scholarly journals Comparative Evaluation of Analgesic, Anti-inflammatory and Antipyretic Effects of Synthetic Derivatives of Organoantimony (?) Ferocenyl Benzoate with Piroxicam

2016 ◽  
Vol 19 (1) ◽  
pp. 15-24
Author(s):  
Muhammad Shoaib Akhtar ◽  
Zulfiqar Khan ◽  
Muhammad Naveed Mushtaq ◽  
Muhammad Salman Akhtar
Keyword(s):  
Pharmaceutical Journal ◽  
Significant Inhibition ◽  
Diffusion Method ◽  
Dependent Manner ◽  
Standard Drug ◽  
Compound A ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Synthetic Derivatives ◽  
Dose Dependent

The current study was planned to evaluate comparative anti-inflammatory, analgesic and anti-pyretic activities of two newly synthesized organo-antimony (v) ferrocenyl benzoate derivatives with piroxicam. Anti-microbial activity of these compounds was also screened against two microorganisms. Analgesic effect of test compounds was evaluated by formalin-induced paw licking test in mice. The test compounds at 50 and 100 mg/kg b.w. doses exhibited significant (p<0.001) reduction of paw licking in treated mice comparable with standard drug piroxicam. Anti-inflammatory activity was assessed against carrageenan-induced paw oedema. The compound A produced anti-inflammatory effects comparable with standard piroxicam in dose dependent manner whereas compound B showed better effects than piroxicam at dose of 100 mg/kg body weight. To investigate anti-pyretic activity, fever was induced by administration of Brewer’s yeast in mice. Compound A showed highly significant inhibition of pyrexia (p<0.001) comparable to piroxicam after 3 hours while compound B (50 and 100 mg/kg) produced relatively lower anti-pyretic effect than standard drug. Antibacterial activity determined by disc diffusion method showed that compound B was relatively more effective than compound A against Staphylococcus aureus and Klebsiella pneumoniae. It is conceivable that both the tested compounds possessed anti-inflammatory, analgesic, anti-pyretic and anti-microbial effects even after the structural modification of parent compound.Bangladesh Pharmaceutical Journal 19(1): 15-24, 2016

scholarly journals Antinociceptive and Anti-Inflammatory Activities ofBridelia retusaMethanolic Fruit Extract in Experimental Animals

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Tekeshwar Kumar ◽  
Vishal Jain
Keyword(s):  
Acetic Acid ◽  
Animal Models ◽  
Methanolic Extract ◽  
Significant Inhibition ◽  
Dependent Manner ◽  
Paw Oedema ◽  
Antinociceptive Effects ◽  
Anti Inflammatory ◽  
Wbc Count ◽  
Dose Dependent

Antinociceptive and anti-inflammatory potentials of methanolic extract ofBridelia retusafruit (BRME) were evaluated against different animal models in rodents. Antinociceptive effects of BRME were assessed in mice using the acetic acid-induced writhing and formalin test. Anti-inflammatory effects of BRME in three different doses, namely, 100, 200, and 400 mg/kg, were evaluated by utilizing different animal models representing various changes associated with inflammation, namely, carrageenan-induced paw oedema, histamine and serotonin-induced paw oedema, arachidonic acid-induced paw oedema, formalin-induced paw oedema, TPA-induced ear oedema, acetic acid-induced vascular permeability, total WBC count in paw fluid, and myeloperoxidase assay. Also BRME was phytochemically evaluated using chromatographic method. The BRME did not exhibit any signs of toxicity up to a dose of 2000 mg/kg. The extract showed statistical significant inhibition of induced nociception and inflammation in dose dependent manner. The higher dose of extract significantly inhibited pain and inflammation against control (P<0.001). HPLC results revealed the presence of gallic acid and ellagic acid as phytoconstituents in BRME and it was proven as anti-inflammatory agents. The present study scientifically demonstrated the antinociceptive and anti-inflammatory potential of fruit ofB. retusamethanolic extract. These effects may be attributed to the presence of polyphenolic phytoconstituents in the extract.

scholarly journals Anti-inflammatory and Anti-arthritic Activities ofMerremia tridentate(L.) Hall. f.

