scholarly journals Treatment of COVID-19 patients using plasma therapy: Letter to Editor

2020 ◽  
pp. 84-87
Keyword(s):  
Side Effects ◽  
Respiratory Infection ◽  
Therapeutic Approach ◽  
Population Studies ◽  
Specific Drug ◽  
Plasma Therapy ◽  
Severe Respiratory Infection

The symptoms of COVID-19, caused by the newly known type of coronavirus, vary widely from asymptomatic, mild to severe respiratory infection leading to hospitalization or death of patients. To date, no specific drug has been reported for the treatment of patients affected by this virus. One of the approaches adopted for the treatment of this disease is the use of plasma therapy, which contains antibodies against the virus. Following of the plasma therapy have not been reported any serious side effects. Currently, the numbers of these studies are limited, and evaluation of the larger population studies can provide stronger evidence for treating physicians about the effectiveness of this therapeutic approach.

Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis

2020 ◽  
Vol 20 (11) ◽  
pp. 1288-1299
Author(s):  
Paromita Kundu ◽  
Deepika Singh ◽  
Abhalaxmi Singh ◽  
Sanjeeb K. Sahoo
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Diagnosis ◽  
Specific Drug ◽  
Novel Therapies ◽  
Future Directions ◽  
Normal Tissues ◽  
Cancer Management ◽  
Single Probe ◽  
Therapy And Diagnosis

The panorama of cancer treatment has taken a considerable leap over the last decade with the advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific biological system. This review presents an overview of the nano theranostics approach in cancer management and a series of different nanomaterials used in theranostics and the possible challenges with future directions.

scholarly journals The Role of Preventive Measures or a Previously Immunized Population: A Pilot Study on Coronavirus Disease-19 in Syria

2020 ◽  
Vol 9 (3) ◽  
pp. 101-104
Author(s):  
Samaher Almousa ◽  
Ammar Suleiman ◽  
Samer Mohsen
Keyword(s):  
Respiratory Infection ◽  
Respiratory Infections ◽  
Previous History ◽  
Preventive Measure ◽  
Immunoglobulin M ◽  
Medical Community ◽  
Study Materials ◽  
Two Samples ◽  
Severe Respiratory Infection ◽  
The Government

Background: A recent ongoing pandemic of coronavirus disease named coronavirus disease 2019 (COVID-19) has spread in Syria from March 2020 with a pattern of a slow case increase. So far, the government has put the country under lock-down orders as a preventive measure. However, there is a considerable belief in the medical community of our country supposes that the virus has previously passed through the country depending on the high numbers of diagnosed severe respiratory infections early in 2020. Thus, this study was designed to determine the number of people with detectable antibodies to SARS-CoV-2 from two samples of healthy adults with and without a previous history of severe respiratory infection in the last 6 months of the study. Materials and Methods: To this end, samples were collected from 123 and 198 subjects with a previous severe respiratory infection and healthy controls, respectively. Then, immunoglobulin M (IgM) and IgG anti-SARS-CoV-2 antibodies were tested as well. Results: None of the samples from both groups tested IgG positive in the assay while four tested IgM samples were positive. Accordingly, these positive samples were re-analyzed and remained IgM positive in the second test although the reverse transcriptase-polymerase chain reaction for the SARS-CoV-2 virus was negative. Conclusion: Based on our findings, there is no evidence concerning the previous COVID-19 infection in Syria thus it is suggested that all isolation and lock-down orders should be respected as an effective preventive tool in this regard.

CLINICO-PATHOLOGIC CONFERENCE: 18-MONTH-OLD BOY WITH FEVER AND SEVERE RESPIRATORY INFECTION

2002 ◽  
Vol 21 (5) ◽  
pp. 491-506
Author(s):  
William F. Pomputius ◽  
Atilano Lacson ◽  
Herbert H. Pomerance
Keyword(s):  
Respiratory Infection ◽  
Severe Respiratory Infection

scholarly journals Can Homeopathy, a Particularly Mild Therapeutic Approach, Survive and Grow in a World of Violence?

Homeopathy ◽  
2020 ◽  
Vol 109 (03) ◽  
pp. 179-181 ◽  
Author(s):  
George Vithoulkas
Keyword(s):  
Side Effects ◽  
Therapeutic Approach ◽  
Modern World ◽  
Contemporary Society ◽  
Philosophical Question ◽  
Therapeutic System ◽  
Personalized Approach ◽  
Positive Results ◽  
Clinical Problems

AbstractThis short treatise addresses a philosophical question concerning the place of homeopathy in our modern world. The question raised is whether a therapeutic system as peaceful, mild, and non-violent as homeopathy can survive and grow within a society that often displays the opposite characteristics.Much of contemporary society is more interested in fast and impressive cures, even if these may also bring side effects; whereas homeopathy can offer solutions with a personalized approach that requires long hours of case study by the homeopath to find the correct personal remedy that aims to bring about positive results, which the therapy can produce in deep chronic diseases.The conclusion drawn is that homeopathy does not readily fit within a modern and violent society that prefers quick and invasive solutions to its clinical problems.

