Malignant Skin Appendage Neoplasm

Authors report on the use of Integra dermal regeneration template after excision of an extended, recurrent skin tumor in the temporal region. The area covered with Integra was 180 cm2. Skin grafting to cover Integra was performed on the 28th day. Both Integra and the skin transplant were taken 100%. Integra dermal regeneration template can provide good functional and aesthetic result in the surgical management of extended skin tumors over the skull. Orv. Hetil., 2013, 154, 225–227.

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Current Progresses of Functional Nanomaterials for Imaging Diagnosis and Treatment of Melanoma

Current Topics in Medicinal Chemistry ◽

10.2174/1568026619666191023130524 ◽

2019 ◽

Vol 19 (27) ◽

pp. 2494-2506 ◽

Cited By ~ 2

Author(s):

Congcong Zhu ◽

Yunjie Zhu ◽

Huijun Pan ◽

Zhongjian Chen ◽

Quangang Zhu

Keyword(s):

Treatment Options ◽

Skin Tumor ◽

Diagnosis And Treatment ◽

Chemotherapeutic Drugs ◽

Imaging Diagnosis ◽

Functional Nanomaterials ◽

Disease Prognosis ◽

Unsuccessful Treatment ◽

Short Period ◽

Malignant Skin

Melanoma is a malignant skin tumor that results in poor disease prognosis due to unsuccessful treatment options. During the early stages of tumor progression, surgery is the primary approach that assures a good outcome. However, in the presence of metastasis, melanoma hasbecome almost immedicable, since the tumors can not be removed and the disease recurs easily in a short period of time. However, in recent years, the combination of nanomedicine and chemotherapeutic drugs has offered promising solutions to the treatment of late-stage melanoma. Extensive studies have demonstrated that nanomaterials and their advanced applications can improve the efficacy of traditional chemotherapeutic drugs in order to overcome the disadvantages, such as drug resistance, low drug delivery rate and reduced targeting to the tumor tissue. In the present review, we summarized the latest progress in imaging diagnosis and treatment of melanoma using functional nanomaterials, including polymers, liposomes, metal nanoparticles, magnetic nanoparticles and carbon-based nanoparticles. These nanoparticles are reported widely in melanoma chemotherapy, gene therapy, immunotherapy, photodynamic therapy, and hyperthermia.

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The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders

Cells ◽

10.3390/cells10051219 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1219

Author(s):

Yan Teng ◽

Yibin Fan ◽

Jingwen Ma ◽

Wei Lu ◽

Na Liu ◽

...

Keyword(s):

Cell Carcinoma ◽

Akt Pathway ◽

Skin Disorders ◽

Phosphatidylinositol 3 Kinase ◽

Skin Development ◽

Wide Range ◽

Malignant Skin ◽

Solid Foundation ◽

And Migration ◽

Poor Outcomes

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates cell proliferation, differentiation, and migration, along with angiogenesis and metabolism. Additionally, it could mediate skin development and homeostasis. There is much evidence to suggest that dysregulation of PI3K/Akt pathway is frequently associated with several human cutaneous malignancies like malignant melanoma (MM), basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (SCC), as well as their poor outcomes. Nevertheless, emerging roles of PI3K/Akt pathway cascade in a group of common non-malignant skin disorders including acne and psoriasis, among others, have been recognized. The enhanced understanding of dysfunction of PI3K/Akt pathway in patients with these non-malignant disorders has offered a solid foundation for the progress of updated therapeutic targets. This article reviews the latest advances in the roles of PI3K/Akt pathway and their targets in the skin homeostasis and progression of a wide range of non-malignant skin disorders and describes the current progress in preclinical and clinical researches on the involvement of PI3K/Akt pathway targeted therapies.

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Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

Scientific Reports ◽

10.1038/s41598-019-56447-2 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Srisathya Srinivasan ◽

Sreya Das ◽

Vishakha Surve ◽

Ankita Srivastava ◽

Sushant Kumar ◽

...

