scholarly journals Trials by application the drugs «Prazitsid®-suspension Plus» and «Dirofen® tablets» at hemorrhagic diarrhea in cats with giardiasis

2019 ◽  
Vol 2019 (7) ◽  
pp. 14-18
Author(s):  
Самат Шибитов ◽  
Samat Shibitov ◽  
Елена Бажибина ◽  
Elena Bazhibina ◽  
Ольга Петрова ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Pilot Study ◽  
Clinical Efficacy ◽  
Acute Diarrhea ◽  
Therapeutic Dose ◽  
Wide Spectrum ◽  
Gastrointestinal Disorders ◽  
Efficacy Criteria ◽  
Parasitological Study

The results of a pilot study of anthelmintics drugs ― «Prazicide®-suspension Plus» and «Dirofen® tablets» in the treatment of diarrhea in cats with giardiosis are given. The studied drugs contain febantel, which has an anti-Giardia effect, it makes possible to recommend them to animals in cases of suspected protozoa invasion. The drugs are developed and introduced into clinical practice as anthelmintics of a wide spectrum of action for the regular deworming of small pets. Data of clinical and laboratory allow us to expand the range of application of these drugs in cats, in particular, to recommend them to animals with gastrointestinal disorders, manifesting symptoms of classical acute diarrhea. The clinical efficacy criteria were: repeated parasitological study of feces, as well as negative samples of laboratory express-tests (IHA, ELISA or PCR) taking into account the dynamics of elimination of diarrhea symptoms and flatulence in cats. A coproscopic analysis was performed by classical parasitological methods ― by microscopy of native of feces and / or supernatant after preparation of the sample according to the Fulleborn method (1920). The results of our studies showed the clinical efficacy in the treatment of feline giardiosis of «Prazicide®-suspension Plus» and «Dirofen® tablets» (developed by API-SAN LLC) with a triple use in a therapeutic dose, according to the instructions.

A Non-inferiority Pilot Study Comparing the Clinical Efficacy and Safety of Generic Wide-spectrum Antibiotic Use in Septic Oncology Patients

Drug Research ◽  
2015 ◽  
Vol 65 (12) ◽  
pp. 635-639 ◽  
Author(s):  
I. Araya ◽  
G. Fasce ◽  
E. Núñez ◽  
J. Opazo ◽  
E. Saez ◽  
...  
Keyword(s):  
Pilot Study ◽  
Clinical Efficacy ◽  
Wide Spectrum ◽  
Antibiotic Use ◽  
Efficacy And Safety ◽  
Oncology Patients

scholarly journals How to improve DAS28 use in daily clinical practice?--a pilot study of a nurse-led intervention

Rheumatology ◽  
2010 ◽  
Vol 49 (4) ◽  
pp. 741-748 ◽  
Author(s):  
L. T. C. van Hulst ◽  
M. C. W. Creemers ◽  
J. Fransen ◽  
L. C. Li ◽  
R. Grol ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Pilot Study ◽  
Daily Clinical Practice

scholarly journals Undertaking Procedure-Based Assessment is Feasible in Clinical Practice

2009 ◽  
Vol 91 (2) ◽  
pp. 110-112 ◽  
Author(s):  
K James ◽  
K Cross ◽  
ME Lucarotti ◽  
AL Fowler ◽  
TA Cook
Keyword(s):  
Clinical Practice ◽  
Pilot Study ◽  
Anterior Resection ◽  
Assessment Tool ◽  
Right Hemicolectomy ◽  
Time Constraints ◽  
Main Study ◽  
Minimal Impact ◽  
The Impact ◽  
Colorectal Procedures

INTRODUCTION With the development of a new curriculum, workplace based assessments such as procedure-based assessment (PBA) are becoming increasingly common within surgical training. However, there have been concerns about the impact of these assessments on clinical practice. This study assessed the time taken to complete PBA forms to determine whether it is feasible in clinical practice. MATERIALS AND METHODS PBAs for three colorectal procedures (anterior resection, right hemicolectomy and anal fistula) were undertaken by various trainers and trainees. A pilot study was performed to identify potential reasons for incomplete forms and procedural modifications subsequently applied in the main study. Times taken to complete the consenting and operative components of the forms were recorded. RESULTS Incomplete forms in the pilot were mainly attributable to time constraints. In the main study, all assessments were completed within 30 min. Assessment times increased with complexity of the procedure. Median times for completing the consenting and operative components in anterior resection were 13 min (range, 8–15 min) and 15 min (range, 10–18 min), respectively. CONCLUSIONS PBAs are feasible in clinical practice and are valued by trainees as a means of enabling focused feedback and targeted training. Commitment from trainers and trainees will be required but, with adequate planning, the assessment tool is effective with minimal impact on clinical practice.

