Pharmacodynamics Interaction of Quercetin and Captopril on Doxorubicin Induced Myocardial Toxic Rats

Captopril (CAP), an ACE inhibitor, is widely used in the therapy of cardiovascular disease. Quercetin (QUE), a plant-derived flavonol that exerts cardioprotective activity through its antioxidant mechanism. A combination of CAP and QUE may produce synergistic or antagonistic cardioprotective effects. Therefore, the present study was designed to evaluate the pharmacodynamics interaction of QUE and CAP in Doxorubicin (Dox) induced oxidative myocardial damage in rats. Rats were pretreated with normal saline, QUE (10 mg/kg), and CAP (30 mg/kg) alone and in combination orally for 14 days. On the 14th day of treatment, rats were injected with Dox (10mg/kg single dose i.p) for the induction of myocardial damage. There was a substantial fall and rise in activities of marker enzymes such as CK-MB, LDH, AST, and ALT in serum and elevation of ST-segment, increased QT interval, and HR upon Dox administration. Pretreatment with QUE and CAP alone significantly restored the above parameters. But, the Concomitant pretreatment with QUE and CAP was found to be less significantly restored the Dox-induced alterations. The present study suggests that concomitant pretreatment with CAP and QUE could attenuate cardiovascular protection than that of alone pretreatment. It may be due to the antagonistic effect between the two drugs.

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Can indicators of myocardial damage predict carbon monoxide poisoning outcomes?

BMC Emergency Medicine ◽

10.1186/s12873-021-00405-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hitoshi Koga ◽

Hideki Tashiro ◽

Kouta Mukasa ◽

Tomohiro Inoue ◽

Aya Okamoto ◽

...

Keyword(s):

Carbon Monoxide ◽

Qt Interval ◽

Troponin I ◽

Morphological Changes ◽

Carbon Monoxide Poisoning ◽

Myocardial Damage ◽

Qt Dispersion ◽

Ecg Changes ◽

Corrected Qt Interval ◽

Logistic Analysis

Abstract Background Carbon monoxide causes electrical, functional, and morphological changes in the heart. It is unclear, however, whether the indicators of myocardial damage can predict the patient’s prognosis after carbon monoxide poisoning. This retrospective study aimed to investigate the relationship between the carboxyhemoglobin level and electrocardiographic (ECG) changes and whether the ECG changes and troponin I levels are related to the patient’s prognosis after carbon monoxide poisoning. Methods Carboxyhemoglobin, troponin I, and ECG parameters were measured in 70 patients with carbon monoxide poisoning. The QT and RR intervals were measured for each ECG lead in all patients, and the corrected QT interval and corrected QT dispersion were calculated. Results The correlation between the maximum corrected QT interval and the carboxyhemoglobin level was significant (P = 0.0072, R2 = 0.1017), as were the relationships between QT dispersion and carboxyhemoglobin (P < 0.001, R2 = 0.2358) and the corrected QT dispersion and carboxyhemoglobin (P < 0.001, R2 = 0.2613). The multivariate logistic analysis showed that the significant predictors of sequential disability were corrected QT dispersion (P = 0.0042), and troponin I level (P = 0.0021). Conclusions Patients’ prognosis following carbon monoxide poisoning can be predicted based on corrected QT dispersion and the troponin I level. Patients with myocardial damage should be monitored not only for their cardiovascular outcome but also for their neurological outcome and their prognosis.

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Electrocardiographic characteristics and associated outcomes in patients with Takotsubo syndrome. Insights from the RETAKO registry

European Heart Journal ◽

10.1093/ehjci/ehaa946.1816 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

I Martin-Demiguel ◽

I Nunez-Gil ◽

A Perez-Castellanos ◽

O Vedia ◽

A Uribarri ◽

...

