scholarly journals Whipple’s Disease: A Rare Cause of Diarreha

2021 ◽  
Vol 6 (6) ◽  
Keyword(s):  
Weight Loss ◽  
Fecal Incontinence ◽  
Physical Examination ◽  
Obese Patient ◽  
Personal History ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Associated Symptoms ◽  
History Of

We describe the case of a 55-year-old man, with a personal history of dyslipidemia, hyperuricemia and obesity, on atorvastatin and allopurinol. He went to a Gastroenterology consultation due to diarrhea with several years of evolution, from 3 daily spills, worsening in the last weeks to 10-12 daily spills, of liquid feces, without blood, mucus or pus, accompanied by defecatory urgency and fecal incontinence. He denied other associated symptoms, such as nausea, vomiting, weight loss or fever. Physical examination showed an obese patient, colored and hydrated skin and mucosa, without palpable adenomegalies, abdomen without changes.

scholarly journals Seronegative Arthritis as a Complication of Whipple’s Disease

2021 ◽  
Vol 14 ◽  
pp. 117954762110177
Author(s):  
Rebecca DeBoer ◽  
Sahani Jayatilaka ◽  
Anthony Donato
Keyword(s):  
Rheumatoid Arthritis ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Gastrointestinal Symptoms ◽  
Whipple’S Disease ◽  
Seronegative Arthritis ◽  
Whipple's Disease ◽  
Caucasian Male

Whipple’s disease (WD) is an uncommon cause of seronegative arthritis. WD is known for its gastrointestinal symptoms of diarrhea, weight loss, and abdominal pain. However, arthritis may precede gastrointestinal symptoms by 6 to 7 years. We describe a case of an 85-year-old Caucasian male with multiple joint complaints, not responsive to traditional treatments for conditions such as rheumatoid arthritis and osteoarthritis. We suggest that WD be considered for seronegative arthritis especially affecting large joints.

scholarly journals Reversible Pulmonary Hypertension Associated with Whipple’s Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-2
Author(s):  
A. Villa ◽  
G. Nucera ◽  
A. Kostihova ◽  
A. Mazzola ◽  
P. Marino
Keyword(s):  
Pulmonary Hypertension ◽  
Antibiotic Therapy ◽  
Respiratory Symptoms ◽  
Systolic Pressure ◽  
Pulmonary Involvement ◽  
Pulmonary Artery Systolic Pressure ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
History Of ◽  
Possible Cause

We describe a case of Whipple’s disease with pulmonary hypertension in a 72-year-old woman in whom the pulmonary hypertension resolved completely after antibiotic therapy. She was admitted to study with a 2-months history of weight loss, diarrhoea, abdominal pain, asthenia, inappetence, and fever. She did not have dyspnoea or respiratory symptoms. A casual echocardiogram showed a pulmonary artery systolic pressure of 95 mmHg. Forty days after starting antibiotic therapy, an echocardiogram showed a complete normalisation of right ventricular involvement. Whipple’s disease is a rare and multisystemic disorder in which pulmonary involvement is not a well-known finding. Although Whipple’s disease is not generally considered as a possible cause of pulmonary hypertension, such awareness is important because it may be potentially resolved with antibiotic therapy.

Concurrent Whipple’s disease and Giardia lamblia infection in a patient presenting with weight loss

2001 ◽  
Vol 12 (6) ◽  
pp. 525-528 ◽  
Author(s):  
Ingrid A.M Gisbertz ◽  
Dennis C.J.J Bergmans ◽  
J.A van Marion-Kievit ◽  
Harm R Haak
Keyword(s):  
Weight Loss ◽  
Giardia Lamblia ◽  
Whipple’S Disease ◽  
Whipple's Disease

scholarly journals Urachal Adenocarcinoma: A Case Report with Key Imaging Findings and Radiologic-Pathologic Correlation

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Willian Schmitt ◽  
Marta Baptista ◽  
Marco Ferreira ◽  
António Gomes ◽  
Ana Germano
Keyword(s):  
Weight Loss ◽  
Differential Diagnosis ◽  
Clinical History ◽  
Imaging Findings ◽  
Lesion Location ◽  
Patient Demographics ◽  
Pathologic Correlation ◽  
Associated Symptoms ◽  
History Of ◽  
Urachal Adenocarcinoma

Urachal pathologies are rare and can mimic numerous abdominal and pelvic diseases. Differential diagnosis of urachal anomalies can be narrowed down by proper assessment of lesion location, morphology, imaging findings, patient demographics, and clinical history. We report a case of a 60-year-old male, with a history of unintentional weight loss without associated symptoms, who was diagnosed with locally invasive urachal adenocarcinoma. With this article, we pretend to emphasize urachal adenocarcinoma clinical features along with its key imaging findings with radiologic-pathologic correlation.

