scholarly journals Vitamin D Status in Prediabetes and its Different Categories

2022 ◽  
Vol 21 (1) ◽  
pp. 120-128
Author(s):  
Md Shahed Morshed ◽  
- Md Fariduddin ◽  
Tahniyah Haq ◽  
Shahjada Selim ◽  
Murshed Ahamed Khan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Glucose Tolerance ◽  
High Performance ◽  
Medical Science ◽  
Normal Glucose Tolerance ◽  
Combination Group ◽  
Hydroxyvitamin D ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Healthy Control

Objectives: Data regarding vitamin D level and status among categories of prediabetes are scarce in the literature. This study is aimed to determine the level and status of vitamin D among adults with prediabetes and its different categories. Materials and methods: This crosssectional study was carried out in 111 newly detected adults with prediabetes according to American Diabetes Association 2018 criteria and 74 matched healthy control (normal glucose tolerance). People with prediabetes were categorized into impaired glucose tolerance, impaired fasting glucose and their combination group. Participants were recruited consecutively from the Department of Endocrinology, BSMMU to measure serum 25 hydroxyvitamin D by high performance liquid chromatography and serum intact parathormone, calcium, albumin and phosphate by chemiluminescent enzyme-labeled immunometric assay. Results: Vitamin D level and status were not significantly different between people with prediabetes & control and also in different categories of prediabetes. Severe vitamin D deficiency was significantly higher in people with prediabetes (27.5% vs 10%, p= 0.05). There were no associations between different blood glucose levels with vitamin D among adults with prediabetes. Conclusions:Vitamin D was not associated with prediabetes or its categories. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 120-128

STUDIES IN CONGENITAL GENERALIZED LIPODYSTROPHY (SEIP-BERARDINELLI SYNDROME)

1973 ◽  
Vol 72 (3) ◽  
pp. 475-494 ◽  
Author(s):  
Svein Oseid
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Juvenile Form ◽  
Congenital Generalized Lipodystrophy ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Glucose Tolerance Tests ◽  
The One ◽  
Adipose Organ

ABSTRACT Six cases of congenital generalized lipodystrophy have been studied at different ages from infancy to adolescence with regard to glucose tolerance, insulin secretion, and insulin sensitivity. During the first few years of life there is normal glucose tolerance. The fasting immuno-reactive insulin (IRI) levels are either slightly elevated or normal. The IRI response to glucose is exaggerated and prolonged, at least from the third year of life. Some degree of insulin resistance is already present in infancy. From the age of 8–10 years glucose tolerance decreases rapidly. The fasting IRI levels are usually grossly elevated, while fasting plasma glucose levels are only moderately elevated or normal. The IRI responses to oral and iv administered glucose, and to tolbutamide are exaggerated; the insulinogenic indices are high. Cortisone primed glucose tolerance tests become abnormal. Insulin resistance is marked, and increases with age. After cessation of growth at approximately 12 years of age, frank diabetes with fasting hyperglycaemia and diabetic glucose tolerance curves developed in the one patient followed beyond this age. Her fasting IRI was increased, but there was a poor IRI response to glucose stimulation, suggesting a partial exhaustion of the β-cells. Her initial IRI response to tolbutamide was still good, but not as brisk as in the younger patients. This type of diabetes is quite different from the juvenile form, and also from the diabetes of older age. It may be causally related to the lack of an adequate adipose organ necessary for the disposal of excesses of glucose, or possibly related to another anti-insulin mechanism.

Effect of High ß-Glucan Barley on Postprandial Plasma Glucose Levels in Subjects with Normal Glucose Tolerance and Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 772-P
Author(s):  
MARIKO HIGA ◽  
AYANA HASHIMOTO ◽  
MOE HAYASAKA ◽  
MAI HIJIKATA ◽  
AYAMI UEDA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Normal Glucose Tolerance ◽  
Postprandial Plasma Glucose ◽  
Glucose Levels ◽  
Normal Glucose

scholarly journals Acute Effect of Black Bean (Phaseolus vulgaris L.) Hydrolyzed Protein on Glucose Levels in Adults with Prediabetes and Normal Glucose Tolerance

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 458-458
Author(s):  
Andrea Ramos-Lopez ◽  
Luis Mojica ◽  
Armando Gomez-Ojeda ◽  
Maciste Macias-Cervantes ◽  
Claudia Luevano-Contreras
Keyword(s):  
Placebo Group ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Acute Effect ◽  
Normal Glucose Tolerance ◽  
Black Bean ◽  
Glucose Levels ◽  
Hydrolyzed Protein ◽  
Normal Glucose ◽  
Different Doses

