scholarly journals Correlation of Neck Nodule Size with Body Mass Index and Karnofsky Status Before and After Neoadjuvant Cisplatin and 5-Fluorouracil Chemotherapy in Nasopharyngeal Carcinoma Type 3 Patients

2021 ◽  
Vol 51 (1) ◽  
Author(s):  
Bagus Harning Efranto ◽  
Soehartono - ◽  
Edi - Handoko
Keyword(s):  
Body Mass Index ◽  
Nasopharyngeal Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Body Mass ◽  
Medical Record Data ◽  
Nodule Size ◽  
Local Spread ◽  
Record Data ◽  
Before And After ◽  
Type 3

AbstractIntroduction: Nasopharyngeal carcinoma (NPC) is a malignancy arising from the nasopharyngeal epithelium, usually present in the Rosenmüller fossa. NPC is a cancer of the head and neck that is most common in East Asia and Southeast Asia, including in Indonesia. The main therapeutic for NPC is radiotherapy. Neoadjuvant chemotherapy reduces the local spread of advanced NPC, eradication of micrometastases, and improved local control. Neoadjuvant chemotherapy's effectiveness can be assessed by changes in the patient's neck nodule size (N), the patient's Body Mass Index (BMI), and Karnofsky's Status. Aim: To determine the correlation between N with BMI and Karnofsky status on neoadjuvant chemotherapy Cisplatin and 5-Fu in WHO type 3 of NPC patients. Methods: This study was an analytical observational study using medical record data. In this study, an assessment of N, BMI and Karnofsky status of NPC WHO type 3 patients who had undergone neoadjuvant chemotherapy using the Cisplatin and 5-Fu regimen for three cycles. Twenty-three study subjects were analyzed for N, BMI and Karnofksy status changes while undergoing neoadjuvant chemotherapy for up to 3 cycles. Result: The N value decreased, p = 0.001. BMI value decreased, p = 0.615. Karnofsky's status value experienced insignificant changes, p = 0.564. The correlation between N and BMI before a cycle I neoadjuvant chemotherapy and three cycles of neoadjuvant chemotherapy obtained r = -0.201 and p = 0.358, respectively; r = -0.070 and p = 0.751. Correlation of N with Karnofsky status was obtained r = 0.155 and p = 0.480, before cycle I neoadjuvant chemotherapy. The correlation between N and Karnofsky status was obtained r = 0.571 and p = 0.004 after cycle III neoadjuvant chemotherapy. Conclusion: Neoadjuvant chemotherapy Cisplatin and 5-Fu is effective against changes in N and correlation between N and BMI but less effective in assessing the correlation between N and Karnofsky status after three cycles of neoadjuvant chemotherapy. Correspondence should be addressed to Bagus Harning Efranto; [email protected]

scholarly journals Evaluation of Body Mass Index and Survival of Nasopharyngeal Carcinoma by Propensity-Matched Analysis

Medicine ◽  
2016 ◽  
Vol 95 (2) ◽  
pp. e2380 ◽  
Author(s):  
Pu-Yun OuYang ◽  
Lu-Ning Zhang ◽  
Jie Tang ◽  
Xiao-Wen Lan ◽  
Yao Xiao ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Nasopharyngeal Carcinoma ◽  
Body Mass

Mechanical effects of obesity on airway responsiveness in otherwise healthy humans

2009 ◽  
Vol 107 (2) ◽  
pp. 408-416 ◽  
Author(s):  
Roberto Torchio ◽  
Alessandro Gobbi ◽  
Carlo Gulotta ◽  
Raffaele Dellacà ◽  
Marco Tinivella ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lung Function ◽  
Body Mass ◽  
Airway Hyperresponsiveness ◽  
Healthy Subjects ◽  
Rest Period ◽  
Healthy Humans ◽  
Before And After ◽  
Maximum Expiratory Flow ◽  
Residual Capacity

We investigated whether obesity is associated with airway hyperresponsiveness in otherwise healthy humans and, if so, whether this correlates with a restrictive lung function pattern or a decreased number of sighs at rest and/or during walking. Lung function was studied before and after inhaling methacholine (MCh) in 41 healthy subjects with body mass index ranging from 20 to 56. Breathing pattern was assessed during a 60-min rest period and a 30-min walk. The dose of MCh that produced a 50% decrease in the maximum expiratory flow measured in a body plethysmograph (PD50MCh) was inversely correlated with body mass index ( r2 = 0.32, P < 0.001) and waist circumference ( r2 = 0.25, P < 0.001). Significant correlations with body mass index were also found with the maximum changes in respiratory resistance ( r2 = 0.19, P < 0.001) and reactance ( r2 = 0.40, P < 0.001) measured at 5 Hz. PD50MCh was also positively correlated with functional residual capacity ( r2 = 0.56, P < 0.001) and total lung capacity ( r2 = 0.59, P < 0.001) in men, but not in women. Neither PD50MCh nor body mass index correlated with number of sighs, average tidal volume, ventilation, or breathing frequency. In this study, airway hyperresponsiveness was significantly associated with obesity in otherwise healthy subjects. In obese men, but not in women, airway hyperresponsiveness was associated with the decreases in lung volumes.

