scholarly journals Topographical distribution of sinonasal malignancy

1970 ◽  
Vol 17 (1) ◽  
pp. 21-28
Author(s):  
Mohammad Idrish Ali ◽  
Belayat Hossain Siddiquee ◽  
Md Azharul Islam ◽  
AFM Ekramuddaula ◽  
Sheikh Hasanur Rahman ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Transitional Cell ◽  
Radiological Finding ◽  
Bone Destruction ◽  
Neck Surgery ◽  
Cross Sectional ◽  
Socioeconomic Condition ◽  
Female Ratio ◽  
Sinonasal Malignancy ◽  
Topographical Distribution

Objective: In this study forty patients of sinonasal malignancy were studied to observe the topographical distribution of the disease. Methods: This cross sectional study was done in the Otolaryngology-Head & Neck Surgery Department of Bangabandhu Sheikh Mujib Medical University during the period of January 2007 to December 2008. The diagnosis was made by detailed history, clinical examination, investigation. Analyzed data presented by various tables, graphs and figures. Results: In this study majority of the patients were within 51-60 years of age. Male to female ratio was 3:1 and came from rural area (62.5%). Most of them were farmers (37.5%), illiterate (35%), poor socioeconomic condition (55%) and habits were smoker (37.5%). Most of the patients presented with multiple symptoms and multiple sinuses involvement (70%) and among single sinus involvement maxillary (58.34%) followed by nasal cavity (33.33%), ethmoidal sinuses (8.33%), primary frontal and sphenoid tumours were not found. About T stage of tumour T3 (42.5%), T4 (37.5%), T2 (15%) and T1 (5%). 08 cases were nodal involvement (20%), submandibular node metastasis were most common (62.5%), squamous cell carcinoma (55%), followed by adenocystic carcinoma (10%). Adenocarcinoma (7.5%), mucoepidermal carcinoma (5%), non Hodgkin’s lymphoma (5%), transitional cell carcinoma (5%), small cell carcinoma (5%), chondosarcoma (2.5%) and malignant fibrous histocytoma (2.5%). Radiological finding with bone destruction (12.5%), without bone destruction (87.5%), intracranial involvement (45%) and orbital extension (17.5%). Conclusion: From the review of the series it is obvious that sinonasal malignancy usually presented at advanced stage with multiple sinus involvement. In case of single sinus involvement maxillary antral carcinoma is significantly common than other sinuses. Key words: Topographical Distribution; Sinonasal Malignancy. DOI: 10.3329/bjo.v17i1.7619 Bangladesh J Otorhinolaryngol 2011; 17(1): 21-28

scholarly journals Clinicopathological study of sinonasal malignancy

1970 ◽  
Vol 15 (2) ◽  
pp. 55-59 ◽  
Author(s):  
Kazi Shameemus Salam ◽  
A Allam Choudhury ◽  
Md Delwar Hossain ◽  
Md Abdul Azim ◽  
Md Shafiqul Islam ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Transitional Cell ◽  
Medical College Hospital ◽  
College Hospital ◽  
Neck Node ◽  
Cross Sectional ◽  
Female Ratio ◽  
Medical College ◽  
Sinonasal Malignancy ◽  
Clinicopathological Study

This cross sectional study was done in the Otolaryngology and Head-Neck Surgery Department of Banghabandhu Sheikh Mujib Medical University, Dhaka Medical College Hospital and Sir Salimullah Medical College Hospital during the period of September 2003 to February 2004. In this study 30 patients of sinonasal malignancy were studied and to observe the clinicopathological pattern of sinonasal malignancy. The diagnosis was made by detailed history, clinical, radiological and histopathological examinations. In this study majority of the patients were within 40 to 70 years of age (77%). Male to female ratio was 2.33:1. Majority of the malignancy came from maxillary sinuses 15(50.00%); ethmoidal sinuses were involved in 8(26.66%) cases, multiple sinuses were involved in 5(16.66%). Neck node metastases was found in 4(14%) cases. Squamous cell carcinoma was the most common histological type (70.00%); the other less common histological types were adenoid cystic carcinoma (06.66%), adenocarcinoma (06.66%), Non-Hodgkin's lymphoma (06.66%), least frequent types were malignant fibrous histocytoma, transitional cell carcinoma, olfactory neuroblastoma. Key words: Sinonasal malignancy; clinicopathological study. DOI: 10.3329/bjo.v15i2.5058 Bangladesh J Otorhinolaryngol 2009; 15(2): 55-59

scholarly journals Evaluation of hearing status after type I tympanoplasty

2020 ◽  
Vol 24 (1) ◽  
pp. 50-55
Author(s):  
Mashuque Mahamud ◽  
Mani Lal Aich ◽  
Abdullah Al Mamun ◽  
Rafiul Alam
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Type I ◽  
Cross Sectional ◽  
Female Ratio ◽  
The Mean ◽  
Type I Tympanoplasty ◽  
Air Conduction

