scholarly journals Metastatic pulmonary adenocarcinoma to the nasopharynx at first clinical presentation: A case report and review of literature

2020 ◽  
Vol 8 ◽  
pp. 2050313X2093982
Author(s):  
Shahad Iqneibi ◽  
Jamil Nazzal ◽  
Runa Amoudi ◽  
Basma Owda ◽  
Akram Al-Ibraheem ◽  
...  
Keyword(s):  
Left Lung ◽  
Cancer Control ◽  
Metastatic Carcinoma ◽  
Pulmonary Adenocarcinoma ◽  
Review Of Literature ◽  
Thyroid Transcription Factor 1 ◽  
Positron Emission ◽  
Recurrent Epistaxis ◽  
Poorly Differentiated ◽  
The Right

Metastatic carcinomas in the nasopharynx are a rarity. We report a case of a 54-year-old male patient who presented with a history of recurrent epistaxis. On evaluation, a mass in the right Rosenmüller fossa was detected, which was biopsied and diagnosed as a poorly differentiated adenocarcinoma, immunoreactive for thyroid transcription factor-1, consistent with metastatic pulmonary adenocarcinoma. Fluorodeoxyglucose–positron emission tomography/computed tomography (FDG-PET/CT) scan confirmed the presence of a mass in the upper lobe of the left lung, proven pathologically to be a poorly differentiated pulmonary adenocarcinoma, with an immunoprofile similar to the nasopharyngeal tumor. The patient underwent palliative chemotherapy, and was then shifted to immunotherapy. He is currently alive and disease free 50 months after the initial diagnosis was made. The unusual presentation of a metastatic carcinoma in the nasopharynx will be discussed, along with a review of literature. The role of immunotherapy in cancer control and greater longevity will also be presented.

scholarly journals Primary mucosal malignant melanoma of the nasal cavity

2020 ◽  
Vol 6 (5) ◽  
pp. 988
Author(s):  
Subrata Mukhopadhyay ◽  
Misbahul Haque
Keyword(s):  
Computed Tomography ◽  
Malignant Melanoma ◽  
Nasal Cavity ◽  
Maxillary Antrum ◽  
Positron Emission ◽  
Recurrent Epistaxis ◽  
Mucosal Malignant Melanoma ◽  
The Right ◽  
Primary Mucosal Malignant Melanoma ◽  
Enhanced Computed Tomography

<p>Primary mucosal melanoma of the nasal cavity and paranasal sinuses is a very aggressive and rare disease with only about 0.5 % of malignant melanoma arising from the nasal cavity. There are only few reports from India. We report a rare case of sino-nasal mucosal malignant melanoma in a 58 years old female who presented with blackish coloured sino-nasal mass involving right nasal cavity, spontaneous and recurrent epistaxis and obliteration of the right naso-labial fold with occasional pain in the past 10 months. Contrast enhanced computed tomography scan showed a heterogenous mass involving right nasal cavity, right maxillary antrum and right ethmoidal area. A positron emission tomography computed tomography was also done which showed increased uptake in the region mentioned above. Initial biopsy, the mass was diagnosed as malignant melanoma. Total maxillectomy was performed with plan of post-operative radiotherapy.</p>

Double primary malignant tumor in a centenarian female: Case report and review of literature

2019 ◽  
Vol 11 (2) ◽  
pp. 223-226
Author(s):  
Ankur K Shrivastava ◽  
Siddhartha Nanda
Keyword(s):  
Cell Carcinoma ◽  
Malignant Tumor ◽  
Review Of Literature ◽  
Upper Eyelid ◽  
Primary Malignant Tumor ◽  
Female Case ◽  
Multiple Primary ◽  
Poorly Differentiated ◽  
Time Gap ◽  
The Right

A hundred and three year old female patient was evaluated for ulcer over the nasion area and a mass arising from the right upper eyelid, appearing two months apart. Histopathology revealed nasion ulcer as basal cell carcinoma while right eyelid mass was diagnosed as poorly differentiated squamous cell carcinoma. Based on these findings and the time gap between two lesions a diagnosis of synchronous double primary malignant tumor was made. Although the prevalence of multiple primary malignant tumor is highest in breast, colo-rectum and prostate cancer we report a rare case of double primary malignant tumor of the eyelid and nasion in a centenarian female.

