scholarly journals Diagnosis of Tuberculous Lymphadenitis from Fine Needle Aspirate by PCR

2017 ◽  
Vol 8 (1) ◽  
pp. 2-6
Author(s):  
Hasina Akhter ◽  
Zakir Hossain Habib ◽  
Imtiaz Ahmed ◽  
Hafiza Akhter ◽  
Abdullah Yusuf ◽  
...  
Keyword(s):  
Lymph Node ◽  
Predictive Value ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Tuberculous Lymphadenitis ◽  
Fine Needle Aspirate ◽  
Fine Needle ◽  
Medical College ◽  
Lymph Node Enlargement ◽  
Node Involvement

Lymph node involvement is the commonest form of extra pulmonary tuberculosis (EPTB). This study was undertaken to evaluate the role of PCR using IS6110 as a target for Mycobacterium tuberculosis complex in the diagnosis of tuberculous lymphadenitis (TB-L) and was done in Microbiology department of Sir Salimullah Medical College from July 2009 to June 2010. Fine needle aspiration was performed on 107 patients with a clinical suspicion of tuberculous lymphadenitis from different hospitals of Dhaka City Corporation area. All the aspirated samples were subjected to culture and PCR for M.tuberculosis. Out of 107 patients with lymphadenopathy most of the patients (85.9%) had cervical lymph node enlargement followed by axillary groups (12.1%) and inguinal groups (1.9%). Out of 107 cases, 65 (60.7%) were PCR positive and 56 (52.3%) were culture positive. Among 51 (47.7%) culture negative cases 9 (17.65) were PCR positive. Sensitivity of PCR was 100% and specificity was 82.4%.The positive predictive value (PPV), negative predictive value (NPV) and accuracy of PCR were 86.2%, 100% and 91.6% respectively. PCR is the most sensitive in the detection of M.tuberculosis in fine needle aspirate and could be useful technique in establishing the diagnosis of tuberculous lymphadenitis.

scholarly journals Extramedullary Plasmacytoma of the Tonsil with Nodal Involvement

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Simon Bazaadut ◽  
Dilshard Soodin ◽  
Pradeep Singh ◽  
Alhossain Khalafallah ◽  
Shannon Withers ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adjuvant Radiotherapy ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Extramedullary Plasmacytoma ◽  
Nodal Involvement ◽  
Careful Planning ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Node Involvement

We present a rare case of extramedullary plasmacytoma of the palatine tonsil with cervical lymph node involvement treated by surgical resection. A 58-year-old Caucasian male presented with a solitary 3 cm×3 cm jugulodigastric lymph node and was found to have an ipsilateral tonsillar swelling. The involved tonsil and lymph node were surgically resected after two inconclusive fine-needle aspirates, and plasmacytoma was confirmed histologically and by immunocytochemistry. Adjuvant radiotherapy was not indicated as adequate resection was achieved at surgery. We also highlight the challenges of diagnosis when fine-needle aspiration is inconclusive and the need for careful planning before surgery.

scholarly journals Fine needle aspiration cytology of cervical lymph node involvement by ovarian serous borderline tumor

CytoJournal ◽  
2016 ◽  
Vol 13 ◽  
pp. 16 ◽  
Author(s):  
Longwen Chen ◽  
Kristina A. Butler ◽  
Debra A. Bell
Keyword(s):  
Lymph Node ◽  
Cervical Lymph Node ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Low Grade ◽  
Borderline Tumor ◽  
Needle Core Biopsy ◽  
Fine Needle ◽  
Serous Borderline Tumor ◽  
Node Involvement

Serous borderline tumor (SBT) involving a cervical lymph node is extremely rare. In addition, fine needle aspiration (FNA) cytology of the involved cervical lymph node shares tremendous morphologic similarity with other low-grade papillary carcinomas. Thus, it can be easily misdiagnosed as metastatic carcinoma. A 42-year-old female had a history of bilateral SBT and postbilateral salpingo-oophorectomy. She presented with left cervical lymphadenopathy 6 months later. FNA cytology showed a low-grade papillary neoplasm with psammoma bodies. Needle core biopsy along with immunostains was diagnostic of cervical lymph node involvement (LNI) of SBT. although extremely rare, cervical LNI can be found in patients with SBTs. FNA cytology, sometimes, is indistinguishable from metastatic papillary adenocarcinoma. Cell block or needle core biopsy is essential to make the correct diagnosis.

The Application of Fine Needle Aspiration Biopsy in the Diagnosis of Axillary Masses

2021 ◽  
pp. 1-7
Author(s):  
Cong-Gai Huang ◽  
Meng-Ze Li ◽  
Shao-Hua Wang ◽  
Xiao-Qin Tang ◽  
Johannes Haybaeck ◽  
...  
Keyword(s):  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Benign Lesions ◽  
Fine Needle ◽  
Significant Difference ◽  
Malignant Lesions ◽  
Axillary Mass

