Thyroarytenoid Muscle

Our laboratory previously reported that active glottal closure was present in 90% of spontaneous central apneas in premature lambs while maintaining a high-apneic lung volume (Renolleau S, Letourneau P, Niyonsenga T, and Praud JP. Am J Respir Crit Care Med 159: 1396–1404, 1999.) The present study aimed at testing whether this mechanism limits postapnea oxygen desaturation. Four premature lambs were instrumented for recording states of alertness, thyroarytenoid muscle and diaphragm electromyographic (EMG) activity, nasal airflow, lung volume changes, and pulse oximetry. One thousand four hundred fifty-two spontaneous central apneas (isolated or during periodic breathing) were analyzed in nonsedated lambs. Apneas, with high lung volume maintained by active glottal closure, were compared with apneas, with a tracheostomy opened at apnea onset. Oxygen desaturation slopes were lower when high-apneic lung volume was actively maintained during both wakefulness and quiet sleep. Furthermore, oxygen desaturation slopes were lower after isolated apneas with continuous thyroarytenoid EMG during wakefulness, compared with apneas with noncontinuous thyroarytenoid EMG (= glottis opened shortly after apnea onset). These results highlight the importance of maintaining high-alveolar oxygen stores during central apneas by active glottal closure to limit desaturation in newborns.

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Cross-Innervation of the Thyroarytenoid Muscle by a Branch from the External Division of the Superior Laryngeal Nerve

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949710600712 ◽

1997 ◽

Vol 106 (7) ◽

pp. 594-598 ◽

Cited By ~ 41

Author(s):

Sina Nasri ◽

Joel A. Sercarz ◽

Pouneh Beizai ◽

Young-Mo Kim ◽

Ming Ye ◽

...

Keyword(s):

Vocal Fold ◽

Superior Laryngeal Nerve ◽

Laryngeal Nerve ◽

Spasmodic Dysphonia ◽

Clinical Implications ◽

Motor Innervation ◽

Vocal Fold Vibration ◽

Adductor Spasmodic Dysphonia ◽

Thyroarytenoid Muscle ◽

Stimulation Of

The neuroanatomy of the larynx was explored in seven dogs to assess whether there is motor innervation to the thyroarytenoid (TA) muscle from the external division of the superior laryngeal nerve (ExSLN). In 3 animals, such innervation was identified. Electrical stimulation of microelectrodes applied to the ExSLN resulted in contraction of the TA muscle, indicating that this nerve is motor in function. This was confirmed by electromyographic recordings from the TA muscle. Videolaryngostroboscopy revealed improvement in vocal fold vibration following stimulation of the ExSLN compared to without it. Previously, the TA muscle was thought to be innervated solely by the recurrent laryngeal nerve. This additional pathway from the ExSLN to the TA muscle may have important clinical implications in the treatment of neurologic laryngeal disorders such as adductor spasmodic dysphonia.

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Impact in Vocal Quality in Partial Myectomy and Neurectomy Endoscopic of Thyroarytenoid Muscle in Patients with Adductor Spasmodic Dysphonia

Brazilian Journal of Otorhinolaryngology ◽

10.1016/s1808-8694(15)30066-5 ◽

2006 ◽

Vol 72 (2) ◽

pp. 261-266 ◽

Cited By ~ 8

Author(s):

Domingos Hiroshi Tsuji ◽

Fernanda Silveira Chrispim ◽

Rui Imamura ◽

Luiz Ubirajara Sennes ◽

Adriana Hachiya

Keyword(s):

Spasmodic Dysphonia ◽

Adductor Spasmodic Dysphonia ◽

Vocal Quality ◽

Thyroarytenoid Muscle

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Numerical Densities of Myonuclei and Satellite Cells in Muscle Fiber Types in the Aging Human Thyroarytenoid Muscle: An Immunohistochemical and Stereological Study Using Confocal Laser Scanning Microscopy

Otolaryngology ◽

10.1067/mhn.2000.109487 ◽

2000 ◽

Vol 123 (4) ◽

pp. 377-384 ◽

Cited By ~ 10

Author(s):

Leslie T. Malmgren ◽

Patricia J. Fisher ◽

Christine E. Jones ◽

Linda M. Bookman ◽

Toshiyuki Uno

Keyword(s):

Confocal Laser Scanning Microscopy ◽

Muscle Fiber ◽

Satellite Cells ◽

Laser Scanning ◽

Laser Scanning Microscopy ◽

Confocal Laser Scanning ◽

Confocal Laser ◽

Muscle Fiber Types ◽

Fiber Types ◽

Thyroarytenoid Muscle

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Denervation and Reinnervation of the Thyroarytenoid Muscle

Pathophysiology and Surgical Treatment of Unilateral Vocal Fold Paralysis ◽

10.1007/978-4-431-55354-0_3 ◽

2015 ◽

pp. 45-88

Author(s):

Eiji Yumoto

Keyword(s):

Thyroarytenoid Muscle

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Thyroarytenoid muscle activity during wakefulness and sleep in normal adults