Quantification of regional V/Q ratios in humans by use of PET. II. Procedure and normal values

1989 ◽  
Vol 66 (4) ◽  
pp. 1905-1913 ◽  
Author(s):  
C. G. Rhodes ◽  
S. O. Valind ◽  
L. H. Brudin ◽  
P. E. Wollmer ◽  
T. Jones ◽  
...  
Keyword(s):  
Left Lung ◽  
Normal Subjects ◽  
Slice Thickness ◽  
Dependent Lung ◽  
Quiet Breathing ◽  
Mean Values ◽  
Positron Emission ◽  
Supine Posture ◽  
Quantitative Manner ◽  
The Right

Regional measurements of tissue isotope concentration, made using positron emission tomography (PET), allow tracer models to be used in a quantitative manner to provide topographic distributions of many structural and functional parameters, each derived for the same well-defined lung element. In this paper we describe a technique to measure regional ventilation-perfusion ratios (V/Q), in absolute units, by use of PET and the continuous intravenous infusion of an inert gas isotope, 13N, and report on measurements made in 12 normal subjects (4 smokers). Data were obtained from a single lung section (slice thickness, 1.7 cm full width at half-maximum response to a line source) at the level of the right ventricle in the supine posture during quiet breathing. For the 12 subjects, volume-weighted mean values of V/Q, averaged over individual right and left lung fields, ranged from 0.50 to 1.29. Analysis of these means showed no difference between lungs: right, 0.80 +/- 0.23 SD; left, 0.76 +/- 0.20 SD. Topographically, a systematic fall of V/Q in the ventrodorsal direction was observed in eight of the subjects (mean ventrodorsal difference 0.39, range 0.19–0.90), whereas two showed a clear increase toward dependent lung regions (range 0.16–0.26). Seven of the subjects with a falling ventrodorsal V/Q gradient also exhibited discrete regions of low V/Q at the dorsal lung border. We conclude that, in normal subjects, ventilation and perfusion are generally well matched in the supine posture, but isolated mismatching often occurs in dependent lung regions.

scholarly journals Renal pelvis metastasis from lung cancer with extension of renal venous thrombus: a case report and literature review

2020 ◽  
Author(s):  
Shengjiang Bai ◽  
Li Lai ◽  
Ming Shi ◽  
Hang Xu ◽  
Haoran Lei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Renal Pelvis ◽  
Nsclc Patient ◽  
Left Lung ◽  
Treatment Strategies ◽  
Venous Invasion ◽  
Metastatic Carcinoma ◽  
Venous Thrombus ◽  
First Case ◽  
The Right

Abstract Background Non-Small Cell Lung Cancer (NSCLC) rarely metastases to the renal pelvis, especially with renal venous tumor thrombus, we presented the first case of a NSCLC patient with renal pelvis metastasis and renal venous invasion.Case presentation A 50-year-old man was referred to the thoracic facility after experiencing a healthy examination revealing solitary pulmonary mass in the left lung, he received surgery of left upper lobe resection and hilar and mediastinal lymph nodes dissection at our hospital in June 2016. Postoperative histopathologic diagnosis was NSCLC (pT3N0M0), and regular follow-up was performed after operation. After eighteen months, he was referred to the urology facility complaining of visible hematuria and pain in the right waist. Abdominal enhanced computed tomography (CT) indicated a neoplasm in the right renal pelvis, and filling coloboma could be seen in the right renal vein during the CT enhancement period. Simultaneously two nodules were found in his right lung. He received radical nephrectomy (RN) for the right kidney and removal of renal venous thrombus in December 2017. The neoplasm occupying the right pelvis and the solid ingredient occupying the right renal venous lumen were histologically considered as a metastatic carcinoma from the NSCLC. Icotinib Hydrochloride Tablets were adminstrated to treat nodules in the right lung since the RN. According to the last re-examination in March 2020, the efficacy was evaluated as partial remission.Conclusions Renal venous invasion of renal tumor not only occurs in renal cell carcinoma (RCC) and upper urinary tract urothelial carcinoma (UTUC), but also can be seen in the state of metastasis. Acquiring correct preoperative diagnosis is of great importance in determining proper treatment strategies. Besides, the aggressive RN for patients suffering advanced metastatic carcinoma of renal pelvis is safe under perfect perioperative management and favorable to treat metastatic carcinoma in other sites.