Objective: To evaluate hearing outcome after type I tympanoplasty in inactive mucous type of chronic otitis media. Methods: It was a cross-sectional study conducted in the department of Otolaryngology & Head Neck Surgery, Sir Salimullah Medical College and Mitford Hospital, Dhaka, from July 2014 to June 2016. 50 cases were selected by matching inclusion and exclusion criteria. Paired t-test and Z test was used to analyze the variables. P values <0.05 was considered as statistically significant. Results: The mean age was found 28.5 years with range from 15 to 41 years and male female ratio was 1.3:1. All patients had intermittent otorrhoea and varying degree of hearing loss. The mean air conduction threshold was 40.2 dB preoperatively and 27.1 dB post-operatively. Air-bone gap was found 26.9 dB in preoperative and 16.1 dB in post-operative group. The differences were statistically significant between preoperative and post-operative group. Thus mean improvement of air conduction threshold was 13.1 dB and air-bone gap was 10.8 dB. Two third (66.%) patients improved <15 db air conduction thresholds and 17(34%) improved ≥15 db air conduction thresholds. Using the proportion of patients with a postoperative hearing within 40 dB as the criterion, this study showed 46(92%) patients achieving this and 40(80%) patients achieving AB gap within 20 db postoperatively. Conclusion: Improvement of air conduction threshold and AB gap after type I tympanoplasty was statistically significant. Thus from this study it can be concluded that type I tympanoplasty is an effective technique for hearing improvement in inactive mucous type of chronic otitis media. Bangladesh J Otorhinolaryngol; April 2018; 24(1): 50-55

scholarly journals Immunohistochemical Expression of EGFR, NF-kB and Cyclin D1 in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma

2020 ◽  
Vol 12 (3) ◽  
pp. 239-44
Author(s):  
Pudji Rahaju ◽  
Rio Auricknaga Kintono ◽  
Ahmad Dian Wahyudiono ◽  
Arif Satria ◽  
Ferry Sandra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Inverted Papilloma ◽  
Cross Sectional ◽  
Sinonasal Inverted Papilloma

BACKGROUND: Sinonasal inverted papilloma (SIP), a benign epithelial growth in the sinonasal region with epidermoid epithelial transformation, has been known for its invasiveness, recurrency, and its link with malignancy. Meanwhile sinonasal squamous cell carcinoma (SSCC) is an epithelial malignancy on squamous cells from the sinonasal region. Epidermal growth factor receptor (EGFR), Nuclear Factor kB (NF-kB), and Cyclin D1 are factors those might play important role in proliferation of SIP and SSCC. This research was conducted to investigate the expressions of EGFR, NF-kB and Cyclin D1 in SIP and SSCC.METHODS: A cross-sectional study by examining the EGFR, NF-kB, and Cyclin D1 immunohistochemical expressions of SIP and SSCC was conducted. Subjects whose blocks were used in this research, were diagnosed as SIP and SSCC at the Otorhinolaryngology-Head and Neck Surgery Clinic, Dr. Saiful Anwar General Hospital. Samples were selected, processed for inmmunohistochemistry, evaluated and statistical analyzed.RESULTS: Twenty-four SIP and 9 SSCC subjects with their paraffin blocks were selected. Clear immunohistochemical expressions of EGFR, NF-kB, and Cyclin D1 were observed for both SIP and SSCC. Significantly higher immunostaining levels of EGFR (45.6%, p=0.001) and NF-kB (42.2%, p=0.013) were observed in SSCC. Immunostaining levels of EGFR vs. NF-kB were moderately correlated (p=0.03, r=0.437), while the immunostaining levels of NF-kB vs. Cyclin D1 were strongly correlated (p=0.002, r=0.602).CONCLUSION: Expression of EGFR and NF-kB in SSCC were higher than the EGFR and NF-kB expression in SIP, suggesting that EGFR and NF-kB play important role in sinonasal malignancy.KEYWORDS: sinonasal, inverted papilloma, SCC, EGFR, NF-kB, Cyclin D1

scholarly journals Prevalence of Perinatal Asphyxia with Evaluation of Associated Risk Factors in a Rural Tertiary Level Hospital