<b><i>Introduction:</i></b> We intend to determine the diagnostic power of fine needle aspiration biopsy (FNAB) for differentiation between malignant and benign lesions on axillary masses and draw the physicians’ attention to the benefits of FNAB cytology in the diagnosis of axillary masses. <b><i>Methods:</i></b> In this study, 1,328 patients with an axillary mass diagnosed by FNAB were retrospectively reviewed. These cases were registered at the affiliated hospital of Southwest Medical University (China), July 2014 to June 2017. Cytological results were verified either by histopathology following surgical resection or clinical follow-up. <b><i>Results:</i></b> Of the 1,328 patients affected by axillary masses, 987 (74.3%) cases were female, and 341 (25.7%) cases were male. The highest incidence of patients was in the age group of 41–50 years (375, 28.2%). There were 1,129 (85.0%) patients with benign lesions and 199 (15.0%) with malignant lesions. Of the 199 malignant lesions cases, 21 cases were lymphomas, 2 cases were accessory breast cancers, and 176 cases were lymph node metastatic tumors. Under lymph node metastases, the most frequent primary tumors were breast cancer (141, 80.1%), followed by lung cancer (21, 11.9%). According to the study, the characters of 1,328 cases showed statistically significant difference (χ<sup>2</sup> = 4.534, <i>p</i> = 0.033), and the incidence of females with axillary mass was significantly higher than that of males. There was a statistically significant difference in the distribution of benign and malignant cases in the patient age groups (χ<sup>2</sup> = 1.129, <i>p</i> = 0.000), and the incidence of patients of 41–50 years of age was significantly higher than that of other patients. The diagnostic accuracy of FNAB in axillary masses was analyzed with the results of 95.98% of sensitivity, 99.56% of specificity, 97.45% of positive predictive value, and 99.29% of negative predictive value. <b><i>Conclusion:</i></b> Our results confirm that FNAB is a valuable initial screening method regarding pathologic diagnosis of axillary mass, in particular with respect to malignancy in 41- to 50-year-old female patients.

scholarly journals Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity

Cancer ◽  
2009 ◽  
Vol 115 (7) ◽  
pp. 1489-1497 ◽  
Author(s):  
Shao Hui Huang ◽  
David Hwang ◽  
Gina Lockwood ◽  
David P. Goldstein ◽  
Brian O'Sullivan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Lymph Node Involvement ◽  
Tumor Thickness ◽  
Node Involvement

scholarly journals A case report of Rosai Dorfman disease

2018 ◽  
Vol 4 (3) ◽  
pp. 868
Author(s):  
Jyotika Waghray ◽  
Pradyut Waghray
Keyword(s):  
Lymph Node ◽  
Plasma Cells ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Unknown Etiology ◽  
Low Grade ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
Node Involvement

<p>Rosai-Dorfman’s disease also known as sinus histiocytosis with massive lymphadenopathy (SHML) is characterized by distorted lymph node architecture with marked dilation of lymphatic sinuses occupied by numerous lymphocytes, as well as histiocytes with vesicular nucleus and abundant clear cytoplasm with phagocytized lymphocytes or plasma cells, also known as ‘emperipolesis’. This disease of unknown etiology progresses with a benign prognosis strictly and only when an early diagnosis and treatment is made. A late diagnosis and a generalized lymph node involvement contribute to a poor prognosis. We reported a case of a 29-year-old Indian female with a 4-month history of painful unilateral cervical mass and low-grade fever with the final diagnosis of Rosai-Dorfman disease. The final diagnosis was made by fine needle aspiration (FNA) biopsy of the cervical lymph node. In conclusion, FNA biopsy can be enough to make the diagnosis in most cases due to the distinct cytological features of SHML, thereby avoiding more invasive approaches that potentially are unnecessary.</p>

scholarly journals A Study of Peripheral Lymphadenopathy with Correlation between Fine Needle Aspiration Cytology (FNAC) and Biopsy in A Tertiary Care Hospital

2015 ◽  
Vol 26 (2) ◽  
pp. 49-54
Author(s):  
Mohammad Rafiqul Islam ◽  
Md Azizul Hoque ◽  
ARM Saifuddin Ekram
Keyword(s):  
Lymph Node ◽  
Likelihood Ratio ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Tertiary Care ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Care Hospital ◽  
Fine Needle ◽  
Test Result

Background: Lymphadenopathy is a common clinical problem in our country among all age groups and in both sexes. In this study an attempt has been made to evaluate the clinical presentation and diagnosis of peripheral lymphadenopathy, which is commonly encountered in medical wards and diagnostic value of FNAC has been evaluated.Methodology: This hospital-based descriptive study was done in thirty adult cases, of clinically apparent peripheral lymphadenopathy of at least more than two weeks of duration. Study was conducted over a period of 6 months from July, 2005 to December, 2005 in inpatients and outpatients of Rajshahi Medical College Hospital. After thorough examination, fine needle aspiration from several accessible enlarged lymph node groups were taken and sent for cytopathological examination and later biopsy of the significantly enlarged lymph node from the same anatomical region was performed and was sent for histopathological examination.Results: Cytopathological study was successful in correctly identifying 84.6% of tubercular case, 85.7% of non-Hodgkin’s lymphoma, 66.7% of Hodgkin’s lymphoma, 83.3% of mitotic nodes and 100% of reactive nodes. Statistical correlation between aetiology of lymphadenopathy and cytopathological diagnosis with Spearman’s rank correlation coefficient revealed a strong positive statistically significant correlation of cytopathology with aetiology, i.e. histopathology. Calculation of sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio for a positive test result and likelihood ratio for a negative test result confirms the diagnostic value of cytopathology in peripheral lymphadenopathy by demonstrating high values for different aetiology.Conclusion: The result of this study may not exactly reflect that of similar studies conducted home or abroad, probably due to smaller sample size and limited scope, but its strength remains in the fact that it attempted to address a widely prevalent condition in a practical way.Bangladesh J Medicine Jul 2015; 26 (2) : 49-54

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