Inflammatory Sarcomatoid Carcinoma: A Case Report and Discussion of a Malignant Tumor With Benign Appearance

2005 ◽  
Vol 129 (10) ◽  
pp. 1334-1337 ◽  
Author(s):  
Tatjana Antic ◽  
Umesh Kapur ◽  
Wickii T. Vigneswaran ◽  
Kiyoko Oshima
Keyword(s):  
Frozen Section ◽  
Left Lung ◽  
Sarcomatoid Carcinoma ◽  
High Clinical Suspicion ◽  
Spindle Cell Proliferation ◽  
Epithelial Phenotype ◽  
History Of ◽  
Mixed Inflammatory Infiltrate ◽  
Poorly Differentiated ◽  
The Right

Abstract Inflammatory sarcomatoid carcinoma is an aggressive tumor with an unusually benign appearance. We report the case of a 65-year-old man with a history of inoperable poorly differentiated carcinoma of the right lung, for which he had received chemoradiotherapy. A new solitary mass was discovered 4 years later in the left lung on surveillance computed tomography. The patient underwent thoracotomy with a wedge biopsy on which frozen section was performed. The nodule was vaguely granulomatous and associated with a mixed inflammatory infiltrate and a deceptively bland spindle cell proliferation. Results of immunoperoxidase studies, however, showed that the nodule contained neoplastic cells with an epithelial phenotype that were invading the pulmonary vessels. These are features of the rare inflammatory sarcomatoid carcinoma. In contrast to sarcomatoid carcinomas, this case highlights the deceptively benign appearance of inflammatory sarcomatoid carcinoma. This leads us to concur with the recommendation to exercise caution when attempting the diagnosis of apparently benign lesions on intraoperative frozen section in patients with high clinical suspicion of malignancy.

An Unusual Case of Three Synchronous Tumors in a Young Woman

2005 ◽  
Vol 91 (3) ◽  
pp. 267-269 ◽  
Author(s):  
Raffaele Longo ◽  
Guido Carillio ◽  
Antonietta Torrisi ◽  
Maria Pia Tocco ◽  
Giovanni Battista Grassi ◽  
...  
Keyword(s):  
Left Lung ◽  
Wide Resection ◽  
Clear Correlation ◽  
Caucasian Woman ◽  
Synchronous Tumors ◽  
Sclerosing Hemangioma ◽  
Positron Emission ◽  
Chest X Ray ◽  
The Right

The occurrence in the same young patient of three synchronous tumors deriving from different embryogenic tissues and without a clear correlation with a common etiopathogenic factor is very unusual. We report a case of a Caucasian woman submitted to wide resection of a large retroperitoneal liposarcoma and right radical nephrectomy for suspected tumor infiltration. Histological examination of the right ureter and renal pelvis showed the presence of a multifocal urothelial carcinoma that was clinically asymptomatic. Two months later, during follow-up, chest X-ray and computed tomography documented a coin lesion of the upper left lung, confirmed by positron emission tomography. This nodule was surgically removed and examined histologically, resulting in a diagnosis of sclerosing hemangioma. The patient is alive without evidence of recurrent disease.

scholarly journals A Poorly Differentiated Pulmonary Squamous Cell Carcinoma in a Free-Ranging Atlantic Bottlenose Dolphin (Tursiops Truncatus)

2003 ◽  
Vol 15 (2) ◽  
pp. 162-165 ◽  
Author(s):  
Ruth Y. Ewing ◽  
Antonio A. Mignucci-Giannoni
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bottlenose Dolphin ◽  
Tursiops Truncatus ◽  
Left Lung ◽  
Mesothelial Cell ◽  
Thyroid Transcription Factor 1 ◽  
Poorly Differentiated ◽  
Free Ranging

A free-ranging, adult, female offshore bottlenose dolphin ( Tursiops truncatus) was found freshly dead in 1999 on Ocean Park Beach in San Juan, Puerto Rico. The left-lung and right-lung pleura had multiple white, firm-to-hard nodules with coagulative necrosis. Histologically, the neoplasms were characterized by multiple well-circumscribed, nonencapsulated expansile masses consisting mostly of polygonal cells with fewer circumferential flattened basaloid cells that compressed alveoli, bronchioles, and bronchi. Neoplastic cells stained positive for cytokeratin, with sporadic vimentin staining, and were negative for epithelial membrane antigen, thyroid transcription factor-1, calretinin, and human mesothelial cell antigen. A diagnosis of poorly differentiated pulmonary squamous cell carcinoma with lymph node and renal metastases was made on the basis of histomorphology and immunohistochemical staining. This is the first documentation of pulmonary squamous cell carcinoma in a dolphin.

