scholarly journals Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography

2021 ◽  
Author(s):  
Valentin Demidov
Keyword(s):  
Optical Coherence Tomography ◽  
Soft Tissues ◽  
Low Frequency ◽  
Depth Resolution ◽  
Biological Tissues ◽  
Phase Changes ◽  
Optical Coherence ◽  
Ac Electric Field ◽  
Novel Approach ◽  
Phase Images

This thesis reports on developing a novel approach to imaging the electro-kinetic response of biological tissues with optical coherence tomography (OCT). The changes of backscattered OCT signal from tissues were investigated with a low frequency AC electric field being applied to the tissues. Advanced processing algorithms were developed to analyze the amplitude and phase changes of OCT signal. Two-dimensional electrically induced optical changes (EIOC) amplitude and phase images related to the electro-kinetic response of soft tissues were obtained with depth resolution and compared with structural OCT images. The procedure for removing the background noise from EIOC images was introduced.

scholarly journals Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography

2021 ◽  
Author(s):  
Valentin Demidov
Keyword(s):  
Optical Coherence Tomography ◽  
Soft Tissues ◽  
Low Frequency ◽  
Depth Resolution ◽  
Biological Tissues ◽  
Phase Changes ◽  
Optical Coherence ◽  
Ac Electric Field ◽  
Novel Approach ◽  
Phase Images

This thesis reports on developing a novel approach to imaging the electro-kinetic response of biological tissues with optical coherence tomography (OCT). The changes of backscattered OCT signal from tissues were investigated with a low frequency AC electric field being applied to the tissues. Advanced processing algorithms were developed to analyze the amplitude and phase changes of OCT signal. Two-dimensional electrically induced optical changes (EIOC) amplitude and phase images related to the electro-kinetic response of soft tissues were obtained with depth resolution and compared with structural OCT images. The procedure for removing the background noise from EIOC images was introduced.

Imaging the electro-kinetic response of biological tissues with phase-resolved optical coherence tomography

2014 ◽  
Vol 3 (4) ◽  
Author(s):  
Valentin Demidov ◽  
Vladislav Toronov ◽  
Yuan Xu ◽  
Barry Vuong ◽  
Carry Sun ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Electric Field ◽  
Low Frequency ◽  
Biological Tissues ◽  
Optical Coherence ◽  
Phase Images ◽  
Speckle Patterns ◽  
Phase Variations ◽  
And Function

AbstractIn this study, the electro-kinetic phenomena (EKP) induced in biological tissue by external electric field, while not directly visible in optical coherence tomography (OCT) images, were detected by analyzing their textural speckle features. During application of a low-frequency electric field to the tissue, speckle patterns changed their brightness and shape depending on the local tissue EKP. Since intensities of OCT image speckle patterns were analyzed and discussed in our previous publications, this work is mainly focused on OCT signal phase analysis. The algorithm for extracting local spatial phase variations from unwrapped phases is introduced. The detection of electrically induced optical changes manifest in OCT phase images shows promise for monitoring the fixed charge density changes within tissues through their electro-kinetic responses. This approach may help in the identification and characterization of morphology and function of healthy and pathologic tissues.

Imaging of the interaction of low-frequency electric fields with biological tissues by optical coherence tomography

2013 ◽  
Vol 38 (14) ◽  
pp. 2629 ◽  
Author(s):  
Adrian F. Peña ◽  
Jack Devine ◽  
Alexander Doronin ◽  
Igor Meglinski
Keyword(s):  
Optical Coherence Tomography ◽  
Electric Fields ◽  
Low Frequency ◽  
Biological Tissues ◽  
Optical Coherence

Polarization contrast imaging of biological tissues by polarization-sensitive Fourier-domain optical coherence tomography

2006 ◽  
Vol 45 (6) ◽  
pp. 1142 ◽  
Author(s):  
Shuichi Makita ◽  
Yoshiaki Yasuno ◽  
Takashi Endo ◽  
Masahide Itoh ◽  
Toyohiko Yatagai
Keyword(s):  
Optical Coherence Tomography ◽  
Biological Tissues ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Contrast Imaging ◽  
Polarization Contrast

Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography

2021 ◽  
Author(s):  
Marino de Jesus Maciel ◽  
Hugo M Pereira ◽  
Sara Pimenta ◽  
Alice Miranda ◽  
Eduardo Jorge Nunes-Pereira ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Attenuation Coefficient ◽  
Light Attenuation ◽  
Biological Tissues ◽  
Mammary Glands ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Subjective Analysis ◽  
Coefficient Estimation ◽  
Cross Sectional Imaging

Abstract Optical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary mouse glands with the OCT attenuation coefficient. Using several OCT images of normal and tumor mammary mouse glands (n=26), a statistical analysis was performed. The attenuation coefficient was calculated in depth, considering a slope of 0.5 mm. The normal glands present a median attenuation coefficient of 0.403 mm-1, comparatively to 0.561 mm-1 obtained for tumor mammary glands. This translates in an attenuation coefficient approximately 39 % higher for tumor mammary glands when compared to normal mammary glands. The OCT attenuation coefficient estimation eliminates the subjective analysis provided by direct visualization of the OCT images.

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