scholarly journals Investigation of the morphology of longus colli among patients with neck pain using ultrasonography – a preliminary study

2013 ◽  
Vol 12 (4) ◽  
pp. 419-426
Author(s):  
RI Hussain ◽  
LJ Henry ◽  
A Ramli ◽  
SN Othman ◽  
V Mohan ◽  
...  
Keyword(s):  
Neck Pain ◽  
Healthy Subjects ◽  
Medical Science ◽  
Normal Subjects ◽  
Healthy Controls ◽  
Contraction Ratio ◽  
Longus Colli ◽  
Preliminary Study ◽  
Shape Ratio ◽  
Anterior Posterior

Objective: Longus colli provides stability to cervical spine during movements. In clinical practice, the clinicians teach exercises to longus colli to manage neck pain. The aim of this study was to investigate differences in thickness or anterior-posterior dimension (APD), shape ratio and contraction ratio of longus colli between subjects with neck pain and healthy controls. Materials and methods: A total of 12 subjects (6 with neck pain and 6 healthy controls) were recruited by predefined selection criteria. Ultrasound imaging of bilateral longus colli was conducted at the level C5-C6. Anterior-posterior dimension (APD) and lateral dimension (LD) were measured using Ultrasonography. Shape ratio (LD/APD) and contraction ratio (APD during contraction/APD during rest) were calculated. Mann-Whitney U test was used to compare the thickness of longus colli between healthy and neck pain subjects. Results and discussion: The results showed that the subjects with neck pain had smaller APD (Mean Rank=4.83, n=6) than healthy subjects (Mean Rank=8.17, n=6), U=16.00, z=-1.601 (corrected for ties), p=0.109, two tailed. Also, shape ratio showed higher values in neck pain subjects (Mean Rank=7.17, n=6) than normal subjects (Mean Rank=5.83, n=6), U=14.00, z=-0.641(corrected for ties) p=0.522, two tailed. In addition, contraction ratio was smaller in neck pain subjects (Mean Rank=4.83, n=6) than those healthy subjects (Mean Rank=8.17, n=6), U=8.00, z=- 1.601(corrected for ties) p=0.109, two tailed. Conclusion: There is a trend of reduced size of longus colli with the median of APD and smaller contraction ratio among patients with neck pain when compared to healthy controls. DOI: http://dx.doi.org/10.3329/bjms.v12i4.13692 Bangladesh Journal of Medical Science Vol. 12 No. 04 October ’13 Page 419-426

Effect of dihydroergocristine administration on serum prolactin and growth hormone levels in normal, hyperprolactinaemic, and acromegalic subjects: further evidence for pituitary dopamine deficiency in these conditions

1983 ◽  
Vol 103 (1) ◽  
pp. 1-6 ◽  
Author(s):  
C. Ferrari ◽  
M. Romussi ◽  
R. Benco ◽  
P. Rampini ◽  
F. Mailland
Keyword(s):  
Growth Hormone ◽  
Healthy Subjects ◽  
Normal Subjects ◽  
Serum Prolactin ◽  
Pharmacological Properties ◽  
Healthy Controls ◽  
Oral Doses ◽  
Resumption Of Menses ◽  
Lowering Activity

Abstract. To evaluate further the pharmacological properties of dihydroergocristine in vivo, this drug (6 mg) or a placebo were administered orally on separate days to 11 healthy controls, 11 patients with adenomatous (n = 4) or idiopathic hyperprolactinaemia (n = 7), and 5 acromegalics with raised serum prolactin levels; serum prolactin (Prl) and growth hormone (GH) were measured at hourly intervals for 6 h. Dihydroergocristine induced a significant Prl decrease versus placebo in hyperprolactinaemics and acromegalics, but had no effect in healthy subjects. GH levels did not change in normals and hyperprolactinaemics, but decreased significantly in acromegalics. The Prl decrease induced by dihydroergocristine was significantly lower than that induced by l-dopa (500 mg po) in 9 hyperprolactinaemics so tested. Nomifensine (200 mg po) administered to 7 hyperprolactinaemics had no effect. Similarly, the GH decrease induced by the drug in acromegalics was significantly lower than that exerted by l-dopa, while nomifensine had no effect. Five hyperprolactinaemic patients were also given 12–18 mg dihydroergocristine daily for 3 months. There was evidence of partial or total Prl suppression and resumption of menses in all patients. These data indicate that dihydroergocristine is a relatively weak dopamine agonist at pituitary level and that oral doses, insufficient to exert Prl-lowering activity in normal subjects, are able to inhibit Prl and GH release in hyperprolactinaemics and dopamine-responsive acromegalics. These findings further support the existence of a 'denervation' supersensitivity to dopamine in these conditions, in which dopamine deficiency at pituitary level has been suggested on the basis of other experiments.