Abstract Objectives In silico, biochemical, in vitro, and in vivo assays have shown that black bean hydrolyzed protein (HPF) could decrease glucose absorption by inhibiting digestive enzymes and blocking gastrointestinal transporters. Therefore, the objective was to evaluate the acute effect of different doses of HPF on glucose levels in adults with normal glucose tolerance (NGT) and with prediabetes. Methods A double-blind, placebo-controlled, randomized clinical trial was conducted on 31 adults with NGT and 24 adults with prediabetes. Participants were 25–50-year-old and with a body mass index (BMI) between 25–34.9 kg/m2. After consent, participants were randomized into four groups, placebo or the corresponding HPF (powder) treatment (D1:2.5 g, D2:3.7 g, D3:5 g). Subjects received the placebo, 120 mL of a commercial beverage (Be-light), or the corresponding HPF dose dissolved in 120 mL of Be-light. An oral glucose tolerance test (OGTT) (75 g glucose) was used to measure glucose tolerance before treatment (initial). A second OGTT was used to evaluate the acute effect of the HPF, and blood samples were collected at 0, 60, 120, and 150 min, and blood glucose levels were measured. Data were analyzed using a one-way ANOVA and paired Student's t-test. Results Participants with NGT: the D3 group showed a decrease in blood glucose area under the curve (AUC) when compared with the D1 group (13,639.2 ± 1585.9 vs. 16,756.6 ± 2709 mg · min/dL; P = 0.05). However, there was no difference with the placebo group (14,073.7 ± 1825.9 mg · min/dL, P = 0.9). When comparing the initial AUC vs. treatment AUC, the placebo, D2, and D3 groups decreased significantly (P = 0.01). Participants with prediabetes: the D3 group also show a significantly decreased in AUC when compared with the D2 group (19,815 ± 3153 vs. 27,545 ± 5398 mg · min/dL; P = 0.01). However, there was no difference with the placebo group (21,743.5 ± 4503 mg · min/dL, P = 0.8). Additionally, when comparing initial AUC vs. treatment AUC, only the D3 group decreased significantly (P = 0.01). Conclusions The comparison of the acute effect of three different doses of HPF showed a decrease in blood glucose (AUC) in a dose-dependent manner in participants with prediabetes. Funding Sources CONACYT Problemas Nacionales 2016-2081.

THE RESPONSE OF INFANTS OF DIABETIC WOMEN TO TOLBUTAMIDE AND LEUCINE AT BIRTH, AND TO GLUCOSE AND TOLBUTAMIDE AT 2 YEARS OF AGE

PEDIATRICS ◽  
1969 ◽  
Vol 43 (4) ◽  
pp. 546-557
Author(s):  
Mutya S. A. Velasco ◽  
Elsa P. Paulsen
Keyword(s):  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Newborn Infants ◽  
Normal Glucose Tolerance ◽  
Diabetic Woman ◽  
Oral Glucose ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Diabetic Mothers

Twelve newborn infants, 2 to 8 days old, of gestational (IGDM) and insulin-requiring (IDM) diabetic mothers responded to intravenous tolbutamide (20 mg/kg) with abnormally large decreases in plasma glucose and marked rises in plasma insulin (the latter was measured only in IGDM). Only 3 of 13 IGDM tested with leucine had significant decreases in plasma glucose. Newborn infants of normal mothers showed no changes in glucose or insulin in response to intravenous tolbutamide, and one of five had a small decrease in glucose levels after leucine. The results suggest the presence of large stores of pancreatic insulin in newborn infants of diabetic mothers which are more readily released by stimulation with tolbutamide than with leucine. The offspring of the diabetic women were restudied at 2 years of age for their response to intravenous tolbutamide and oral glucose. Seven of nine children had normal glucose and insulin levels after intravenous tolbutamide, and two had abnormally low glucose levels with high insulin levels. Three of the nine had normal glucose tolerance with normal insulin levels. The other six had abnormally elevated glucose levels which varied in duration from one-half to 2 hours. Four of the six had an accompanying hyperinsulinemia; two, who had diabetic glucose tolerance, had poor insulin responses. The findings in the 2-year-old children support a concept that the fetal environment provided by a diabetic woman has effects on carbohydrate tolerance which extend beyond the newborn period.

scholarly journals The Comparison of Glycated Hemoglobin and Homeostasis Model Assessment Values to 30, 60 and 90-Min Glucose Levels During OGTT in Subjects with Normal Glucose Tolerance

2014 ◽  
Vol 33 (3) ◽  
pp. 237-244
Author(s):  
Şerif Ercan ◽  
Nihal Yücel ◽  
Asuman Orçun
Keyword(s):  
Glucose Tolerance ◽  
Glycated Hemoglobin ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Glucose Levels ◽  
Increased Risk ◽  
Normal Glucose ◽  
Optimal Values

Abstract Background: The subjects with impaired glucose tolerance have an increased risk for future type 2 diabetes (T2DM); however, a significant number of individuals who develop T2DM have normal glucose tolerance (NGT) at baseline. The study aims to compare glycated hemoglobin (HbA1C) and homeostasis model assessment (HOMA-IR) levels to 30, 60 and 90-min glucose levels in subjects with NGT. Methods: A 75-g oral glucose tolerance test (OGTT) at 0, 30, 60, 90 and 120-min was performed in 1118 subjects without known T2DM. Blood samples were also drawn for fasting insulin and HbA1C levels. Results: Forty percent of the subjects with NGT had increased post-challenge values above the determined optimal glucose levels (10.2, 10.3 and 8.9 mmol/L at 30, 60 and 90-min, respectively). Compared to the subjects with NGT whose glucose levels were below the determined optimal values at 30, 60 and 90-min, we found significantly elevated HbA1C and HOMA-IR levels in the subjects with NGT whose glucose levels were above the determined optimal values (p<0.001). Conclusions: We conclude that the subjects with NGT have different HbA1C and HOMA-IR levels considering glucose levels measured earlier than at 2-h during OGTT. Further well-designed prospective studies are needed to define the significance of 30-min, 60-min and 90-min glucose levels in the prediction of disease in subjects with T2DM.

scholarly journals Elevated 1‐h post‐load plasma glucose levels in Thai people with normal glucose tolerance associated with high diabetes and cardiovascular risk

2019 ◽  
Vol 37 (4) ◽  
pp. 705-706
Author(s):  
Y. Thewjitcharoen ◽  
A. Elizabeth Jones ◽  
S. Butadej ◽  
S. Nakasatien ◽  
P. Chotwanvirat ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Normal Glucose Tolerance ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Thai People
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