A 60 Years Old Man with Adenocarcinoma of Colon and Lung with an Isolated Adrenal Metastasis: A Case Report

The incidence of synchronous colorectal and lung cancer associated with adrenal metastasis is relatively rare. We report of patient with tumour located in the right colic flexure adjoining ascending colon, mid and partly upper lobe of right lung. Pathological examination showed the colorectal and lung cancer were poorly differentiated adenocarcinoma. Right adrenal mass was adrenocortical metastatic carcinoma. Surgical treatment and postoperative adjuvant chemotherapy for the lung cancer were different from those for colorectal cancer with pulmonary metastasis. If possible, radical resection should be performed for each cancer when synchronicity is found. CBMJ 2020 January: Vol. 09 No. 01 P: 30-37

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Intestinal obstruction caused by neoplasms in two cows

Ciência Rural ◽

10.1590/0103-8478cr20151488 ◽

2016 ◽

Vol 46 (7) ◽

pp. 1252-1255

Author(s):

Antônio Carlos Lopes Câmara ◽

Márcio Botelho de Castro ◽

Eraldo Barbosa Calado ◽

Benito Soto-Blanco

Keyword(s):

Intestinal Obstruction ◽

Clinical Signs ◽

Abdominal Distension ◽

Metastatic Carcinoma ◽

Pathological Examination ◽

Ovarian Teratoma ◽

Abdominal Tumors ◽

Poorly Differentiated ◽

The Right ◽

Crossbred Cow

ABSTRACT: In cattle, abdominal tumors leading to partial or total intestinal obstruction are rare. Here, it is described the clinico-pathological findings of two cows with intestinal obstruction by neoplasms. A crossbred cow presented apathy, weight loss, constipation, enophthalmos, ruminal and intestinal hypomotility, and abdominal distension in the right ventral quadrant. Pathological examination revealed bilateral ovarian teratoma. The other case was a cow that in the past 2 years had several episodes of squamous cell carcinoma in the third eyelid and vulva. During the 6 days prior to investigation, clinical signs of constipation and tenesmus were noted. Nodular and friable masses were located in the vulva, right third eyelid and cranially to the right kidney that were identified as poorly differentiated metastatic carcinoma of the adrenal cortex. To our knowledge, these are probably the first reports of ovarian teratoma and adrenal carcinoma causing clinical signs of intestinal obstruction in cattle.

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Colonic metastasis of hepatocellular carcinoma with repeated retroperitoneal bleeding: a case report

Surgical Case Reports ◽

10.1186/s40792-021-01349-7 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Wataru Miyauchi ◽

Manabu Yamamoto ◽

Makinoya Masahiro ◽

Yuji Shishido ◽

Kozo Miyatani ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Muscularis Propria ◽

Metastatic Tumor ◽

Radical Resection ◽

Right Hemicolectomy ◽

Pathological Examination ◽

Ascending Colon ◽

Colonic Metastasis ◽

Case Presentation ◽

The Right

Abstract Background Colonic metastasis is uncommon in patients with hepatocellular carcinoma (HCC). In the past, extrahepatic metastasis of HCC was not treated aggressively because of its poor prognosis. Herein, we describe the case of a patient with HCC who survived for 30 months following resection of a metastatic tumor in the ascending colon. Case presentation An 80-year-old man presented at our hospital with symptoms of abdominal pain on the right side and fever. He had undergone transcatheter arterial chemoembolization and posterior segment resection of the liver because of HCC, followed by radiofrequency ablation for a recurrent intrahepatic lesion 5 and 3 years, respectively, prior to the visit. He was diagnosed with retroperitoneal hematoma, which was thought to be associated with diverticulitis and an extramural tumor in the ascending colon. A definitive diagnosis could not be reached; however, a right hemicolectomy of the colon was performed because of progression to anemia. A pathological examination revealed a metastatic tumor in the ascending colon extending from the subserosal layer to the muscularis propria layer. The patient was treated with lenvatinib after surgery, but presented with intrahepatic recurrence, lymph node metastasis, and peritoneal dissemination metastasis 15 months later. The progression of the disease could not be controlled and his postoperative survival time was 30 months. Conclusion Resection of metastasis of HCC might contribute to prolonged survival in cases, where radical resection is possible.

