scholarly journals Hemi agenesis of Thyroid Gland in a Euthyroid Child having Positive Family History of Thyroid Disorder

2015 ◽  
Vol 17 (1) ◽  
pp. 104-110
Author(s):  
Mohammad Simoon Salekin ◽  
Fatima Begum ◽  
Mohshi Um Mokaddema ◽  
Md Sunny Anam Chowdhury ◽  
Sadia Sultana ◽  
...  
Keyword(s):  
Family History ◽  
Thyroid Gland ◽  
Positive Family History ◽  
Left Lobe ◽  
Developmental Defect ◽  
Thyroid Disorder ◽  
Thyroid Scan ◽  
Hormonal Dysfunction ◽  
History Of

Thyroid Hemiagenesis (THA) is a rare form of thyroid developmental anomaly. This developmental defect may or may not coincide with hormonal dysfunction. The detection of anomaly is quite incidental and infrequently found during investigations assessing thyroid functions. A three years old boy presented with gradual swelling in front of neck during last 2 months. He had no history of delayed milestones. Ultrasound imaging and thyroid scan by 99m -Technetium- pertechnetate revealed hemi agenetic development of left lobe of thyroid gland. His biochemical assessment showed euthyroid state. He had positive family history with hypothyroid maternal grandmother and congenital hypothyroid maternal cousin. Ultrasonography and thyroid scan are useful tools for demonstrating this form of dysgenesis of thyroid gland. Follow up monitoring of thyroid function at regular interval in children with congenital anomaly of thyroid gland should be done to take timely measures, if required. DOI: http://dx.doi.org/10.3329/bjnm.v17i1.22501 Bangladesh J. Nuclear Med. 17(1): 104-110, January 2014

Abstract 12688: Long Term Use of Calcium Channel Blockers and Risk of Breast Cancer Development

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Uyen T Lam ◽  
Stacey Knight ◽  
Tami L Bair ◽  
Viet T Le ◽  
Joseph B Muhlestein ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Positive Family History ◽  
Channel Blockers ◽  
Increased Risk ◽  
History Of ◽  
Incident Breast Cancer

Introduction: Calcium channel blockers (CCBs) are a mainstay in treating hypertension (HTN). Recently, Li et-al published a population based case-control study (JAMA 2013; 289:2354) reporting CCB use to be associated with incident breast cancer (odds ratio 2.6). We prospectively analyzed 2 Intermountain Healthcare (IHC) databases (db) to confirm or refute this provocative report. Methods: Two separate analyses were conducted using general patients (GP) seen at IHC and patients undergoing coronary angiography (CV) at IHC facilities. Subjects were females aged 50-70 with no history of breast cancer. Those prescribed CCB were matched 1:1 to subjects not on CCB based on age, race, tobacco, alcohol, body mass index, HTN and follow up time. Multivariable Cox proportional hazards regression was used for the primary analysis of time to incident breast cancer by CCB use adjusting for history of other cancers and family history of breast cancer. Results: A total of 2612 GP subjects (cases/controls) and 1106 CV subjects (cases/controls) were studied. In the GP db, there was a statistically significant increased risk of breast cancer for subjects using CCB (HR=1.58; 95% CI: 1.10-2.26). Risk was also associated with a positive family history (HR=2.79; 1.96-3.97) and a personal history of cancer (HR=1.87; 1.07-3.26). Breast cancer predominantly developed in <5 y of follow up (64% of cases). However, a reverse relationship was found in the CV db, where the HR was 0.51 (95% CI: 0.27-0.97). This observation was found despite consistent associations with several secondary outcomes, including for incident diabetes, coronary and renal disease. Conclusion: A modest association between CCB use and incident breast cancer was observed in the GP db, but results were not reproducible in the CV db. Given lack of a credible mechanism and failure of previous randomized CCB studies to detect a signal, we interpret these modest and conflicting associations to likely represent uncorrected confounding, e.g. prescriber bias or drug interactions. Similarly, we believe the results of Li et-al may represent confounding. Given the important role of CCBs in clinical medicine, further studies are warranted, including randomized trials to assess CCB safety with respect to breast cancer risk.

scholarly journals Investigation of Tissue Transglutaminase Antibody Normalization in Response to Gluten-Free Diet in Children with Celiac Disease

2021 ◽  
Vol 11 (01) ◽  
pp. e60-e64
Author(s):  
Mohsen Pour Ebrahimi ◽  
Hosein Alimadadi ◽  
Mehri Najafi ◽  
Mohammad Vasei ◽  
Parisa Rahmani
Keyword(s):  
Celiac Disease ◽  
Family History ◽  
Tissue Transglutaminase ◽  
Positive Family History ◽  
Gluten Free Diet ◽  
Histological Evaluation ◽  
Gluten Free ◽  
Significant Difference ◽  
History Of

