scholarly journals THE ROLE OF SERUM UREA, CREATININE, URIC ACID IN DIAGNOSIS OF PRE-ECLAMPSIA AND ECLAMPSIA

Author(s):  
Dr. Ranjit S. Ambad ◽  
Dr. Archana Dhok

Eclampsia is a serious medical condition that affects women during pregnancy. Symptoms of eclampsia appear in pregnancy as a condition known as pre-eclampsia, (condition follows a high blood pressure) , the condition can go undetected until it develops into eclampsia. This can create additional complications during pregnancy. Each case of eclampsia is unique, and the pregnant woman may share few or no characteristics with other women who develop the condition. Pregnancy histories, Patient age, Family history, Obesity, High blood pressure are major high risk factors for preeclampsia and eclampsia will vary from patient to patient. Aims and Objectives of Study: To detect the level of urea, creatinine and uric acid in the diagnosis of preeclampsia and eclampsia. Material and Method: Total 100 subjects were selected for study. Out of 40 were normal pregnant womens, 30 were suffered from preeclampsia and 30 were suffered eclampsia. Blood sample were collected in plane test tube for assay of urea, creatinine and uric acid. Results of Study: The concentration of urea, creatinine and uric acid is significantly increased found in eclampsia compare to normal subjects. The level of serum urea and serum creatinine increased but insignificant in pre-eclampsia (40.08 ± 9.20 ; 0.78 ± 0.32) compare to normal group (30.47 ± 6.18 ; 0.58 ± 0.14). The level of uric acid was significantly increased found in pre-eclampsia subject (6.42 ± 1.42) than normal pregnant woman (4.82 ± 0.86) (p >0.0001). Conclusion: On the basis of study findings we, concluded that the increased levels of serum uric acid, serum creatinine and serum urea are better diagnostic and predictive marker for PE and eclampsia and immediate medical attention required for preeclampsia and eclampsia. With the help of these parameters most cases are detected early in the pregnancy before they can progress to eclampsia. While there is no cure for preeclampsia, doctors will often prescribe medications to lower blood pressure or anticonvulsant medications to prevent seizures. Keywords: PE, ECLAMPSIA, UREA, URIC ACID, CREATININE

1978 ◽  
Vol 55 (s4) ◽  
pp. 263s-270s ◽  
Author(s):  
A. Amery ◽  
P. Berthaux ◽  
W. Birkenhäger ◽  
A. Boel ◽  
P. Brixko ◽  
...  

1. A total of 450 hypertensive patients above the age of 60 years have entered the double-blind multicentre trial of the European Working Party on High blood pressure in Elderly (EWPHE). After stratification and randomization half were treated with one capsule daily containing 25 mg of hydrochlorothiazide and 50 mg of triamterene and half were given placebo. In those receiving active treatment, if blood pressure control was not adequate they were given a second capsule and if necessary up to 2 g of methyldopa/day. 2. No significant differences between the groups were present before randomization. A significant blood pressure difference of 25/10 mmHg was obtained between the groups and maintained during 4 years of follow-up. No major disturbances in serum potassium or serum sodium were noted with the present drug combination. 3. During the initial phase an increase in serum creatinine and serum uric acid was noted in the actively treated group, which was maintained during the later years. This increase in serum creatinine in the actively treated group was related (P = 0·003 and r = −0·247) to the decrease in sitting systolic blood pressure. Changes in serum uric acid were (r = 0·3 and P = 0·003) correlated with the changes in serum creatinine both in the placebo and in the actively treated group, but independent of the change in creatinine; the serum uric acid was on average 1 mg higher in the actively treated than in the placebo group. 4. Fasting blood glucose did not change significantly in the placebo-treated group but in the active treatment group the rise was statistically significant. 5. A favourable influence on prognosis by active treatment can be expected on the basis of the blood pressure reduction and in the absence of major electrolytes disturbances. However, the balance between this decreased risk and the increased risk produced by the rise in blood glucose and the other treatment effects remains to be determined. Therefore the trial continues and more patients are being admitted.


