scholarly journals Coronavirus Disease 2019 with Comorbid Pulmonary Tuberculosis: A Case Report

2020 ◽  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Blood Test ◽  
Clinical Presentation ◽  
Antiviral Treatment ◽  
Test Results ◽  
Tuberculosis Case ◽  
Case Presentation ◽  
Treatment Measures ◽  
New Type ◽  
Acid Test

Introduction: Since December 2019, a new type of pneumonia named coronavirus disease 2019 (COVID-19) has been reported in Wuhan, Hubei province, China. At present, there are no relevant reports on cases of COVID-19 and comorbid pulmonary tuberculosis. We herein report a case of a patient with COVID-19 and comorbid pulmonary tuberculosis. Case Presentation: A 47-year-old female patient with COVID-19 positive pharyngeal swabs. She did not have fever, coughing or breathing difficulties. The patient diagnosed as COVID-19, and pulmonary tuberculosis based on the patient's epidemiological history, routine blood test, imaging findings, and COVID-19 nucleic acid test results. Contact and droplet precautions were implemented. Antiviral treatment, anti-tuberculosis treatment, and liver protection treatment were given. The patient has not complained of discomfort, and her condition is stable. Conclusions: COVID-19 and comorbid tuberculosis is suspected, epidemiological history, clinical presentation, laboratory tests, and imaging examinations must be combined to make a comprehensive diagnosis and prompt quarantine and treatment measures should be implemented.

scholarly journals Two case reports of COVID-19: A 6-year-old boy and his 66-year-old grandmother

2020 ◽  
Author(s):  
Wanwan Yi ◽  
Hengwei Fan ◽  
Zhong Wei Lv ◽  
Xuan Long ◽  
hengmei zhu
Keyword(s):  
Clinical Manifestations ◽  
The Elderly ◽  
Imaging Features ◽  
Test Results ◽  
Imaging Diagnosis ◽  
Case Presentation ◽  
Global Pandemic ◽  
Family Aggregation ◽  
Multiple Detection ◽  
Acid Test

Abstract Background: Currently, COVID-19 is a global pandemic disease that has caused a large number of infections worldwide. Reports of COVID-19 cases are not uncommon, but there is no report that SAMS-CoV-2 RNA test results for grandma and grandchildren in family aggregation infections are completely different.Case presentation: A 6-year-old boy's chest CT indicated lung infection, but SAMS-CoV-2 RNA test was negative. His grandmother's imaging showed lung inflammation absorption, and nucleic acid test was positive. Conclusions: Children and the elderly people have different clinical manifestations during the course of SAMS-CoV-2 infection, it is challenging to identify whether they are infectious. Therefore, the diagnosis of COVID-19 requires a combination of multiple detection measures, including clinical features, imaging features, and SAMS-CoV-2 RNA test results.Keywords: COVID-19; SAMS-CoV-2 RNA test; Imaging diagnosis; Case report

scholarly journals Recurrent recurrence of positive SARS-CoV-2 RNA in a COVID-19 patient

2020 ◽  
Author(s):  
Shugang Cao ◽  
Aimei Wu ◽  
Jiaxia Li ◽  
Yuancheng Li ◽  
Mingwu Xia ◽  
...  
Keyword(s):  
Small Proportion ◽  
Clinical Symptoms ◽  
Antiviral Treatment ◽  
Chest Ct ◽  
Test Results ◽  
Case Presentation ◽  
Negative Results ◽  
Discharged Patients ◽  
Discharge Criteria ◽  
Positive Results

Abstract Background: Coronavirus disease 2019 (COVID-19) is a highly infectious disease. A small proportion of discharged patients may become positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, even if they meet the discharge criteria. Herein, we report a rare COVID-19 patient with recurrent recurrence of positive SARS-CoV-2 RNA.Case presentation: A 68-year-old man was admitted due to fever, muscle pain, and fatigue. He was initially diagnosed with COVID-19 according to two consecutive positive results for SARS-CoV-2 RNA plus clinical symptoms and chest CT findings, and was discharged from hospital when meeting the discharge criteria, including two consecutive negative results. He was tested positive for SARS-CoV-2 RNA twice during the quarantine and was hospitalized again. He was asymptomatic then, but IgG and IgM were both positive. He was discharged in the context of four consecutive negative test results for SARS-CoV-2 RNA after antiviral treatment. However, he was tested positive once again on the 3rd and 4th day after the second discharge, although still asymptomatic. IgG and IgM were still positive. After antiviral treatment, the results of SARS-CoV-2 RNA were negative in three consecutive retests, and he was finally discharged and quarantined for further surveillance. Conclusion: This case suggests that a small proportion of convalescent patients may become positive again for SARS-CoV-2 RNA and be a virus carrier.

scholarly journals Recurrent recurrence of positive SARS-CoV-2 RNA in a COVID-19 patient