Keyword(s):

Heart Rate ◽

Primary Endpoint ◽

Qt Interval ◽

Protective Factor ◽

Independent Predictor ◽

Prognostic Significance ◽

Takotsubo Syndrome ◽

St Segment Elevation ◽

Corrected Qt Interval ◽

St Segment

Abstract Background Our aim was to describe the prevalence and prognostic significance of electrocardiographic features in patients with Takotsubo syndrome (TTS). Methods Our data come from the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO). All patients with complete electrocardiogram were included. Results 246 patients were studied, mean age was 71.3±11.5 and 215 (87.4%) were women. ST-segment elevation was seen in 143 patients (59.1%) and was present in ≥2 wall leads in 97 (39.8%). Exclusive elevation in inferior leads was infrequent (5 - 2.0%). After 48 hours, 198 patients (88.0%) developed negative T-waves in a median of 8 leads with a mean amplitude of 0.7±0.5 mV. Mean corrected QT interval was 520±72 ms and it was independently associated with the primary endpoint of all-cause death and nonfatal cardiovascular events (p=0.002) and all-cause death (p=0.008). A higher heart rate at admission was also an independent predictor of the primary endpoint (p=0.001) and of developing acute pulmonary edema (p=0.04). ST-segment elevation with reciprocal depression was an independent predictor of all-cause death (p=0.04). Absence of ST-segment deviation was a protective factor (p=0.005) for the primary endpoint. Arrhythmias were independently associated with cardiogenic shock (p<0.001). Conclusion Prolonged corrected QT interval, arrhythmia, heart rate at admission and broader repolarization alterations are associated with a poor outcome in TTS. Typical ECG at admission and after 48h. Funding Acknowledgement Type of funding source: None

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Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Cells ◽

10.3390/cells10040899 ◽

2021 ◽

Vol 10 (4) ◽

pp. 899

Author(s):

Clara Liu Chung Ming ◽

Kimberly Sesperez ◽

Eitan Ben-Sefer ◽

David Arpon ◽

Kristine McGrath ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiovascular Disease ◽

Ex Vivo ◽

Myocardial Damage ◽

Cardiovascular Disorder ◽

Model Systems ◽

Ex Vivo Model ◽

Disease Manifestation

Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.

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PHYSIOLOGICAL ROLES AND ASSOCIATED DISORDERS OF ADIPONECTIN

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i1.114928 ◽

2016 ◽

Vol 10 (1) ◽

pp. 32

Author(s):

Preeti Sharma ◽

Shailaza Shrestha ◽

Pradeep Kumar ◽

Saxena Sp ◽

Rachna Sharma

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Adipose Tissue ◽

Human Plasma ◽

Mode Of Action ◽

Skeletal Muscles ◽

High Concentration ◽

Peripheral Tissues ◽

Cardioprotective Effects

ABSTRACTAmong the adipokines, adiponectin is the first one to be described just over a decade ago. It is produced exclusively by adipose tissue and circulatesin high concentration in human plasma accounting for 0.01% of proteins in plasma, almost thousand times higher than that of leptin. The normalcirculating level of adiponectin ranges from 2 to 30 µg/ml. It is now observed that besides adipose tissue, adiponectin can also be produced byseveral other tissues such as hepatocytes, cardiomyocytes, and placenta. Adiponectin executes its action via autocrine as well as and paracrine effects.Researchers working in this area have revealed that adiponectin has insulin-sensitizing, anti-inflammatory and cardioprotective effects. Our reviewfocuses on adiponectin, its mode of action on different peripheral tissues such as skeletal muscles, heart, liver, brain and its the correlative accountin various diseases.Keywords: Adiponectin, Obesity, Type 2 diabetes, Inflammation, Malignancies, Cardiovascular disease.

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Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/407580 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13 ◽

Cited By ~ 61

Author(s):

Yang Bai ◽

Xiaolu Wang ◽

Song Zhao ◽

Chunye Ma ◽

Jiuwei Cui ◽

...