scholarly journals Ultrasonography of longus colli muscle: A reliability study on healthy subjects and patients with chronic neck pain

2011 ◽  
Vol 15 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Khodabakhsh Javanshir ◽  
Mohammad Ali Mohseni-Bandpei ◽  
Asghar Rezasoltani ◽  
Mohsen Amiri ◽  
Mehdi Rahgozar
Keyword(s):  
Neck Pain ◽  
Healthy Subjects ◽  
Chronic Neck Pain ◽  
Reliability Study ◽  
Longus Colli ◽  
Longus Colli Muscle

scholarly journals Levels of Serum Magnesium among Recently Diagnosed Glucose Intolerance Patients and its Comparison with Serum Magnesium Level of Sex and Age Controlled Healthy Subjects

2021 ◽  
Vol 15 (5) ◽  
pp. 1721-1724
Author(s):  
Kashif Ali Samin ◽  
Muhammad Mujtaba Hashir ◽  
Shaheera Batool ◽  
Jazib Andleeb ◽  
Nisar Khan Sajid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Healthy Volunteers ◽  
Glucose Intolerance ◽  
Healthy Subjects ◽  
Serum Magnesium ◽  
Medical Science ◽  
Normal Subjects ◽  
Control Group

Background: Hypomagnesaemia is related with diabetes mellitus (DM) and its complications and insulin resistance. On the other hand, the patients of Diabetes mellitus have decreased levels of magnesium. This analysis was planned to assess levels of serum magnesium in patients with newly diagnosedimpaired glucose intolerance and the severity of intolerance e.g., DM or impaired glucose tolerance, impaired fasting glucoseand compare the serum levels of magnesiumwith sex and age matched healthy individuals. Methods: This case-control study was carried out in the Outpatient department of Diabetes Hospital Peshawar and CMH Multan Institute of Medical Science Multanfor six months duration from February 2020 to July 2020. New patients of glucose intolerance (IGT 2, DM 54) were matched with same number of sex and age matched healthy subjects (n=56). All participants in the study done with the level of serum magnesium and comparisons were made between the case and the healthy subjects. Results: This study evaluated 56 patients (studied group) and 56 healthy volunteers of similar gender and age (control group) with glucose intolerance.There was no substantial difference between the control group in terms of sex, body mass index (p = 0.39) and age (p = 0.88). The level of serum magnesium was according to standard in 30 patients and 39 healthy subjects, and decrease in 26 patients and 17 normal subjects. The mean concentration of serum magnesium was lower in the experimental group (0.69±0.16m. Mol / L) than in the control group (0.84±0.17 m. Mol / L), though the variance was not substantial (p = 0.37). Conclusions: The levels of Serum magnesium were lesser in individuals with IGT and DM compared to healthy volunteers of the same sex and age and levels of serum magnesium were related to blood glucose levels. Key words: Serum magnesium, Diabetes mellitus, Glucose intolerance, Impaired glucose tolerance, Impaired fasting glucose.