2020 ◽  
Author(s):  
Shugang Cao ◽  
Aimei Wu ◽  
Jiaxia Li ◽  
Yuancheng Li ◽  
Mingwu Xia ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Nucleic Acid ◽  
Severe Acute Respiratory Syndrome ◽  
Antiviral Treatment ◽  
Future Research ◽  
Test Results ◽  
Case Presentation ◽  
Discharged Patients ◽  
Discharge Criteria ◽  
Positive Results

Abstract Background: Coronavirus disease 2019 (COVID-19) is a highly infectious disease. A small proportion of discharged patients became positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, even though they met the discharge criteria. Herein, we report a rare COVID-19 patient with recurrent recurrence of positive SARS-CoV-2 RNA.Case presentation: A 68-year-old man was admitted due to fever, muscle pain, and fatigue. He was initially diagnosed with COVID-19 according to two consecutive positive results for SARS-CoV-2 RNA. He was discharged from hospital when meeting the discharge criteria. He tested positive for SARS-CoV-2 RNA twice during the quarantine and was hospitalized again. He was asymptomatic then, but IgG and IgM anti-SARS-CoV-2 were both positive. He was discharged in the context of four consecutive negative test results for SARS-CoV-2 RNA after antiviral treatment. However, he tested positive once again on the 3rd and 4th days after the second discharge. Two days later, the SARS-CoV-2 RNA results became negative in three consecutive retests, and he was finally discharged. Conclusion: This case suggests that convalescent patients may become positive again for SARS-CoV-2 RNA after discharge due to prolonged nucleic acid transition. However, the potential infectivity of these patients needs to be further confirmed in future research.

scholarly journals Mononucleosis-like illnesses due to co-infection with severe fever with thrombocytopenia syndrome virus and spotted fever group rickettsia:a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bin Zhao ◽  
Haohua Hou ◽  
Ran Gao ◽  
Bing Tian ◽  
Baocheng Deng
Keyword(s):  
Clinical Presentation ◽  
Spotted Fever ◽  
Spotted Fever Group ◽  
Test Results ◽  
Blood Cell Count ◽  
Case Presentation ◽  
Igm Antibody ◽  
History Of ◽  
Spotted Fever Group Rickettsia ◽  
Severe Fever

Abstract Background We report a mononucleosis-like illnesses case due to co-infection with severe fever with thrombocytopenia syndrome virus (SFTSV) and spotted fever group rickettsia (SFGR), which to the best of our knowledge, has never been reported . Case presentation A 64-year-old male with an 11-day history of fever, sore throat, malaise, nausea, and non-pruritic rash was admitted to our emergency department. Prior to admission, he was bitten by ticks. Laboratory tests revealed a white blood cell count of 24,460 cells/μL with 25% atypical lymphocytes and 20% mononucleosis, thrombocytopenia. Test results were positive for SFTSV RNA, SFTSV-specific IgM antibody, and SFGR-specific IgM antibody. He was diagnosed with mononucleosis-like illnesses due to co-infection with SFTSV and SFGR. After administration of doxycycline, he recovered completely. Conclusions The clinical presentation may be atypical in co-infection with SFTSV and SFGR. This finding highlighted the importance of considering SFGR infection, as well as a SFSTV and SFGR co-infection for the differential diagnosis of patients bitten by ticks in SFTSV-endemic areas.

scholarly journals Atypical anti-glomerular basement membrane disease with anti-GBM antibody negativity and ANCA positivity: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Na Guo ◽  
Qinghua Yin ◽  
Song Lei ◽  
Yanjun He ◽  
Ping Fu
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Rare Case ◽  
Test Results ◽  
Serum Samples ◽  
Tissue Samples ◽  
Case Presentation ◽  
Severe Renal Insufficiency ◽  
Laboratory Test Results ◽  
Organ Specific

Abstract Background Anti-glomerular basement membrane (anti-GBM) disease is an organ-specific autoimmune disease that involves the lung and kidneys and leads to rapid glomerulonephritis progression, with or without diffuse alveolar hemorrhage, and even respiratory failure. Classic cases of anti-GBM disease are diagnosed based on the presence of the anti-GBM antibody in serum samples and kidney or lung biopsy tissue samples. However, atypical cases of anti-GBM disease are also seen in clinical practice. Case presentation We herein report the rare case of a patient with atypical anti-GBM disease whose serum was negative for the anti-GBM antibody but positive for the myeloperoxidase (MPO) anti-neutrophil cytoplasmic antibody (p-ANCA) and another atypical ANCA. Laboratory test results showed severe renal insufficiency with a creatinine level of 385 μmol/L. Renal biopsy specimen analysis revealed 100% glomeruli with crescents; immunofluorescence showed immunoglobulin G (IgG) linearly deposited alongside the GBM. Finally, the patient was discharged successfully after treatment with plasmapheresis, methylprednisolone and prednisone. Conclusion This patient, whose serum was negative for the anti-GBM antibody but positive for p-ANCA and another atypical ANCA, had a rare case of anti-GBM disease. Insights from this unusual case might help physicians diagnose rare forms of glomerulonephritis and treat affected patients in a timely manner.

scholarly journals The use of routine blood tests to assist the diagnosis of COVID-19 in symptomatic hospitalized patients