2018 ◽  
Vol 11 (3) ◽  
pp. 213
Author(s):  
Khairun Nahar ◽  
Ferdousi Islam ◽  
Naila Atik Khan

<p class="Abstract">The aim of this study was to determine the relationship between the severity of hypertension and renal impairment in preeclampsia. This study was conducted on 92 diagnosed cases of mild (n=42) and severe (n=50) preeclampsia patients from August 2010 to July 2011. All the patients were almost identical in terms of age and socioeconomic status. The results of the study showed that the mean serum creatinine and uric acid levels were significantly high in severe preeclampsia patient compared to mild preeclampsia and both systolic and diastolic blood pressures had the positive and significant effects on the serum creatinine and uric acid levels. In conclusion, impairment of renal function has the positive and significant relationship with the severity of blood pressure in the preeclamptic patient.</p>


1975 ◽  
Vol 49 (4) ◽  
pp. 353-358 ◽  
Author(s):  
P. L. Padfield ◽  
M. E. M. Allison ◽  
J. J. Brown ◽  
A. F. Lever ◽  
R. G. Luke ◽  
...  

1. Intravenous frusemide produced in normal subjects a prompt rise of plasma renin concentration which correlated with urinary sodium. 2. The renin response to frusemide was suppressed in patients with primary hyperaldosteronism. 3. In patients with low-renin hypertension and normal renin essential hypertension, the renin response to frusemide was similarly suppressed. 4. Suppression of the renin response to frusemide is therefore a feature of hypertension not confined to patients with primary hyperaldosteronism and low-renin hypertension. 5. Thus low-renin hypertension does not appear to constitute a distinct diagnostic entity. 6. It is suggested that suppression of the renin response is part of a long-term renal adaptation to high blood pressure.


2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Ernawati Ernawati ◽  
Rebekah Malik ◽  
Yoanita Widjaja

Increased life expectancy is an advantage but at the same time becomes a condition that can be a source of problems in the health sector, especially non-communicable diseases. Currently non-communicable diseases that are often found are cardiovascular diseases such as high blood pressure, coronary heart disease, metabolic disorders such as diabetes, dyslipidemia, muscle and joint diseases such as arthritis, gout, osteoarthritis, nutritional disorders: obesity or malnutrition. The prevalence of various non-communicable diseases from 2013-2016 strokes increased from 7% to 10.9%; and chronic kidney disease rose from 2% to 3.8%. Based on blood sugar tests, diabetes mellitus rose from 6.9% to 8.5%; and blood pressure measurement results, hypertension rose from 25.8% to 34.1%. The increase in the prevalence of non-communicable diseases is related to lifestyle, including smoking, consumption of alcoholic beverages, physical activity, and consumption of fruits and vegetables. Problems require comprehensive handling and reach as broad as possible. One form of expansion of service coverage is posbindu. Posbindu in Kelurahan Kembangan Selatan is one of the posbindu that aims to provide comprehensive services to the age group> 15 years to make efforts to prevent non-communicable diseases and prevent complications for participants who have experienced interference so that no further complications occur. Activities are carried out routinely every month on Saturdays in the form of weighing, height, blood pressure, blood sugar levels, cholesterol and gout for every visitor of Posbindu. In addition to health checks, counseling activities are also carried out both individuals and groups and health consultations for visitors posbindu both experiencing health problems or not. This activity was carried out for 1 year from August 2018 to July 2019 (June Eid holidays) with the number of Posbindu visitors between 28-45 people with an average visitor 38. The average cases of high blood pressure were 33.45% (12), high cholesterol 27.24% (10), high blood sugar 24.74 (9), and high uric acid 19.87 (8). The results obtained for 1 year showed that the control of blood pressure, blood sugar, cholesterol and uric acid was still fluctuating even though counseling and consultation had been given based on the results of the examination. The conclusion from this activity shows that blood pressure, blood sugar, cholesterol and gout are not only influenced by regularity of control and knowledge but also diet, activity and environment. The advantage of this postbindu activity is that the health condition of visitors is monitored and health information can be conveyed on an ongoing basis. Suggestions for the future harmonious cooperation between health workers, patients and families / closest people of the patient must always be maintained through this posbindu activityABSTRAK:Peningkatan usia harapan hidup merupakan suatu keuntungan tetapi sekaligus menjadi suatu kondisi yang dapat menjadi sumber permasalahan di bidang kesehatan terutama penyakit tidak menular. Saat ini penyakit tidak menular yang banyak dijumpai adalah penyakit kardiovaskular seperti darah tinggi, jantung koroner, penyakit kelainan metabolik seperti kencing manis, dislipidemia, penyakit otot dan persendian seperti radang sendi, gout, osteoartritis, gangguan gizi: obesitas atau gizi kurang. Prevalensi berbagai penyakit tidak menular dari tahun 2013-2016 stroke naik dari 7% menjadi 10,9%; dan penyakit ginjal kronik naik dari 2% menjadi 3,8%. Berdasarkan pemeriksaan gula darah, diabetes melitus naik dari 6,9% menjadi 8,5%; dan hasil pengukuran tekanan darah, hipertensi naik dari 25,8% menjadi 34,1%. Kenaikan prevalensi penyakit tidak menular ini berhubungan dengan pola hidup, antara lain merokok, konsumsi minuman beralkohol, aktivitas fisik, serta konsumsi buah dan sayur. Permasalahan membutuhkan penanganan yang bersifat menyeluruh dan menjangkau seluas mungkin. Salah satu bentuk perluasan jangkauan pelayanan adalah posbindu. Posbindu di Kelurahan Kembangan Selatan merupakan salah satu posbindu yang bertujuan memberikan pelayanan yang secara menyeluruh pada kelompok usia > 15 tahun untuk melakukan upaya pencegahan penyakit tidak menular dan mencegah komplikasi bagi peserta yang sudah mengalami gangguan agar tidak terjadi komplikasi lebih lanjut. Kegiatan dilakukan rutin setiap bulan pada hari Sabtu berupa penimbangan berat badan, tinggi badan, tekanan darah, kadar gula darah, kolesterol dan asam urat bagi setiap pengunjung posbindu. Selain pemeriksaan kesehatan, juga dilakukan kegiatan penyuluhan baik perorangan maupun kelompok dan konsultasi kesehatan bagi pengunjung posbindu baik yang mengalami gangguan kesehatan maupun tidak. Kegiatan ini dilakukan selama 1 tahun dari Agustus 2018 sampai Juli 2019 (Juni libur lebaran) dengan jumlah pengunjung posbindu antara 28-45 orang dengan rata-rata pengunjung 38. Rata-rata kasus tekanan darah tinggi 33,45% (12), kolesterol tinggi 27.24% (10), gula darah tinggi 24,74 (9), dan asam urat tinggi 19,87 (8). Hasil yang didapat selama 1 tahun ini menunjukkan bahwa pengendalian tekanan darah, gula darah, kolesterol dan asam urat masih naik turun walaupun sudah diberikan penyuluhan maupun konsultasi berdasarkan hasil pemeriksaan. Simpulan dari kegiatan ini menunjukkan bahwa tekanan darah, gula darah, kolesterol dan asam urat tidak hanya dipengaruhi oleh keteraturan kontrol dan pengetahuan tetapi juga pola makan, aktivitas dan lingkungan. Keuntungan dari kegiatan posbindu ini adalah termonitornya kondisi kesehatan pengunjung dan informasi kesehatan dapat tersampaikan secara berkelanjutan. Saran ke depannya kerjasama yang harmonis antara petugas kesehatan, pasien dan keluarga/orang terdekat pasien harus selalu dijaga lewat kegiatan posbindu ini