2009 ◽  
Vol 6 (4) ◽  
pp. 943-948 ◽  
Author(s):  
M. Kamalutheen ◽  
S. Gopalakrishnan ◽  
T. Syed Ismail
Keyword(s):  
Ethanol Extract ◽  
Albino Rats ◽  
Standard Drug ◽  
Arthritis Model ◽  
Paw Oedema ◽  
Dependent Activity ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Dose Dependent ◽  
Rat Paw Oedema

The various extracts ofMerremia tridentatewere investigated for its anti-inflammatory and anti-arthritic activities in male albino rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw oedema model and the anti-arthritic activity was carried out using complete Freund’s adjuvant induced arthritis model. Indomethacin (10 mg/kg bw) was used as a standard drug. The ethanol extract ofM. tridentateexhibited significant dose dependent activity in acute inflammation and the doses of 100 mg/kg bw and 200 mg/kg bw produced 38.3% and 42.8% inhibition respectively after 3 h as compared with that of the standard drug which showed 48.5% inhibition. In arthritis model, the doses of 100 mg/kg bw and 200 mg/kg bw of the ethanol extract produced 49.0% and 51.7% inhibition respectively after 19 days when compared with that of the standard drug (55.5%). Both doses of the ethanol extract ofM. tridentateexhibit significant anti-inflammatory and anti-arthritic activities.

scholarly journals INVESTIGATION ON PHARMACOGNOSY AS WELL AS THE ANTIOXIDANT, ANTI-INFLAMMATORY POTENTIAL OF THE KATHA POWDER

2021 ◽  
pp. 125-132
Author(s):  
PANKAJ SHARMA ◽  
RAJU L
Keyword(s):  
Diclofenac Sodium ◽  
In Vitro Study ◽  
Alcoholic Solution ◽  
Hot Water ◽  
Dependent Manner ◽  
Standard Drug ◽  
Anti Inflammatory ◽  
Acacia Catechu ◽  
Dose Dependent

Objective: The objective of the study was to investigate the pharmacognosy as well as the antioxidant, anti-inflammatory potential of the Katha powder. Methods: The Coarsely dried chips of Acacia catechu heartwood were treated with 10 % hydro-alcoholic solution to obtain Katha as the final product. The powdered Katha was standardized through pharmacognostic parameters. This Katha power is showing the good solubility in the hot water having astringent in the taste. The powder microscopy of the Katha powder is to be demonstrated fragments of acicular crystals, fibers, and bordered pitted vessels. Katha powder antioxidant potential is to be accessed by using the 2, 2-diphenyl-1-picryl hydrazyl assay and NO Scavenging assay using ascorbic acid as a standard drug. Further, the Katha powder is to be subjected for the assessment of its anti-inflammatory potential by the use of heat-induced hemolysis as well as hypotonicity-induced hemolysis approach by the use of the aspirin or diclofenac sodium as a standard drug. Results: Microscopical investigations were showed that Katha showing the presence of fragments of acicular crystals, fibers, and bordered pitted vessels. In vitro study shows that the Katha powder has excellent antioxidant as well as anti-inflammatory potential in a dose-dependent manner in comparison of the result of heartwood of A. catechu. Conclusion: So from this investigation, it is to be suggested that the Katha powder is rich in the phenolic compound and the experimentation study shows that the drug is to possess a good antioxidant as well as anti-inflammatory property.

scholarly journals Anti-inflammatory activity of Syzygium cumini leaf against experimentally induced acute and chronic inflammations in rodents

2011 ◽  
Vol 1 (1) ◽  
pp. 6 ◽  
Author(s):  
Anirban Roy ◽  
Sanjib Bhattacharya ◽  
Jitendra N. Pandey ◽  
Moulisha Biswas
Keyword(s):  
Inflammatory Activity ◽  
Dependent Manner ◽  
Syzygium Cumini ◽  
Large Size ◽  
Paw Oedema ◽  
Chronic Models ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Dose Dependent ◽  
Rat Paw Oedema