Dietary flavonoids as a potential intervention to improve redox balance in obesity and related co-morbidities: a review

2018 ◽  
Vol 31 (2) ◽  
pp. 239-247 ◽  
Author(s):  
Daniela Gentile ◽  
Matteo Fornai ◽  
Carolina Pellegrini ◽  
Rocchina Colucci ◽  
Corrado Blandizzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Scientific Evidence ◽  
Cell Cycle Control ◽  
Cell Signalling ◽  
Gastrointestinal Disorders

AbstractObesity represents one of major health problems strongly linked to other co-morbidities, such as type 2 diabetes, CVD, gastrointestinal disorders and cognitive impairment. In this context, nutritional stress, such as an excess of fat intake, promotes a systemic oxidative stress, characterised by hyperproduction of reactive oxygen species, leading to cellular alterations that include impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity. Flavonoids, dietary components of plant foods, are endowed with a wide spectrum of biological activities, including antioxidant activity, and have been proposed to reduce the risk of major chronic diseases. The present review intends to highlight and critically discuss the current scientific evidence on the possible effects of flavonoids in counteracting obesity and related co-morbidities (i.e. type 2 diabetes mellitus, CVD, gastrointestinal disorders and cognitive impairment) through a decrease in oxidative stress and related inflammatory conditions.

Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action

2021 ◽  
pp. 1-22
Author(s):  
Richard Y. Cao ◽  
Yuntao Zheng ◽  
Ying Zhang ◽  
Lingling Jiang ◽  
Qing Li ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Biological Activities ◽  
Heart Diseases ◽  
Wide Spectrum ◽  
Adenosine Monophosphate ◽  
Ionic Channels ◽  
Cardiometabolic Disease ◽  
Therapeutic Effects ◽  
Ampk Signaling ◽  
Traditional Chinese Herbal Medicine

Berberine is an alkaloid from several medicinal plants originally used to treat diarrhea and dysentery as a traditional Chinese herbal medicine. In recent years, berberine has been discovered to exhibit a wide spectrum of biological activities in the treatment of diverse diseases ranging from cancer and neurological dysfunctions to metabolic disorders and heart diseases. This review article summarizes the clinical practice and laboratory exploration of berberine for the treatment of cardiometabolic and heart diseases, with a focus on the novel insights and recent advances of the underlying mechanisms recognized in the past decade. Berberine was found to display pleiotropic therapeutic effects against dyslipidemia, hyperglycemia, hypertension, arrhythmia, and heart failure. The mechanisms of berberine for the treatment of cardiometabolic disease involve combating inflammation and oxidative stress such as inhibiting proprotein convertase subtilisin/kexin 9 (PCSK9) activation, regulating electrical signals and ionic channels such as targeting human ether-a-go-go related gene (hERG) currents, promoting energy metabolism such as activating adenosine monophosphate-activated protein kinase (AMPK) signaling pathway, modifying gut microbiota to promote transforming of berberine into its intestine-absorbable form, and interacting with non-coding RNAs via targeting multiple signaling pathways such as AMPK, mechanistic target of rapamycin (mTOR), etc. Collectively, berberine appears to be safe and well-tolerated in clinical practice, especially for those who are intolerant to statins. Knowledge from this field may pave the way for future development of more effective pharmaceutical approaches for managing cardiometabolic risk factors and preventing heart diseases.

Information technology in the evaluation of RWD / RWE (Real-World Data / Real-World Evidence)

2021 ◽  
Author(s):  
OV Zhukova ◽  
AL Khokholov
Keyword(s):  
Health Care ◽  
Information Technology ◽  
Clinical Practice ◽  
Clinical Efficacy ◽  
Real World ◽  
Information Technologies ◽  
Real World Data ◽  
Real World Evidence ◽  
Software Modules ◽  
Real Clinical Practice

The features of evaluating data from real clinical practice are discussed. Approaches to material processing for decision support in medicine and health care are also given. The development of standardized methods of analysis with the possibility of obtaining a unified indicator for assessing data from routine clinical practice, combined with the development of information technology is the direction of development of the concept of result-oriented health care. The classification of information technologies used in medicine and public health is presented. The main characteristics and functioning features of the developed software modules for automated data evaluation of real clinical practice are presented: a program for the distribution of drugs on the levels of clinical efficacy, a program to assess the effectiveness of therapy for the specified period; a program to determine the interval of clinical efficacy of drugs.

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