2021 ◽  
pp. 000456322199907
Author(s):  
IT Parsons ◽  
AT Parsons ◽  
E Balme ◽  
G Hazell ◽  
R Gifford ◽  
...  
Keyword(s):  
Cell Count ◽  
Retrospective Review ◽  
Blood Test ◽  
Patient Flow ◽  
White Cell Count ◽  
Area Under The Curve ◽  
White Cell ◽  
Test Results ◽  
Rt Pcr ◽  
Blood Tests

Introduction Specific patterns of blood test results are associated with COVID-19 infection. The aim of this study was to identify which blood tests could be used to assist in diagnosing COVID-19. Method A retrospective review was performed on consecutive patients referred to hospital with a clinical suspicion of COVID-19 over a period of four weeks. The patient’s clinical presentation and severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction (SARS-CoV-2 RT-PCR) were recorded. The patients were divided by diagnosis into COVID (COVID-19 infection) or CONTROL (an alternate diagnosis). A retrospective review of consecutive patients over a further two-week period was used for the purposes of validation. Results Overall, 399 patients (53% COVID, 47% CONTROL) were analysed. White cell count, neutrophils and lymphocytes were significantly lower, while lactate dehydrogenase and ferritin were significantly higher, in the COVID group in comparison to CONTROL. Combining the white cell count, lymphocytes and ferritin results into a COVID Combined Blood Test (CCBT) had an area under the curve of 0.79. Using a threshold CCBT of –0.8 resulted in a sensitivity of 0.85 and a specificity of 0.63. Analysing this against a further retrospective review of 181 suspected COVID-19 patients, using the same CCBT threshold, resulted in a sensitivity of 0.73 and a specificity of 0.75. The sensitivity was comparable to the SARS-CoV-2 RT PCR. Discussion Mathematically combining the blood tests has the potential to assist clinical acumen allowing for rapid streaming and more accurate patient flow pending definitive diagnosis. This may be of particular use in low-resource settings.

scholarly journals Improvement in mild anti-IgLON5 encephalopathy without immunotherapy: a case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuting Wang ◽  
Xiuling Wu ◽  
Baoquan Lu
Keyword(s):  
Sleep Disorder ◽  
Clinical Symptoms ◽  
Antiviral Treatment ◽  
Primary Treatment ◽  
Serum Analysis ◽  
Autonomic Nervous System Dysfunction ◽  
Case Presentation ◽  
Mild Disease ◽  
Prominent Symptom ◽  
Vertical Gaze

Abstract Background Anti-IgLON5 antibody-related encephalopathy is a recently discovered and rare autoimmune disease, and its diagnosis and treatment are more challenging than for other autoimmune encephalopathic diseases. Sleep disorder is the most prominent symptom of the disease. It can also present with gait instability, dysarthria, dysphagia, dementia, ataxia, autonomic nervous system dysfunction, chorea, vertical gaze paralysis, and other symptoms. Immunotherapy remains the primary treatment for this disease; however, there is no definitive conclusion regarding the effect of immunotherapy. The clinical symptoms of the reported cases of anti-IgLON5 antibody-related encephalopathy were generally severe. However, the symptoms in our patient were mild and relieved without immunotherapy, unlike the previously reported cases. Case presentation A 62-year-old man presented with behavioural abnormalities and involuntary movements after nearly 2 months of fever and headache. He also had symptoms of mild sleep disorder. Due to the abnormal levels of infection-related indicators, antiviral treatment was started on the day of admission. The serum analysis confirmed the presence of IgLON5 antibody, and the patient was found to be genetically susceptible. The patient’s symptoms resolved rapidly without immunotherapy and did not recur. Conclusions This case demonstrated that IgLON5 antibody-related encephalopathy might have mild manifestations. Infection and a genetic predisposition may be important causes for the disease. Patients with a mild disease may have a better prognosis.

scholarly journals Tuberculosis in Otorhinolaryngology: Clinical Presentation and Diagnostic Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rajiv C. Michael ◽  
Joy S. Michael
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Clinical Presentation ◽  
Extrapulmonary Tuberculosis ◽  
Common Type ◽  
The Body ◽  
Diagnostic Challenge ◽  
Cervical Adenitis ◽  
Important Form

Tuberculosis affects all tissues of the body, although some more commonly than the others. Pulmonary tuberculosis is the most common type of tuberculosis accounting for approximately 80% of the tuberculosis cases. Tuberculosis of the otorhinolaryngeal region is one of the rarer forms of extrapulmonary tuberculosis but still poses a significant clinical and diagnostic challenge. Over three years, only five out of 121 patients suspected to have tuberculosis of the otorhinolaryngeal region (cervical adenitis excluded) hadMycobacterium tuberculosisculture-proven disease. Additional 7 had histology-proven tuberculosis. Only one patient had concomitant sputum-positive pulmonary tuberculosis. We look at the various clinical and laboratory aspects of tuberculosis of the otorhinolaryngeal region that would help to diagnose this uncommon but important form of extrapulmonary tuberculosis.

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