Journal of Applied Physiology ◽

10.1152/jappl.1988.65.3.1332 ◽

1988 ◽

Vol 65 (3) ◽

pp. 1332-1339 ◽

Cited By ~ 56

Author(s):

S. T. Kuna ◽

G. Insalaco ◽

G. E. Woodson

Keyword(s):

Eye Movement ◽

Progressive Increase ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Adult Males ◽

Tidal Breathing ◽

Quiet Breathing ◽

Discharge Patterns ◽

Normal Adults ◽

Thyroarytenoid Muscle

To determine the respiratory-related activity of the thyroarytenoid (TA) muscle in normal adults, intramuscular electromyographic recordings were performed in eight normal adult males during wakefulness and sleep. Phasic expiratory TA activity was present during normal tidal breathing in all subjects during wakefulness. Tonic activity was frequently present during inspiration. After an initial rapid rise in activity near the onset of expiration, phasic TA activity generally exhibited one of three different discharge patterns: a plateau, a progressive increase, or, less commonly, a progressive decrease in activity. In four of five subjects examined, peak TA activity during quiet breathing in wakefulness appeared to be directly related to time of expiration. At a particular lung volume above end-expiratory volume during wakefulness, measurements of expiratory resistance were directly related to the level of TA activity. TA activity disappeared during stable periods of non-rapid-eye-movement sleep and exhibited paroxysmal bursts of activity during rapid-eye-movement sleep. The results during wakefulness indicate that the TA contributes to an active adduction of the vocal cords in expiration and suggest the presence of an active laryngeal braking mechanism during exhalation.

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Thyroarytenoid muscle activity during hypoxia in awake lambs

Journal of Applied Physiology ◽

10.1152/jappl.1990.69.6.1998 ◽

1990 ◽

Vol 69 (6) ◽

pp. 1998-2003 ◽

Cited By ~ 6

Author(s):

J. P. Praud ◽

E. Canet ◽

D. Dalle ◽

A. Bairam ◽

M. Bureau

Keyword(s):

Lung Volume ◽

Muscle Activity ◽

Early Life ◽

Face Mask ◽

Flow Volume ◽

Adductor Muscles ◽

Thyroarytenoid Muscle

It is generally accepted that hypoxia in early life results in active laryngeal braking of expiratory airflow via the recruitment of glottic adductor muscles. We examined the electromyogram expiratory activity of the thyroarytenoid muscle in seven 11- to 18-day-old awake nonsedated lambs exposed to an inspired O2 fraction of 0.08 for 18 min. The lambs breathed through a face mask and a pneumotachograph. During baseline prehypoxic breathing, the thyroarytenoid muscle was largely inactive in each awake lamb. Unexpectedly, no recruitment of the thyroarytenoid muscle was recorded during hypoxia in any of the seven lambs; simultaneous examination of the flow-volume curves revealed an absence of expiratory airflow braking. Also unexpectedly, marked expiratory activity of the thyroarytenoid muscle was recorded, with each expiration occurring within less than 10 s after the return to room air. The resulting delay of expiration was apparent in the flow-volume loops. Thus, in awake 11- to 18-day-old lambs, 1) active expiratory glottic adduction is absent during hypoxia and 2) a return from hypoxia to room air results in prolonged expiration as well as active glottic adduction that controls end-expiratory lung volume.

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Effects of Vocal Training on Thyroarytenoid Muscle Neuromuscular Junctions and Myofibers in Young and Older Rats

The Journals of Gerontology Series A ◽

10.1093/gerona/glaa173 ◽

2020 ◽

Author(s):

Adrianna C Shembel ◽

Charles Lenell ◽

Sophia Chen ◽

Aaron M Johnson

Keyword(s):

Neuromuscular Junction ◽

Muscle Fiber ◽

Acoustic Analysis ◽

Neuromuscular Junctions ◽

Fiber Type ◽

Male Rats ◽

Brown Norway ◽

Control Group ◽

Vocal Training ◽

Thyroarytenoid Muscle

Abstract The purpose of this investigation was to determine the effects of vocal training on neuromuscular junction (NMJ) morphology and muscle fiber size and composition in the thyroarytenoid muscle, the primary muscle in the vocal fold, in younger (9-month) and older (24-month) Fischer 344 × Brown Norway male rats. Over 4 or 8 weeks of vocal training, rats of both ages progressively increased their daily number of ultrasonic vocalizations (USVs) through operant conditioning and were then compared to an untrained control group. Neuromuscular junction morphology and myofiber size and composition were measured from the thyroarytenoid muscle. Acoustic analysis of USVs before and after training quantified the functional effect of training. Both 4- and 8-week training resulted in less NMJ motor endplate dispersion in the lateral portion of the thyroarytenoid muscle in rats of both ages. Vocal training and age had no significant effects on laryngeal myofiber size or type. Vocal training resulted in a greater number of USVs with longer duration and increased intensity. This study demonstrated that vocal training induces laryngeal NMJ morphology and acoustic changes. The lack of significant effects of vocal training on muscle fiber type and size suggests vocal training significantly improves neuromuscular efficiency but does not significantly influence muscle strength changes.

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