The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
Keyword(s):
Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatments effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure.
2021 ◽
Vol 170
(4)
◽
pp. 522-527
1998 ◽
Vol 42
(1)
◽
pp. 171
2008 ◽
Vol 51
(3)
◽
pp. 215-223
◽
2005 ◽
Vol 281
(4)
◽
pp. 2120-2127
◽
2002 ◽
Vol 24
(2)
◽
pp. 165-186
◽
1995 ◽
Vol 5
(3)
◽
pp. 327-334
◽