scholarly journals EVALUATION OF RISK FACTORS FOR MORBIDITY AND MORTALITY IN CHILDREN AGED 6 MONTH- 5 YEARS PRESENTING WITH LOWER RESPIRATORY TRACT INFECTION TO A REFERRAL HOSPITAL

Author(s):  
Tarun Kumar ◽  
Bhupendra Narain ◽  
A.K. Jaiswal

Acute lower respiratory tract infection in children is a major cause of mortality and morbidity worldwide. A simple clinical score predicting the probability of death and poor outcome in a young child with lower respiratory tract infection (LRTI) could aid clinicians in case management and provide a standardized severity measure during epidemiologic studies. Therefore, our study was aimed to assess the usefulness of one such scoring model, the RISC score, in an urban setting in eastern part of India and also to determine significant risk factors for LRTI in young children Our study concluded that the RISC score maybe used as an index of severity in children with LRTI, as a complementary tool to the current IMCI framework, to ensure appropriate treatment and hospitalization in children, who are most in need. Also, recognizing the risk factors at presentation, may facilitate decisions about the most appropriate site of treatment (i.e., home vs. hospital) or the need for additional supportive care (i.e., supplemental oxygen or intensive care). Keywords: Morbidity, Mortality in Children, Lower Respiratory Tract Infection, LRTI, etc.

1970 ◽  
Vol 42 (3) ◽  
pp. 188-193
Author(s):  
PA Ahmed ◽  
KK Yusuf ◽  
A Dawodu

Background: Childhood Acute Lower Respiratory Tract Infection (ALRTI) remains an important public health problem in the developing world, with significant morbidity and mortality a challenge. An understanding of risk factors in the development of childhood ALRTI may offer clues to prevention of the disease; identify conditions that lead to progression to severe disease, complications and even death in a child receiving treatment.Aim: to determine risk factors for ALRTI among Under five children hospitalized.Methods: A prospective study of children aged 2-60 months admitted into hospital with diagnosis of pneumonia and bronchiolitis from November 2011 to September 2012 at the National Hospital, Abuja, Nigeria. With a questionnaire data on socio- demographic and potential risk factors for ALRTI were obtained.Results: A total of 50 children aged 2-60 months were enrolled, 92.0 % had pneumonia while 8.0% had bronchiolitis. 86.0% of pneumonia subjects were 24months and below, while all those with bronchiolitis were infants. 43(86.0%) of subjects were hospitalized in the rainy season. The weights for height z score was less than minus 2 in 12 (24.0 %) of the subjects. Significant risk factor for ALRTI was the use of kerosene and solid fuel for domestic cooking, 33 (66.0%), p value 0.0001; Mortality was four percent among the infants. We conclude that younger age under 24 months and exposure to hydrocarbon and biomass from indoor pollution was contributing risk factors for ALRTI in Under five children.Key words: Acute lower respiratory tract infection, risk factors, hospitalization, under-five.


2007 ◽  
Vol 166 (12) ◽  
pp. 1267-1272 ◽  
Author(s):  
Giovanni A. Rossi ◽  
Maria Cristina Medici ◽  
Maria Cristina Arcangeletti ◽  
Marcello Lanari ◽  
Rocco Merolla ◽  
...  

2021 ◽  
Vol 5 (7) ◽  
pp. 1903-1914
Author(s):  
Chikara Ogimi ◽  
Hu Xie ◽  
Alpana Waghmare ◽  
Masumi Ueda Oshima ◽  
Kanwaldeep K. Mallhi ◽  
...  

Abstract Data are limited regarding risk factors for lower respiratory tract infection (LRTI) caused by seasonal human coronaviruses (HCoVs) and the significance of virologic documentation by bronchoalveolar lavage (BAL) on outcomes in hematopoietic cell transplant (HCT) recipients. We retrospectively analyzed patients undergoing allogeneic HCT (4/2008-9/2018) with HCoV (OC43/NL63/HKU1/229E) detected by polymerase chain reaction during conditioning or post-HCT. Risk factors for all manifestations of LRTI and progression to LRTI among those presenting with HCoV upper respiratory tract infection (URTI) were analyzed by logistic regression and Cox proportional hazard models, respectively. Mortality rates following HCoV LRTI were compared according to virologic documentation by BAL. A total of 297 patients (61 children and 236 adults) developed HCoV infection as follows: 254 had URTI alone, 18 presented with LRTI, and 25 progressed from URTI to LRTI (median, 16 days; range, 2-62 days). Multivariable logistic regression analyses showed that male sex, higher immunodeficiency scoring index, albumin <3 g/dL, glucose >150 mg/dL, and presence of respiratory copathogens were associated with occurrence of LRTI. Hyperglycemia with steroid use was associated with progression to LRTI (P < .01) in Cox models. LRTI with HCoV detected in BAL was associated with higher mortality than LRTI without documented detection in BAL (P < .01). In conclusion, we identified factors associated with HCoV LRTI, some of which are less commonly appreciated to be risk factors for LRTI with other respiratory viruses in HCT recipients. The association of hyperglycemia with LRTI might provide an intervention opportunity to reduce the risk of LRTI.


2017 ◽  
Vol 4 (2) ◽  
pp. 442
Author(s):  
Alex Aiswariya ◽  
Kundoly Velayudhan Suseela ◽  
Das Subi

Background: Moraxella catarrhalis is a Gram-negative diplococcus, commonly found as a normal flora in the human upper respiratory tract. Recently, M. catarrhalis has emerged as an important and common human respiratory tract pathogen. This study was aimed to determine the rate of isolation of M. Catarrhalis in patients attending a tertiary care hospital with lower respiratory tract infection (LRTI), antibiotic susceptibility pattern and predisposing factors responsible for their infection.Methods: A prospective study was carried out in 1001 lower respiratory specimens from patients (above 20 years’ age) with suspected LRTI.  The study investigated by microscopic examination, culture and antibiotic sensitivity test according to the standard guidelines. Assessment of clinical significance of M. Catarrhalis was ascertained on the basis of preformed criteria.Results: A total of 60 clinically significant M. Catarrhalis were isolated from the 930 culture positive samples. The isolates showed maximum sensitivity to second and third generation cephalosporins (95%), azithromycin (90%) followed by amoxicillin clavulanic acid (85%). Rate of isolation was more in males (70%) and elderly people above 60 years (63.33%) were found to be more affected. Patients (58.33%) with Chronic Obstructive Pulmonary Diseases (COPD) were found to be more prone to get infection by M. Catarrhalis.Conclusions: Moraxella catarrhalis should be considered as significant lower respiratory tract pathogen especially in elderly patients with underlying risk factors like COPD.


2021 ◽  
Vol 8 (4) ◽  
pp. 479-484
Author(s):  
Chinmaya Mahapatra ◽  
Vinod Kumar Sharma ◽  
Siddhant Singhal ◽  
Roshan Kumar Jangid ◽  
Tagaram Karthik Laxminath

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