Granulomatous lung disease and immune reconstitution inflammatory syndrome in Whipple’s disease

2021 ◽  
Vol 14 (6) ◽  
pp. e243633
Author(s):  
Patrick Hofmann ◽  
Nina Durisch ◽  
Claudia Buetikofer ◽  
Birgit Maria Helmchen
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Epithelioid Cell ◽  
Intestinal Biopsy ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Granulomatous Lung Disease ◽  
History Of ◽  
Inflammatory Syndrome ◽  
Recurrent Pleural Effusion

We present the case of a 70-year-old woman with a history of seronegative arthritis, recurrent pleural effusion and weight loss. A prior lung biopsy had revealed non-caseating epithelioid cell granulomas without evidence for microbial organisms on special stains. Intestinal biopsy findings where suspicious for Whipple’s disease, which was confirmed by PCR testing, both on the intestinal and retrospectively on the lung tissue. Treatment with ceftriaxone resulted in clinical deterioration with fever, arthritis and recurrent pleuritis consistent with immune reconstitution inflammatory syndrome. Dose increase of glucocorticoids and therapy rotation to doxycycline and hydroxychloroquine resulted in rapid clinical improvement.

scholarly journals Induction of general anaesthesia by blowpipe darting in a fractious companion horse

2018 ◽  
Vol 6 (3) ◽  
pp. e000629
Author(s):  
Sabina Diez Bernal ◽  
Simone Lanz ◽  
Isabelle Schmutz ◽  
Tosso Leeb ◽  
Claudia Spadavecchia
Keyword(s):  
Weight Loss ◽  
Physical Examination ◽  
General Anaesthesia ◽  
Stress Level ◽  
Therapeutic Approach ◽  
Present Report ◽  
Genetic Mutations ◽  
History Of ◽  
Progressive Weight Loss ◽  
Hindlimb Lameness

A fractious nine-year-old, 520-kg, neutered Swiss Warmblood was presented with a history of anorexia, progressive weight loss and mild hindlimb lameness. Because of its temperament, standard physical examination was considered to be only feasible under general anaesthesia. For safety reasons, general anaesthesia was planned to be induced by blowpipe darting. Two attempts are described and discussed in the present report. The first attempt, using a combination of medetomidine and tiletamine-zolazepam, was unsuccessful. Conversely, detomidine combined with butorphanol, followed by a second dart of detomidine and tiletamine-zolazepam, proved to be adequate to induce anaesthesia. Factors that could have influenced the outcome, such as different therapeutic approach, drug protocol and dosages, stress level, or genetic mutations, are presented and discussed.

scholarly journals Unintentional weight loss as presenting form of Whipple’s disease. Role of PET-CT scanning and review of the literature.

2020 ◽  
Vol 81 (3) ◽  
pp. 90
Author(s):  
Emilio Páez Guillán ◽  
Alba García Villafranca ◽  
H�ctor Lazaré Iglesias ◽  
Jos� Antonio Díaz Peromingo
Keyword(s):  
Weight Loss ◽  
Ct Scanning ◽  
Whipple’S Disease ◽  
Review Of The Literature ◽  
Whipple's Disease ◽  
Unintentional Weight Loss ◽  
Pet Ct

Cutaneous Rosai–Dorfman disease: a challenging diagnosis

2021 ◽  
Vol 14 (2) ◽  
pp. e239244
Author(s):  
Rita Sampaio ◽  
Leandro Silva ◽  
Goreti Catorze ◽  
Isabel Viana
Keyword(s):  
Weight Loss ◽  
Differential Diagnosis ◽  
Physical Examination ◽  
Plasma Cells ◽  
Oral Prednisolone ◽  
Inflammatory Cells ◽  
Rosai Dorfman Disease ◽  
History Of ◽  
Nodular Lesions ◽  
Proliferative Disease

Rosai–Dorfman disease is a rare benign histiocytic proliferative disease of unknown cause that, in exceptional cases, presents with lesions confined to the skin. Clinically variable types of lesions such as papules, nodules and plaques have been reported. We present a case of a 27-year-old woman with a 1-year history of erythematous papular and nodular lesions on the malar and right axillary regions, previously misdiagnosed as acne. She reported no fever, malaise or weight loss, while physical examination and laboratory workup were normal. Bacteriological and mycobacteriological cultures were negative. Histopathological findings showed dense infiltration of inflammatory cells involving the entire dermis, consisting of large macrophages with emperipolesis, S100 and CD68 positive, neutrophils, eosinophils, lymphocytes and plasma cells. The patient was treated with oral prednisolone without improvement. Dapsone was subsequently initiated with favourable clinical response. The present article aimed to emphasise the clinical and histological differential diagnosis and share the treatment experience.

scholarly journals An 11-year-old boy with chronic diarrhea and weight loss

2020 ◽  
Vol 13 (1) ◽  
pp. 35-41
Author(s):  
Maimuna Sayeed ◽  
Nazmul Hassan ◽  
Md. Rukunuzzaman ◽  
Bishnu Pada Dey
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Fecal Incontinence ◽  
Small Volume ◽  
Chronic Diarrhea ◽  
Significant Weight Loss ◽  
History Of

This article has no abstract. The first 100 words appear below: An 11-year-old boy presented with 15 months history of diarrhea with up to 10-20 times small volume stool daily with mucus. It was associated with a feeling of incomplete defecation and excessive straining. The frequency of diarrhea increased to 20-30 times per day over the last 8 months. Subsequently, he developed fecal incontinence, for which he couldn't attend his school. He also had a history of significant weight loss in the last 7 months. According to his mother's statement, his body weight was reduced to 64 kg from 77 kg during this illness.

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