AbstractA very limited amount of data are available regarding the follow-up of celiac disease (CD) treatment in Iran. The aim of this study is to investigate antitissue transglutaminase (atTG) normalization interval and the associated factors in CD patients. This retrospective study included CD patients enrolled in Children's Medical Center, Tehran University of Medical Sciences. The initial atTG titer and histological evaluation (with Marsh grade ≥2) were recorded. The atTG titer was assessed in each follow-up until the time of normalization where children were strictly on gluten-free diet. The age at the time of diagnosis, gender, Marsh grade at the time of diagnosis, other comorbidities, and family history of CD patients were recorded to determine the association of these factors with antibody normalization interval. In total, 71 patients were recruited in the study of which 34 (47.89%) subjects had atTG level below 20 U/mL at the average interval of 31.36 ( ±  2.89) months (95% confidence interval: 25.7–37.02). There was no significant difference between the antibody normalization interval and different age ranges and Marsh grade. Cox regression demonstrated that gender, age ranges, Marsh grade, positive family history of CD, and the presence of comorbidities did not significantly predict longer antibody normalization interval.

scholarly journals Thyroid hemiagenesis with a TI-RADS 2 nodule in the contralateral lobe

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Senai Goitom Sereke ◽  
Anthony Oriekot ◽  
Felix Bongomin
Keyword(s):  
Thyroid Gland ◽  
Thyroid Tissue ◽  
Left Lobe ◽  
Thyroid Disorders ◽  
Case Presentation ◽  
Thyroid Hemiagenesis ◽  
History Of ◽  
Right Lobe

Abstract Background Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of the thyroid gland fails to develop. There is an increased incidence of associated thyroid disorders in patients with thyroid hemiagenesis. Case presentation A 32-year-old Ugandan woman presented with a complaint of painless neck swelling of 3-months duration. The swelling was associated with a globus sensation. There was no history of thyroid – related problems or treatment prior to this presentation. Physical examination demonstrated a mobile right thyroid swelling without an obvious nodular contour. Neck ultrasound showed an absent left lobe of thyroid gland, a right lobe with a solitary nodule scoring two points on the Thyroid Imaging, Reporting and Data System (TI-RADS) and an isthmus in situ. Extensive search for possible ectopic thyroid tissue was negative. She was biochemically euthyroid. The patient was counseled about thyroid hemiagenesis and was put on a regular follow up in the clinic for the TI-RADS 2 nodule. Conclusion Thyroid hemiagenesis is often associated with other thyroid disorders. Its diagnosis should prompt an active search for other associated morphological or functional thyroid abnormalities.

scholarly journals Abdominal Aortic Aneurysms No Not Develop More Aggressively Among Patients With a Positive Family History of the Disease

2020 ◽  
pp. 1-7
Author(s):  
Trine Maria Mejnert Joergensen
Keyword(s):  
Family History ◽  
Growth Rates ◽  
Positive Family History ◽  
Aortic Aneurysms ◽  
Study Materials ◽  
Abdominal Aortic ◽  
Significant Difference ◽  
History Of ◽  
Time Of Operation

Introduction: It is well known that a family history of Abdominal Aortic Aneurysm (AAA) strongly increases the risk of developing AAA, but it is still unknown whether familial AAAs develop differently than non-familial AAAs. Objectives: To investigate whether familial AAAs develop more aggressively than non-familial AAAs by looking at the growth rate, risk of surgery and rupture, as well as the size of the aneurysm at the time of diagnosis and the patient’s age at the time of operation, rupture and diagnosis. Design: Observational retrospective longitudinal study. Materials and Methods: 318 patients with AAA diagnosed between 1996-2008 in Jutland, Denmark with information on family history of AAA, the diameter of AAA throughout follow-up, surgery, ruptures, comorbidity, smoking, and use of medication. Patients with and without a family history of AAA were compared regarding mean age at diagnosis and surgery, the diameter of AAA at diagnosis, risk of surgery and rupture as well as comorbidity and use of medication. Mean growth rates were compared between the two groups and a mixed-effects model was fitted to control for confounders. Results: We included 93 patients with and 225 without a family history of AAA. Patients with a family history of AAA ere significantly younger than patients with no family history of the disease (69.8 vs. 72.4 years, p=0.032), but we found no significant differences in age at operation (72.2 vs. 70.6, p=0.204), the proportion of patients experiencing rupture (16.0 vs. 10.6%, p=0.226) or undergoing surgery (78.2% vs. 81.7%, p=0.484). We found no significant difference in growth rates between the two groups; 5.25 mm/year for patients with positive family history and 6.19 mm/year for patients with no family history of AAA (p=0.490). Conclusions: We found no evidence to suggest that AAA develops more aggressively in patients with a positive family history of the disease.