Keyword(s):

Oxidative Stress ◽

Cardiovascular Disease ◽

Leucine Zipper ◽

Defense Mechanism ◽

Myocardial Damage ◽

Related Factor ◽

Anticancer Activities ◽

Basic Leucine Zipper ◽

Nrf2 Activation

Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Oxidative stress plays a major role in the pathophysiology of cardiac disorders. Several studies have highlighted the cardinal role played by the overproduction of reactive oxygen or nitrogen species in the pathogenesis of ischemic myocardial damage and consequent cardiac dysfunction. Isothiocyanates (ITC) are sulfur-containing compounds that are broadly distributed among cruciferous vegetables. Sulforaphane (SFN) is an ITC shown to possess anticancer activities by bothin vivoand epidemiological studies. Recent data have indicated that the beneficial effects of SFN in CVD are due to its antioxidant and anti-inflammatory properties. SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes. This review will summarize the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD.

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Single-dose ziprasidone associated with QT interval prolongation

The American Journal of Emergency Medicine ◽

10.1016/j.ajem.2011.03.019 ◽

2012 ◽

Vol 30 (5) ◽

pp. 837.e1-837.e2 ◽

Cited By ~ 6

Author(s):

Joanne C. Witsil ◽

Michele Zell-Kanter ◽

Mark B. Mycyk

Keyword(s):

Single Dose ◽

Qt Interval ◽

Interval Prolongation ◽

Qt Interval Prolongation

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Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

10.20944/preprints202104.0240.v1 ◽

2021 ◽

Author(s):

Clara Liu Chung Ming ◽

Kimberly Sesperez ◽

Eitan Ben-Sefer ◽

David Arpon ◽

Kristine McGrath ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiovascular Disease ◽

Ex Vivo ◽

Myocardial Damage ◽

Cardiovascular Disorder ◽

Model Systems ◽

Ex Vivo Model ◽

Disease Manifestation

Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation that is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD) including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion, however, that therapeutic approach leads to ischemic/reperfusion injury (IRI) often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.

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The diagnostic value of exercise stress testing for cardiovascular disease is more than just st segment changes: A review

Journal of Integrative Cardiology ◽

10.15761/jic.1000173 ◽

2016 ◽

Vol 2 (4) ◽

pp. 41-55 ◽

Cited By ~ 2

Author(s):

Salaheddin Sharif ◽

Stephen E Alway

Keyword(s):

Cardiovascular Disease ◽

Stress Testing ◽

Diagnostic Value ◽

Exercise Stress ◽

Exercise Stress Testing ◽

St Segment

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Cardioprotective effects of compound ALM-802 on subendocardial ischemia models

Pharmacokinetics and Pharmacodynamics ◽

10.37489/2587-7836-2021-1-18-22 ◽

2021 ◽

pp. 18-22

Author(s):

I. B. Tsorin ◽

V. V. Barchukov ◽

M. B. Vititnova ◽

A. M. Likhosherstov ◽

G. V. Mokrov ◽

...

Keyword(s):

Myocardial Ischemia ◽

Cardioprotective Effect ◽

Rat Models ◽

Subendocardial Ischemia ◽

Anesthetized Rats ◽

St Segment ◽

Cardioprotective Effects

The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dobutamine. Material and methods. Acute subendocardial myocardial ischemia in anesthetized rats (urethane 1300 mg/kg, i.p.) was caused by infusion of isoproterenol (20 µg/kg/min i.v.) or dobutamine (80 µg/kg/min i.v.). Results. It was shown that in anesthetized rats, isoproterenol and dobutamine caused almost the same ST-segment depression in the II standard ECG lead. The compound ALM-802 (2 mg/kg i.v.), administered 2 minutes before the infusion start of isoproterenol or dobutamine, equally prevented the occurrence of ischemic changes on the ECG. Conclusion. The non-selective beta-adrenomimetic isoproterenol and the selective β1-adrenomimetic dobutamine cause subendocardial ischemia of the same intensity in anesthetized rats. The compound ALM-802 has a pronounced anti-ischemic effect on both models.

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