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METASTASIS OF AN ADENOCARCINOMA OF THE STOMACH TO THE 4TH METACARPAL BONE

Hand Surgery ◽

10.1142/s0218810401000515 ◽

2001 ◽

Vol 06 (02) ◽

pp. 239-242 ◽

Cited By ~ 6

Author(s):

H. C. Chang ◽

K. H. Lew ◽

C. O. Low

Keyword(s):

Metastatic Lesion ◽

Metacarpal Bone ◽

Review Of The Literature ◽

Poorly Differentiated Adenocarcinoma ◽

Poorly Differentiated ◽

The Right

Metastatic tumours of the hand are uncommon. The majority of these tumours affect the phalanges and the primary tumours are usually bronchogenic in origin, with breast and kidney tumours next in frequency. Metastatic gastrointestinal to the hand is rare and usually from the colon. We report a case of poorly differentiated adenocarcinoma of the stomach antrum presenting with a metastatic lesion to the right 4th metacarpal bone. A review of the literature is included.

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A Case of Collision Tumor of Primary Malignant Lymphoma and Poorly-differentiated Adenocarcinoma in the Ascending Colon

The Japanese Journal of Gastroenterological Surgery ◽

10.5833/jjgs.37.213 ◽

2004 ◽

Vol 37 (2) ◽

pp. 213-216 ◽

Cited By ~ 6

Author(s):

Eiji Minato ◽

Ippei Fujino ◽

Nobuhito Sugihira ◽

Kazuo Matsumoto ◽

Kouichi Shima

Keyword(s):

Malignant Lymphoma ◽

Collision Tumor ◽

Ascending Colon ◽

Poorly Differentiated Adenocarcinoma ◽

Poorly Differentiated

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Diffuse Cutaneous Metastases as the Only Sign of Extranodal Tumor Spread in a Patient with Adenocarcinoma of the Colon

ISRN Surgery ◽

10.5402/2011/902971 ◽

2011 ◽

Vol 2011 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Serenella Civitelli ◽

Barbara Civitelli ◽

Jacopo Martellucci ◽

Gabriello Tanzini

Keyword(s):

Right Colon ◽

Cutaneous Metastases ◽

Tumor Spread ◽

Site Specific ◽

Poorly Differentiated Adenocarcinoma ◽

Anatomical Relationship ◽

Poorly Differentiated ◽

Adenocarcinoma Of The Colon ◽

The Right ◽

A Site

Cutaneous metastases from large bowel cancer are uncommon and are usually associated with organ involvement. Localization of lesions to the skin is mainly attributed to vascular and anatomical relationship, since most of them are seen in the abdominal wall or in a surgical scar. We report a 73-year-old woman in whom metastatic nodules from a poorly differentiated adenocarcinoma of the right colon developed throughout the skin (buttock, trunk, chest wall, arms, and neck) and remained the only sign of extranodal tumor spread until patient's death, seven months later. This unusual behaviour suggests that localization of neoplastic cells to the skin may be a site-specific process, determined by adhesion molecules and/or by growth factors found at that site.

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Primary Malignant Melanoma of the Rectum: Report of Two Cases

Case Reports in Surgery ◽

10.1155/2012/247348 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Kodai Tomioka ◽

Hitoshi Ojima ◽

Makoto Sohda ◽

Akiko Tanabe ◽

Yasuyuki Fukai ◽

...

Keyword(s):

Malignant Melanoma ◽

Systemic Treatment ◽

Early Stage ◽

Immunohistochemical Analysis ◽

Pathological Examination ◽

Anorectal Melanoma ◽

Stage Iiic ◽

Poorly Differentiated Adenocarcinoma ◽

Poorly Differentiated ◽

Tumor Node Metastasis Classification

We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-45 and negative for cytokeratin AE1/AE3, CD45, and synaptophysin. Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. To improve prognosis, it is important to detect anorectal melanoma at an early stage.

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Bone Metastasis of Non-Small-Cell Lung Cancer Showing Pathological Complete Response to Osimertinib Monotherapy

Case Reports in Oncology ◽

10.1159/000520473 ◽

2021 ◽

pp. 1876-1881

Author(s):

Hiroshi Shintani ◽

Shoji Oura ◽

Tomoyuki Yamaguchi ◽

Shinichiro Makimoto

Keyword(s):