Long-term mild jogging increases insulin action despite no influence on body mass index or VO2 max

1989 ◽  
Vol 66 (5) ◽  
pp. 2206-2210 ◽  
Author(s):  
Y. Oshida ◽  
K. Yamanouchi ◽  
S. Hayamizu ◽  
Y. Sato
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Clearance Rate ◽  
Insulin Action ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Before And After ◽  
Plasma Insulin Levels ◽  
Improve Glucose Tolerance

Physical training has been shown to improve glucose tolerance and insulin sensitivity. In the present study, insulin action was determined using the euglycemic clamp technique in six untrained nonobese subjects before, during, and after long-term mild regular jogging. After 1 yr of jogging, steady-state plasma insulin levels (I) decreased significantly, and the metabolic clearance rate of insulin was increased by 87%, although insulin infusion rate during the clamp was constant for each individual. The amount of glucose infused (glucose metabolism, M) tended to increase from 6.16 +/- 0.94 to 8.15 +/- 1.94 mg.kg-1.min-1 after regular jogging for 1 yr, although that was not statistically significant. However, M/I increases significantly from 0.060 +/- 0.012 to 0.184 +/- 0.056 (P less than 0.05) after 1 yr. The concentrations of plasma free fatty acids during the hyperinsulinemic clamp decreased more significantly after 1 yr of jogging (P less than 0.05). The concentrations of plasma glycerol decreased gradually before and after long-term regular jogging, showing only a 50–60% reduction in 120 min. Therefore, long-term mild regular jogging, which did not influence either body mass index or maximal O2 uptake, appears to improve insulin action in both carbohydrate and lipid metabolism and to increase the metabolic clearance rate of insulin.

Three Wheel Bike as Physical Therapy Equipment for Post-Stroke Patient

2015 ◽  
Vol 776 ◽  
pp. 337-342 ◽  
Author(s):  
I. Made Londen Batan ◽  
Rodika ◽  
Muhamad Riva'i
Keyword(s):  
Body Mass Index ◽  
Energy Consumption ◽  
Physical Therapy ◽  
Body Mass ◽  
Stroke Patient ◽  
Stroke Patients ◽  
Post Stroke ◽  
A Value ◽  
Risk Of Injury ◽  
Before And After

Three wheel bike as a physical therapy equipment for post-stroke patients was designed with length of 1937 mm, 1010 mm in width and height of 905 mm. The bike is designd ergonomic and can be driven by rider foot or hand simultaneously. By using CATIA software the strength of material bike frame was analyst to support 100 kg of load. The design is realized into a prototype. The performance of bike prototype is tested, and the result sows that the function of bike mechanisme is fulfilled. By 10 respondents, who have a standard body mass index, the pedal test was conducted, and the result indicates that, the higher the speed of the pedal, the higher the energy consumption to pedaling. Leg tension muscles is measured by leg-dynamometer before and after pedaling, and the result shows the tension muscle is proportional to the increase of pedal speed. In order to evaluate the ergonomic aspect of bike design, the risk angle of extrem position of body during cycling are measured by goneo-set. By RULA method the risk of injury value of rider body is calculated while pedaling, and the result showed that 70% of respondents have a value of risk injury 2, while 30% had a value of 3. It means that, the bike design is ergonomic and comfortable to ride. In oder to evaluate the benefits of disigned bike, the pedal test is conducted by 4 post-stroke patients for 30 days periodical once every 3 days. The result shows that during 1 month exercise, the average number of cycling to pedal increase up to 100%. This means that the ability of post-stroke patients to pedal the bike increase significantly. That result showed that the bike design is useful as a tool for physical therapy post-stroke patients.

scholarly journals A High-Fat Diet Elicits Differential Responses in Genes Coordinating Oxidative Metabolism in Skeletal Muscle of Lean and Obese Individuals

2011 ◽  
Vol 96 (3) ◽  
pp. 775-781 ◽  
Author(s):  
K. E. Boyle ◽  
J. P. Canham ◽  
L. A. Consitt ◽  
D. Zheng ◽  
T. R. Koves ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Mass Index ◽  
Lipid Oxidation ◽  
Body Mass ◽  
High Fat Diet ◽  
High Fat ◽  
Insulin Resistant ◽  
Before And After ◽  
Mrna Content ◽  
Obese Subjects

Context: In lean individuals, increasing dietary lipid can elicit an increase in whole body lipid oxidation; however, with obesity the capacity to respond to changes in substrate availability appears to be compromised. Objective: To determine whether the responses of genes regulating lipid oxidation in skeletal muscle differed between lean and insulin resistant obese humans upon exposure to a high-fat diet (HFD). Design and Setting: A 5-d prospective study conducted in the research unit of an academic center. Participants: Healthy, lean (n = 12; body mass index = 22.1 ± 0.6 kg/m2), and obese (n=10; body mass index = 39.6 ± 1.7 kg/m2) males and females, between ages 18 and 30. Intervention: Participants were studied before and after a 5-d HFD (65% fat). Main Outcome Measures: Skeletal muscle biopsies (vastus lateralis) were obtained in the fasted and fed states before and after the HFD and mRNA content for genes involved with lipid oxidation determined. Skeletal muscle acylcarnitine content was determined in the fed states before and after the HFD. Results: Peroxisome proliferator activated receptor (PPAR) α mRNA content increased in lean, but not obese, subjects after a single high-fat meal. From Pre- to Post-HFD, mRNA content exhibited a body size × HFD interaction, where the lean individuals increased while the obese individuals decreased mRNA content for pyruvate dehydrogenase kinase 4, uncoupling protein 3, PPARα, and PPARγ coactivator-1α (P ≤ 0.05). In the obese subjects medium-chain acylcarnitine species tended to accumulate, whereas no change or a reduction was evident in the lean individuals. Conclusions: These findings indicate a differential response to a lipid stimulus in the skeletal muscle of lean and insulin resistant obese humans.

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