scholarly journals Itraconazole Coated Super Paramagnetic Iron Oxide Nanoparticles for Antimicrobial Studies

2020 ◽  
Vol 10 (5) ◽  
pp. 6218-6225 ◽  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Iron Oxide Nanoparticles ◽  
Release Kinetics ◽  
Diffusion Method ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Drug Release Profile ◽  
The Core ◽  
Antimicrobial Studies

In this present study, Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were produced using FeCl3 and FeCl2 which were reduced to iron oxides using NaOH and ammonia solution (chemical co-precipitation). These naked SPIONs were further fabricated to form drug laden core-shell for controlled drug release and delivery. The fabrication was achieved by subjugating the naked SPIONs for oleic acid functionalization, drug tagging (Itraconazole) and finally encapsulated with a microbial derived polyester namely Polyhydroxybutyrate (PHB). Every stage of fabrication was characterized by scanning electron microscopy (SEM). The core-shell produced was checked for drug release kinetics, antibacterial and antifungal activities. These synthesized core-shells were carrying the drug and showed a slow drug release profile. The antimicrobial studies against bacteria - Pseudomonas aeruginosa & Brevibacillus brevis and fungi - Candida albicans by diffusion method proved that the core-shells inhibited bacterial and fungal activity. Furthermore, the naked SPIONs was found to be a good contrasting agent in X-ray imaging.

scholarly journals Multifunctional Silver Nanoparticles: Synthesis and Applications

2021 ◽  
Author(s):  
Nguyen Hoang Nam
Keyword(s):  
Silver Nanoparticles ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Silica Matrix ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
The Core ◽  
Methods Of Synthesis ◽  
Potential Applications

Multifunctional silver nanoparticles have attracted widely due to their potential applications. Based on the properties of individual silver nanoparticles, such as plasmonic and antibacterial properties, silver nanoparticles can become multifunctional by surface modifications with various surfactants or they can be combined in core-shell and composite structures with the magnetic nanoparticles to form bifunctional nanoparticles. After reviewing the methods of synthesis and applications of silver nanoparticles, the chapter describes the synthesis and the properties of the new types of multifunctional silver nanomaterials based on the plasmonic behaviors of silver nanoparticles and the iron oxide Fe3O4 superparamagnetic nanoparticles. One type is a simple combination of silver nanoparticles and iron oxide nanoparticles in a silica matrix Fe3O4/Ag-4ATP@SiO2. Other types are the core-shell structured nanoparticles, where Fe3O4 nanoparticles play as the core and silver nanoparticles are the outer shell, so-called Fe3O4@SiO2-Ag and Fe3O4-Ag. In the Fe3O4@SiO2-Ag, silver nanoparticles are reduced on the surface of silica-coated magnetic core, while in Fe3O4-Ag, silver nanoparticles are directly reduced on the amino groups functionalized on the surface of magnetic nanoparticles without coating with silica. Both of types of the multifunctional silver nanoparticles show the plasmonic and magnetic properties similar as the individual silver and iron oxide nanoparticles. Finally, some applications of those multifunctional silver nanoparticles will be discussed.

Iron Oxide Nanoparticles: Tunable Size Synthesis and Analysis in Terms of the Core–Shell Structure and Mixed Coercive Model

2017 ◽  
Vol 46 (4) ◽  
pp. 2533-2539 ◽  
Author(s):  
P. T. Phong ◽  
V. T. K. Oanh ◽  
T. D. Lam ◽  
N. X. Phuc ◽  
L. D. Tung ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Shell Structure ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
The Core ◽  
Core Shell Structure

scholarly journals Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Morteza Hasanzadeh Kafshgari ◽  
Delf Kah ◽  
Anca Mazare ◽  
Nhat Truong Nguyen ◽  
Monica Distaso ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hela Cells ◽  
Release Kinetics ◽  
Drug Loading ◽  
Oxide Nanoparticles ◽  
Site Specific ◽  
Therapeutic Drugs ◽  
Wide Range

Abstract Hollow titanium dioxide (TiO2) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO2 nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO2 nanotubes (TiO2NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO2 nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO2NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO2NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs.

Core-shell iron–iron oxide nanoparticles: magnetic properties and interactions

2004 ◽  
Vol 272-276 ◽  
pp. 1485-1486 ◽  
Author(s):  
L. Theil Kuhn ◽  
A. Bojesen ◽  
L. Timmermann ◽  
K. Fauth ◽  
E. Goering ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Iron Iron

Human Alveolar Epithelial Cell Responses to Core–Shell Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Langmuir ◽  
2015 ◽  
Vol 31 (13) ◽  
pp. 3829-3839 ◽  
Author(s):  
Doris Antoinette Mbeh ◽  
Laura Karina Mireles ◽  
Dimitri Stanicki ◽  
Lyes Tabet ◽  
Karim Maghni ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Epithelial Cell ◽  
Iron Oxide Nanoparticles ◽  
Alveolar Epithelial Cell ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Alveolar Epithelial ◽  
Cell Responses ◽  
Human Alveolar Epithelial Cell

Core/shell iron/iron oxide nanoparticles: are they promising for magnetic hyperthermia?

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 38697-38702 ◽  
Author(s):  
Z. Nemati ◽  
J. Alonso ◽  
H. Khurshid ◽  
M. H. Phan ◽  
H. Srikanth
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Heating Efficiency ◽  
Surface Disorder ◽  
Iron Iron

Core/shell iron/iron oxide nanoparticles are promising for magnetic hyperthermia provided their size is big enough (>14 nm) in order to minimize surface disorder and hollowing effects that seriously deteriorate their heating efficiency.

Core–Shell Iron–Iron Oxide Nanoparticles Synthesized by Laser-Induced Pyrolysis

Small ◽  
2006 ◽  
Vol 2 (12) ◽  
pp. 1476-1483 ◽  
Author(s):  
Oscar Bomatí-Miguel ◽  
Pedro Tartaj ◽  
Maria P. Morales ◽  
Pierre Bonville ◽  
Ute Golla-Schindler ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Iron Iron

scholarly journals Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents

2021 ◽  
Vol 9 ◽  
Author(s):  
Antonino Puglisi ◽  
Simone Bassini ◽  
Erik Reimhult
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cholesterol Metabolism ◽  
Genetic Disorders ◽  
Superparamagnetic Iron Oxide ◽  
Binding Activity ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Full Characterization

Cholesterol plays a crucial role in major cardiovascular and neurodegenerative diseases, including Alzheimer’s disease and rare genetic disorders showing altered cholesterol metabolism. Cyclodextrins (CDs) have shown promising therapeutic efficacy based on their capacity to sequester and mobilise cholesterol. However, the administration of monomeric CDs suffers from several drawbacks due to their lack of specificity and poor pharmacokinetics. We present core-shell superparamagnetic iron oxide nanoparticles (SPIONs) functionalised with CDs appended to poly (2-methyl-2-oxazoline) polymers grafted in a dense brush to the iron oxide core. The CD-decorated nanoparticles (CySPIONs) are designed so that the macrocycle is specifically cleaved off the nanoparticle’s shell at a slightly acidic pH. In the intended use, free monomeric CDs will then mobilise cholesterol out of the lysosome to the cytosol and beyond through the formation of an inclusion complex. Hence, its suitability as a therapeutic platform to remove cholesterol in the lysosomal compartment. Synthesis and full characterization of the polymer as well as of the core-shell SPION are presented. Cholesterol-binding activity is shown through an enzymatic assay.

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