Lung Cancer ◽

Bone Metastasis ◽

Lung Adenocarcinoma ◽

Kinase Inhibitors ◽

Pathological Complete Response ◽

Lung Nodule ◽

Growth Factor Receptor ◽

Complete Response ◽

Pathological Examination ◽

The Right

A 70-year-old man with lung adenocarcinoma had undergone right lower lobectomy and lymph node dissection. Only 6 months later under adjuvant uracil and futraful therapy, the patient developed a solitary bone metastasis in the right 8th rib. Due to positive mutation of epidermal growth factor receptor (EGFR) exon 21 L858R in the primary cancer, the patient received osimertinib monotherapy, leading to massive calcification of the osteolytic bone metastasis with significant decrease of standard uptake value on positron emission tomography. After 12 months of osimertinib monotherapy, slight enlargement of the ground glass nodule, i.e., presumed noninvasive lung cancer, in the right upper lobe, and no further occurrence of metastatic foci made us to resect both the lung nodule and the bone metastasis. Pathological examination showed the lung nodule to be noninvasive adenocarcinoma and the bone metastasis to have no viable cancer cells. The patient was discharged on the 8th postoperative day without any complication. On developing a therapeutic strategy for advanced/recurrent EGFR mutation-positive lung adenocarcinoma, oncologists should note the possibility of pathological complete response to newly developed EGFR tyrosine kinase inhibitors including osimertinib for a presumed cure of oligometastatic lung adenocarcinoma.

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Right diaphragm metastasis of endometrial cancer: a case report

Journal of International Medical Research ◽

10.1177/0300060520961706 ◽

2020 ◽

Vol 48 (10) ◽

pp. 030006052096170

Author(s):

Tianyu Zhang ◽

Xiao Li ◽

Ganwei Liu ◽

Xiuyuan Chen ◽

Yanguo Liu

Keyword(s):

Lung Cancer ◽

Endometrial Cancer ◽

Endometrial Carcinoma ◽

Mediastinal Tumor ◽

Pathological Examination ◽

Curative Surgery ◽

Malignant Thymoma ◽

Anterior Mediastinal Tumor ◽

The Right ◽

Diaphragmatic Tumor

A diaphragmatic tumor is usually caused by metastasis from lung cancer, malignant mesothelioma, and malignant thymoma. Endometrial cancer is rarely involved in metastasis to the diaphragm. A right anterior mediastinal tumor was found in a 60-year-old woman who was initially diagnosed with endometrial carcinoma. There was initially no relationship between the right anterior mediastinal tumor and endometrial carcinoma. Radical curative surgery was performed for endometrial carcinoma. The endometrial carcinoma stage was IA. The patient was admitted to the Department of Thoracic Surgery 6 months after the curative surgery. Intraoperative exploration showed a tumor growing in the right diaphragm. Right diaphragmotomy was performed. Immunohistochemistry showed metastasis of endometrial carcinoma to the diaphragm. Endometrial cancer solitary metastasis to the diaphragm is rare. Clinicians should be aware of this possibility. Surgical treatment followed by a pathological examination is the most useful method for determining the diagnosis of a diaphragmatic tumor due to metastasis of endometrial cancer.

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Metastatic pulmonary adenocarcinoma to the nasopharynx at first clinical presentation: A case report and review of literature

SAGE Open Medical Case Reports ◽

10.1177/2050313x20939826 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2093982

Author(s):

Shahad Iqneibi ◽

Jamil Nazzal ◽

Runa Amoudi ◽

Basma Owda ◽

Akram Al-Ibraheem ◽

...

Keyword(s):

Left Lung ◽

Cancer Control ◽

Metastatic Carcinoma ◽

Pulmonary Adenocarcinoma ◽

Review Of Literature ◽

Thyroid Transcription Factor 1 ◽

Positron Emission ◽

Recurrent Epistaxis ◽

Poorly Differentiated ◽

The Right

Metastatic carcinomas in the nasopharynx are a rarity. We report a case of a 54-year-old male patient who presented with a history of recurrent epistaxis. On evaluation, a mass in the right Rosenmüller fossa was detected, which was biopsied and diagnosed as a poorly differentiated adenocarcinoma, immunoreactive for thyroid transcription factor-1, consistent with metastatic pulmonary adenocarcinoma. Fluorodeoxyglucose–positron emission tomography/computed tomography (FDG-PET/CT) scan confirmed the presence of a mass in the upper lobe of the left lung, proven pathologically to be a poorly differentiated pulmonary adenocarcinoma, with an immunoprofile similar to the nasopharyngeal tumor. The patient underwent palliative chemotherapy, and was then shifted to immunotherapy. He is currently alive and disease free 50 months after the initial diagnosis was made. The unusual presentation of a metastatic carcinoma in the nasopharynx will be discussed, along with a review of literature. The role of immunotherapy in cancer control and greater longevity will also be presented.

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