Predicting Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infection Incidence Rates using Canadian Nosocomial Infection Surveillance Program (CNISP)

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Jona Gjevori ◽  
Kahina Abdesselam
Keyword(s):  
Public Health ◽  
Staphylococcus Aureus ◽  
Nosocomial Infection ◽  
Bloodstream Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Incidence Rates ◽  
Surveillance Program ◽  
Methicillin Resistant ◽  
Infection Surveillance ◽  
Healthcare Associated

Methicillin-Resistant Staphylococcus aureus (MRSA) is among the most prevalent nosocomial pathogens globally, causing significant morbidity, mortality, and healthcare costs. MRSA bloodstream infection (BSI) incidence rates in Canadian hospitals have significantly risen by almost 60% and have a mortality of over 20% upon Intensive Care Unit admission. MRSA is believed to be spread through healthcare workers; thus, high hand hygiene compliancy in addition to environmental cleaning are the cornerstone countermeasures to disrupting its transmission. The Public Health Agency of Canada (PHAC), in collaboration with the Canadian Nosocomial Infection Surveillance Program (CNISP), conducts national, sentinel surveillance on healthcare-associated infections like MRSA. As a Student Epidemiologist, I developed a research proposal detailing two study objectives: 1) develop a regression model to predict all incident MRSA BSI rates among acute-care hospitals in Canada using CNISP MRSA BSI incident cases from 2000 to 2019, and 2) create a compartmental (Susceptible-Infected-Recovered-Deceased) model to determine the impact of various Infection Prevention and Control (IPC) measures on the risk of healthcare-associated MRSA BSI transmission specifically. This study hopes to demonstrate that proper IPC compliance is associated with lower incident MRSA BSI rates with the goal being to produce a manuscript draft by 2021. MRSA poses a serious threat to patient safety globally and is becoming a growing national public health concern in Canada; determining which IPC strategy is most effective at disrupting MRSA transmission is essential to reducing incidence and mortality rates.

scholarly journals Methicillin-Resistant Staphylococcus aureus Bloodstream Infection Surveillance: National Healthcare Safety Network’s Laboratory-Identified Event Reporting versus Traditional Laboratory-Confirmed Bloodstream Infection Surveillance

2014 ◽  
Vol 35 (10) ◽  
pp. 1286-1289 ◽  
Author(s):  
Arthur W. Baker ◽  
Michael J. Durkin ◽  
Kristen V. Dicks ◽  
Sarah S. Lewis ◽  
Rebekah W. Moehring ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bloodstream Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Healthcare Facility ◽  
Event Reporting ◽  
Methicillin Resistant ◽  
National Healthcare ◽  
Infection Surveillance ◽  
Staphylococcus Aureus Bloodstream Infection ◽  
Traditional Surveillance

Hospitals must report cases of methicillin-resistant Staphylococcus aureus bloodstream infection (BSI) using a new laboratory-identified (LabID) event reporting module. BSI rates obtained using LabID differ from rates of BSI obtained from traditional surveillance (concordance of healthcare facility–onset cases, 61%–76%) because definitions used to report LabID events are inconsistent with traditional BSI definitionsInfect Control Hosp Epidemiol 2014;35(10):1286–1289

Incidence and Epidemiology of Methicillin-Resistant Staphylococcus aureus Infection in a Saudi Arabian Hospital, 1999-2003

2006 ◽  
Vol 27 (10) ◽  
pp. 1137-1139 ◽  
Author(s):  
Jaffar A. Al-Tawfiq
Keyword(s):  
Staphylococcus Aureus ◽  
Nosocomial Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Saudi Arabian ◽  
The Other ◽  
Healthcare Associated Infection ◽  
Methicillin Resistant ◽  
Aureus Infection ◽  
Healthcare Associated ◽  
Community Acquired Infection

