scholarly journals Signal Transduction Pathway in Chronic Leukemia

2017 ◽  
Vol 16 (1) ◽  
pp. 21-23
Author(s):  
Faris Q Alenzi
Keyword(s):  
Signal Transduction ◽  
Control Cell ◽  
Medical Science ◽  
Signal Transduction Pathway ◽  
Cell Types ◽  
Cell Development ◽  
Transduction Pathway ◽  
Chronic Leukemia ◽  
Ras Genes ◽  
Human Infections

It is becoming progressively clearer that the three RAS genes, N-. H-and K-RAS, encode 21 kDa proteins which act as intracellular switches, playing important roles in the signal transduction pathway that control cell development and maturation. These three genes are profoundly homologous, yet more recent findings indicate they have important roles in the functions various cell types playing focal roles in numerous human infections. This article briefly reviews the regulation of RAs-dependent signaling mechanisms.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.21-23

Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1

1990 ◽  
Vol 10 (7) ◽  
pp. 3824-3827
Author(s):  
M Chedid ◽  
S B Mizel
Keyword(s):  
Signal Transduction ◽  
Cyclic Amp ◽  
Protein Kinases ◽  
Gene Transcription ◽  
Interleukin 1 ◽  
Signal Transduction Pathway ◽  
Cell Types ◽  
Specific Protein ◽  
Transduction Pathway ◽  
Dependent Protein

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

scholarly journals Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.

1990 ◽  
Vol 10 (7) ◽  
pp. 3824-3827 ◽  
Author(s):  
M Chedid ◽  
S B Mizel
Keyword(s):  
Signal Transduction ◽  
Cyclic Amp ◽  
Protein Kinases ◽  
Gene Transcription ◽  
Interleukin 1 ◽  
Signal Transduction Pathway ◽  
Cell Types ◽  
Specific Protein ◽  
Transduction Pathway ◽  
Dependent Protein

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

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