KYAMC Journal ◽  
2017 ◽  
Vol 8 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Mohammed Solayman ◽  
Sayama Hoque ◽  
Taslima Akber ◽  
Md Imtiajul Islam ◽  
Md Anwarul Islam
Keyword(s):  
Risk Factors ◽  
Perinatal Asphyxia ◽  
Cross Sectional Study ◽  
Neonatal Unit ◽  
Cross Sectional ◽  
Socioeconomic Condition ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
Fetal Risk ◽  
Associated Risk Factors

Background: Perinatal asphyxia (PNA) is one of the most important causes of perinatal mortality and morbidity which can be preventable and managable.Objectives: The purpose of the study was to determine the prevalence of perinatal asphyxia and to explore the factors influencing or related to the development of the PNA.Materials and Methods: It is a cross-sectional study conducted in the neonatal unit of department of pediatrics, KYAMC hospital from January 2015 to December 2016. Two hundred eleven neonates admitted in neonatal unit including SCABU were enrolled in the study considering inclusion criteria. Necessary information about sociodemography, peri-natal history (including antepartum, intrapartum and fetal risk factors) were collected by detailed history taking on a pre-designed questionnaire. Clinical examinations and outcomes were also recorded. We used Student's t-test and ?2-test to determine the association of PNA with various risk factors.Results: The male to female ratio was 1.6:1. The mean age of the neonates during admission time was 3.66 (±5.506) days (in PNA 1.8±2.803 days and in normal group 6.11±7.047 days). The overall prevalence of PNA was 56.9% (120); male 60.8% (73) and female 39.2% (47). Identified significant materno-fetal risk factors were maternal young age (p= .038), low socioeconomic condition (p = .000,) primiparity (p = .003), muconium stained amniotic fluid (p = .004), obstructed labour (p = .019), low birth weight (p = .009) and home vaginal delivery by local dai and midwives (p = .017). Serious neonatal complications noted among the asphyxiated babies were hypoxic ischemic encephalopathy with convulsion, neonatal jaundice, septicemia, transient tachypnoea of neonate, hypoglycemia, respiratory distress syndrome, caput succedaneum and feeding problem.Conclusions: Findings of this study highlight the need for the better obstetrical care and awareness of the possible presence of the risk factors of PNA among mothers and fetus, so that the occurrence and worsening of PNA could be prevented or at least appropriately managed. It can reduce the high incidence of morbidity and mortality due to birth asphyxia.KYAMC Journal Vol. 8, No.-1, Jul 2017, Page 43-48

scholarly journals Relationship between squamous cell carcinoma of the anterior two thirds of the tongue and removable denture use: a pioneer study in a Portuguese population

2011 ◽  
Vol 22 (5) ◽  
pp. 410-414 ◽  
Author(s):  
Rui Alburqueque ◽  
Jose López-López ◽  
Antonio Marí-Roig ◽  
Enrique Jané-Salas ◽  
Eduardo Chimenos-Küstner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Surgery ◽  
Tobacco Consumption ◽  
Etiologic Factor ◽  
Portuguese Population ◽  
Cross Sectional ◽  
Removable Denture ◽  
Carcinoma Of The Tongue

The aim of the study was to determine whether there is any relationship between the presence of removable dentures and squamous cell carcinoma of the anterior two thirds of the tongue in a Portuguese population. A retrospective cross-sectional study was conducted on patients with a biopsy-proven diagnosis of squamous cell carcinoma of the tongue, who were seen and treated at the Department of Head and Neck Surgery of the Portuguese Institute of Oncology 'Francisco Gentil', Lisbon, Portugal, during a 3-year period. Several factors were examined: gender, use of removable dentures, age, location of the lesion, and alcohol and tobacco consumption. One hundred and six cases were selected from the initial 151 cases, with a male:female ratio of 3:1 and the lateral borders being the most commonly affected site. The prevalence in both genders was between the sixth and seventh decade of life. Men were more likely to consume alcohol and tobacco than women, and no relationship was observed between denture use and presence of carcinoma of the tongue. In light of the data obtained, it may be considered that female use of a denture plays an important role, but it cannot be identified as a remarkable etiologic factor.

scholarly journals Clinical Presentation of Thyroglossal Cyst and its Management Study of Two Hundred Cases

2018 ◽  
Vol 25 ◽  
pp. 26-29
Author(s):  
Subrata Ghosh ◽  
Milon Kumar Chowdhury ◽  
Ashik Iqbal ◽  
Monowar Hussain ◽  
Belayat Hussain Siddique
Keyword(s):  
Clinical Presentation ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Thyroglossal Cyst ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Complication Of Surgery ◽  
Head Neck Surgery ◽  
Head Neck