<p><em>Syzygium cumini<strong> </strong></em>(L.) Skeels (Myrtaceae), commonly known as <em>Jam </em>in Bengali, <em>Jamun</em> in Hindi and <em>Black Plum</em> or <em>Black Berry</em> in English, is a large size evergreen tree indigenous to India and is cultivated for its fruits. In the present study, the methanol extract of leaves from <em>S. cumini </em>(MESC) was evaluated for anti-inflammatory activity in experimental acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic models (cotton pellet induced rat granuloma). In all models, the MESC (100 and 200 mg/kg body wt. p.o.) exhibited significant anti-inflammatory activity (<em>p &lt; 0.001</em>) in a dose dependent manner. These findings revealed that the <em>S. cumini </em>leaf had remarkable acute and chronic anti-inflammatory actions in the tested rodent models.</p>

scholarly journals Anti-inflammatory potential of ethanol leaf extract of Sphenocentrum jollyanum in experimental mice

2021 ◽  
Vol 7 (1) ◽  
pp. 146-156
Author(s):  
Emmanuel Uka ◽  
Efosa Godwin Ewere ◽  
Grace Sylvester Effiong
Keyword(s):  
Leaf Extract ◽  
Folk Medicine ◽  
Control Group ◽  
Standard Drug ◽  
Egg Albumin ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Ear Oedema

Anti-inflammatory potential of the ethanol leaf extract of Sphenocentrum jollyanum (ELESJ) was assessed in-vivo in mice by using carrageenan-induced paw oedema, egg albumin-induced paw oedema, and xylene-induced ear oedema model at doses of 474.34, 948.68, and 1423.03 mg/kgbw respectively. A total of seventy-five matured mice of both sexes weighing between 20 g and 24 g (divided into three groups of 25 mice each for the 3 different studies) were used for this study. Treatment was done intraperitoneally. Distilled water (10 mL/kgbw), acetylsalicylic acid (ASA) (100 mg/kgbw) or dexamethasone (4 mg/kgbw) served as the normal and standard drugs respectively. The results showed that ELESJ produced significant (p < 0.05), dose-dependent and time-dependent reductions in mean paw thickness in groups III-V compared with control group. Similarly, the extract caused a dose-dependent increase in percentage inhibition of carrageenan-induced paw oedema and egg-albumin induced paw oedema (34.49%, 36.71%) at the highest dose (1423.03 mg/kg), comparable with the anti-inflammatory effects of the standard drug ASA (34.69%, 31.54%). The ELESJ also caused significant (p < 0.05), dose-dependent decreases in xylene-induced ear oedema weight in all the test groups relative to control group and standard drug group. In addition, ELESJ showed a dose-dependent percentage inhibitory effect (44%) at the highest dose (1423.03 mg/kg) comparable with that of the standard drug, dexamethasone (48%). The results obtained from this study support the use of the leaf in folk medicine as it has significant anti-inflammatory properties and this may be attributed to the phytochemical constituents of the leaf.

In vivo anti-inflammatory activity of two anthrones from the leaf latexes of Aloe adigratana reynolds and Aloe elegans todaro

2019 ◽  
Vol 34 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Mengsteab Tsegay ◽  
Yitagesu Tewabe ◽  
Daniel Bisrat ◽  
Kaleab Asres
Keyword(s):  
Preparative Thin Layer Chromatography ◽  
Northern Ethiopia ◽  
Dependent Manner ◽  
Standard Drug ◽  
Paw Oedema ◽  
Phytochemical Investigation ◽  
Anti Inflammatory ◽  
Morphological Differences ◽  
Layer Chromatography

Aloe adigratana Reynolds and Aloe elegans Todaro are traditionally used for the treatment of various illnesses, including wounds, infections and inflammation in northern Ethiopia. Despite their morphological differences, the leaf latexes of both Aloes showed the same chemical profile when analyzed by TLC. Further phytochemical investigation of these latexes by preparative thin layer chromatography (PTLC) afforded two anthrones, which were identified as aloin A/B and microdontin A/B on the basis of NMR and MS analysis. In the present study, in vivo anti-inflammatory activities of the leaf latexes of A. adigratana and A. elegans as well as the two isolated anthrones were evaluated using carrageenan-induced mouse paw oedema model. It was noted that the latexes as well as the isolated compounds possess anti-inflammatory activities in a dose-dependent manner. The results also showed that microdontin A/B has a better activity than aloin A/B, in both the early and late phases of inflammation. At a tested dose of 200 mg/kg, microdontin A/B showed oedema inhibition of 35.9%, one h after carrageenan injection, while the inhibition caused by the standard drug indomethacin (10 mg/kg) was 18.6%. In conclusion, the results of the present work confirmed that A. adigratana and A. elegans have genuine anti-inflammatory activities attributed at least in part to the presence of aloin A/B and microdontin A/B in the leaves supporting their use in traditional medicine. Keywords: Aloe adigratana, Aloe elegans, anti-inflammatory, microdontin A/B, aloin A/B

scholarly journals Anti-inflammatory and antipyretic activity of Fioria vitifolia

