in hypothyroid patients (6.4±0.3 pmol/l). No significant differences were found between controls and hypothyroid patients. The propranolol-induced decrease in heart rate in hyperthyroid patients did not significantly affect the plasma ANH values. Conversely, after the methimazole-induced euthyroidism a return within the normal range of ANH values was observed. The thyroxine replacement in hypothyroid patients determined a small but significant (p<0.05) increase in plasma ANH values. Observed data suggest that in humans thyroid hormones may influence plasma ANH concentrations independently of their effect on heart rate.

Clinico-epidemiological spectrum of thyroid illness after salt iodination program in Nepal

2021 ◽  
Author(s):  
Arabinda Mohan Bhattarai ◽  
Dipendra Raj Pandeya ◽  
Sulochana Parajuli ◽  
Salina Pradhananga
Keyword(s):  
Learning Disabilities ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Free Triiodothyronine ◽  
Neonatal Hypothyroidism ◽  
Endocrine Disorder ◽  
Detailed History ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

Abstract Background Thyroid disorder is an important endocrine disorder in Nepal which is mostly due to environmental deficiency of iodine. The earliest and potentially most damaging result of iodine deficiency is neonatal hypothyroidism and cretinism characterised by learning disabilities and poor motivation to achieve. Methods We selected one thousand known cases of thyroid disorders who visited biochemistry department of shree Birendra Hospital, chaunni for routine tests. A detailed history was obtained and free triiodothyronine (fT3), thyroxine (fT4) and thyroid stimulating hormone (TSH) estimation was done in Seimens CP Chemiluminiscence Immunoassay analyser. Result Puffiness of face, hoarseness of voice and weight gain were the presenting features in hypothyroid patients, whereas weight loss and restlessnes were predominant features in hyperthyroid patients. In our study the prevalence of hypothyroidism and hyperthyroidism was 27% and 12.5% respectively. Conclusion None of our patients had visible neck swellings or goiter which had subsided after salt iodination program in Nepal as environmental deficiency of iodine was the primary factor for development of goiter in Nepal.

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