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Franziska A. Meister ◽  
Zoltan Czigany ◽  
Katharina Rietzler ◽  
Hannah Miller ◽  
Sophie Reichelt ◽  
...  

Abstract Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria-donation (ECD) kidney allografts (KA). Fifteen ECD-KA were submitted to 152 ± 92 min of end-ischemic HOPE and were compared to a matched group undergoing conventional-cold-storage (CCS) KT (n = 30). Primary (delayed graft function-DGF) and secondary (e.g. postoperative complications, perfusion parameters) endpoints were analyzed within 6-months follow-up. There was no difference in the development of DGF between the HOPE and CCS groups (53% vs. 33%, respectively; p = 0.197). Serum urea was lower following HOPE compared to CCS (p = 0.003), whereas the CCS group displayed lower serum creatinine and higher eGFR rates on postoperative days (POD) 7 and 14. The relative decrease of renal vascular resistance (RR) following HOPE showed a significant inverse association with serum creatinine on POD1 (r = − 0.682; p = 0.006) as well as with serum urea and eGFR. Besides, the relative RR decrease was more prominent in KA with primary function when compared to KA with DGF (p = 0.013). Here we provide clinical evidence on HOPE in ECD-KT after brain death donation. Relative RR may be a useful predictive marker for KA function. Further validation in randomized controlled trials is warranted. Trial registration: clinicaltrials.gov (NCT03378817, Date of first registration: 20/12/2017).


2001 ◽  
Vol 161 (9) ◽  
pp. 1207 ◽  
Author(s):  
Josef Coresh ◽  
G. Laura Wei ◽  
Geraldine McQuillan ◽  
Fredrick L Brancati ◽  
Andrew S. Levey ◽  
...  

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