scholarly journals SCREENING FOR CONGENITAL HYPOTHYROIDISM AND THE ASSOCIATION OF CONGENITAL HYPOTHYROIDISM WITH SCREENING THYROID-STIMULATING HORMONE LEVELS OF 10–20 MIU/L AMONG INBORN NEONATES IN A GOVERNMENT TERTIARY CARE HOSPITAL OF NORTH KERALA

2019 ◽  
Vol 06 (04) ◽  
pp. 431-434
Author(s):  
AMBILI SUSAN JACOB . ◽  
REETHA GOPINATH . ◽  
BINOO DIVAKARAN .
Keyword(s):  
Congenital Hypothyroidism ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals Perinatal variables influencing cord blood thyroid stimulating hormone

2018 ◽  
Vol 5 (4) ◽  
pp. 1537 ◽  
Author(s):  
Manasi D. Garg ◽  
Poornima Kumar ◽  
Sakthi Abirami ◽  
Manikandan M. ◽  
Lalitha Krishnan
Keyword(s):  
Newborn Screening ◽  
Cord Blood ◽  
Congenital Hypothyroidism ◽  
Gestational Age ◽  
Maternal Age ◽  
Tertiary Care ◽  
Mode Of Delivery ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Stimulating Hormone

Background: Newborn screening using cord blood Thyroid Stimulating Hormone (TSH) is an effective and an easy way to screen babies for congenital hypothyroidism. Congenital hypothyroidism is a common preventable and treatable cause of mental retardation. Early diagnosis with the help of newborn screening aids in timely management and decreased morbidity. Various maternal and neonatal variables can affect cord blood TSH level thereby affecting the accurate diagnosis of congenital hypothyroidism. This study aims at studying the perinatal variables affecting cord blood TSH.Methods: In a retrospective cross-sectional study conducted in a tertiary care hospital, the hospital case records of 1465 newborn and their mother were studied for variables including cord blood TSH, maternal age, mode of delivery, parity, gender of baby, gestational age and growth of baby. The effect of these perinatal variables on cord blood TSH was analysed statistically. P value below 0.05 was considered as statistically significant. The statistical analysis was done used the SPSS software version 18.0.Results: The median cord blood TSH was 8 microIU/ml (IQR= 6-12) with 8.1% newborns having values more than 20 microIU/ml. Cord blood TSH was significantly raised in male babies (p <0.01) and in neonates born by assisted vaginal delivery (p <0.01).  Significant increase in cord blood TSH (p <0.02) was observed in neonates born to primiparous mothers. Maternal age, gestational age of the newborn and growth of the newborn did not have significant effect on cord blood TSH values.Conclusions: The mode of delivery, parity and gender of the baby were found to be significant variables affecting cord blood TSH values. Hence, cord blood TSH values should be interpreted in the light of these perinatal variables.

Prevalence of Congenital Hypothyroidism and G6PD Deficiency in Newborns in a Tertiary Care Hospital of Central India

2021 ◽  
pp. 097321792098771
Author(s):  
Suprava Patel ◽  
Ritu Priya ◽  
Phalguni Padhi ◽  
Tripty Naik ◽  
Jessy Abraham ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Tertiary Care Hospital ◽  
Screening Program ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Enzyme Deficiency ◽  
Screening Tests ◽  
Care Hospital ◽  
Cross Sectional ◽  
Diagnostic Center

Objectives: The fundamental prerequisite of a screening program is the accessible epidemiological data regarding disease burden and awareness regarding the disorder. This is the foremost study in this state to estimate the burden of congenital hypothyroidism (CH) and glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency in infants born or attending a tertiary care hospital, pursuing skill development for the technical staffs, and creating awareness for parents. Study Design: A cross-sectional study for 21 months was conducted in the Department of Biochemistry in collaboration with the Department of Pediatrics and Department of Obstetrics and Gynecology. Methods: The screening was conducted on 1282 babies, 48 hours subsequent to birth and up to 8 weeks of age. The dried blood spot specimens collected were analyzed for thyroid stimulating hormone (TSH) level and G6PD enzyme activity by fluoroimmunoassay method. Prevalence was calculated by percentage. Results: The proficiency of the program for all live birth babies delivered in the institute was 94.6%. In consequence to improper sampling, 4.1% samples could not be analyzed. The screening tests reported elevated TSH levels in 1.6% of total population and G6PD enzyme deficiency in 2.6% of all babies enrolled. Confirmatory tests revealed that 4 (3.1/1000) babies were declared positive for CH and 8 (6.2/1000) were announced to be G6PD deficient. Conclusion: The new prevalence observed is one of the highest prevalence of CH published in India that urges mandatory and immediate need for development of newborn screening program in the state, and improvisation and upgradation of regional diagnostic center with facilities for primary- and secondary-level testing.

Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels

2018 ◽  
Vol 55 (12) ◽  
pp. 1059-1061 ◽  
Author(s):  
Maria Scavone ◽  
Elena Carboni ◽  
Ettore Stefanelli ◽  
Giusy Romano ◽  
Anna Vero ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10 μIU/mL have congenital hypothyroidism

2017 ◽  
Vol 93 (6) ◽  
pp. 649-654 ◽  
Author(s):  
Flávia C. Christensen-Adad ◽  
Carolina T. Mendes-dos-Santos ◽  
Maura M.F. Goto ◽  
Letícia E. Sewaybricker ◽  
Lília F.R. D'Souza-Li ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Filter Paper ◽  
Neonatal Screening ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals Thyroid Status in Patients with Dysfunctional Uterine Bleeding in a Tertiary Care Hospital of Assam

2016 ◽  
Vol 20 (1) ◽  
pp. 11-15
Author(s):  
Jadab K Phukan ◽  
Gautom K Saharia ◽  
Rohini Goswami
Keyword(s):  
Menstrual Cycle ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Clinical History ◽  
Thyroid Stimulating Hormone ◽  
Uterine Bleeding ◽  
Care Hospital ◽  
Thyroid Status ◽  
Dysfunctional Uterine Bleeding

ABSTRACT Background Dysfunctional uterine bleeding (DUB) is a major form of abnormal uterine bleeding, seen in at least 10% of all new outpatient department patients. The thyroid gland is known to play an important role in maintaining a healthy menstrual cycle. Aims To assess the thyroid hormone status in apparently euthyroid patients with DUB and to correlate it with incidence of DUB. Materials and methods Fifty DUB patients were selected on the basis of clinical history, examination, and relevant investigations. Equal numbers of age-matched women with normal menstrual cycle were taken as controls. Thyroid hormones, viz., thyroid-stimulating hormone, total triiodothyronine and tetraiodothyronine, were estimated by radioimmunoassay. Statistical analysis of the data was performed by using Microsoft Excel software. Results The most common menstrual abnormality was menorrhagia (48%) followed by metrorrhagia and polymenorrhea (14% each). Hypothyroidism was more prevalent among cases (85.7%) as compared with controls (14.3%). In patients with menorrhagia, 33.3% of patients had hypothyroidism. Conclusion Hypothyroidism occurs in DUB patients commonly. There is a need for mandatory thyroid screening in all patients with menstrual irregularities to help in early detection of the cause and treatment of DUB patients to avoid surgery. How to cite this article Phukan JK, Saharia GK, Goswami R. Thyroid Status in Patients with Dysfunctional Uterine Bleeding in a Tertiary Care Hospital of Assam. Indian J Med Biochem 2016;20(1):11-15.

scholarly journals Thyroid status and treatment responses of hypothyroid infertile women: a study in a tertiary care hospital of Bangladesh

2021 ◽  
Vol 8 (5) ◽  
pp. 1450
Author(s):  
A. H. M. Aktaruzzaman ◽  
Afsar Ahmmed ◽  
Sabina Yasmin ◽  
M. Shafiqul Islam Dewan
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Reproductive Age ◽  
Care Hospital ◽  
Thyroid Status ◽  
Infertile Women ◽  
Orthopedic Rehabilitation ◽  
Treatment Responses ◽  
Reproductive Age Group

Background: Recently, the prevalence of hypothyroidism in the reproductive age group is found up to 4%. In many studies it had been claimed that, thyroid status is directly involved in women reproductive system. Hypothyroidism can be easily detected by assessing serum thyroid stimulating hormone (TSH) levels. The aim of this study was to dig out the prevalence of hypothyroidism in infertile women and to assess their responses in treatment procedures.Methods: This observational study was conducted National Institute of Traumatology and Orthopedic Rehabilitation (NITOR), Dhaka, Bangladesh during the period from January 2019 to December 2019 in total 236 women of Endocrinology Department treatment. Patients were followed up for six months even if pregnancy was attained.Results: In total 22% (n=52) patients were hypothyroid. Among them 35 (15%) were subclinical hypothyroid and 17 (7%) were frank hypothyroid. Besides these, 73% (n=172) were euthyroid and the rest 5% (n=12) were hyperthyroid. On the other hand, in analysing the outcome (treatment responses) among the hypothyroid subjects we observed regular menstruation, normal ovulation, clinical pregnancy and chemical pregnancy were achieved by 92.31% (n=48), 88.46% (n=46), 50% (n=26) and 69.23% (n=36) subjects respectively.Conclusions: According to the study, the careful diagnosis and treatment of hypothyroidism can ensure benefit a lot rather than going for unnecessary hormone assays and costly invasive procedures in for women of infertility.

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