Familial susceptibility to severe respiratory infection in early life

2004 ◽  
Author(s):  
Tessa Goetghebuer ◽  
Dominic Kwiatkowski ◽  
Anne Thomson ◽  
Jeremy Hull
Keyword(s):  
Respiratory Infection ◽  
Early Life ◽  
Severe Respiratory Infection

scholarly journals Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery

2020 ◽  
Vol 11 (12) ◽  
pp. 3268-3280 ◽  
Author(s):  
Gayathri R. Ediriweera ◽  
Joshua D. Simpson ◽  
Adrian V. Fuchs ◽  
Taracad K. Venkatachalam ◽  
Matthias Van De Walle ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Drug Release ◽  
Standard Of Care ◽  
Release Profile ◽  
Specific Drug ◽  
Bioorthogonal Chemistry ◽  
Drug Release Profile ◽  
Therapeutic Delivery

There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo, as well as reducing side-effects for an increased standard of care.

Familial susceptibility to severe respiratory infection in early life

2004 ◽  
Vol 38 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Tessa Goetghebuer ◽  
Dominic Kwiatkowski ◽  
Anne Thomson ◽  
Jeremy Hull
Keyword(s):  
Respiratory Infection ◽  
Early Life ◽  
Severe Respiratory Infection

Investigation of Side Effects of Plasmaexchange In the Treatment of Thrombotic Thrombocytopenic Purpura

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4661-4661
Author(s):  
Sarah Steinemann ◽  
Tanja Falter ◽  
Mirjeta Qorraj ◽  
Thomas Vigh ◽  
Inge Scharrer
Keyword(s):  
Side Effects ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Side Effect ◽  
Conflicts Of Interest ◽  
Allergic Reactions ◽  
Adamts13 Activity ◽  
Plasma Therapy ◽  
Thrombocytopenic Purpura ◽  
Wide Range ◽  
Von Willebrand

Abstract Abstract 4661 Introduction: Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia, hemolytic anemia and microthrombi. A deficiency of the metalloprotease ADAMTS 13, which cleaves a Tys1605-Met1606 bond in the A2 subunit of von Willebrand factor (VWF), leads to formation of ultra large von Willebrand multimers (UL-VWF) and can cause platelet aggregation and mircovascular thrombosis. Treatment of choice is the substitution of plasma with plasmaexchange. There are two different plasma types available: Fresh Frozen Plasma (FFP) and solvent/detergent (s/d) treated plasma. This treatment may carry significant risks and side effects for the patients. Therefore we investigated the side effects of the therapy and furthermore the ADAMTS13 activity of the two plasma types. Methods: A questionnaire was send to 66 TTP patients of the Department of Hematology to evaluate different side effects of the therapy. 20 batches of FFP and 4 batches of s/d plasma of all blood groups were investigated on ADAMTS13 activity. The ADAMTS13 activity was detected with BCS-Method according to Böhm and two commercial FRET assays. Results: So far 34 patients were inquired about age, weight and suspected trigger situations that might have caused their TTP manifestation. The mean age of the patients was 34 years with a mean weight of 70kg. A previous infection caused TTP manifestation in 42% of the patients; drug therapy (22%) and pregnancy (17%) were other mentioned triggers. 94% of the patients suffered from an acquired TTP and only 6% had a hereditary TTP. The patients had 2.88 relapses and were treated with 16.27 plasmaexchanges. 56% had an additional therapy with Rituximab to achieve a faster remission of the disease. These patients needed less plasmaexchanges for recovery, which proofed to be significant at 2% level in a one sided t-test. Tingling (64.7%) and shivering (51%) were the most often mentioned side effects and simultaneously described as the strongest. Shivering was significantly correlated to tachycardia (p<0.01). Headaches were significantly correlated to hot flushes, tingling and collapse (p< 0.05). Side effects and allergic reactions occurred in the therapy with FFP as well as with s/d plasma. Another side effect was the complication that came along with infection of the venous access. Most patients had a central venous catheter (72%) and described infections and pruritus (60%), 50% of them mentioned this complication more than once. We found in usual FFP slightly higher ADAMTS13 activity levels (696.97 ng/ml) than in s/d virus inactivated plasma (643.86 ng/ml). The ADAMTS13 activity varied between the different assays (normal range: 666 ± 135ng/ml). Conclusion: Our investigation demonstrated that plasmaexchange therapy is still associated with a wide range of side effects. Side effects of plasmaexchange that were most frequently described by patients were tingling and shivering. Headaches also occurred in various cases. Patients suffered generally from more than one side effect at the same time during the treatment. Allergic reactions to the plasma therapy were mentioned by 65% of the patients. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Prison and community outbreak of severe respiratory infection due to adenovirus type 14p1 in Tayside, UK

2014 ◽  
Vol 37 (1) ◽  
pp. 64-69 ◽  
Author(s):  
B. J. Parcell ◽  
P. G. McIntyre ◽  
D. L. Yirrell ◽  
A. Fraser ◽  
M. Quinn ◽  
...  
Keyword(s):  
Respiratory Infection ◽  
Adenovirus Type ◽  
Severe Respiratory Infection
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