scholarly journals Hashimoto's thyroiditis in children and adolescents

2008 ◽  
Vol 136 (5-6) ◽  
pp. 262-266 ◽  
Author(s):  
Slavica Markovic ◽  
Gordana Kostic ◽  
Zoran Igrutinovic ◽  
Biljana Vuletic
Keyword(s):  
Family History ◽  
Children And Adolescents ◽  
Thyroid Disease ◽  
Hashimoto’S Thyroiditis ◽  
Positive Family History ◽  
Clinical Manifestations ◽  
Hashimoto's Thyroiditis ◽  
Long Term Outcome ◽  
History Of

INTRODUCTION Hashimoto's thyroiditis (HT) is a common cause of goitre and hypothyroidism in children and adolescents. Spontaneous remission may occur in up to 50% patients, but the development of hypothyroidism is possible. OBJECTIVE We investigated the clinical manifestations, course and long-term outcome of HT. METHOD We reviewed charts of 43 children (36 females) with HT, mean age at presentation 12.3 years, and mean follow-up duration 4.6 years. RESULTS HT is five times more common in females. The common complaints leading to referral were goitre in 19 children (44.3%), diffuse in 17 children (89.5%). As to the prevalence of goitre, it accounted for significantly more referrals in females (14 girls, and 5 boys; 73.7% vs 26.3%, t-test; p<0.005). Goitre was either isolated in 15 (34.4%) or associated with other complaints in 4 children: anemia in 7 (16.2%), fatigue in 5 (11.8%), increased appetite in 4 (9.7%), weight gain in 3 (7.0%), growth retardation in 2 children (4.7%), at irregular menses in 3 pubertal girls. Hypothyroidism was present in 18 patients (41.1%), 7 (38.8%) on initial admission, and 11 (61.8%) had the mean follow-up duration of 4.6 years. There were 25 euthyroid HT patients (59.9%). The family history of the thyroid disease was positive in 16 children (37.1%) and 12 of them (71.4%) had hypothyroidism. There were 6 patients (13.9%) in whom the disease was associated with some other autoimmune disease. CONCLUSION HT is five times more common in females. The usual complaints leading to referral were diffuse goitre, which accounted for significantly more referrals in females. A positive family history of autoimmune thyroid disease is associated with a higher risk of hypothyroidism in children with HT. Hypothyroid patients may appear in higher percentage of children and adolescents than previously reported.

scholarly journals Evaluation of Subclinical Hypothyroidism in Children and Adolescents: A Single-Center Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Kamila Such ◽  
Aneta Gawlik ◽  
Aleksandra Dejner ◽  
Malgorzata Wasniewska ◽  
Agnieszka Zachurzok ◽  
...  
Keyword(s):  
Family History ◽  
Subclinical Hypothyroidism ◽  
Clinical Symptoms ◽  
Positive Family History ◽  
Analysis Data ◽  
Overt Hypothyroidism ◽  
Treatment Indications ◽  
Single Center Study ◽  
History Of

The main purpose of our retrospective study was to evaluate the medical care of the patients with subclinical hypothyroidism (sHT) and to investigate the rationale for administering L-thyroxine (LT-4) to young sHT patients.Patients and Methods. Based on a retrospective review of the charts of 261 patients referred to the Endocrinology Outpatient Clinic between 2009 and 2014 with suspicion of sHT, 55 patients were enrolled for further analysis. Data collected was baseline age, anthropometric measurements, serum TSH, fT4, fT3, anti-thyroid autoantibodies, positive family history, absence/presence of clinical symptoms, length of follow-up, and data concerning LT-4 therapy (therapy: T1; no therapy: T0).Results. T1 encompassed 33 (60.0%) patients. There were no differences between T1 and T0 (p>0.05) with regard to age, TSH concentrations, BMIZ-score, and hSDS values, though follow-up was longer in T1 (p<0.01). Four (11.8%) children in T1 and none in T0 had a positive family history of thyroid disorders. Fifteen (68.2%) patients in group T0 became euthyroid. One (1.8%) girl (T1) developed overt hypothyroidism.Conclusions. A small percentage of patients can proceed to overt hypothyroidism. Only positive family history seemed to influence the decision to initiate LT-4 therapy. Further prospective studies are warranted in order to establish treatment indications, if any, and the mean recommended dosage of LT-4.