Objectives – To find out clinical presentation, management & Complication of surgery of Thyroglossal cyst.Methods – It was a cross sectional study done in the Department of Otolaryngology and Head-Neck Surgery, BSMMU, DMCH & RMCH, from January 2009 to June 2015. 200 Patients undergoing Sistrunk’s operation for cytologically proven Thyroglossal cyst were included in this study. Patients were reviewed after sugary and any complication that occurred were recorded. Results – Within 200 patients, most (34%) were in 1st decade, mean age19.17 years, male-female ratio 1.2 : 1, in 92.5% cases cyst in midline, Complication of surgical management in 8.5% cases and recurrence is 1.5% cases after Sistrunk’s operation.Conclusions – Thyroglossal cysts commonly present as midline neck swelling within 2nd decade of life and can be successfully treated with Sistrunk’s operation with minimal recurrence.TAJ 2012; 25: 26-29

scholarly journals Basal Cell Carcinoma in Cases with or without Xeroderma Pigmentosum

2017 ◽  
Vol 56 (208) ◽  
pp. 432-7
Author(s):  
Dilasma Ghartimagar ◽  
Arnab Ghosh ◽  
Sushil Ram Shrestha ◽  
Sachet Shrestha ◽  
Raghavan Narasimhan ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Xeroderma Pigmentosum ◽  
Age Groups ◽  
Cross Sectional ◽  
Female Ratio ◽  
Younger Age ◽  
Ethical Approval ◽  
Keywords Basal Cell Carcinoma

Introduction: Basal cell carcinoma is the most common form of cancer in humans and comprises the vast majority of skin cancers. It predominantly affects fair-skinned individuals, and its incidence is rapidly increasing. The objective of the study is to identify the epidemiology, its topography and different histological subtypes of basal cell carcinoma in patients with or without Xeroderma Pigmentosum. Methods: A cross-sectional descriptive study was conducted at Manipal Teaching Hospital, Pokhara from Jan 2009 to Dec 2016. Ethical approval was taken from MEMG/IRC/GA. The study included patients with a confirmed diagnosis of basal cell carcinoma irrespective of their age and sex. Results: This study showed 77 individuals with 91 biopsies of BCC including 5 cases of Xeroderma Pigmentosum. The predominant histological subtype was nodular with 41 (53.94%) cases, followed by the 14 (18.42%) cases of pigmented and 10 (13.15%) cases baso-squamous subtype. The most frequent sites of involvement were the head and neck, with predominance in the nasal and orbital region. The mean age was 57.68 years but the basal cell carcinoma in cases of Xeroderma Pigmentosum was seen more in younger age groups. There were 43 (55.84 %) male patients and 34 (44.16 %) female patients with a male to female ratio of 1.26:1. Conclusions: Nodular and pigmented varieties were the most frequent subtypes with nose being the commonest site of involvement. Basal cell carcinomas in cases of Xeroderma Pigmentosum were noted in younger age group with multiple lesions. Keywords:   basal cell carcinoma; recurrence; topography; xeroderma pigmentosum.

scholarly journals Metastatic neck node with unknown primary

2014 ◽  
Vol 19 (2) ◽  
pp. 94-98
Author(s):  
Md Abdul Karim ◽  
Belayat Hossain Siddiquee ◽  
Mostafa Kamal Masud ◽  
Abdullah Al Harun ◽  
Sheikh Hasanur Rahman
Keyword(s):  
Cell Carcinoma ◽  
Primary Tumour ◽  
Unknown Primary ◽  
Age Group ◽  
Elderly Age ◽  
Primary Methods ◽  
Neck Node ◽  
Cross Sectional ◽  
Unknown Primary Tumour ◽  
Female Ratio

Objective: To find out the clinical presentation of metastatic neck node with unknown primary. Methods: A cross-sectional study done on the admitted patient from four tertiary level hospitals in Dhaka city from January 2010 to September 2010. Results: Most of the cases were squamous cell carcinoma (68.75%). the next common was adenocarcinoma (15.62%) and undifferentiated carcinoma (12.5%). Melanoma was a rare condition (3.13%). The commonest age group was 6th decade (40.63%) which was followed by 5th decade (28%). None of the case was found bellow the age of 30 years. The male to female ratio was 2:1. Commonest metastatic group of lymph node was Level II (50%), followed by Level- III (22%) Level- IV (19%), Level- V (6%) and Level- I (3%). Staging of lymph nodes were N2A (35%), N1 (31%), N2B (16%), N3 (12.5%) and N2C (6.25%) in decreasing order of frequency. About 72% cases are smoker. Conclusion: Metastatic carcinoma with unknown primary tumour commonly present in elderly age group and majority of cases are squmous cell carcinoma. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17631 Bangladesh J Otorhinolaryngol 2013; 19(2): 94-98