2013 ◽  
Vol 2 (7) ◽  
pp. 119-121
Author(s):  
Krishnamoorthi Mahalakshmi ◽  
Senthil Kumar Natesan ◽  
Kugalur Ganesan Parthiban ◽  
Ganesan Sekar
Keyword(s):  
Body Temperature ◽  
Respiratory Infections ◽  
Folk Medicine ◽  
Pharmaceutical Journal ◽  
Maximal Effect ◽  
Dependent Manner ◽  
Antipyretic Activity ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Pre Treatment

Fioria vitifolia Linn., (Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also as an immune system booster. Steroids, flavonoids, and triterpenes, gossypin alkaloids have been isolated from the whole part of the plant. In the present study, the methanolic extract of dried plant of Fioria vitifolia (MEFV) was investigated for anti-inflammatory (carrageenan induced rat paw oedema) and anti-pyretic (brewer’s yeast induced pyrexia) activities. Pre-treatment with the extract (250-500mg/ kg, p. o) significantly prevented increase in volume of paw oedema in dose dependent manner. A maximal effect was observed at 500mg/kg which was comparable to diclofenac (20mg/kg, orally). Ceiling effect at the dose of 500mg/kg was observed. The anti-pyretic effect of MEFV (measured as % reduction in body temperature) was compared with paracetamol (150mg/kg, orally). MEFV in dose of 500mg/kg caused significant decrease in body temperature of rats. In conclusion, this study has established the anti-inflammatory activity and anti pyretic activity of Fioria vitifolia and thus, justifies the ethnicuses of the plant.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15154 International Current Pharmaceutical Journal, June 2013, 2(7): 119-121

Anti-nociceptive and Anti-inflammatory Activities of Crotalaria pallida Aiton (Fam: Fabaceae) Leaves

2018 ◽  
Vol 20 (2) ◽  
pp. 165-171
Author(s):  
Israt Jahan Bulbul ◽  
Sumaiya Binta Fashiuddin ◽  
Mohammad R Haque ◽  
Md Zakir Sultan ◽  
Mohammad A Rashid
Keyword(s):  
Ethanolic Extract ◽  
Pharmaceutical Journal ◽  
Immersion Test ◽  
Significant Inhibition ◽  
External Application ◽  
Traditional Uses ◽  
Paw Oedema ◽  
Tail Immersion ◽  
Crotalaria Pallida ◽  
Anti Inflammatory

The present study was designed to evaluate the anti-nociceptive and anti-inflammatory properties of the ethanolic extract of Crotalaria pallida Aiton (Family: Fabaceae) leaves based on its traditional uses in the treatment of urinary disorders, external application as a poultice to treat painful swelling of joints and to reduce fever. The anti-nociceptive effect was assessed in mice using acetic acidinduced writhing, formalin-induced paw licking and tail immersion assays. Anti-inflammatory activity was evaluated by carrageenan induced paw oedema in rats. In acetic acid-induced writhing test, the extract at different doses (50 mg/kg and 100 mg/kg bw) significantly (p<0.001) and dose-dependently reduced pain by 37.50% and 47.70%, respectively. The extract also significantly inhibited formalininduced paw licking in mice at both the early and late phases. In the tail immersion test, the extract caused a significant inhibition of pain (64.91% inhibition after 4 hrs) at a dose of 100 mg/kg. C. pallida exhibited a considerable inhibition of paw oedema development in the carrageenan-induced oedema test. The findings of the study suggested that C. pallida leaves have significant anti-nociceptive and antiinflammatory effects, confirming the traditional uses of this plant in the treatment of various diseases associated with pain and inflammation.Bangladesh Pharmaceutical Journal 20(2): 165-171, 2017

scholarly journals Scrutinizing pharmacological efficiency for Acacia auriculiformis by experimental and computational approach