Thyroid Hemiagenesis With TI-RADS 2 Nodule in the Contralateral Lobe: a Case Report

2021 ◽  
Author(s):  
Senai Goitom Sereke ◽  
Anthony Oriekot ◽  
Felix Bongomin
Keyword(s):  
Thyroid Gland ◽  
Thyroid Tissue ◽  
Thyroid Function Test ◽  
Left Lobe ◽  
Case Presentation ◽  
Hormonal Function ◽  
Thyroid Hemiagenesis ◽  
History Of

Abstract Background: Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of thyroid gland fails to develop. There is a higher incidence of associated thyroid disorders in patients with thyroid hemiagenesis. Case presentation: A 32-year-old female presented to a hospital with complaint of painless neck swelling of 3-month duration with associated globus sensations. There were no history of thyroid related problems or thyroid related treatment prior to her presentation. Physical examination demonstrated a mobile right thyroid swelling but no obvious nodular contour. Neck ultrasound demonstrated absent left lobe of thyroid gland, right thyroid gland with solitary nodule of TI-RADS 2 and isthmus in situ. Extensive search for possible ectopic thyroid tissue was negative. Thyroid function test was euthyroid. Conclusion: Early detection of this entity and follow up monitoring of thyroid morphologic and hormonal function have paramount importance.

scholarly journals Evaluation of Breast Cancer Awareness Campaign, Screening Drivers

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 26s-26s
Author(s):  
K. Ammar ◽  
S. Alsater
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Early Detection ◽  
Strong Predictor ◽  
Positive Family History ◽  
Diagnostic Group ◽  
Screening Rate ◽  
Significant Difference ◽  
History Of

Background: King Hussein Cancer Foundation and Center (KHCF & KHCC) lead Breast Cancer (BC) awareness in Jordan through the Jordan Breast Cancer Program. The program aims to reduce morbidity and mortality from BC, and shift the current state of diagnosis from late stages to earlier ones, where the disease is curable, survival rates are higher, and treatment costs are lower. In October, the international BC awareness month, many activities are organized to encourage Jordanian women to undergo screening. Aim: To find out predictors of screening visits at KHCC early detection clinic in October 2015 to evaluate echo of the campaign. In addition, we aim to find the screening rate among women at KHCC early detection clinic. Methods: This is a cross sectional study, using a self-administered questionnaire, carried out in October 2015 and follow-up was completed on August 2016. Results: 291 women responded to the questionnaire, they were categorized into two groups; screening and diagnostic. Screening rate was 57.8% (N=166). In women above 40 years old, 69.3% (N=113) were in the screening group and 30.7% (N= 50) in the diagnostic group. There was no statistically significant difference in the average ages between two groups (49.49 year, 47.82 year, P = 0.218). Positive family history of BC in a first-degree relative was found to be a strong predictor for mammogram screening in comparison with screening group (65.4% vs 16%, P = 0.05); other screening behaviors like commitment to self-breast exam, clinical breast exam and attending educational lecture about BC did not significantly affect screening rates. In addition, screened women were more likely to complete their investigations and follow-up procedures. In this sample, five women were diagnosed with BC; two in advanced stages among the diagnostic group 4%, (N=50) with mean age 54.5 year, and three in early stage among screened group 2.7%, (N=113) with a mean age of 50 year. Conclusion: First-degree family history of BC is a strong predictor of BC screening. Awareness activities might lead to higher screening rates among women in general. Further studies need to be conducted on larger scale to confirm the results of this study.

The consumption of cigarettes, coffee and sweets in detoxified alcoholics and its association with relapse and a family history of alcoholism

2005 ◽  
Vol 20 (5-6) ◽  
pp. 451-455 ◽  
Author(s):  
Klaus Junghanns ◽  
Jutta Backhaus ◽  
Ulrike Tietz ◽  
Wolfgang Lange ◽  
Lothar Rink ◽  
...  
Keyword(s):  
Family History ◽  
Depressive Disorder ◽  
Inpatient Treatment ◽  
Positive Family History ◽  
Coffee Consumption ◽  
Degree Relative ◽  
History Of ◽  
Discharge From Hospital ◽  
Alcohol Dependent

AbstractThirty male alcohol dependent inpatients without concurrent depressive disorder, 13 of them with a positive family history of alcohol dependence in a first degree relative (PFH), were questioned about their desire and consumption habits with respect to cigarettes, coffee, and sweets while on a three-week inpatient treatment after detoxification from alcohol. Six weeks after discharge from hospital, the patients were reassessed for relapse. Eleven patients (36.6%) had relapsed at follow-up. Relapsers were younger than abstainers. The days until relapse correlated negatively with intensity of desire to drink alcohol, desire to smoke cigarettes, and with a higher consumption of cigarettes. PFH patients did not relapse earlier but they had a stronger desire to drink coffee and eat sweets and had a higher coffee consumption.

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