Prevalence of Congenital Hypothyroidism and G6PD Deficiency in Newborns in a Tertiary Care Hospital of Central India

2021 ◽  
pp. 097321792098771
Author(s):  
Suprava Patel ◽  
Ritu Priya ◽  
Phalguni Padhi ◽  
Tripty Naik ◽  
Jessy Abraham ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Tertiary Care Hospital ◽  
Screening Program ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Enzyme Deficiency ◽  
Screening Tests ◽  
Care Hospital ◽  
Cross Sectional ◽  
Diagnostic Center

Objectives: The fundamental prerequisite of a screening program is the accessible epidemiological data regarding disease burden and awareness regarding the disorder. This is the foremost study in this state to estimate the burden of congenital hypothyroidism (CH) and glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency in infants born or attending a tertiary care hospital, pursuing skill development for the technical staffs, and creating awareness for parents. Study Design: A cross-sectional study for 21 months was conducted in the Department of Biochemistry in collaboration with the Department of Pediatrics and Department of Obstetrics and Gynecology. Methods: The screening was conducted on 1282 babies, 48 hours subsequent to birth and up to 8 weeks of age. The dried blood spot specimens collected were analyzed for thyroid stimulating hormone (TSH) level and G6PD enzyme activity by fluoroimmunoassay method. Prevalence was calculated by percentage. Results: The proficiency of the program for all live birth babies delivered in the institute was 94.6%. In consequence to improper sampling, 4.1% samples could not be analyzed. The screening tests reported elevated TSH levels in 1.6% of total population and G6PD enzyme deficiency in 2.6% of all babies enrolled. Confirmatory tests revealed that 4 (3.1/1000) babies were declared positive for CH and 8 (6.2/1000) were announced to be G6PD deficient. Conclusion: The new prevalence observed is one of the highest prevalence of CH published in India that urges mandatory and immediate need for development of newborn screening program in the state, and improvisation and upgradation of regional diagnostic center with facilities for primary- and secondary-level testing.

scholarly journals Colposcopic Findings among VIA Positive Women: Experience at a Tertiary Care Hospital

2014 ◽  
Vol 1 (1) ◽  
pp. 8-12
Author(s):  
Farzana Rabee Choudhury ◽  
ABM Zakir Uddin ◽  
M Abdullah Yusuf
Keyword(s):  
Tertiary Care Hospital ◽  
Screening Program ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Number Of Patients ◽  
The Status ◽  
Cervical Cancer Screening Program

Background: Visual inspections of the cervix after acetic acid application (VIA) are widely recommended as the method of choice in cervical cancer screening program in resource-limited settings.Objective: The purpose of the present study was to see the status of VIA test result at a tertiary care hospital. Methodology: This cross sectional study was carried out at Shaheed Suhrawardy Medical College, Dhaka and Dhaka Medical College, Dhaka from April 2012 to March 2013 for a period of one year. VIA was performed and colposcopy was done among the VIA positive patients.Results: A total number of 65 VIA positive patients were evaluated colposcopically In all VIA positive patients, colposcopically positive was in 47.7% cases. Among colposcopically positive patients CIN-I was 27.69%; CIN-II was 18.46% and CIN-III was 1.54%. Conclusion: VIA test is positive in a high number of patients which has a great number of abnormalities were found.DOI: http://dx.doi.org/10.3329/jcamr.v1i1.19559J Curr Adv Med Res 2014;1(1):8-12]

scholarly journals Study of the prevalence of G6PD deficiency in the RBCs of new borns

2020 ◽  
Vol 11 (3) ◽  
pp. 4016-4023
Author(s):  
Surbhi Garg ◽  
Joag G. G.
Keyword(s):  
G6pd Deficiency ◽  
Tertiary Care Hospital ◽  
Screening Program ◽  
Tertiary Care ◽  
Age Distribution ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Newborn Screening Program ◽  
Cross Sectional ◽  
High Prevalence

This study we attempt to search the need for a newborn screening program for G6PD deficiency because of high prevalence in some areas and no such study was done in part of Maharashtra. Also routinely administered vitamin K prophylaxis can cause hemolysis in G6PD deficient newborns and may prove potentially fatal, which can be prevented if babies are screened for G6PD deficiency. The current study was a retrospective cross-sectional study conducted to determine the prevalence of G6PD deficiency in Red Blood Cells of born live neonates in tertiary care hospital. The research was performed at a tertiary care hospital with the 350 newborns, showing the age distribution of newborns revealed that the highest number of newborns was in the age group of 0-10 hours (96.29 percent). Of the 350 newborns, 181 (51.71 percent) were females and 169 (48.29 percent) were males and the ratio of females to males was 1.07:1. Many newborns had between 2500-3000 g (52.86 percent) of birth weight led by > 3000 g (28 percent) and < 2500 g (19.14 percent). The majority of newborns were Hindu by religion (67.14%) followed by Muslims (22.86%), Buddhists (6%), as well as other religions (4%). Most of the newborns came from 1st gravida (42.86%) and led by 2nd gravida (37.14%)