During 1999-2003 in a Saudi Arabian Hospital, methicillin-resistant Staphylococcus aureus constituted 6% of all S. aureus isolates; the proportion had increased from 2% in 1999, to 9.7% in 2002, to 8% in 2003. Of all MRSA isolates, 62% represented community-acquired infection, 20.4% represented healthcare-associated infection, and 17.6% represented nosocomial infection. The proportion of community-acquired isolates increased from 41.7% in 1999 to 66.6% in 2002, and the proportion representing nosocomial infection decreased from 33% in 1999 to 19% in 2003. Isolates representing nosocomial infection showed higher rates of resistance to ciprofloxacin (76.6%), clindamycin (76.6%), erythromycin (68%) and trimethoprim-sulfamethoxazole (68%) than did isolates in the other categories (P<.001).

scholarly journals Methicillin-resistant Staphylococcus aureus bloodstream infection: risk factors and clinical outcome in non-intensive-care units

2012 ◽  
Vol 45 (2) ◽  
pp. 189-193 ◽  
Author(s):  
Karinne Spirandelli Carvalho Naves ◽  
Natália Vaz da Trindade ◽  
Paulo Pinto Gontijo Filho
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Bloodstream Infection ◽  
Antimicrobial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bloodstream Infection

INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is spread out in hospitals across different regions of the world and is regarded as the major agent of nosocomial infections, causing infections such as skin and soft tissue pneumonia and sepsis. The aim of this study was to identify risk factors for methicillin-resistance in Staphylococcus aureus bloodstream infection (BSI) and the predictive factors for death. METHODS: A retrospective cohort of fifty-one patients presenting bacteraemia due to S. aureus between September 2006 and September 2008 was analysed. Staphylococcu aureus samples were obtained from blood cultures performed by clinical hospital microbiology laboratory from the Uberlândia Federal University. Methicillinresistance was determined by growth on oxacillin screen agar and antimicrobial susceptibility by means of the disk diffusion method. RESULTS: We found similar numbers of MRSA (56.8%) and methicillin-susceptible Staphylococcus aureus (MSSA) (43.2%) infections, and the overall hospital mortality ratio was 47%, predominantly in MRSA group (70.8% vs. 29.2%) (p=0.05). Age (p=0.02) was significantly higher in MRSA patients as also was the use of central venous catheter (p=0.02). The use of two or more antimicrobial agents (p=0.03) and the length of hospital stay prior to bacteraemia superior to seven days (p=0.006) were associated with mortality. High odds ratio value was observed in cardiopathy as comorbidity. CONCLUSIONS: Despite several risk factors associated with MRSA and MSSA infection, the use of two or more antimicrobial agents was the unique independent variable associated with mortality.

scholarly journals CIRCULATING CLONES OF COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (CA-MRSA) IN WESTERN AUSTRALIA IN THE PAST 11 YEARS (2002-2013)

2016 ◽  
Vol 78 (5) ◽  
Author(s):  
A. M. Setiawan
Keyword(s):  
Public Health ◽  
Staphylococcus Aureus ◽  
Disease Prevention ◽  
Infection Control ◽  
Western Australia ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Health Concerns ◽  
The Past ◽  
Mrsa Strains

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most complicated problems in infection control and disease prevention. Imported strains or group of similar strains called clones were introduced from other states within Australia and also from other countries. Western Australia (WA) MRSA clones known to be the most predominant clones circulating in Western Australia (WA). However, MRSA strains originally from other states and countries outside Australia (imported) have increased in number in the last decades. The aim of this study was to examine the epidemiology of CA MRSA clones in Western Australia for the past 11 year’s period (2003-2013). There were 10 predominant clones of CA-MRSA circulating in WA with WA MRSA-1 (32,82%), Queensland (22,67 %) and WA MRSA-2 (22,67 %) clones as the top three predominant clones. The percentage of PVL positive CA-MRSA clones such as Queensland (Qld) clone has been increasing significantly (R2=0,67) from 2,38 % in 2002 to 25,69% in 2013. In contrast, the percentages of two major PVL negative clones, WA MRSA-1 and WA MRSA 2, have been decreasing nearly by half from 52,38 % to 27,71 % and 30,95 % to 16,59 % respectively in the last 11 years. PVL positive clones have been introduced in WA from other states and overseas in the last eleven years. Due to the virulence factor of PVL toxin, the emergence of PVL positive CA-MRSA should be considered as public health concerns.

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