scholarly journals Intestinal obstruction caused by neoplasms in two cows

2016 ◽  
Vol 46 (7) ◽  
pp. 1252-1255
Author(s):  
Antônio Carlos Lopes Câmara ◽  
Márcio Botelho de Castro ◽  
Eraldo Barbosa Calado ◽  
Benito Soto-Blanco
Keyword(s):  
Intestinal Obstruction ◽  
Clinical Signs ◽  
Abdominal Distension ◽  
Metastatic Carcinoma ◽  
Pathological Examination ◽  
Ovarian Teratoma ◽  
Abdominal Tumors ◽  
Poorly Differentiated ◽  
The Right ◽  
Crossbred Cow

ABSTRACT: In cattle, abdominal tumors leading to partial or total intestinal obstruction are rare. Here, it is described the clinico-pathological findings of two cows with intestinal obstruction by neoplasms. A crossbred cow presented apathy, weight loss, constipation, enophthalmos, ruminal and intestinal hypomotility, and abdominal distension in the right ventral quadrant. Pathological examination revealed bilateral ovarian teratoma. The other case was a cow that in the past 2 years had several episodes of squamous cell carcinoma in the third eyelid and vulva. During the 6 days prior to investigation, clinical signs of constipation and tenesmus were noted. Nodular and friable masses were located in the vulva, right third eyelid and cranially to the right kidney that were identified as poorly differentiated metastatic carcinoma of the adrenal cortex. To our knowledge, these are probably the first reports of ovarian teratoma and adrenal carcinoma causing clinical signs of intestinal obstruction in cattle.

scholarly journals A 60 Years Old Man with Adenocarcinoma of Colon and Lung with an Isolated Adrenal Metastasis: A Case Report

2021 ◽  
Vol 9 (1) ◽  
pp. 30-37
Author(s):  
Netay Kumer Sharma ◽  
Sankar Narayan Dey ◽  
Md Masudur Rahman ◽  
Mahzabeen Islam ◽  
- Mukthadira ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radical Resection ◽  
Metastatic Carcinoma ◽  
Adrenal Metastasis ◽  
Pathological Examination ◽  
Ascending Colon ◽  
Postoperative Adjuvant Chemotherapy ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
The Right

The incidence of synchronous colorectal and lung cancer associated with adrenal metastasis is relatively rare. We report of patient with tumour located in the right colic flexure adjoining ascending colon, mid and partly upper lobe of right lung. Pathological examination showed the colorectal and lung cancer were poorly differentiated adenocarcinoma. Right adrenal mass was adrenocortical metastatic carcinoma. Surgical treatment and postoperative adjuvant chemotherapy for the lung cancer were different from those for colorectal cancer with pulmonary metastasis. If possible, radical resection should be performed for each cancer when synchronicity is found. CBMJ 2020 January: Vol. 09 No. 01 P: 30-37

SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Review of Literature

2019 ◽  
Vol 28 (1) ◽  
pp. 102-108 ◽  
Author(s):  
Brian D. Stewart ◽  
Frederic Kaye ◽  
Tiago Machuca ◽  
Hiren J. Mehta ◽  
Tan-Lucien Mohammed ◽  
...  
Keyword(s):  
Genetic Alterations ◽  
Care Physician ◽  
Smoking History ◽  
Review Of Literature ◽  
Heavy Smoking ◽  
Pulmonary Parenchyma ◽  
Poorly Differentiated ◽  
The Right ◽  
Time Of Presentation ◽  
Generation Sequencing

SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently described entity with a poor prognosis that is defined by certain genetic alterations in the BAF chromatin remodeling complex, specifically SMARCA4 and SMARCA2. We present a case of a SMARCA4-DTS in a 59 year-old male with a heavy smoking history who was found to have an unexpected right upper lobe lung mass on routine chest radiograph after a visit to his primary care physician. This led to a biopsy with a diagnosis of poorly differentiated carcinoma at an outside institution. The patient was subsequently seen at our facility for surgical intervention. The right upper lobectomy contained a 7.2-cm poorly differentiated malignancy with slightly discohesive cells arranged in sheets and nests, abundant geographic necrosis, and with many areas showing rhabdoid morphology. The tumor was focally reactive for CK7, AE1/3, Cam5.2, and SALL4 and showed scattered reactivity for CD34 and SOX2. There was complete loss of reactivity for both SMARCA4 and SMARCA2. The histology and immunophenotype were all consistent with the diagnosis of a SMARCA4-DTS. Next-generation sequencing showed a frameshift mutation in the SMARCA4 gene and no abnormality with the SMARCA2 gene. Interestingly, this tumor was confined to the pulmonary parenchyma with no invasion of the visceral pleura nor the mediastinum and with no clinically apparent metastases at the time of presentation. This case is presented to add to the cohort of cases described to date and to discuss the immunohistochemical and molecular findings with regard to SMARCA2.

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