Confidence toward vaccination as reported by parents of children admitted to a tertiary care hospital in Riyadh, Saudi Arabia: A cross sectional study

Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Association of Rugae Pattern with Skeletal Malocclusion in Orthodontic Patients Visiting Tertiary Care Hospital

2020 ◽  
Author(s):  
Sarwat Memon
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Class Iii ◽  
Chi Square ◽  
Cross Sectional ◽  
Skeletal Malocclusion ◽  
Palatal Rugae ◽  
Significant Difference ◽  
Orthodontic Patients

Background: The palatal rugae are special constructions that are inalterable in their position and pattern during the lifestyles of an individual. This imparts them an exceptional role in the forensic dentistry and may play potential role in malocclusion identification. This study was aimed to see association of rugae pattern with sagittal skeletal malocclusion in orthodontic patients visiting tertiary care hospital. Methods: This cross-sectional examination was completed on pretreatment records (lateral Cephalometric radiographs and maxillary dental casts) of 384 subjects at the orthodontic department of Ziauddin Dental Hospital, Karachi. The study duration was from January to July 2019. The samples were sub-divided into three sagittal skeletal groups based on ANB angle proposed by Steiner’s on lateral Cephalometric radiographs (Class I with ANB angle between 0° to 4°; Class II: ANB angle greater than 5°; Class III: ANB angle less than 0°). The shapes of three most-anterior primary rugae were then evaluated bilaterally using Kapali et al., Classification. Chi Square test was applied to find association of rugae pattern among sagittal skeletal malocclusions groups. Results: Circular and curved rugae shapes were the most prevalent in all skeletal malocclusions. The primary palatal rugae pattern was seen to be significantly different among three skeletal malocclusion groups (p<0.05). The right and left sided palatal rugae pattern showed significant difference in all three skeletal malocclusion groups (p<0.05). Conclusion: The present study showed no specific palatal rugae pattern associated with sagittal skeletal malocclusion. Further studies on larger sample and use of modern 3D technologies to scan the maxillary casts are required for results that are more precise.

A Cross-sectional Study of Undiagnosed Fever in a Rural Population at a Tertiary Care Hospital of West Bengal

2018 ◽  
Vol 4 (3) ◽  
Author(s):  
Nandini Chatterjee ◽  
Supratick Chakraborty ◽  
Mainak Mukhopadhyay ◽  
Sinjon Ghosh ◽  
Bikramjit Barkandaj ◽  
...  
Keyword(s):  
Rural Population ◽  
West Bengal ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Virulence factors associated with organisms causing asymptomatic bacteriuria in pregnant females attending a tertiary care hospital

2017 ◽  
Vol 6 (05) ◽  
pp. 5373
Author(s):  
Prabha Ponnusamy* ◽  
Radhika Katragadda ◽  
Thyagarajan Ravinder
Keyword(s):  
Virulence Factors ◽  
Host Defense ◽  
Virulence Factor ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Asymptomatic Bacteriuria ◽  
Phenotypic Expression ◽  
Care Hospital ◽  
Cross Sectional ◽  
Pregnant Females

Asymptomatic bacteriuria (ASB), most common during pregnancy is endangering as it may lead to maternal and fetal complications. Various organisms causing ASB combats the host defense mechanisms through virulence factors exhibited by them. In order to understand the pathogenesis and sequelae of infections, virulence factors like hemolysin production, gelatinase production, haemagglutination, biofilm production and many more should be identified. Hence, we aimed at studying the distribution of virulence factors among each organism causing asymptomatic bacteriuria in pregnant females attending a tertiary care hospital. Materials and Methods: This cross-sectional study was conducted in Department of Microbiology over a period of one year and six months (January 2014 to June 2015) at a tertiary care teaching hospital. A total of 1000 urine samples were included in study taken from pregnant women with asymptomatic bacteriuria. Isolation, identification of organisms was done according to standard microbiological techniques and virulence factors for individual organisms by phenotypic method were tested. Results: Out of 1000 samples screened for ASB, organisms were isolated in following frequency distribution: Escherichia coli, the commonest 54/118 (45.76%), Klebsiella pneumoniae 21/118 (17.80%), Staphylococcus aureus 19/118 (16.10%), Staphylococcus saprophyticus 10/118 (8.45%), Enterococcus faecalis 9/118 (7.63%), Pseudomonas aeruginosa 3/118 (2.54%) and Proteus mirabilis 2/118 (1.69%). Virulence factors for individual organisms and biofilm detection for all organisms were done. Conclusion: Multifactorial mechanisms determine the pathogenicity of an organism and it needs to be explored by analyzing each virulence factor and mechanism of invasion in combating the host defense systems. Hence analyzing the phenotypic expression of each virulence factor helps in better understanding about the complications of ASB.

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