Assessment the Incidence of Transitional Cell Carcinoma (TCC) of the Bladder Cancer

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Mahdi M Al-Thuwaini ◽  
Sabah H Enayah ◽  
Mohammed Abdul Azeez Ali Alwzy ◽  
Alyaa Abed_Al Husieen Hafeh
Keyword(s):  
Bladder Cancer ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Population Attributable Risk ◽  
Age Groups ◽  
Older Age ◽  
Specific Rate ◽  
Female Ratio ◽  
Number Of Patients

Background: Transitional cell carcinoma (TCC) of the bladder is the second most common malignancy of the genitourinary tract and the third most common cause of death among people with genitourinary tumors, besides, tumors of the bladder are an important source of both morbidity and mortality. Objectives: The purpose of the study are 1. formulate an idea about the number of patients with bladder cancer (TCCs) in sample of Iraqi population. 2. Study the histopathological features of TCCs of bladder 3. Assessment the prevalence of (TCC) of bladder in both sex (male and female) with smoking as risk factor. Patients and Methods: A study was conducted at one institution were identified that teaching-hospital of Baghdad. All patients included in the present study diagnostic with TCC of bladder. The total of subjects participated in the study were 42 patients and 20 subjects as control through six months’ period from July 2014 to January 2015. Results: The mean of participates age was 655.7 years and the youngest was 21years and the oldest was 75 years. Out of 42 patients, the most common age group was 54-64years (52.38%) with Male to female ratio was 5.2:1.32 were male 32 and 10 were females. However, the prevalence bladder cancer (TCCs) was higher in male than in female, with more pronounced decreases in younger age (≤31year) 3(7.14), have been found. In addition, age specific rate was observed higher in the older age groups for most patients with cancer. The population attributable risk for ever smoking in our study was 33(78.57) out of 42 patients. Moreover, current study shows there was a correlation between grade and stage of bladder TCC, 24(57.14%) bladder TCCs that classified as grade I, while 2(4.76%) of bladder TCC were classified as grade II. Conversely, of the bladder TCC lesions (11.9%, 14.28%, 57.14 and 4.76) were stage (pTa-T1-T2-T3) respectively. Although this study showed 5(11.9) little-known stage and grade. The area of histopathological changes included were showed hyperplastic changes, involving the entire bladder lining, that ranged from flat hyperplasia to small areas of nodular and papillary hyperplasia. The smallest recognizable nodular and papillary lesions were associated with angiogenesis in the contiguous stroma. In addition, there were chromatin irregularities and nucleoli of variable numbers, shape and size. Nuclear chromatin irregularity and mitoses were easily identified, these cells continued to have the appearance of hyperplastic epithelium. The changes noted by generalized and orderly proliferative reaction and appeared reparative. Conclusions: Our study has revealed that the bladder TCC, where appeared the high prevalence and incidence rate of TCC of bladder in sample of Iraqi population were of concern, especially for older age groups.

scholarly journals Presentation of sinonasal carcinoma

2014 ◽  
Vol 19 (2) ◽  
pp. 99-103
Author(s):  
Md Momenul Haque ◽  
Mohammad Idrish Ali ◽  
Md Harun-Ar-Rashid ◽  
Md Tariqul Islam ◽  
Mujibur Rahman ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Economic Condition ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Medical College ◽  
Sinonasal Carcinoma ◽  
Age Limits

Objective: To observe the pattern of clinical presentation according to site of origin of sinonasal carcinoma. Methods: This cross-sectional study was done in the Department of Otolaryngology-Head and Neck Surgery, BSMMU and Dhaka Medical College Hospital, Dhaka during the period from January 2008 to December 2009. Patients of sinonasal carcinoma were evaluated by detailed history, clinical examination and relevant investigations. Results: The present study included 40 patients of sinonasal malignancy bearing age limits of 4 years to 75 years with mean age 48.29. Male and female ratio was 2.6:1. Most patients (77.5%) came from rural area and illiterate (40%) and most of them were farmers (40%), having poor socio-economic condition (50%). About 35% of them were smokers and more than one other personal habit. Majority patients presented with multiple sinuses involvements (72.5%) and among single sinus involvement maxillary sinus was most common (63.63%), followed by nasal cavity (27.27%) and ethmoidal sinus (9.09%) as primary site. Conclusion: Though carcinoma of the nose and paranasal sinuses is relatively uncommon, it is not uncommon in our country. This disease generally presents in an advanced stage. Overall prognosis was directly related to diseases stages. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17632 Bangladesh J Otorhinolaryngol 2013; 19(2): 99-103

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