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shafinaz Nur ◽  
Md. Mohotasin Hossain ◽  
Nadia Islam ◽  
Abu Montakim Tareq ◽  
Nujhat Binte Hanif ◽  
...  
Keyword(s):  
Protein Denaturation ◽  
Acacia Auriculiformis ◽  
Dependent Manner ◽  
Binding Interaction ◽  
Standard Drug ◽  
Brine Shrimp Lethality Assay ◽  
Anti Inflammatory ◽  
Dose Dependent

Abstract Background The study sought to investigate the biological efficacy of methanol leave extract of Acacia auriculiformis (MEAA) via in vitro, in vivo, in silico approaches. The in vitro cytotoxicity was evaluated through brine shrimp lethality assay, and anti-inflammatory activity was determined by membrane stabilisation and protein denaturation methods (BSA and egg albumin). The in vivo antipyretic activity was examined via Brewer’s yeast induced pyrexia model. Results A. auriculiformis extract unveiled moderate cytotoxicity with significant anti-inflammatory efficacy (p < 0.001) compared to standard drug. This extract also exhibited dose-dependent time of paralysis and death for the worm (p < 0.001) in the anthelmintic test which was directly proportional to employed concentrations. A notable percentage of clot lysis effect (36.42 ± 1.95%, p < 0.001) was also observed for MEAA in human blood compared to control. However, this extract significantly (p < 0.05) reduced fever in a dose-dependent manner during the antipyretic experiment. Besides, in computer-aided investigations, two compounds (2,4-ditert-butylphenol and 3-hydroxy-β-damascone) revealed the best binding interaction with six proteins for cytotoxicity, inflammation, helminthic, thrombolytic and pyretic effect. Moreover, these two compounds satisfy Lipinski’s ‘Rule of Five’ and revealed drug-likeness profiles in the toxicological study. Conclusions These findings disclosed that methanol leaves extract of A. auriculiformis might be a potent source for anti-inflammatory, anti-helminthic, thrombolytic and antipyretic agents.

scholarly journals Bioactivities of Colocasia affinis Schott and Profiling of its Bioactive Polyphenols by HPLC-DAD

2021 ◽  
Vol 24 (1) ◽  
pp. 1-10
Author(s):  
Shrabanti Dev ◽  
Rabindra Nath Acharyya ◽  
Manik Chandra Shill ◽  
Md Abdullah Al Bari ◽  
Kaniz Asma ◽  
...  
Keyword(s):  
Indian Subcontinent ◽  
Pharmaceutical Journal ◽  
Dependent Manner ◽  
Traditional Medicines ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Anti Inflammatory ◽  
Assessment Of Evidence ◽  
First Time ◽  
Dose Dependent

Traditional medicines including Ayurveda, Unani have been used as therapeutics in the Indian subcontinent since 5000 BC. Because of the abundance of secondary metabolites, medicinal plants are becoming priceless natural resources for better drug development. Till date almost no ethnopharmacological evidences were available on Colocasia genus except Colocasia esculenta. As a part of our continuing assessment of evidence based use of traditional medicine, we have identified bioactive polyphenols in the ethanolic leaves extract of Colocasia affinis Schott using HPLC-DAD method and evaluated its anti-allergy, anti-inflammatory and anti-diabetic potentials for the first time. Chromatographic investigation showed the presence of p-coumaric acid, trans-ferulic acid, rosmarinic acid, myricetin and kaempferol in the leaves extract. Pharmacological profile exploration demonstrated its anti-inflammatory activity at a dose of 250- and 500-mg/kg in xylene-induced ear edema in mice. The extract significantly reduced the allergy like symptoms such as sneezing, scratching, rhinorrhea, redness and swelling in Tolune diisocyanate (TDI) sensitized allergy model mice at 250- and 500-mg/kg doses. Besides, the extract also exhibited reduction in the level of neutrophils, lymphocytes and eosinophils in a dose dependent manner in the experimental animal. The extract also confirmed reduction of blood glucose levels in the experimental mice at a dose of 250- and 500-mg/kg. Therefore, it is evident that C. affinis demonstrated possesses medicinal values through its anti-inflammatory, anti-allergic and anti-hyperglycaemic potentials. Bangladesh Pharmaceutical Journal 24(1): 1-10, 2021

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