Keyword(s):

Light Chain ◽

Myosin Light Chain ◽

Focal Adhesions ◽

Primary Keratinocytes ◽

Skin Cells ◽

Physiological Processes ◽

Actomyosin Contractility ◽

Malignant Skin ◽

And Migration ◽

Mlc Phosphorylation

AbstractActomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC. However, the distinct roles of these kinases in regulating actomyosin contractility and their subsequent impact on the migration of healthy and malignant skin cells is poorly understood. We observed that blockade of ROCK in healthy primary keratinocytes (HPKs) and epidermal carcinoma cell line (A-431 cells) resulted in loss of migration, contractility, focal adhesions, stress fibres, and changes in morphology due to reduction in phosphorylated MLC levels. In contrast, blockade of MLCK reduced migration, contractile dynamics, focal adhesions and phosphorylated MLC levels of HPKs alone and had no effect on A-431 cells due to the negligible MLCK expression. Using genetically modified A-431 cells expressing phosphomimetic mutant of p-MLC, we show that ROCK dependent phosphorylated MLC controls the migration, focal adhesion, stress fibre organization and the morphology of the cells. In conclusion, our data indicate that ROCK is the major kinase of MLC phosphorylation in both HPKs and A-431 cells, and regulates the contractility and migration of healthy as well as malignant skin epithelial cells.

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Genital human papillomavirus–associated (pre-) malignant skin diseases drastically increase in the era of highly active antiretroviral therapy for HIV infection

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2006.05.016 ◽

2006 ◽

Vol 55 (6) ◽

pp. 1116-1117 ◽

Cited By ~ 2

Author(s):

Alexander Kreuter ◽

Ulrike Wieland ◽

Norbert H. Brockmeyer

Keyword(s):

Human Papillomavirus ◽

Antiretroviral Therapy ◽

Hiv Infection ◽

Highly Active Antiretroviral Therapy ◽

Skin Diseases ◽

Highly Active ◽

Malignant Skin

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p63 in Skin Appendage Development

Cell Cycle ◽

10.4161/cc.6.3.3798 ◽

2007 ◽

Vol 6 (3) ◽

pp. 285-290 ◽

Cited By ~ 34

Author(s):

Marja L. Mikkola

Keyword(s):

Appendage Development ◽

Skin Appendage

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Pre-malignant skin lesions

Medicine ◽

10.1016/j.mpmed.2021.04.008 ◽

2021 ◽

Author(s):

Catherine Drislane ◽

Katie Lacy

Keyword(s):

Skin Lesions ◽

Malignant Skin

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Common Benign and Malignant Skin Lesions

Principles and Practice of Geriatric Surgery ◽

10.1007/978-1-4757-3432-4_61 ◽

2001 ◽

pp. 867-884

Author(s):

Maryam M. Asgari ◽

David J. Leffell

Keyword(s):

Skin Lesions ◽

Malignant Skin

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Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review

Anais Brasileiros de Dermatologia ◽

10.1590/s0365-05962012000200004 ◽

2012 ◽

Vol 87 (2) ◽

pp. 212-219 ◽

Cited By ~ 24

Author(s):

Pedro Andrade ◽

Maria Manuel Brites ◽

Ricardo Vieira ◽

Angelina Mariano ◽

José Pedro Reis ◽

...

Keyword(s):

Skin Cancer ◽

Squamous Cell ◽

Basal Cell ◽

Skin Neoplasms ◽

Squamous Cell Carcinomas ◽

Exposed Skin ◽

Non Melanoma Skin Cancer ◽

Basal Cell Carcinomas ◽

Malignant Skin ◽

Melanoma Skin

BACKGROUND: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm. OBJECTIVE: Epidemiologic characterization of the population with Non-melanoma skin cancer. METHODS: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology. RESULTS: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493) diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443) were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers. CONCLUSION: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.

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