Responses of Platelets to Strains of Streptococcus sanguis: Findings in Healthy Subjects, Bernard-Soulier, Glanzmann’s, and Collagen-Unresponsive Patients

1987 ◽  
Vol 57 (02) ◽  
pp. 222-225 ◽  
Author(s):  
A H Soberay ◽  
M C Herzberg ◽  
J D Rudney ◽  
H K Nieuwenhuis ◽  
J J Sixma ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Healthy Subjects ◽  
Normal Subjects ◽  
Membrane Glycoprotein ◽  
Response Mechanism ◽  
Platelet Response ◽  
Induce Platelet Aggregation ◽  
Streptococcus Sanguis ◽  
Lag Times ◽  
Bernard Soulier Syndrome

SummaryThe ability of endocarditis and dental strains of Streptococcus sanguis to induce platelet aggregation in plasma (PRP) from normal subjects were examined and compared to responses of PRP with known platelet membrane glycoprotein (GP) and response defects. S. sanguis strains differed in their ability to induce normal PRPs to aggregate. Strains that induced PRP aggregation in more than 60% of donors were significantly faster agonists (mean lag times to onset of aggregation less than 6 min) than those strains inducing response in PRPs of fewer than 60% of donors.Platelets from patients with Bernard-Soulier syndrome aggregated in response to strains of S. sanguis. In contrast, platelets from patients with Glanzmann’s thrombasthenia and from a patient with a specific defect in response to collagen were unresponsive to S. sanguis. These observations show that GPIb and V are not essential, but GPIIb-IIIa and GPIa are important in the platelet response mechanism to S. sanguis. Indeed, the data suggests that the platelet interaction mechanisms of S. sanguis and collagen may be similar.

scholarly journals Comparison of Brain Activation Patterns during Olfactory Stimuli between Recovered COVID-19 Patients and Healthy Controls: A Functional Near-Infrared Spectroscopy (fNIRS) Study

2021 ◽  
Vol 11 (8) ◽  
pp. 968
Author(s):  
Roger C. Ho ◽  
Vijay K. Sharma ◽  
Benjamin Y. Q. Tan ◽  
Alison Y. Y. Ng ◽  
Yit-Shiang Lui ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Time Interval ◽  
Healthy Controls ◽  
Functional Near Infrared Spectroscopy ◽  
Activation Patterns ◽  
Identification Test ◽  
Olfactory Stimuli ◽  
Preliminary Study

Impaired sense of smell occurs in a fraction of patients with COVID-19 infection, but its effect on cerebral activity is unknown. Thus, this case report investigated the effect of COVID-19 infection on frontotemporal cortex activity during olfactory stimuli. In this preliminary study, patients who recovered from COVID-19 infection (n = 6) and healthy controls who never contracted COVID-19 (n = 6) were recruited. Relative changes in frontotemporal cortex oxy-hemoglobin during olfactory stimuli was acquired using functional near-infrared spectroscopy (fNIRS). The area under curve (AUC) of oxy-hemoglobin for the time interval 5 s before and 15 s after olfactory stimuli was derived. In addition, olfactory function was assessed using the Sniffin’ Sticks 12-identification test (SIT-12). Patients had lower SIT-12 scores than healthy controls (p = 0.026), but there were no differences in oxy-hemoglobin AUC between healthy controls and patients (p > 0.05). This suggests that past COVID-19 infection may not affect frontotemporal cortex function, and these preliminary results need to be verified in larger samples.

Over-expression of IL-6 coding gene in the peripheral blood of migraine with aura patients

2021 ◽  
pp. 1-5
Author(s):  
Mahdi Ramezani ◽  
Alireza Komaki ◽  
Mohammad Mahdi Eftekharian ◽  
Mehrdokht Mazdeh ◽  
Soudeh Ghafouri-Fard
Keyword(s):  
Migraine With Aura ◽  
Peripheral Blood ◽  
Healthy Subjects ◽  
Migraine Without Aura ◽  
P Value ◽  
Healthy Controls ◽  
Over Expression ◽  
Significant Difference ◽  
Male Patients ◽  
Years Lived With Disability

Migraine is a common disorder which is placed among the top ten reasons of years lived with disability. Cytokines are among the molecules that contribute in the pathophysiology of migraine. In the current study, we evaluated expression levels of IL-6 coding gene in the peripheral blood of 120 migraine patients (54 migraine without aura and 66 migraine with aura patients) and 40 healthy subjects. No significant difference was detected in expression of IL-6 between total migraine patients and healthy controls (Posterior beta = 0.253, P value = 0.199). The interaction effect between gender and group was significant (Posterior beta =-1.274, P value = 0.011), therefore, we conducted subgroup analysis within gender group. Such analysis revealed that while expression of this gene is not different between male patients and male controls (Posterior beta =-0.371, P value > 0.999), it was significantly over-expressed in female patients compared with female controls (Posterior beta = 0.86, P= 0.002). Expression of IL-6 was significantly higher in patients with aura compared with controls (Posterior beta = 0.63, adjusted P value = 0.019). However, expression of this cytokine coding gene was not different between patients without aura and healthy subjects (Posterior beta = 0.193, adjusted P value = 0.281). Therefore, IL-6 might be involved in the pathophysiology of migraine among females and migraine with aura among both sexes.

Mode of action of cupping—Local metabolism and pain thresholds in neck pain patients and healthy subjects

2014 ◽  
Vol 22 (1) ◽  
pp. 148-158 ◽  
Author(s):  
M. Emerich ◽  
M. Braeunig ◽  
H.W. Clement ◽  
R. Lüdtke ◽  
R. Huber
Keyword(s):  
Neck Pain ◽  
Mode Of Action ◽  
Healthy Subjects ◽  
Pain Thresholds ◽  
Pain Patients ◽  
Local Metabolism

Template bleeding time after ingestion of ultra low dosages of acetyl salicylic acid in healthy subjects. Preliminary study

1987 ◽  
Vol 48 (4) ◽  
pp. 501-504 ◽  
Author(s):  
C. Doutremepuich ◽  
D. Pailley ◽  
M.C. Anne ◽  
O. de Séze ◽  
J. Paccalin ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Healthy Subjects ◽  
Bleeding Time ◽  
Acetyl Salicylic Acid ◽  
Preliminary Study

scholarly journals Lingual–Alveolar Contact Pressure During Speech in Amyotrophic Lateral Sclerosis: Preliminary Findings

2017 ◽  
Vol 60 (4) ◽  
pp. 810-825 ◽  
Author(s):  
Jeff Searl ◽  
Stephanie Knollhoff ◽  
Richard J. Barohn
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Healthy Volunteers ◽  
Contact Pressure ◽  
Statistical Difference ◽  
Healthy Controls ◽  
Perceptual Judgments ◽  
Before And After ◽  
Preliminary Study ◽  
Contact Pressures ◽  
Lateral Sclerosis

Purpose This preliminary study on lingual–alveolar contact pressures (LACP) in people with amyotrophic lateral sclerosis (ALS) had several aims: (a) to evaluate whether the protocol induced fatigue, (b) to compare LACP during speech (LACP-Sp) and during maximum isometric pressing (LACP-Max) in people with ALS (PALS) versus healthy controls, (c) to compare the percentage of LACP-Max utilized during speech (%Max) for PALS versus controls, and (d) to evaluate relationships between LACP-Sp and LACP-Max with word intelligibility. Method Thirteen PALS and 12 healthy volunteers produced /t, d, s, z, l, n/ sounds while LACP-Sp was recorded. LACP-Max was obtained before and after the speech protocol. Word intelligibility was obtained from auditory–perceptual judgments. Results LACP-Max values measured before and after completion of the speech protocol did not differ. LACP-Sp and LACP-Max were statistically lower in the ALS bulbar group compared with controls and PALS with only spinal symptoms. There was no statistical difference between groups for %Max. LACP-Sp and LACP-Max were correlated with word intelligibility. Conclusions It was feasible to obtain LACP-Sp measures without inducing fatigue. Reductions in LACP-Sp and LACP-Max for bulbar speakers might reflect tongue weakness. Although confirmation of results is needed, the data indicate that individuals with high word intelligibility maintained LACP-Sp at or above 2 kPa and LACP-Max at or above 50 kPa.

scholarly journals The involvement of the styloid process in head and neck pain-a preliminary study

2000 ◽  
Vol 27 (4) ◽  
pp. 275-287 ◽  
Author(s):  
P. Palesy ◽  
G. M. Murray ◽  
J. De Boever ◽  
I. Klineberg
Keyword(s):  
Neck Pain ◽  
Head And Neck ◽  
Styloid Process ◽  
Preliminary Study
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